Dye-sensitized destabilization of liposomes bearing photooxidizable lipid head groups.

Abstract:

:Liposomes were prepared from mixtures of dipalmitoyl-L-alpha-phosphatidylcholine and up to 40% mol:mol of N-stearoyl-L-histidine (NSH) in the presence of the hydrophobic sensitizer DHE. In the dark such liposomes are stable and retain entrapped salts. On photolysis with visible light, liposomes leak trapped ions at NSH concentrations greater than 10% mol:mol. Up to 15% mol:mol NSH concentration leakage is seen only during the illumination period, whereas at higher concentration the liposomes continue to leak contents after illumination and fuse to form larger structures. Photolysis of the liposomes is accompanied by oxygen uptake in proportion to the NSH concentration within the bilayer. Photocontrol of liposome permeability through oxidation of membrane additives such as NSH offers a potential means for controlled drug delivery and might be useful as an adjunct to photodynamic therapy.

journal_name

Photochem Photobiol

authors

Chowdhary RK,Green CA,Morgan CG

doi

10.1111/j.1751-1097.1993.tb09575.x

subject

Has Abstract

pub_date

1993-09-01 00:00:00

pages

362-6

issue

3

eissn

0031-8655

issn

1751-1097

journal_volume

58

pub_type

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