Abstract：
:We studied the effect on the intraocular pressure (IOP) and the ciliary body (CB) morphology after four consecutive contact transcleral photodynamic treatments of the ciliary body (CB-PDT) with verteporfin in pigmented rabbits. Twenty-two pigmented rabbits underwent CB-PDT (study group), performed once (six rabbits) or repeated for up to four times (16 rabbits). Six additional rabbits received only laser treatment without photosensitizer administration (control group). CB-PDT was performed in one eye in rabbits of the study group, with the fellow eye serving as internal control. Verteporfin dosage was 1 mg kg(-1) as bolus injection and laser settings were 40 mW (600 microm core optical fiber) for 1.5 min per spot, for 10 spots. In repeated CB-PDT, treatments were performed in 4-day intervals. Daily IOP measurements were recorded. Histological studies were performed at selected time points. An IOP reduction, more sustained following repeated treatments, was detected in all treated eyes but not in fellow eyes or in the control group. On the average, the IOP was restored to pretreatment levels 4 days after the last treatment. No serious adverse events were observed and the CB architecture was intact at the end of the experiment. Repeated CB-PDT is safe and results in a short-term reduction of IOP. Induced CB alterations are reversible.
journal_name
Photochem Photobioljournal_title
Photochemistry and photobiologyauthors
Charisis SK,Naoumidi II,Ginis HS,Detorakis ET,Tsilimbaris MKdoi
10.1111/j.1751-1097.2009.00638.xsubject
Has Abstractpub_date
2010-01-01 00:00:00pages
194-9issue
1eissn
0031-8655issn
1751-1097pii
PHP638journal_volume
86pub_type
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doi：
更新日期：1998-01-01 00:00:00
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journal_title：Photochemistry and photobiology
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doi：
更新日期：1998-07-01 00:00:00
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journal_title：Photochemistry and photobiology
pub_type： 杂志文章
doi：10.1111/j.1751-1097.1996.tb03103.x
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更新日期：2001-07-01 00:00:00
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更新日期：2011-03-01 00:00:00
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更新日期：2003-12-01 00:00:00
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journal_title：Photochemistry and photobiology
pub_type： 杂志文章,评审
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更新日期：2017-11-01 00:00:00
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journal_title：Photochemistry and photobiology
pub_type： 杂志文章
doi：10.1562/0031-8655(2000)072<0146:IVNIRS>2.0.CO;2
更新日期：2000-07-01 00:00:00
