Abstract:
:Cyclooxygenase (COX)-2 inhibitors are known to be used as chemopreventative agents against certain malignancies. Thus far, there has been very limited information on whether COX-2 inhibitors protect against chronic narrow-band UVB (NB-UVB)-induced immunosuppression. The present study investigated the effect of nonselective and specific COX-2 inhibitors, indomethacin and celecoxib, on epidermal Ia+ Langerhans cells (LCs) and Thy-1+ dendritic epidermal T cells (DETCs) in mice irradiated with NB-UVB. Sixty female BALB/c mice were divided randomly into the control group (sham) and the experimental groups (irradiated with NB-UVB for 17 weeks, further divided into five groups according to the diets containing different concentrations of either COX-2 inhibitors). Alterations in the density and morphology of epidermal Ia+ LCs and Thy-1+ DETCs in mice were documented using fluorescence microscopy. Chronic NB-UVB irradiation substantially decreased the density and altered the morphology of the epidermal Ia+ LCs and Thy-1+ DETCs in control mice. The dietary supplementation of both COX-2 inhibitors displayed a dosage-dependent protective effect on the murine dendritic cells irradiated by NB-UVB. In conclusion, COX-2 inhibitors protected against chronic NB-UVB-induced density and morphologic changes in epidermal Ia+ LCs and Thy-1+ DETCs in mice.
journal_name
Photochem Photobioljournal_title
Photochemistry and photobiologyauthors
Wu Y,Tai CL,Wei H,He F,Wang Y,Zhao Y,Chen HDdoi
10.1111/j.1751-1097.2007.00289.xsubject
Has Abstractpub_date
2008-03-01 00:00:00pages
484-8issue
2eissn
0031-8655issn
1751-1097pii
PHP289journal_volume
84pub_type
杂志文章abstract::Photo-Fries rearrangements of 4-dodecylphenyl phenylacetate have been investigated in polyethylene films with 0-71% crystallinity and in hexane over a range of temperatures. The results are compared to those reported previously from phenyl phenylacetate and 1-naphthyl tetradecanoate to assess the influence of a long a...
journal_title:Photochemistry and photobiology
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doi:10.1562/2005-05-26-RA-546
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journal_title:Photochemistry and photobiology
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1111/j.1751-1097.1993.tb09575.x
更新日期:1993-09-01 00:00:00
abstract::Accurate determination of the diurnal variability and daily insolation of surface (0(+) ) and subsurface (0(-) ) irradiance are essential to estimate several physical, chemical and biological processes occurring at the surface layer of marine environments. Natural downwelling PAR and spectral UVR were examined on eigh...
journal_title:Photochemistry and photobiology
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doi:10.1111/php.12474
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abstract::Multichromophoric dyes for use in tumor imaging have been synthesized and photophysically characterized. Structurally, these dyes are dyads and triads that consist of one or two carotenoid polyenes covalently attached to hematoporphyrin (HP) or hematoporphyrin dimethyl ester (HPDME) moieties via ester linkages. The gr...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:
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abstract::Photodynamic therapy (PDT) is an established therapeutic modality that uses nonionizing near-infrared light to activate photocytotoxicity of endogenous or exogenous photosensitizers (PSs). An ongoing avenue of cancer research involves leveraging PDT to stimulate antitumor immune responses; however, these effects appea...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:
更新日期:1998-08-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
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pub_type: 杂志文章
doi:10.1562/0031-8655(2001)074<0712:iosnri>2.0.co;2
更新日期:2001-11-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1111/j.1751-1097.2008.00424.x
更新日期:2008-11-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1111/j.1751-1097.1993.tb09588.x
更新日期:1993-09-01 00:00:00
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pub_type: 杂志文章
doi:10.1111/j.1751-1097.1997.tb03236.x
更新日期:1997-12-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1111/j.1751-1097.1985.tb01642.x
更新日期:1985-01-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 信件
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更新日期:2019-11-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1111/j.1751-1097.1989.tb09204.x
更新日期:1989-04-01 00:00:00
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journal_title:Photochemistry and photobiology
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更新日期:2001-10-01 00:00:00
abstract::Excessive sun exposure can cause sunburn, suntan, skin photoaging, and even skin cancer. Skin photoaging conflicts with the human pursuit of a young and beautiful appearance. Some research data indicate that the incidence of skin cancer in the Chinese has been increasing, although it remains lower than in whites. To e...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
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更新日期:2018-09-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/2005-09-28-ra-700
更新日期:2006-07-01 00:00:00
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journal_title:Photochemistry and photobiology
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更新日期:2006-01-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1111/j.1751-1097.1990.tb04194.x
更新日期:1990-08-01 00:00:00
abstract::Direct irradiation of estrone aryl and methyl sulfonates in different organic solvents under nitrogen atmosphere was investigated under steady-state conditions. The estrone derivatives reacted efficiently through the photo-Fries rearrangement reaction involving [1;3]-sulfonyl migration providing the ortho-sulfonyl est...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
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更新日期:2021-01-01 00:00:00
abstract::Skin cancer is the most prevalent cancer, and its assessment remains a challenge for physicians. This study reports the application of an optical sensing method, elastic scattering spectroscopy (ESS), coupled with a classifier that was developed with machine learning, to assist in the discrimination of skin lesions th...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
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更新日期:2019-11-01 00:00:00
abstract::The progressive loss of visual faculties with advancing age is attributed, sometimes, mainly to allegedly inevitable optical deterioration, such as clouding of the media, or again to neurosenescence, as typified by cell-death. The relevant factors are assessed, and it is not thought likely that changes in normal ocula...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章,评审
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更新日期:1989-09-01 00:00:00
abstract::Polarized steady-state fluorescence and fluorescence excitation spectra as well as time-resolved fluorescence for B-phycoerythrin (B-PE) from red algae, Porphyridium cruentum, embedded in polyvinyl stretched films were measured. The lifetimes of polarized fluorescence were analyzed using exponential components and fra...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:
更新日期:2004-01-01 00:00:00
abstract::The efficacy of photodynamic therapy (PDT) depends upon the amount of photosensitizer accumulated in the malignant tissues. Radachlorin is a popular photosensitizer used in photodynamic therapy to treat various types of cancer. In this study, we have studied the main organelles responsible for the accumulation of rada...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1111/php.12273
更新日期:2014-09-01 00:00:00