Photodynamic activity of substituted zinc trisulfophthalocyanines: role of plasma membrane damage.

abstract：:Photobiomodulation therapy (PBMT) has anti-inflammatory, analgesic and regenerative properties. This systematic review aimed to critically appraise the published data of in vivo human randomized clinical trials (RCTs), and present a comprehensive overview of the efficacy of PBMT, as an adjunct to the nonsurgical perio...

journal_title：Photochemistry and photobiology

authors： Dalvi S,Benedicenti S,Hanna R

更新日期：2020-10-24 00:00:00

abstract：:Advanced glycation endproducts (AGEs) have been suggested as photosensitizers that are capable of mediating eye lens photo-damage during aging. In the present work, we investigate the photo-crosslinking and oxidation of bovine lens proteins sensitized by AGEs, with special regard to low oxygen conditions. A mechanisti...

journal_title：Photochemistry and photobiology

authors： Fuentealba D,Friguet B,Silva E

更新日期：2009-01-01 00:00:00

abstract：:Evidence is mounting that UV-B and UV-A radiation affect skin differently in responses as diverse as erythema and elastosis. We found in this study that collagen metabolism was also differentially affected. Albino hairless mice were irradiated with two UV-A sources: (1) UVASUN 3000 (340-400 nm) for cumulative exposure...

journal_title：Photochemistry and photobiology

authors： Kligman LH,Gebre M

更新日期：1991-08-01 00:00:00

abstract：:Efficient phagocytosis of photoreceptor outer segments (POS) membranes by retinal pigment epithelium (RPE) plays a key role in biological renewal of these highly peroxidizable structures. Here, we tested whether photodynamic treatment, mediated by merocyanine 540 (MC 540), rose Bengal or a zinc-substituted chlorophyll...

journal_title：Photochemistry and photobiology

authors： Olchawa M,Szewczyk G,Zareba M,Piłat A,Bzowska M,Mikołajczyk T,Sarna T

更新日期：2010-07-01 00:00:00

abstract：:The progressive loss of visual faculties with advancing age is attributed, sometimes, mainly to allegedly inevitable optical deterioration, such as clouding of the media, or again to neurosenescence, as typified by cell-death. The relevant factors are assessed, and it is not thought likely that changes in normal ocula...

journal_title：Photochemistry and photobiology

authors： Weale RA

更新日期：1989-09-01 00:00:00

abstract：:Cypridina luciferase (Cluc), a secreted luminescent protein identified from Cypridina noctiluca, has two N-glycosylation sites. In this study, we evaluated the effects of N-glycosylation on Cluc properties by creating site-directed mutagenic modifications at the consensus sequence for N-glycosylation (Asn-X-Ser/Thr). ...

journal_title：Photochemistry and photobiology

authors： Yasuno R,Mitani Y,Ohmiya Y

更新日期：2018-03-01 00:00:00

abstract：:Although histochemical and immunohistochemical methods are the standard procedures in diagnosis of lymphoproliferative disorders, useful improvements in evidencing histopathologic manifestations can be obtained with the introduction of tissue autofluorescence analyses. We used microspectrofluorometry and a Multispectr...

journal_title：Photochemistry and photobiology

authors： Rigacci L,Alterini R,Bernabei PA,Ferrini PR,Agati G,Fusi F,Monici M

更新日期：2000-06-01 00:00:00

abstract：:The proton channels of the bacteriorhodopsin (BR) proton pump contain bound water molecules. The channels connect the purple membrane surfaces with the protonated retinal Schiff base at the membrane center. Films of purple membrane equilibrated at low relative humidity display a shift of the 570 nm retinal absorbance ...

journal_title：Photochemistry and photobiology

authors： Renthal R,Gracia N,Regalado R

更新日期：2000-11-01 00:00:00

abstract：:Synovial sarcoma (SS) is one of common malignant soft-tissue tumors and is encountered most commonly in children and young adults. It frequently involves or invades major neurovascular structures and bones, and its local recurrence rate after simple resection has been reported to be as high as up to 80%. Because major...

journal_title：Photochemistry and photobiology

authors： Kusuzaki K,Murata H,Matsubara T,Miyazaki S,Shintani K,Seto M,Matsumine A,Hosoi H,Sugimoto T,Uchida A

更新日期：2005-05-01 00:00:00

abstract：:Unidirectional blue light directs the rhizoid-thallus axis in the apolar zygote of the brown alga, Silvetia compressa. This effect is mediated by an increase in the intracellular concentration of guanosine 3', 5'-cyclic monophosphate. In this study we show the identification of a rhodopsin-like protein, by means of an...

journal_title：Photochemistry and photobiology

authors： Gualtieri P,Robinson KR

更新日期：2002-01-01 00:00:00

abstract：:In the present study, hypericin analogs with an increased hydrophilic character were synthesized. As chemical modifications alter the lipophilicity/hydrophilicity balance together with the photophysical/chemical background of the molecule the influence of these structural changes on the cellular uptake, retention and ...

