Photoinduced nitric oxide and singlet oxygen release from ZnPC liposome vehicle associated with the nitrosyl ruthenium complex: synergistic effects in photodynamic therapy application.

Abstract:

:Under continuous photolysis at 675 nm, liposomal zinc phthalocyanine associated with nitrosyl ruthenium complex [Ru(NH.NHq)(tpy)NO](3+) showed the detection and quantification of nitric oxide (NO) and singlet oxygen ((1)O(2)) release. Photophysical and photochemical results demonstrated that the interaction between the nitrosyl ruthenium complex and the photosensitizer can enable an electron transfer process from the photosensitizer to the nitrosyl ruthenium complex which leads to NO release. Synergistic action of both photosensitizers and the nitrosyl ruthenium complex results in the production of reactive oxygen species and reactive nitrogen species, which is a potent oxidizing agent to many biological tissues, in particular neoplastic cells.

journal_name

Photochem Photobiol

authors

Maranho DS,de Lima RG,Primo FL,da Silva RS,Tedesco AC

doi

10.1111/j.1751-1097.2008.00481.x

subject

Has Abstract

pub_date

2009-05-01 00:00:00

pages

705-13

issue

3

eissn

0031-8655

issn

1751-1097

pii

PHP481

journal_volume

85

pub_type

杂志文章
  • Potential in vivo UVC disinfection of catheter lumens: estimation of the doses received by the blood flow outside the catheter tip hole.

    abstract::We have demonstrated that it is possible to launch UVC LED light into bacterial contaminated polymer tubes/catheters and disinfect the intraluminal space of these tubes. This can be achieved by UVC treatment of the catheters on a regular basis. Catheters are in the distal end equipped with an exit hole for administrat...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.2011.00887.x

    authors: Bak J,Jørgensen TM,Helfmann J,Gravemann U,Vorontsova I

    更新日期:2011-03-01 00:00:00

  • Photointeraction of benzophenone triplet with lysozyme.

    abstract::The quenching of the benzophenone triplet by lysozyme and its constituent amino acids in aqueous solutions have been studied. Native lysozyme quenches the benzophenone triplet with a high rate constant, 4 x 10(9) M-1 s-1. The quenching process takes place with production of significant amounts of free ketyl radicals, ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1989.tb08424.x

    authors: Encinas MV,Lissi EA,Vasquez M,Olea AF,Silva E

    更新日期:1989-05-01 00:00:00

  • Determination by fluorimetric titration of the ionization constants of ciprofloxacin in solution and in the presence of liposomes.

    abstract::A fluorescence titration method was applied for the determination of pKa of ciprofloxacin (CPX) in solution. Values of 6.18 +/- 0.05 and 8.76 +/- 0.03 were obtained for pKa1 and pKa2, respectively. The method was used to determine the ionization constants in the presence of liposomes of dipalmitoylphosphatidylcholine ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/0031-8655(2001)073<0014:dbftot>2.0.co;2

    authors: Vázquez JL,Berlanga M,Merino S,Domènech O,Viñas M,Montero MT,Hernández-Borrell J

    更新日期:2001-01-01 00:00:00

  • Molecular mechanism of drug photosensitization. 7. Photocleavage of DNA sensitized by suprofen.

    abstract::Ultraviolet-A irradiation of a suprofen (2-[4-2(2-thenoyl) phenyl]propionic acid) (SPF) buffered solution (pH 7.4) in the presence of supercoiled pBR322 DNA leads to single strand breaks with the formation of an open circular form and subsequent linearization of the plasmid. On the basis of agarose gel electrophoresis...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1995.tb05252.x

    authors: Condorelli G,Constanzo LL,De Guidi G,Giuffrida S,Sortino S

    更新日期:1995-07-01 00:00:00

  • Near-UV activation of enzymatic conversion of 5-hydroxytryptophan to serotonin.

    abstract::Near-UV (337 nm) photoactivation of the 5-hydroxytryptophan decarboxylation reaction producing serotonin has been observed. The photoactivation effect was investigated as a function of fluence rate and fluence, and pH. Photoactivation of decarboxylase activity was found to occur at nearly neutral pH values (low activi...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1989.tb09197.x

    authors: Fraikin GY,Strakhovskaya MG,Ivanova EV,Rubin AB

    更新日期:1989-04-01 00:00:00

  • In vitro Studies of Antitumor Effect, Toxicity/Cytotoxicity and Skin Permeation/Retention of a Green Fluorescence Pyrene-based Dye for PDT Application.

    abstract::Photosensitizers (PS) are compounds that can generate reactive oxygen species under irradiation of appropriate light and are widely used in photodynamic therapy (PDT). Currently, topical PDT is an effective treatment for several skin diseases, including bacterial infections, fungal mycoses and psoriasis. In addition, ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.13335

    authors: de França BM,Ghasemishahrestani Z,de Souza GFM,da Silva RN,Queiroz DD,Pierre MBR,Pereira MD,Forero JSB,Corrêa RJ

