Photosensitizers in dermatology.

Abstract:

:Systemic injection of hematoporphyrin derivative (HpD) in contribution with visible light (red or blue-green) delivered by laser was used to treat a patient with psoriasis. The psoriatic lesions responded vigorously to laser treatments, forming eschars by 1 week post irradiation. In contrast, only minimal erythema was observed in the noninvolved, clinically normal appearing skin. Two approaches for localized HpD administration were investigated in the guinea-pig and minipig models as a means of achieving local photodynamic effects. Intracutaneous injection of HpD produced localized cutaneous photosensitization with either UVA or red light. Azone increased percutaneous penetration of HpD in human skin in vitro. Topical application of HpD and irradiation with UVA produced localized cutaneous photosensitivity and inhibition of epidermal DNA synthesis.

journal_name

Photochem Photobiol

authors

McCullough JL,Weinstein GD,Douglas JL,Berns MW

doi

10.1111/j.1751-1097.1987.tb04739.x

subject

Has Abstract

pub_date

1987-07-01 00:00:00

pages

77-82

issue

1

eissn

0031-8655

issn

1751-1097

journal_volume

46

pub_type

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