Topical bioadhesive patch systems enhance selectivity of protoporphyrin IX accumulation.

Abstract:

:In clinical 5-aminolevulinic acid (ALA)-based photodynamic therapy (PDT) of skin tumors it is desirable to develop vehicles that minimize the penetration of ALA through normal stratum corneum and maximize it through the compromised stratum corneum of the tumors to improve tumor selectivity. We have designed a bioadhesive patch, which may be able to achieve this aim. It induces levels of protoporphyrin IX (PpIX) in skin overlying tumors similar to those induced by the proprietary cream (Porphin) but at the same time induces less PpIX to form in normal skin and at distant sites. The mechanisms of action of the patch, as compared with that of the cream, were studied by means of Cuprophan barriers that mimic compromised tumor stratum corneum and in a mouse model with transplanted tumors.

journal_name

Photochem Photobiol

authors

Donnelly RF,Ma LW,Juzenas P,Iani V,McCarron PA,Woolfson AD,Moan J

doi

10.1562/2005-08-08-RA-641

subject

Has Abstract

pub_date

2006-05-01 00:00:00

pages

670-5

issue

3

eissn

0031-8655

issn

1751-1097

pii

2005-08-08-RA-641

journal_volume

82

pub_type

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