    更新日期:2020-09-23 00:00:00

  • Laser thermal ablation.

    abstract::Continuous wave and pulsed laser ablation of tissue is described as an explosive event. A subsurface temperature maximum and superheated tissue produce high pressures that eject fragments from the tissue. Decreased water content due to dehydration and vaporization decreases thermal conductivity which reduces heat cond...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1751-1097.1991.tb09896.x

    authors: Welch AJ,Motamedi M,Rastegar S,LeCarpentier GL,Jansen D

    更新日期:1991-06-01 00:00:00

  • Biochemical changes in hairless mouse skin collagen after chronic exposure to ultraviolet-A radiation.

    abstract::Evidence is mounting that UV-B and UV-A radiation affect skin differently in responses as diverse as erythema and elastosis. We found in this study that collagen metabolism was also differentially affected. Albino hairless mice were irradiated with two UV-A sources: (1) UVASUN 3000 (340-400 nm) for cumulative exposure...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1991.tb02011.x

    authors: Kligman LH,Gebre M

    更新日期:1991-08-01 00:00:00

  • Reactions of excited states of phenoxazin-3-one dyes with amino acids.

    abstract::The interaction with amino acids of the excited states of the N-oxide resazurin and its deoxygenation product resorufin, has been studied in aqueous solution at pH 7.5. Steady-state and time-resolved studies show that the fluorescence is quenched by amino acids. Complexation of the dyes in the ground state with aromat...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/2004-10-12-RA-342

    authors: Villegas ML,Bertolotti SG,Previtali CM,Encinas MV

    更新日期:2005-07-01 00:00:00

  • Constraints of opsin structure on the ligand-binding site: studies with ring-fused retinals.

    abstract::Ring-fused retinal analogs were designed to examine the hula-twist mode of the photoisomerization of the 9-cis retinylidene chromophore. Two 9-cis retinal analogs, the C11-C13 five-membered ring-fused and the C12-C14 five-membered ring-fused retinal derivatives, formed the pigments with opsin. The C11-C13 ring-fused a...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/0031-8655(2002)076<0606:coosot>2.0.co;2

    authors: Hirano T,Lim IT,Kim DM,Zheng XG,Yoshihara K,Oyama Y,Imai H,Shichida Y,Ishiguro M

    更新日期:2002-12-01 00:00:00

  • Effect of psoralen + ultraviolet-A on the chemotactic activity of polymorphonuclear neutrophils towards anaphylatoxin C5a des Arg.

    abstract::It was shown that psoralen + UV-A inhibits the chemotactic activity of polymorphonuclear neutrophils towards anaphylatoxin C5a des Arg. This reaction required oxygen and there is a high possibility that the active oxygen species was in a singlet state. Oxygen did not act directly on C5a des Arg, but rather produced ox...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:

    authors: Esaki K,Mizuno N

    更新日期:1992-05-01 00:00:00

  • Photochemically induced binding of Rh(phen)2Cl2+ to DNA.

    abstract::The photoinduced covalent binding of the title compound to native and heat denatured DNA is described. The level of binding has been measured by UV (for DNA) and atomic absorption (for Rh) analysis. Quantum efficiencies of 6.4 x 10(-4) mol Rh per mol photons and 1.6 x 10(-3) mol Rh per mol photons have been determined...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1989.tb09204.x

    authors: Mahnken RE,Bina M,Deibel RM,Luebke K,Morrison H

    更新日期:1989-04-01 00:00:00

  • Role of xanthurenic acid 8-O-beta-D-glucoside, a novel fluorophore that accumulates in the brunescent human eye lens.

    abstract::We have been able to identify a blue fluorophore from the low-molecular weight soluble fraction of human adult nondiabetic brunescent cataract lenses as xanthurenic acid 8-O-beta-D-glucoside (XA8OG) (excitation = 338 nm and emission = 440 nm). To determine the role of this fluorophore in the lens, we have examined its...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/0031-8655(2002)076<0368:roxaod>2.0.co;2

    authors: Thiagarajan G,Shirao E,Ando K,Inoue A,Balasubramanian D

    更新日期:2002-09-01 00:00:00

  • Urokinase activity in corneal fibroblasts may be modulated by DNA damage and secreted proteins.

    abstract::Proteases like urokinase-type plasminogen activator (uPA) play an important role in tumor invasion. Cells derived from ultraviolet radiation (UVR)-induced corneal sarcomas of Monodelphis domestica produce relatively high levels of uPA compared to the untransformed keratocytes suggesting a mechanism for their invasiven...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/0031-8655(2001)073<0318:uaicfm>2.0.co;2

    authors: Green WB,McGuire PG,Miska KB,Kusewitt DF

    更新日期:2001-03-01 00:00:00

  • Blue light irradiation inhibits the production of HGF by human retinal pigment epithelium cells in vitro.

