Paraptosis and Photodynamic Therapy: A Progress Report.

Abstract:

:Photodamage to the endoplasmic reticulum (ER) can initiate a death pathway termed paraptosis. The "canonical" model of paraptosis, initiated by certain drugs and other stimuli, requires a brief interval of protein synthesis, involves the action of MAP kinases and can be followed by biochemical markers. The latter include changes in expression of AIP-1/Alix and IGF-1R proteins and translocation of HMGB-1 from nucleus to plasma membrane. There is also a report indicating that an enhanced level of autophagy can impair death by paraptosis. The pathway to paraptosis follows the canonical pathway when ER photodamage is minor (

journal_name

Photochem Photobiol

authors

Kessel D

doi

10.1111/php.13242

subject

Has Abstract

pub_date

2020-09-01 00:00:00

pages

1096-1100

issue

5

eissn

0031-8655

issn

1751-1097

journal_volume

96

pub_type

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