Cancer Cell-targeted and Activatable Photoimmunotherapy Spares T Cells in a 3D Coculture Model.

abstract：:Although the first reactive oxygen species (ROS) formed during irradiation of photosensitized cells is almost invariably singlet molecular oxygen (1O2), other ROS have been implicated in the phototoxic effects of photodynamic therapy (PDT). Among these are superoxide anion radical (*O2(-)), hydrogen peroxide (H2O2) an...

journal_title：Photochemistry and photobiology

authors： Price M,Terlecky SR,Kessel D

更新日期：2009-11-01 00:00:00

abstract：:We studied the effect on the intraocular pressure (IOP) and the ciliary body (CB) morphology after four consecutive contact transcleral photodynamic treatments of the ciliary body (CB-PDT) with verteporfin in pigmented rabbits. Twenty-two pigmented rabbits underwent CB-PDT (study group), performed once (six rabbits) o...

journal_title：Photochemistry and photobiology

authors： Charisis SK,Naoumidi II,Ginis HS,Detorakis ET,Tsilimbaris MK

更新日期：2010-01-01 00:00:00

abstract：:SV40 DNA was irradiated in vitro and in vivo with UV-C (240-280 nm) and UV-B (280-320 nm) light, and damaged sites sensitive to digestion with Escherichia coli endonuclease III (endo III) and bacteriophage T4 endonuclease V (endo V) were quantified. The frequency of endo III-sensitive sites (primarily cytosine photohy...

journal_title：Photochemistry and photobiology

authors： Mitchell DL,Jen J,Cleaver JE

更新日期：1991-11-01 00:00:00

abstract：:This review deals with the biophysical aspects of flavin-based photosensors, comprising cryptochromes, LOV (Light, Oxygen and Voltage) and BLUF (Blue Light sensing Using FAD) proteins. Special emphasis is given to structural issues, photocycle quantum yields and energetics, mechanism of the light-triggered reactions, ...

journal_title：Photochemistry and photobiology

authors： Losi A

更新日期：2007-11-01 00:00:00

abstract：:Although histochemical and immunohistochemical methods are the standard procedures in diagnosis of lymphoproliferative disorders, useful improvements in evidencing histopathologic manifestations can be obtained with the introduction of tissue autofluorescence analyses. We used microspectrofluorometry and a Multispectr...

journal_title：Photochemistry and photobiology

authors： Rigacci L,Alterini R,Bernabei PA,Ferrini PR,Agati G,Fusi F,Monici M

更新日期：2000-06-01 00:00:00

abstract：:An approximate formula for the UV Index (UVI) under cloud-free, unpolluted, low surface albedo conditions is: UVI approximately 12.5mu(o)(2.42)(Omega/300)(-1.23) where mu(o) is the cosine of the solar zenith angle and Omega is the total vertical ozone column (in Dobson Units, DU). The dependence on mu(o) and Omega is ...

journal_title：Photochemistry and photobiology

authors： Madronich S

更新日期：2007-11-01 00:00:00

abstract：:Photosensitizers (PS) are compounds that can generate reactive oxygen species under irradiation of appropriate light and are widely used in photodynamic therapy (PDT). Currently, topical PDT is an effective treatment for several skin diseases, including bacterial infections, fungal mycoses and psoriasis. In addition, ...

journal_title：Photochemistry and photobiology

authors： de França BM,Ghasemishahrestani Z,de Souza GFM,da Silva RN,Queiroz DD,Pierre MBR,Pereira MD,Forero JSB,Corrêa RJ

更新日期：2020-09-23 00:00:00

abstract：:Photoautotrophic growth of Chlamydomonas reinhardtii was shown to be independent of the presence of atmospheric oxygen. Under constant light and photoautotrophic conditions, C. reinhardtii grew equally well in either air or 367 PPM CO2-in-He. During 12-h light-dark cycles, the cells in air grew substantially faster th...

journal_title：Photochemistry and photobiology

authors： Graves DA,Spradlin GM,Greenbaum E

更新日期：1990-09-01 00:00:00

abstract：:The XPA gene-deficient mouse, an animal model of xeroderma pigmentosum (XP), develops enhanced photobiologic reactions including acute inflammation, immunosuppression and skin carcinogenesis, because of the defect in the excision repair of ultraviolet-induced DNA lesions. The results strongly suggest that nuclear DNA ...

journal_title：Photochemistry and photobiology

authors： Horio T,Miyauchi-Hashimoto H,Kuwamoto K,Yamazaki F,Okamoto H

更新日期：2007-01-01 00:00:00

abstract：:We describe here the development of monoclonal antibodies to the hapten tryptophan-riboflavin, generated by irradiation of a solution of bovine serum albumin in the presence of riboflavin. The specificity of the three obtained monoclonal antibodies, named 1E6, 5H5, 5A8 all belonging to the IgG1 isotype, was assessed b...

