Preclinical evaluation of a novel water-soluble chlorin E6 derivative (BLC 1010) as photosensitizer for the closure of the neovessels.

abstract：:Light is a very important environmental factor that governs many cellular responses in organisms. As a consequence, organisms possess different kinds of light-sensing photoreceptors to regulate their physiological variables and adapt to a given habitat. The cryptochrome/photolyase family (CPF) includes photoreceptors ...

journal_title：Photochemistry and photobiology

authors： Kavakli IH,Baris I,Tardu M,Gül Ş,Öner H,Çal S,Bulut S,Yarparvar D,Berkel Ç,Ustaoğlu P,Aydın C

更新日期：2017-01-01 00:00:00

abstract：:Analysis of phosphorescence lifetimes using the Stern-Volmer equation is a reliable means of determining quencher concentration for a uniform sample. Methods of analysis for heterogeneous systems are based on the assumption that the excitation is produced by a momentary flash. This condition is an idealization because...

journal_title：Photochemistry and photobiology

authors： Golub AS,Popel AS,Zheng L,Pittman RN

更新日期：1999-06-01 00:00:00

abstract：:Spatio-temporal patterns in sun exposure underlie variations in skin cancer incidence and vitamin D deficiency, indicate effectiveness of sun protection programs and provide insights into future health risks. From 558 adults across four regions of Australia (Brisbane (27°S), Newcastle (33°S), Geelong and the Western D...

journal_title：Photochemistry and photobiology

authors： Lucas RM,Valery P,van der Mei I,Dwyer T,Pender MP,Taylor B,Ponsonby AL,Ausimmune Investigator Group.

更新日期：2013-05-01 00:00:00

abstract：:In photodynamic therapy with topically applied delta-aminolevulinic acid porphyrins are acting as photosensitizers. The profile of porphyrin metabolites in normal or in neoplastic skin after administration of delta-aminolevulinic acid has not been determined in detail yet. Thus, to study porphyrin biosynthesis in huma...

journal_title：Photochemistry and photobiology

authors： Fritsch C,Batz J,Bolsen K,Schulte KW,Zumdick M,Ruzicka T,Goerz G

更新日期：1997-07-01 00:00:00

abstract：:Experimental studies have recently demonstrated that fluorescence emission can be quenched by laser light pulses from modern high-repetition rate lasers, a phenomenon we call "light quenching." In this overview article, we describe the possible effects of light quenching on the steady-state and time-resolved intensity...

journal_title：Photochemistry and photobiology

authors： Lakowicz JR,Gryczyński I,Kuśba J,Bogdanov V

更新日期：1994-12-01 00:00:00

abstract：:The photodegradation of the herbicide clomazone in the presence of S(2)O(8) (2-) or of humic substances of different origin was investigated. A value of (9.4 +/- 0.4) x 10(8) m(-1) s(-1) was measured for the bimolecular rate constant for the reaction of sulfate radicals with clomazone in flash-photolysis experiments. ...

journal_title：Photochemistry and photobiology

authors： David Gara PM,Bosio GN,Arce VB,Poulsen L,Ogilby PR,Giudici R,Gonzalez MC,Mártire DO

更新日期：2009-05-01 00:00:00

abstract：:The size of excision repair patches corresponding to excision of (6-4) pyrimidine-pyrimidone photoproducts and (5-5, 6-6) cyclobutane dimers have been independently determined by using bromodeoxyuridine substitution and density increases in isopycnic gradients of small DNA fragments. The two classes of photoproducts w...

journal_title：Photochemistry and photobiology

authors： Cleaver JE,Jen J,Charles WC,Mitchell DL

更新日期：1991-09-01 00:00:00

abstract：:Leaf discs, enclosed in a photoacoustic (PA) chamber, generate two types of PA gas-uptake signals under certain conditions. Type I is manifested by a severe signal decrease that develops slowly under very low-light intensity and often reaches negative values. It is partially reversed by low-intensity far-red light. Ty...

journal_title：Photochemistry and photobiology

authors： Malkin S,Havaux M

更新日期：2001-10-01 00:00:00

abstract：:Syntheses for the new photosensitizers HOSiPcOSi(CH3)2(CH2)3N(CH1)1 or 3(CH3)2, Pc 34 and Pc 25, have been developed and the order of activity of these photosensitizers and the previously reported photosensitizer Pc 4, HOSiPcOSi(CH3)2(CH2)3N(CH3)2, in the dark and with broad-band red light toward Plasmodium falciparum...

journal_title：Photochemistry and photobiology

authors： Zhao XJ,Lustigman S,Li YS,Kenney ME,Ben-Hur E

更新日期：1997-08-01 00:00:00

abstract：:We report here the design and synthesis of porphyrin-metallocene dyads consisting of a metallocene [either ferrocene or mixed sandwich η(5)-[C5H4(COOH)]Co(η(4)-C4Ph4) connected via an ester linkage at meso phenyl position of either free-base or zinc porphyrin. All these dyad systems were characterized by various spect...

