Abstract:
:A key challenge for microbiology is to understand how evolution has shaped the wiring of regulatory networks. This is amplified by the paucity of information of power-spectra of physicochemical stimuli to which microorganisms are exposed. Future studies of genome evolution, driven by altered stimulus regimes, will therefore require a versatile signal transduction system that allows accurate signal dosing. Here, we review the general stress response of Bacillus subtilis, and its upstream signal transduction network, as a candidate system. It can be activated by red and blue light, and by many additional stimuli. Signal integration therefore is an intricate function of this system. The blue-light response is elicited via the photoreceptor YtvA, which forms an integral part of stressosomes, to activate expression of the stress regulon of B. subtilis. Signal transfer through this network can be assayed with reporter enzymes, while intermediate steps can be studied with live-cell imaging of fluorescently tagged proteins. Different parts of this system have been studied in vitro, such that its computational modeling has made significant progress. One can directly relate the microscopic characteristics of YtvA with activation of the general stress regulon, making this system a very well-suited system for network evolution studies.
journal_name
Photochem Photobioljournal_title
Photochemistry and photobiologyauthors
van der Steen JB,Hellingwerf KJdoi
10.1111/php.12499subject
Has Abstractpub_date
2015-09-01 00:00:00pages
1032-45issue
5eissn
0031-8655issn
1751-1097journal_volume
91pub_type
杂志文章,评审abstract::In the vertebrate retina, rods mediate twilight vision and cones mediate daylight vision. Their photoresponse characteristics are different. The light-sensitivity of a cone is 10(2)-10(3) times lower than that of a rod. In addition, the photoresponse time course is much faster in cones. The mechanism characterizing co...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章,评审
doi:10.1562/2006-02-28-IR-823
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abstract::Persister bacteria tolerate bactericidal antibiotics due to transient and reversible phenotypic changes. As these bacteria can limit the effectiveness of antibiotics to eradicate certain infections, their elimination is a relevant issue. Photodynamic therapy seems suitable for this purpose, but phenotypic tolerance to...
journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1111/php.12843
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1111/php.13085
更新日期:2019-07-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章,评审
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1111/php.12321
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
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更新日期:1996-07-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1111/php.12805
更新日期:2017-11-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1111/php.13291
更新日期:2020-09-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1111/php.13089
更新日期:2019-07-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1111/j.1751-1097.2008.00424.x
更新日期:2008-11-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1111/php.13361
更新日期:2020-12-03 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章,评审
doi:10.1111/j.1751-1097.1996.tb02988.x
更新日期:1996-01-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/0031-8655(2002)075<0076:arlpit>2.0.co;2
更新日期:2002-01-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 评论,杂志文章
doi:10.1111/php.13102
更新日期:2019-09-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1562/0031-8655(1998)067<0227:mihshm>2.3.co;2
更新日期:1998-02-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
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pub_type: 杂志文章,评审
doi:10.1111/php.12790
更新日期:2017-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:2021-02-02 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
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更新日期:2006-03-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1111/j.1751-1097.2008.00367.x
更新日期:2008-11-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1111/j.1751-1097.1997.tb08569.x
更新日期:1997-02-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
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更新日期:2003-01-01 00:00:00
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pub_type: 杂志文章
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
doi:10.1111/j.1751-1097.1990.tb01733.x
更新日期:1990-04-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
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更新日期:2017-11-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章
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更新日期:1994-10-01 00:00:00
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journal_title:Photochemistry and photobiology
pub_type: 杂志文章,评审
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更新日期:2015-01-01 00:00:00