Photooxidation products of merocyanine 540 formed under preactivation conditions for tumor therapy.

Abstract:

:In order to gain insight into the preactivation of merocyanine 540 (MC540) 1 for the photodynamic therapy (Gulliya et al., 1990a, Photochem. Photobiol. 52, 831-838) its photo-oxidation was investigated. After irradiation of MC540 1 on a preparative scale three main photodegradation products were isolated with 16-20% yields. They turned out to be derivatives of benzoxazole, thiouracil and thiohydantoin with the structures 4, 5 and 6, respectively. It may be possible that they contribute to the cytostatic and antiviral activity of preactivated MC540 1.

journal_name

Photochem Photobiol

authors

Franck B,Schneider U

doi

10.1111/j.1751-1097.1992.tb02157.x

subject

Has Abstract

pub_date

1992-08-01 00:00:00

pages

271-6

issue

2

eissn

0031-8655

issn

1751-1097

journal_volume

56

pub_type

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