    abstract::Blue visible light damage to retinal pigment epithelial cells occurs through a photooxidative mechanism and the resultant damage is hypothesized to induce or exacerbate age-related macular degeneration. The purpose of the present study was to identify changes in the cell growth and the expression of hepatocyte growth ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/2006-04-19-RA-880

    authors: Chu R,Zheng X,Chen D,Hu DN

    更新日期:2006-09-01 00:00:00

  • Feasibility of using fluoresceinyl Cypridina luciferin analog in a novel chemiluminescence method for real-time photodynamic therapy dosimetry.

    abstract::Singlet oxygen ((1)O(2)) is the most important cytotoxic agent in photodynamic therapy (PDT). The feasibility of using a chemiluminescence (CL) probe, 3,7-dihydro-6-[4-(2-(N'-(5-fluoresceinyl)thioureido)ethoxy)phenyl]-2-methylimidazo{1,2-a}pyrazin-3-one sodium salt (fluoresceinyl Cypridina luciferin analog, FCLA), to ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1562/2005-05-20-RA-536

    authors: Qin Y,Xing D,Luo S,Zhou J,Zhong X,Chen Q

    更新日期:2005-11-01 00:00:00

  • Implication of ultraviolet light in the etiology of uveal melanoma: A review.

    abstract::Uveal melanoma is the most frequent intraocular cancer and the second most common form of melanoma. It metastasizes in half of the patients and the prognostic is poor. Although ultraviolet (UV) radiation is a proven risk factor for skin melanoma, the role of UV light in the etiology of uveal melanoma is still contradi...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章,评审

    doi:10.1111/php.12161

    authors: Mallet JD,Gendron SP,Drigeard Desgarnier MC,Rochette PJ

    更新日期:2014-01-01 00:00:00

  • Photophysics and photochemistry of z-chlorprothixene in acetonitrile.

    abstract::Chlorprothixene (CPTX, Taractan) is a low potency antipsychotic mainly used for the treatment of psychotic disorders (e.g. schizophrenia) and acute mania occurring as part of bipolar disorders. As in the case of other numerous drugs used in the treatment of psychiatric disorders, CPTX presents geometric isomerism. The...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.2009.00584.x

    authors: Piñero LE,García C,Lhiaubet-Vallet V,Oyola R,Miranda MA

    更新日期:2009-07-01 00:00:00

  • Effects of the menstrual cycle on the red and near-infrared optical properties of the human breast.

    abstract::Time-resolved reflectance and transmittance spectroscopy was applied to measure in vivo the absorption and transport scattering spectra of the female breast from 610 to 1010 nm. Three measurement configurations were used to probe different breast regions, and data were collected two or three times in each of the five ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:

    authors: Cubeddu R,D'Andrea C,Pifferi A,Taroni P,Torricelli A,Valentini G

    更新日期:2000-09-01 00:00:00

  • Comparative analysis of GPCR crystal structures.

    abstract::The phototransduction cascade is perhaps the best understood model system for G protein-coupled receptor (GPCR) signaling. Phototransduction links the absorption of a single photon of light to a decrease in cytosolic cGMP. Depletion of the cGMP pool induces closure of cGMP-gated cation channels resulting in the hyperp...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1751-1097.2008.00516.x

    authors: Lodowski DT,Angel TE,Palczewski K

    更新日期:2009-03-01 00:00:00

  • Low-level laser therapy ameliorates CCl4-induced liver cirrhosis in rats.

    abstract::This study investigated the effects of low-level laser therapy (LLLT) in the liver function, structure and inflammation in a experimental model of carbon tetrachloride (CCl(4))-induced liver cirrhosis. Wistar rats were divided into Control, LLLT, CCl(4) and CCl(4) +LLLT groups. CCl(4) groups received CCl(4) (0.4 g kg(...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.2012.01211.x

    authors: Oliveira-Junior MC,Monteiro AS,Leal-Junior EC,Munin E,Osório RA,Ribeiro W,Vieira RP

    更新日期:2013-01-01 00:00:00

  • Photoisomerization of alfa calcidol by a sensitized quantum chain reaction.

    abstract::The production of vitamin D3 is a pharmaceutically relevant process, producing high added-value products. Precursors are extracts from vegetal origin but bearing mainly an E geometry in the 5,6 double bond. The synthesis of vitamin D3 (5-E-α-calcidol) with the correct Z stereochemistry in the 5,6 double bond from the ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.2011.01054.x

    authors: Estruch GA,Aramendía PF

    更新日期:2012-07-01 00:00:00

  • Photobiological information obtained from XPA gene-deficient mice.