journal_title：Photochemistry and photobiology

authors： Delaey EM,Obermuëller R,Zupkó I,De Vos D,Falk H,de Witte PA

更新日期：2001-08-01 00:00:00

abstract：:The tetraruthenated porphyrin, mu-[meso-5,10,15,20-tetra(pyridyl)porphyrin]tetrakis[bis-(bipyridine) chloride ruthenium(II)] (TRP) is a supramolecular cationic species. The aim of the present investigation was to evaluate the photodynamic properties of TRP and Zn-TRP to damage DNA with emphasis on the mechanistic aspe...

journal_title：Photochemistry and photobiology

authors： Ravanat JL,Cadet J,Araki K,Toma HE,Medeiros MH,Mascio PD

更新日期：1998-11-01 00:00:00

abstract：:Photodynamic therapy (PDT) with photosensitizer verteporfin is a clinically approved vascular disrupting modality that is currently in clinical trial for cancer treatment. In this study, we evaluated PDT in combination with either mTORC1 inhibitor rapamycin or mTORC1/C2 dual inhibitor AZD2014 for therapeutic enhanceme...

journal_title：Photochemistry and photobiology

authors： Kraus D,Palasuberniam P,Chen B

更新日期：2020-03-01 00:00:00

abstract：:Because metallothionein (MT) is elevated and may be protective in UV-irradiated skin, we have studied the effects of UV and other agents on MT transcription using the sheep MT 1A promoter, linked to the beta-galactosidase gene and stably transfected into human cell lines. beta-galactosidase reporter activity was induc...

journal_title：Photochemistry and photobiology

authors： Hansen C,Ablett E,Green A,Sturm RA,Dunn IS,Fairlie DP,West ML,Parsons PG

更新日期：1997-03-01 00:00:00

abstract：:The energy and oscillator strength of electronic transitions of chlorophyll (Chl)-amino acid complexes were calculated by using molecular orbital methods. The energies varied widely with coordinated amino acids and the difference between the maximum and minimum energy was about 830 cm-1. This energy difference was com...

journal_title：Photochemistry and photobiology

authors： Nishigaki A,Ohshima S,Nakayama K,Okada M,Nagashima U

更新日期：2001-03-01 00:00:00

abstract：:We have used the complex of antigen with class II major histocompatibility proteins (Ia) in membrane-bound form to target a phototoxic compound to antigen-specific T cell hybridomas in vitro. The iodoacetamidyl ester of phototoxic pyrene was bound covalently to antigen-presenting cells (APC), and protein antigens were...

journal_title：Photochemistry and photobiology

authors： Chang NH,Rayner DC,Boggs JM

更新日期：1995-05-01 00:00:00

abstract：:Leaf discs, enclosed in a photoacoustic (PA) chamber, generate two types of PA gas-uptake signals under certain conditions. Type I is manifested by a severe signal decrease that develops slowly under very low-light intensity and often reaches negative values. It is partially reversed by low-intensity far-red light. Ty...

journal_title：Photochemistry and photobiology

authors： Malkin S,Havaux M

更新日期：2001-10-01 00:00:00

abstract：:The interaction of photodynamic therapy (PDT) with 5-aminolevulinic acid (ALA) and hyperthermia is not well understood. In the present study, significant enhancement of tumor damage was observed after simultaneous application of ALA-PDT and IR-induced hyperthermia using a broad-band incoherent light source. One hour a...

journal_title：Photochemistry and photobiology

authors： Orenstein A,Kostenich G,Kopolovic Y,Babushkina T,Malik Z

更新日期：1999-06-01 00:00:00

abstract：:The multifunctional polypeptide cyclosporin synthetase (CySyn) remains one of the most complex nonribosomal peptide synthetase described. In this study we used a highly specific photoaffinity labeling procedure with the natural cofactor S-adenosyl-L-methionine (AdoMet), 14C-isotopically labeled at the Sdelta methyl gr...

journal_title：Photochemistry and photobiology

authors： Velkov T,Lawen A

更新日期：2003-02-01 00:00:00

abstract：:Drug delivery systems (DDS) capable of releasing an active molecule at the appropriate site and at a rate that adjusts in response to the progression of the disease or to certain functions/biorhythms of the organism are particularly appealing. Biocompatible materials sensitive to certain physiological variables or ext...

journal_title：Photochemistry and photobiology

authors： Alvarez-Lorenzo C,Bromberg L,Concheiro A

更新日期：2009-07-01 00:00:00

abstract：:The effect of netropsin on the oxidative reactions of duplex DNA was examined. One-electron oxidation of DNA creates a radical cation that migrates through duplex DNA and reacts primarily at GG steps. Netropsin is a dication that specifically binds primarily by hydrogen bonding in the minor groove at sites that have f...