journal_title：Photochemistry and photobiology

authors： Diaz M,Becker MI,De Ioannes AE,Silva E

更新日期：1996-06-01 00:00:00

abstract：:In cultured human keratinocytes, the tumor suppressor p53 acts as a control element in the protective response to UVB radiation and is affected by a variety of factors linked to cellular adhesion and differentiation. Because keratinocytes within the epidermis are not a homogeneous population but differ in their prolif...

journal_title：Photochemistry and photobiology

authors： Will K,Neben M,Schmidt-Rose T,Deppert W,Wittern KP,Bergemann J

更新日期：2000-03-01 00:00:00

abstract：:A noninvasive in situ fluorescence-based method for the quantification of the photosensitizer chloroaluminum disulfonated phthalocyanine was compared to the highly accurate but nonreal time ex vivo spectrofluorometry method. Our in vivo fluorescence technique is designed to allow real-time assessment of photosensitize...

journal_title：Photochemistry and photobiology

authors： Lee CC,Pouge BW,Strawbridge RR,Moodie KL,Bartholomew LR,Burke GC,Hoopes PJ

更新日期：2001-09-01 00:00:00

abstract：:The proton channels of the bacteriorhodopsin (BR) proton pump contain bound water molecules. The channels connect the purple membrane surfaces with the protonated retinal Schiff base at the membrane center. Films of purple membrane equilibrated at low relative humidity display a shift of the 570 nm retinal absorbance ...

journal_title：Photochemistry and photobiology

authors： Renthal R,Gracia N,Regalado R

更新日期：2000-11-01 00:00:00

abstract：:Towards our overall objectives of developing potent antimicrobial materials to combat the escalating threat to human health posed by the transmission of surface-adhering pathogenic bacteria, we have investigated the photobactericidal activity of cellulose nanocrystals that have been modified with a porphyrin-derived p...

journal_title：Photochemistry and photobiology

authors： Carpenter BL,Feese E,Sadeghifar H,Argyropoulos DS,Ghiladi RA

更新日期：2012-05-01 00:00:00

abstract：:Systemic injection of hematoporphyrin derivative (HpD) in contribution with visible light (red or blue-green) delivered by laser was used to treat a patient with psoriasis. The psoriatic lesions responded vigorously to laser treatments, forming eschars by 1 week post irradiation. In contrast, only minimal erythema was...

journal_title：Photochemistry and photobiology

authors： McCullough JL,Weinstein GD,Douglas JL,Berns MW

更新日期：1987-07-01 00:00:00

abstract：:Reflectance spectrophotometry from 400 to 800 nm on different cutaneous pigmented lesions, including primary and metastatic malignant melanoma, pigmented nevi, lentigo and seborrhoeic keratosis, has been performed by using an external integrating sphere coupled to a spectrophotometer. Measurements show that reflectanc...

journal_title：Photochemistry and photobiology

authors： Marchesini R,Brambilla M,Clemente C,Maniezzo M,Sichirollo AE,Testori A,Venturoli DR,Cascinelli N

更新日期：1991-01-01 00:00:00

abstract：:Although allergic rhinitis is not life threatening, it significantly influences the quality of a patient's life. This study is intended to evaluate the safety and efficacy of phototherapy with low-level energy of a 650 nm laser irradiation system in perennial allergic rhinitis patients. This clinical trial was an open...

journal_title：Photochemistry and photobiology

authors： Lee HM,Park MS,Park IH,Lee SH,Lee SK,Kim KS,Choi H

更新日期：2013-05-01 00:00:00

abstract：:Photodamage to the endoplasmic reticulum (ER) can initiate a death pathway termed paraptosis. The "canonical" model of paraptosis, initiated by certain drugs and other stimuli, requires a brief interval of protein synthesis, involves the action of MAP kinases and can be followed by biochemical markers. The latter incl...

journal_title：Photochemistry and photobiology

authors： Kessel D

更新日期：2020-09-01 00:00:00

abstract：:In current clinical practice, photodynamic therapy (PDT) is carried out with prescribed drug doses and light doses as well as fixed drug-light intervals and illumination fluence rates. This approach can result in undesirable treatment outcomes of either overtreatment or undertreatment because of biological variations ...

journal_title：Photochemistry and photobiology

authors： Zeng H,Korbelik M,McLean DI,MacAulay C,Lui H

更新日期：2002-04-01 00:00:00

abstract：:The role of water molecules in spectral tuning of proteins has been left largely unexplored. This topic is important because changing hydrogen bond patterns during the activation process may lead to spectral shifts which can be of diagnostic value for the underlying structures. Arguments put forward in this article ar...