journal_title：Photochemistry and photobiology

authors： Gokulnath S,Achary BS,Kumar CK,Trivedi R,Sridhar B,Giribabu L

更新日期：2015-01-01 00:00:00

abstract：:Reflectance spectrophotometry from 400 to 800 nm on different cutaneous pigmented lesions, including primary and metastatic malignant melanoma, pigmented nevi, lentigo and seborrhoeic keratosis, has been performed by using an external integrating sphere coupled to a spectrophotometer. Measurements show that reflectanc...

journal_title：Photochemistry and photobiology

authors： Marchesini R,Brambilla M,Clemente C,Maniezzo M,Sichirollo AE,Testori A,Venturoli DR,Cascinelli N

更新日期：1991-01-01 00:00:00

abstract：:There is a need to improve the selectivity of photodynamic therapy and for better targeting of tumor cells within specific tumor compartments. Selective in vitro phototoxicity of a human bladder carcinoma cell line 647V has been achieved by targeting sulfonated aluminum phthalocyanines (AlSPc) with monoclonal antibodi...

journal_title：Photochemistry and photobiology

authors： Morgan J,Lottman H,Abbou CC,Chopin DK

更新日期：1994-11-01 00:00:00

abstract：:It is generally assumed that a central metal is essential for the efficiency of phthalocyanines in photodynamic therapy (PDT) of cancer. Contrary to the set opinion, the results of the present study indicate that the metal-free sulfonated phthalocyanines (H2PcSn, where n is the number of sulfonate groups per molecule)...

journal_title：Photochemistry and photobiology

authors： Feofanov A,Grichine A,Karmakova T,Kazachkina N,Pecherskih E,Yakubovskaya R,Luk'yanets E,Derkacheva V,Egret-Charlier M,Vigny P

更新日期：2002-05-01 00:00:00

abstract：:Although histochemical and immunohistochemical methods are the standard procedures in diagnosis of lymphoproliferative disorders, useful improvements in evidencing histopathologic manifestations can be obtained with the introduction of tissue autofluorescence analyses. We used microspectrofluorometry and a Multispectr...

journal_title：Photochemistry and photobiology

authors： Rigacci L,Alterini R,Bernabei PA,Ferrini PR,Agati G,Fusi F,Monici M

更新日期：2000-06-01 00:00:00

abstract：:This article presents a facile method to prepare CdS/SiO(2) composite microspheres and their good catalytic properties. In our method, monodispersed SiO(2) particles bearing amino groups (-NH(2)) were synthesized at first and then used as carriers to load nanosized CdS particles to form CdS/SiO(2) composite microspher...

journal_title：Photochemistry and photobiology

authors： Peng C,Cheng X,Chen S,Li X,Li T,Zhang D,Huang Z,Zhang A

更新日期：2012-11-01 00:00:00

abstract：:Ultraviolet A radiation participates in cytotoxicity and carcinogenesis of the skin by a mechanism involving the generation of reactive oxygen species. Endogenous antiradical defense systems utilize metalloenzymes including Se-dependent glutathione peroxidase and Cu and Zn superoxide dismutase. The aim of the present ...

journal_title：Photochemistry and photobiology

authors： Leccia MT,Richard MJ,Beani JC,Faure H,Monjo AM,Cadet J,Amblard P,Favier A

更新日期：1993-10-01 00:00:00

abstract：:The XPA gene-deficient mouse, an animal model of xeroderma pigmentosum (XP), develops enhanced photobiologic reactions including acute inflammation, immunosuppression and skin carcinogenesis, because of the defect in the excision repair of ultraviolet-induced DNA lesions. The results strongly suggest that nuclear DNA ...

journal_title：Photochemistry and photobiology

authors： Horio T,Miyauchi-Hashimoto H,Kuwamoto K,Yamazaki F,Okamoto H

更新日期：2007-01-01 00:00:00

abstract：:A solution of iodouracil (0.2 mg/mL) and KI (0.1 M) in 0.23 M borate buffer (pH 7) forms triiodide upon exposure to UVB. In the presence of thyodene, the blue starch-iodine complex is formed, the intensity of which is proportional to the amount of UVB exposure. Studies were conducted using either a sunlamp or solar ir...

journal_title：Photochemistry and photobiology

authors： Rahn R,Lee MA

更新日期：1998-08-01 00:00:00

abstract：:Photosensitized protein cross-linking has been recently developed to seal wounds and strengthen tissue. Although the photosensitizing dye, Rose Bengal (RB), is phototoxic to cultured cells, cytotoxicity does not accompany RB-photosensitized tissue repair in vivo. We investigated whether the environment surrounding cel...

journal_title：Photochemistry and photobiology

authors： Yao M,Gu C,Doyle FJ Jr,Zhu H,Redmond RW,Kochevar IE

更新日期：2014-03-01 00:00:00

abstract：:Persister bacteria tolerate bactericidal antibiotics due to transient and reversible phenotypic changes. As these bacteria can limit the effectiveness of antibiotics to eradicate certain infections, their elimination is a relevant issue. Photodynamic therapy seems suitable for this purpose, but phenotypic tolerance to...

