Photocytotoxicity of water-soluble metalloporphyrin derivatives.

Abstract:

:A new water-soluble porphyrin derivative, 2,4-bis(1-decyloxyethyl)-deuteroporphyrinyl-6,7-bisaspart ic acid (C10-DP), and its metal complexes (Ga, I(n), Zn, Mn, Cu, Ni and Fe) were examined for their physicochemical properties (absorption, fluorescence, triplet lifetime and partition coefficient) and photocytotoxicity on HeLa cells. The five derivatives with longer (> 1 ms) triplet lifetimes (free base, Zn, Ga, I(n) and Sn complexes) exhibited remarkable photocytotoxicity, and the other derivatives (Mn, Cu, Ni and Fe), which had or were deduced to have fairly short (< 0.01 ms) triplet lifetimes, manifested no photocytotoxicity, indicating that the triplet lifetime of these derivatives played a significant role in their photocytotoxicity. Cellular fluorescence due to C10-DP and its gallium complex was observed mainly on the plasma membrane at the concentrations showing significant photocytotoxicity with low (< 32.6%) cytotoxicity in the dark (2-10 microM).

journal_name

Photochem Photobiol

authors

Ando T,Irie K,Koshimizu K,Takemura T,Nishino H,Iwashima A,Takeda N,Nakajima S,Sakata I

doi

10.1111/j.1751-1097.1993.tb02928.x

subject

Has Abstract

pub_date

1993-04-01 00:00:00

pages

629-33

issue

4

eissn

0031-8655

issn

1751-1097

journal_volume

57

pub_type

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