journal_title：Photochemistry and photobiology

authors： Sekharan S

更新日期：2009-03-01 00:00:00

abstract：:We have been able to identify a blue fluorophore from the low-molecular weight soluble fraction of human adult nondiabetic brunescent cataract lenses as xanthurenic acid 8-O-beta-D-glucoside (XA8OG) (excitation = 338 nm and emission = 440 nm). To determine the role of this fluorophore in the lens, we have examined its...

journal_title：Photochemistry and photobiology

authors： Thiagarajan G,Shirao E,Ando K,Inoue A,Balasubramanian D

更新日期：2002-09-01 00:00:00

abstract：:In clinical 5-aminolevulinic acid (ALA)-based photodynamic therapy (PDT) of skin tumors it is desirable to develop vehicles that minimize the penetration of ALA through normal stratum corneum and maximize it through the compromised stratum corneum of the tumors to improve tumor selectivity. We have designed a bioadhes...

journal_title：Photochemistry and photobiology

authors： Donnelly RF,Ma LW,Juzenas P,Iani V,McCarron PA,Woolfson AD,Moan J

更新日期：2006-05-01 00:00:00

abstract：:Inflammatory stimuli result in the production of cutaneous eicosanoids, which are known to contribute to the process of tumor promotion. Cyclooxygenase (COX), the rate-limiting enzyme for the production of prostaglandins (PG) from arachidonic acid, exists in at least two isoforms, COX-1 and COX-2. COX-1 is constitutiv...

journal_title：Photochemistry and photobiology

authors： An KP,Athar M,Tang X,Katiyar SK,Russo J,Beech J,Aszterbaum M,Kopelovich L,Epstein EH Jr,Mukhtar H,Bickers DR

更新日期：2002-07-01 00:00:00

abstract：:Synthesis of extracellular matrix (ECM) proteins and their degradation by matrix metalloproteinases (MMP) are part of the dermal remodeling resulting from chronic exposure of skin to ultraviolet radiation (UVR). We have compared two alternative mechanisms for these responses, namely, a direct mechanism in which UV-B o...

journal_title：Photochemistry and photobiology

authors： Kossodo S,Wong WR,Simon G,Kochevar IE

更新日期：2004-01-01 00:00:00

abstract：:We have previously demonstrated the ability of UVC (254 nm) radiation to induce asynchronous polyoma replication in rat fibroblast cells (H3 line) that contain an integrated copy of polyoma virus. In the present study we show that general purpose lamps can induce polyoma replication in these cells as well. The amount ...

journal_title：Photochemistry and photobiology

authors： Rutberg SE,Ronai Z

更新日期：1993-08-01 00:00:00

abstract：:High intensity two-photon picosecond excitation at 266 nm (effective energy 9.2 eV) has been shown to cause efficient photolysis of thymine in aqueous solution. Experimental results for the quantum yield of solvated electrons, phi (eaq-), and the net consumption of thymine, phi(-Thy) have been interpreted (Oraevsky an...

journal_title：Photochemistry and photobiology

authors： Daniels M

更新日期：1991-07-01 00:00:00

abstract：:Quantitative and qualitative changes in dermal collagen and elastin occur in response to chronic ultraviolet (UV) irradiation. These changes have been implicated in the genesis of the wrinkling seen in chronically irradiated, or photoaged skin. We examined the relationship between wrinkle formation and changes in derm...

journal_title：Photochemistry and photobiology

authors： Moloney SJ,Edmonds SH,Giddens LD,Learn DB

更新日期：1992-10-01 00:00:00

abstract：:Herein, we present a comparative study about the photoinactivation of Staphylococcus aureus (Gram-positive model) and Escherichia coli (Gram-negative model) employing a neutral and a dicationic axially functionalized SiIV -phthalocyanine. Depending on the charge of the siloxane moiety (neutral monosaccharide or cation...

journal_title：Photochemistry and photobiology

authors： Grüner MC,Niemann S,Faust A,Strassert CA

更新日期：2018-09-01 00:00:00

abstract：:Photosensitizer-functionalized reduced graphene oxide (rGO) nanoparticles are promising materials for photodynamic therapy in cancer management. In this study, rGO is synthesized by a green route employing glucose as the reducing agent and functionalized with photosensitizer, protoporphyrin IX (PPIX) in a convenient, ...

journal_title：Photochemistry and photobiology

authors： Shuvra Smita S,Das A,Barui A

更新日期：2020-11-01 00:00:00

abstract：:Herpes simplex virus (HSV) normally causes vescular lesions on mucocutaneous surfaces but can also cause encephalitis. The virus can reactivate from the latent state in neurons to form recrudescent lesions. One common stimulus for reactivation is exposure to sunlight. In the present study, the effects of irradiating r...

journal_title：Photochemistry and photobiology

authors： Garssen J,van der Molen R,de Klerk A,Norval M,van Loveren H

更新日期：2000-11-01 00:00:00