journal_title：Photochemistry and photobiology

authors： Roberts LW,Schuster GB

更新日期：2004-11-01 00:00:00

abstract：:Cryptococus gattii is an emergent primary human pathogen that causes meningismus, papilledema, high intracranial pressure and focal involvement of the central nervous system in immunocompetent hosts. Prolonged antifungal therapy is the conventional treatment, but it is highly toxic, selects for resistant strains, cont...

journal_title：Photochemistry and photobiology

authors： Soares BM,Alves OA,Ferreira MV,Amorim JC,Sousa GR,Silveira Lde B,Prates RA,Avila TV,Baltazar Lde M,de Souza Dda G,Santos DA,Modolo LV,Cisalpino PS,Pinotti M

更新日期：2011-03-01 00:00:00

abstract：:We used GHz frequency-domain fluorometry to investigate the time-dependent intensity decays of N-acetyl-L-trytophanamide (NATA) when collisionally quenched by acrylamide in propylene glycol at 20 degrees C. The intensity decays of NATA became increasingly heterogeneous in the presence of acrylamide. The NATA intensity...

journal_title：Photochemistry and photobiology

authors： Lakowicz JR,Zelent B,Gryczynski I,Kuśba J,Johnson ML

更新日期：1994-09-01 00:00:00

abstract：:Chronic exposure of the gray, short-tailed oppossum, Monodelphis domestica to ultraviolet radiation (UVR) induces mesenchymal tumors of the cornea. High molecular weight DNA samples from 6 UVR-induced corneal tumors were assayed for their ability to transform NIH 3T3 cells to tumorigenicity. NIH 3T3 cells transfected ...

journal_title：Photochemistry and photobiology

authors： Sabourin CL,Freeman AG,Kusewitt DF,Ley RD

更新日期：1992-03-01 00:00:00

abstract：:The assessment model for ultraviolet radiation and risk "AMOUR" is applied to output from two chemistry-climate models (CCMs). Results from the UK Chemistry and Aerosols CCM are used to quantify the worldwide skin cancer risk avoided by the Montreal Protocol and its amendments: by the year 2030, two million cases of s...

journal_title：Photochemistry and photobiology

authors： van Dijk A,Slaper H,den Outer PN,Morgenstern O,Braesicke P,Pyle JA,Garny H,Stenke A,Dameris M,Kazantzidis A,Tourpali K,Bais AF

更新日期：2013-01-01 00:00:00

abstract：:Confocal laser microspectrofluorometric measurements on human T47D mammary tumor cells have been performed to assess the intracellular distribution of hypericin within the various cell compartments: cytoplasmic membrane, cytoplasm and nucleus. Confocal fluorescence measurements obtained from microvolumes (approximatel...

journal_title：Photochemistry and photobiology

authors： Miskovsky P,Sureau F,Chinsky L,Turpin PY

更新日期：1995-09-01 00:00:00

abstract：:A polyclonal, multispecific antiserum was raised against a whole 3[(3-cholamidopropyl)-dimethylammonio]-1-propanesulfonate-extract of nonirradiated Blepharisma japonicum cells. It was used to reveal the composition of solutions that were hypothesized to contain the photoreceptor of the ciliate. A Bio-Gel A 1.5 m fine ...

journal_title：Photochemistry and photobiology

authors： Podestà A,Gioffré D,Grossi T,Montagnoli G

更新日期：2000-05-01 00:00:00

abstract：:Ultraviolet radiation can inhibit immune responses locally as well as systemically. Such effects have been measured in animals and humans exposed to ultraviolet B (wavelength 280-315 nm) (UVB) and ultraviolet A (315-400 nm) (UVA). The precise wavelength dependence is important for the identification of possible molecu...

journal_title：Photochemistry and photobiology

authors： Garssen J,de Gruijl F,Mol D,de Klerk A,Roholl P,Van Loveren H

更新日期：2001-04-01 00:00:00

abstract：:Ultraviolet photolesions endow DNA with distinct structural and dynamic properties. Biophysical studies of photoproduct-containing DNA have shown that these lesions affect the mutagenic properties of DNA and damage recognition by DNA repair systems. Recently obtained high-resolution cocrystal structures of damaged DNA...

journal_title：Photochemistry and photobiology

authors： Park CJ,Lee JH,Choi BS

更新日期：2007-01-01 00:00:00

abstract：:The synthesis of some bromine-substituted rhodamine derivatives viz., 4,5-dibromorhodamine methyl ester (dye 2) and 4,5-dibromorhodamine n-butyl ester (dye 3) are reported. These dyes were synthesized to promote a more efficient cancer cell photosensitizer for potential use in in vitro bone marrow purging in preparati...

journal_title：Photochemistry and photobiology

authors： Pal P,Zeng H,Durocher G,Girard D,Li T,Gupta AK,Giasson R,Blanchard L,Gaboury L,Balassy A,Turmel C,Laperrière A,Villeneuve L

更新日期：1996-02-01 00:00:00