    abstract::The XPA gene-deficient mouse, an animal model of xeroderma pigmentosum (XP), develops enhanced photobiologic reactions including acute inflammation, immunosuppression and skin carcinogenesis, because of the defect in the excision repair of ultraviolet-induced DNA lesions. The results strongly suggest that nuclear DNA ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章,评审

    doi:10.1562/2006-03-02-IR-829

    authors: Horio T,Miyauchi-Hashimoto H,Kuwamoto K,Yamazaki F,Okamoto H

    更新日期:2007-01-01 00:00:00

  • Quantum mechanical/molecular mechanical studies on spectral tuning mechanisms of visual pigments and other photoactive proteins.

    abstract::The protein environments surrounding the retinal tune electronic absorption maximum from 350 to 630 nm. Hybrid quantum mechanical/molecular mechanical (QM/MM) methods can be used in calculating excitation energies of retinal in its native protein environments and in studying the molecular basis of spectral tuning. We ...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章,评审

    doi:10.1111/j.1751-1097.2008.00308.x

    authors: Altun A,Yokoyama S,Morokuma K

    更新日期:2008-07-01 00:00:00

  • Nanoscale hydroxyl radical generation from multiphoton ionization of tryptophan.

    abstract::Exposure of solutions containing both tryptophan and hydrogen peroxide to a pulsed ( approximately 180 fs) laser beam at 750 nm induces luminescence characteristic of 5-hydroxytryptophan. The results indicate that 3-photon excitation of tryptophan results in photoionization within the focal volume of the laser beam. T...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.2008.00447.x

    authors: Bisby RH,Crisostomo AG,Botchway SW,Parker AW

    更新日期:2009-01-01 00:00:00

  • Characterization of psaI and psaL mutants of Synechococcus sp. strain PCC 7002: a new model for state transitions in cyanobacteria.

    abstract::The psaI and psaL genes were characterized from the cyanobacterium Synechococcus sp. strain PCC 7002. The gene organization was different from that reported for other cyanobacteria with psaI occurring upstream and being divergently transcribed from the psaL gene. Mutants lacking PsaI or PsaL were generated by interpos...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/j.1751-1097.1996.tb02421.x

    authors: Schluchter WM,Shen G,Zhao J,Bryant DA

    更新日期:1996-07-01 00:00:00

  • Membrane damage efficiency of phenothiazinium photosensitizers.

    abstract::Structure-activity relationships have been widely reported for porphyrin and phthalocyanine photosensitizers, but not for phenothiazinium derivatives. Here, four phenothiazinium salts (methylene blue, toluidine blue O, 1,9-dimethyl methylene blue and the pentacyclic derivative DO15) were used to investigate how the ab...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.12264

    authors: Bacellar IO,Pavani C,Sales EM,Itri R,Wainwright M,Baptista MS

    更新日期:2014-07-01 00:00:00

  • Photochemical Behavior of Some Estrone Aryl and Methyl Sulfonates in Solution: Preparative and Mechanistic Studies.

    abstract::Direct irradiation of estrone aryl and methyl sulfonates in different organic solvents under nitrogen atmosphere was investigated under steady-state conditions. The estrone derivatives reacted efficiently through the photo-Fries rearrangement reaction involving [1;3]-sulfonyl migration providing the ortho-sulfonyl est...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.13272

    authors: Quindt MI,Gola GF,Ramirez JA,Bonesi SM

    更新日期:2021-01-01 00:00:00

  • Analysis of two kinds of tree as physical barriers against erythemal UVB radiation received.

    abstract::Differences between global radiation UVER (erythemal ultraviolet solar radiation) received under full sun and diffuse radiation received under the shadow of two types of tree are analyzed to check the importance of these components on human exposure to UV radiation. Blue Line spores dosimeters of VioSpor were used for...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.12020

    authors: Ysasi GG,Ribera LJ

    更新日期:2013-05-01 00:00:00

  • Increasing Temperature Counteracts the Negative Effect of UV Radiation on Growth and Photosynthetic Efficiency of Microcystis aeruginosa and Raphidiopsis raciborskii.

    abstract::High temperature can promote cyanobacterial blooms, whereas ultraviolet radiation (UVR) can potentially depress cyanobacterial growth by damaging their photosynthetic apparatus. Although the damaging effect of UVR has been well documented, reports on the interactive effects of UV radiation exposure and warming on cyan...

    journal_title:Photochemistry and photobiology

    pub_type: 杂志文章

    doi:10.1111/php.13377

    authors: Noyma NP,Mesquita MCB,Roland F,Marinho MM,Huszar VLM,Lürling M

    更新日期:2021-01-04 00:00:00