Abstract:
:Liposomes were prepared from mixtures of dipalmitoyl-L-alpha-phosphatidylcholine and up to 40% mol:mol of N-stearoyl-L-histidine (NSH) in the presence of the hydrophobic sensitizer DHE. In the dark such liposomes are stable and retain entrapped salts. On photolysis with visible light, liposomes leak trapped ions at NSH concentrations greater than 10% mol:mol. Up to 15% mol:mol NSH concentration leakage is seen only during the illumination period, whereas at higher concentration the liposomes continue to leak contents after illumination and fuse to form larger structures. Photolysis of the liposomes is accompanied by oxygen uptake in proportion to the NSH concentration within the bilayer. Photocontrol of liposome permeability through oxidation of membrane additives such as NSH offers a potential means for controlled drug delivery and might be useful as an adjunct to photodynamic therapy.
journal_name
Photochem Photobioljournal_title
Photochemistry and photobiologyauthors
Chowdhary RK,Green CA,Morgan CGdoi
10.1111/j.1751-1097.1993.tb09575.xsubject
Has Abstractpub_date
1993-09-01 00:00:00pages
362-6issue
3eissn
0031-8655issn
1751-1097journal_volume
58pub_type
杂志文章abstract::Fibrous proteins discolor on exposure to the UV component of sunlight. This effect is exacerbated in the presence of fluorescent whitening agents (FWAs), which are often applied to textiles to improve product brightness. Tryptophan photoproducts have been identified as significant contributors to protein photoyellowin...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
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更新日期:2009-11-01 00:00:00
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journal_title:Photochemistry and photobiology
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journal_title:Photochemistry and photobiology
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pub_type: 杂志文章
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更新日期:2020-11-01 00:00:00
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pub_type: 杂志文章
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章,评审
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journal_title:Photochemistry and photobiology
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
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更新日期:2017-07-01 00:00:00
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pub_type: 杂志文章,评审
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更新日期:1989-09-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:
更新日期:2000-04-01 00:00:00
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journal_title:Photochemistry and photobiology
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更新日期:1993-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1990-04-01 00:00:00
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更新日期:1990-05-01 00:00:00
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更新日期:2004-11-01 00:00:00