解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::The aim of this study was to establish the mechanisms of action of a novel liposomal nitric oxide (NO) carrier on large-conductance Ca2+-activated channels (BKCa or Maxi-K) expressed in vascular smooth muscle cells (VSMCs) isolated from the rat main pulmonary artery (MPA). Experimental design comprised of both whole-c...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2020.1863424
更新日期:2021-01-08 00:00:00
abstract::Leishmaniasis is a parasitic disease treatable and curable, however, the chemotherapeutic agents for their treatment are limited. In South American countries, pentavalent antimonials are still the first line of treatment for cutaneous leishmaniasis with an efficacy of about 75%, but the toxicity of the drug causes ser...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2020.1749067
更新日期:2020-04-13 00:00:00
abstract::Background and objective: The combination of two or more different mechanisms of drugs in the treatment of cancer has become one of the effective methods. The purpose of this study was to successfully prepare a non-viral delivery system that could efficiently co-delivery siRNA and gambogenic acid (GNA) to improve the ...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2018.1473423
更新日期:2019-12-01 00:00:00
abstract::RNA interference is an effective and naturally occurring post-transcriptional gene regulatory mechanism. This mechanism involves the degradation of a target messenger RNA (mRNA) through the introduction of short interfering RNA (siRNA) that is complementary to the target mRNA. The application of siRNA-based therapeuti...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2018.1531424
更新日期:2019-09-01 00:00:00
abstract::Hepatic carcinoma (HC) is one of the most prevalent cancers, ranked as the second most common cause of cancer-related deaths worldwide. Silymarin (SYL) has been reported for its anticarcinogenic activity against various types of cancer such as prostate, breast, ovary, colon, lung, bladder and liver. Due to poor solubi...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2018.1551408
更新日期:2019-09-01 00:00:00
abstract::The influence of esters based on gamma-aminobutyric acid (GABA) and mono-/bicyclic terpenoids on membrane structure was investigated. The mechanism of action for terpenoid esters on phospholipids of artificial membranes and lipids isolated from the rat stratum corneum was studied by fluorescence and FT-IR spectroscopy...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2018.1538238
更新日期:2019-09-01 00:00:00
abstract::Skin, the largest organ of the body serves as a potential route of drug delivery for local and systemic effects. However, the outermost layer of skin, the stratum corneum (SC) acts as a tough barrier that prevents penetration of hydrophilic and high molecular weight drugs. Ethosomes are a novel phospholipid vesicular ...
journal_title:Journal of liposome research
pub_type: 杂志文章,评审
doi:10.1080/08982104.2018.1517160
更新日期:2019-06-01 00:00:00
abstract::Co-delivery of chemotherapeutic agents using nanocarriers is a promising strategy for enhancing therapeutic efficacy of anticancer agents. The aim of this work was to develop tamoxifen and imatinib dual drug loaded temperature-sensitive liposomes to treat breast cancer. Liposomes were prepared using 1, 2-dipalmitoyl-s...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2018.1502315
更新日期:2019-06-01 00:00:00
abstract::Skin is considered the most accessible organ of the body because of its underlying capillary network. However, stratum corneum (SC), the upper most layer of skin, represents major diffusional barrier for most drugs. Hence, the use of edge activators (EAs) in designing novel elastic vesicles is hypothesized to impart t...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2018.1430831
更新日期:2019-03-01 00:00:00
abstract::By selecting a unique combination of lipids and amphotericin B, the liposome composition for AmBisome® (L-AmBis) has been optimized resulting in a formulation that is minimally toxic, targets to fungal cell walls, and distributes into and remains for days to weeks in various host tissues at drug levels above the MIC f...