journal_title：Photochemistry and photobiology

authors： Oppezzo OJ,Forte Giacobone AF

更新日期：2018-01-01 00:00:00

abstract：:Aspects of different calibration procedures for erythemally weighing broadband radiometers are presented in this study. These instruments are common in projects dealing with ultraviolet radiation effects on humans. Many erythemally weighing broadband radiometers are still operated using a single calibration factor (cf...

journal_title：Photochemistry and photobiology

authors： Oppenrieder A,Hoeppe P,Koepke P,Reuder J,Schween J,Schreder J

更新日期：2003-12-01 00:00:00

abstract：:Phthalocyanine 4 (Pc 4) is a promising photosensitizer currently in clinical trials. Photobiological responses to Pc 4 photodynamic therapy (Pc 4-PDT) have been characterized extensively, but relatively little has been done to evaluate dose metrics for this sensitizer. We describe an irradiation-induced increase in fl...

journal_title：Photochemistry and photobiology

authors： Wang KK,Wilson JD,Kenney ME,Mitra S,Foster TH

更新日期：2007-09-01 00:00:00

abstract：:Owing to the accessibility of skin to light, many applications of photodynamic treatment (PDT) have been developed within dermatology. The recent increase of dermatological antimicrobial PDT investigations is related to the growing problem of bacterial and fungal resistance to antibiotics. This review focuses on the s...

journal_title：Photochemistry and photobiology

authors： Smijs TG,Pavel S

更新日期：2011-01-01 00:00:00

abstract：:The relationship between levels of in vivo accumulated photosensitizer (Photofrin II), photodynamic cell inactivation upon in vitro or in vivo illumination, and changing tumor oxygenation was studied in the radiation-induced fibrosarcoma (RIF) mouse tumor model. In vivo porphyrin uptake by tumor cells was assessed by ...

journal_title：Photochemistry and photobiology

authors： Henderson BW,Fingar VH

更新日期：1989-03-01 00:00:00

abstract：:5-geranoxypsoralen (Bergamottin) does not photosensitize bacteria or a bacterial virus. It does, however, photosensitize mammalian cells in tissue culture. Irradiation with either black light (300-400 nm) or fluorescent ceiling lights produced at least four photobiologically active degradation products, the chemical n...

journal_title：Photochemistry and photobiology

authors： Ashwood-Smith MJ,Ceska O,Warrington PJ,Morris TF,Altamirano M

更新日期：1992-04-01 00:00:00

abstract：:This research examines the behavior of ground-level solar UV radiation as measured by eight broadband meters in the continental United States during the period from late 1994 to late 1998. The goal is to define the variability that occurs in UV irradiance over time scales ranging from one to several years. The monthly...

journal_title：Photochemistry and photobiology

authors： Frederick JE,Slusser JR,Bigelow DS

更新日期：2000-10-01 00:00:00

abstract：:In this work, we have quantified for the first time the fluorescence and singlet oxygen quantum yields of a silicon(IV) phthalocyanine bound to the surface of zeolite L nanocrystals. The photophysical properties were correlated with the absorption spectra and the morphology of the nanoparticles, and most importantly, ...

journal_title：Photochemistry and photobiology

authors： Grüner M,Siozios V,Hagenhoff B,Breitenstein D,Strassert CA

更新日期：2013-11-01 00:00:00

abstract：:Light signals trigger precise changes in gene expression networks that activate distinctive developmental programs in plants. The transcriptome is shaped at different stages, both by the regulation of gene expression and also by posttranscriptional mechanisms that alter the sequence or abundance of the transcripts gen...

journal_title：Photochemistry and photobiology

authors： Hernando CE,Garcia C,Mateos JL

更新日期：2017-05-01 00:00:00

abstract：:Work in the past 8 years, particularly in the past 1-2 years, has greatly expanded our understanding of the mechanisms by which ultraviolet irradiation stimulates melanogenesis in the skin. A direct effect of UV photons on DNA results in up-regulation of the gene for tyrosinase, the rate-limiting enzyme in melanin syn...

journal_title：Photochemistry and photobiology

authors： Gilchrest BA,Park HY,Eller MS,Yaar M

更新日期：1996-01-01 00:00:00

abstract：:This study investigated the effects of low-level laser therapy (LLLT) in the liver function, structure and inflammation in a experimental model of carbon tetrachloride (CCl(4))-induced liver cirrhosis. Wistar rats were divided into Control, LLLT, CCl(4) and CCl(4) +LLLT groups. CCl(4) groups received CCl(4) (0.4 g kg(...

journal_title：Photochemistry and photobiology

authors： Oliveira-Junior MC,Monteiro AS,Leal-Junior EC,Munin E,Osório RA,Ribeiro W,Vieira RP

更新日期：2013-01-01 00:00:00