Abstract:
:The imaging of sentinel lymph nodes (SLN) has been researched for its role in assessing cancer progression and postsurgical lymphedema. Indocyanine green (ICG) is a near-infrared (NIR) optical dye that has been approved by the Food and Drug Administration. It is known that liposome-encapsulated ICG (LP-ICG) has improved stability and fluorescence signal compared with ICG. We designed mannosylated liposome-encapsulated ICG (M-LP-ICG) as an optical contrast agent for SLN. M-LP-ICG has a higher UV absorbance spectrum and fluorescence intensity than LP-ICG. The stability of M-LP-ICG measured in 50% fetal bovine serum solution by a dialysis method was better than that of LP-ICG. M-LP-ICG demonstrated a high uptake in RAW 264.7 macrophage cell because the density of mannose is high. There were differences between M-LP-ICG and glucosylated liposome-encapsulated ICG (G-LP-ICG), which are geometrical isomers. The result of an inhibition study of M-LP-ICG showed a statistically significant decrease in uptake in RAW 264.7 cells after either co-treatment or pre-treatment with D-(+)-mannose as an inhibitor. Results from an in vitro experiment demonstrated that M-LP-ICG was specifically taken up by macrophage cells through the mannose receptor on its surface. The time-series images acquired from a normal mouse model after subcutaneous injection showed that the signal from M-LP-ICG in SLN and other organs appeared early and disappeared quickly in comparison with signals from LP-ICG. Not only the sentinel but also the draining lymph nodes were observed partly in M-LP-ICG. M-LP-ICG appears to increase the specificity of uptake and retention in macrophages, making it a good candidate contrast agent for an optic imaging system for SLN and the lymphatic system.
journal_name
J Liposome Resjournal_title
Journal of liposome researchauthors
Jeong HS,Lee CM,Cheong SJ,Kim EM,Hwang H,Na KS,Lim ST,Sohn MH,Jeong HJdoi
10.3109/08982104.2013.801488subject
Has Abstractpub_date
2013-12-01 00:00:00pages
291-7issue
4eissn
0898-2104issn
1532-2394journal_volume
23pub_type
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journal_title:Journal of liposome research
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journal_title:Journal of liposome research
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journal_title:Journal of liposome research
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journal_title:Journal of liposome research
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journal_title:Journal of liposome research
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journal_title:Journal of liposome research
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journal_title:Journal of liposome research
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journal_title:Journal of liposome research
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journal_title:Journal of liposome research
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journal_title:Journal of liposome research
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journal_title:Journal of liposome research
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journal_title:Journal of liposome research
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