journal_title:Journal of liposome research
pub_type: 杂志文章,评审
doi:10.1080/08982104.2017.1327543
更新日期:2017-09-01 00:00:00
abstract::This work describes the preparation of a PEGylated niosomes-mediated drug delivery systems for Paeonol, thereby improving the bioavailability and chemical stability of Paeonol, prolonging its cellular uptake and enhancing its synergistic anti-cancer effects with 5-Fu. PEGylated niosomes, which are prepared from biocom...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2016.1191021
更新日期:2017-06-01 00:00:00
abstract::The current investigation aims to develop and evaluate novel ocular proniosomal gels of lomefloxacin HCl (LXN); in order to improve its ocular bioavailability for the management of bacterial conjunctivitis. Proniosomes were prepared using different types of nonionic surfactants solely and as mixtures with Span 60. The...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2016.1167737
更新日期:2017-06-01 00:00:00
abstract::In the present work, we show that we obtained nanometric structures made of water, 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC), cholesterol (Chol), and a mixture of ethoxylated and non-ethoxylated sorbitan fatty acid esters (Tween 20, Span 20, Tween 80, and Span 80) by mixing all of them near the cloud poi...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2016.1174944
更新日期:2017-06-01 00:00:00
abstract::Adenosine triphosphate (ATP)-binding cassette (ABC) transporters play a key role in the development of multidrug resistance (MDR) in cancer cells. P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) are important proteins in this superfamily which are widely expressed on the membranes of multidr...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2016.1185731
更新日期:2017-06-01 00:00:00
abstract::Drug-in-CD-in-liposome (DCL) systems which encapsulate the drug/CD inclusion complexes into inner aqueous phase of liposomes have been applied as a novel strategy to improve efficacy of lipophilic antitumor drugs. The aim of this work was to assess the role of transferrin (Tf) modification and phosphatidylcholine (PC)...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2016.1140184
更新日期:2017-03-01 00:00:00
abstract:CONTEXT:Asenapine maleate (ASPM) is an antipsychotic drug for the treatment of schizophrenia and bipolar disorder. Extensive metabolism makes the oral route inconvenient for ASPM. OBJECTIVE:The objective of this study is to increase ASPM bioavailability via transdermal route by improving the skin permeation using comb...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2015.1098659
更新日期:2016-09-01 00:00:00
abstract::The aim of present study was to develop conventional and PEGylated (long circulating), liposomes containing anastrozole (ANS) for effective treatment of breast cancer. ANS is a third-generation non-steroidal aromatase inhibitor of the triazole class used for the treatment of advanced and late-stage breast cancer in po...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2015.1029493
更新日期:2016-01-01 00:00:00
abstract:CONTEXT:Ropivacaine (RVC) is an aminoamide local anesthetic widely used in surgical procedures. Studies with RVC encapsulated in liposomes and complexed in cyclodextrins have shown good results, but in order to use RVC for lengthy procedures and during the postoperative period, a still more prolonged anesthetic effect ...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2015.1022555
更新日期:2016-01-01 00:00:00
abstract::Ag:Au alloy nanoparticles were successfully synthesized through the new route using co-reduction method with silver nitrate, chloroauric acid, cetyl trimethyl ammonium bromide (CTAB) and sodium borohydride at room temperature. The Ag:Au alloy nanoparticles were then loaded within the phosphatidylcholine (97%) liposome...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2014.926917
更新日期:2015-03-01 00:00:00
abstract:CONTEXT:The stability of liposomes in the form of dispersion is a major concern due to drug leakage and fusion or aggregation. The stability can be improved by lyophilization, but the stress induced by the lyophilization process can affect the integrity of liposomes. OBJECTIVE:The objective of this study was to evalua...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2014.992023
更新日期:2015-01-01 00:00:00
abstract::In the current research work, rivastigmine (RV)-loaded in situ gelling nanostructured lipid carriers (NLCs) were developed for nose to brain delivery. NLCs were fabricated by ethanol injection method using glyceryl monosterate, Capmul MCM C8, Lecithin and Tween 80. NLCs showed average particle size of 123.2 ± 2.3 nm w...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2014.954129
更新日期:2015-01-01 00:00:00
abstract::Simvastatin (SIM) is a lipophilic statin that has potential benefits for prevention and treatment of several types of malignancies. However, its low water solubility and the toxicity associated with administration of high doses recommend it for encapsulation in carriers able to deliver the therapeutic dose in the tumo...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2014.987787
更新日期:2015-01-01 00:00:00
abstract::The present study is envisaged to develop nanoethosomal formulation for enhanced topical delivery of amphotericin B (AmB) for the treatment of cutaneous fungal infections. AmB encapsulated nanoethosomes were prepared using mechanical dispersion method in a strength of 0.1% w/w similar to the strength of marketed topic...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2014.995670
更新日期:2015-01-01 00:00:00
abstract::Mefenamic acid (MA) is a BCS II class NSAID drug. It is available only in the form of tablets, capsules, and pediatric suspensions. Oral administration of MA is associated with severe gastrointestinal side effects. The aim of this study was to develop a convenient and low-cost transdermal drug delivery system for MA u...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2014.911313
更新日期:2014-12-01 00:00:00
abstract::Pulmonary lung targeting finds applications in drug delivery to the lung itself and to other body organs, via blood circulation following transfer across alveolar membranes. Understanding pulmonary drug delivery systems towards improving their efficacy needs identification of particle sizes of relevance and elucidatio...
journal_title:Journal of liposome research
pub_type: 杂志文章,评审
doi:10.3109/08982104.2013.802332
更新日期:2013-12-01 00:00:00
abstract::The imaging of sentinel lymph nodes (SLN) has been researched for its role in assessing cancer progression and postsurgical lymphedema. Indocyanine green (ICG) is a near-infrared (NIR) optical dye that has been approved by the Food and Drug Administration. It is known that liposome-encapsulated ICG (LP-ICG) has improv...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2013.801488
更新日期:2013-12-01 00:00:00
abstract::In this study, the electron spin resonance (ESR) method was used to examine the effect of Amphotericin B (AmB) molecules on the fluidity of model membranes made of dipalmitoylphosphatidylcholine (DPPC). The changes occurring under increased AmB concentrations in the spectroscopic parameters of spin probes placed in li...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2013.814139
更新日期:2013-12-01 00:00:00
abstract::Liposomes have the capacity to be used as efficient, biodegradable and nontoxic carriers of bioactive molecules and are able to better control their delivery at the site of interest. The objective of this study was to obtain and characterize an appropriate liposomal formulation of the bioactive molecule chondroitin su...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2013.770016
更新日期:2013-06-01 00:00:00
abstract::Andrographis paniculata is a medicinal herb used extensively for various ailments and contains therapeutically active phytoconstituent, andrographolide (AN). Although hepatoprotective activity of AN is established, but their bioavailability is restricted due to its rapid clearance. The aim of this study, therefore, wa...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2012.753456
更新日期:2013-06-01 00:00:00
abstract::Cutaneous leishmaniasis is caused by different species of Leishmania parasites and its available treatments have not yet provided a strong consistent result. The weak response of current chemotherapeutics is due to their deficient effects on stealth parasites inside macrophages, rapid clearance from the site of action...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2012.762519
更新日期:2013-06-01 00:00:00
abstract::Valsartan (VLT) is a highly selective and orally active antihypertensive drug. However, its oral administration is associated with drawbacks like low bioavailability. The objective of this study was to design and develop a transdermal delivery system for VLT using ethosomal carriers to investigate their enhanced trans...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2012.753457
更新日期:2013-06-01 00:00:00
abstract::The aim of the present study was to characterize a liposome-based benzocaine (BZC) formulation designed for topical use on the oral mucosa and to evaluate its in vitro retention and permeation using the Franz-type diffusion cells through pig esophagus mucosa. To predict the effectiveness of new designed formulations d...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2012.742536
更新日期:2013-03-01 00:00:00
abstract::The aim of this study was to design and optimize a transdermal liposomes gel formulation for paeonol (PAE). A three-factor, three-level Box-Behnken design was used to derive a second-order polynomial equation to construct three-dimensional (3-D) contour plots for prediction of responses. Independent variables studied ...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2012.690159
更新日期:2012-12-01 00:00:00
abstract::Sustained release depot systems have been widely investigated for their potential to improve the efficacy of subunit vaccines and reduce the requirement for boosting. The present study aimed to further enhance the immunogenicity of a sustained release vaccine by combining a depot formulation with a particulate antigen...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2011.637502
更新日期:2012-09-01 00:00:00
abstract::Doxorubicin, as a widely used chemotherapeutic, always causes multidrug resistance in human cancer cells. To circumvent drug resistance, we developed a novel formulation where doxorubicin hydrochloride (DOX) and chloroquine phosphate (CQ) were simultaneously loaded into liposomes by a pH-gradient method where CQ playe...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2012.684150
更新日期:2012-09-01 00:00:00
abstract::Liposomal vinorelbine formulation is desirable, as it might improve the therapeutic activity of vinorelbine. However, because of its lipophilic and membrane-permeable properties, vinorelbine is hard to be formulated into liposomes using conventional drug-loading technologies. To improve vinorelbine retention, ammonium...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2011.584880
更新日期:2012-03-01 00:00:00
abstract::Amphotericin B (AmB) liposome formulations are very successful in the treatment of fungal infections and leishmaniasis. But higher cost limits its widespread use among people in developing countries. Therefore, we have developed a modified ethanol-injection method for the preparation of AmB liposomes. Two liposomal fo...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2011.584317
更新日期:2012-03-01 00:00:00
abstract::Methotrexate (MTX) is indicated in the symptomatic control of severe, recalcitrant, and disabling psoriasis. The oral or parenteral route of administration causes systemic toxicity. The topical route of delivery, though, reduces systemic toxicity and has limited applicability due to restricted permeability. Liposomal ...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2010.492476
更新日期:2011-06-01 00:00:00
abstract::Dopamine delivery to the central nervous system (CNS) undergoes the permeability limitations of the blood-brain barrier (BBB). Condensation of dopamine with neutral amino acids could afford potential prodrugs able to interact with the BBB endogenous transporters and easily enter the brain. To improve the bioavailabili...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982100903384129
更新日期:2010-09-01 00:00:00
abstract::The current study aimed to deliver minoxidil (2,4-diamino-6-piperidinopyrimidine 3-oxide; MXD), a potent hypertrichotic agent, into the pilosebaceous units, exploring the potential of the liposomal system. MXD-loaded liposomes of different compositions were prepared by a thin-film hydration technique and subsequently ...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982100903161449
更新日期:2010-06-01 00:00:00