Doxorubicin and chloroquine coencapsulated liposomes: preparation and improved cytotoxicity on human breast cancer cells.

abstract：:The aim of this study was to establish the mechanisms of action of a novel liposomal nitric oxide (NO) carrier on large-conductance Ca2+-activated channels (BKCa or Maxi-K) expressed in vascular smooth muscle cells (VSMCs) isolated from the rat main pulmonary artery (MPA). Experimental design comprised of both whole-c...

journal_title：Journal of liposome research

authors： Ivanova IV,Melnyk MI,Dryn DO,Prokhorov VV,Zholos AV,Soloviev AI

更新日期：2021-01-08 00:00:00

abstract：:The influence of the lipid composition of arsonoliposomes on their membrane integrity was investigated to evaluate whether it is possible to combine their action with drugs that can be encapsulated in their aqueous interior. This was investigated by measuring the retention of vesicle-encapsulated calcein (100 mM) duri...

journal_title：Journal of liposome research

authors： Piperoudi S,Ioannou PV,Frederik P,Antimisiaris SG

更新日期：2005-01-01 00:00:00

abstract：:This study aimed to investigate the influence of the preparation conditions on the performance of an ethosomal formulation for topical delivery of the local anesthetic agent, benzocaine (BZC). Ethosomes were prepared with different techniques, such as thin-layer evaporation, freezing and thawing, reverse-phase evapora...

journal_title：Journal of liposome research

authors： Maestrelli F,Capasso G,González-Rodríguez ML,Rabasco AM,Ghelardini C,Mura P

更新日期：2009-01-01 00:00:00

abstract：:Background and objective: The combination of two or more different mechanisms of drugs in the treatment of cancer has become one of the effective methods. The purpose of this study was to successfully prepare a non-viral delivery system that could efficiently co-delivery siRNA and gambogenic acid (GNA) to improve the ...

journal_title：Journal of liposome research

authors： Yu Q,Zhang B,Zhou Y,Ge Q,Chang J,Chen Y,Zhang K,Peng D,Chen W

更新日期：2019-12-01 00:00:00

abstract：:To engineer drug carriers capable of spontaneous accumulation in tumors and ischemic areas via the enhanced permeability and retention (EPR) effect and further penetration and drug delivery inside tumor or ischemic cells via the action of the cell-penetrating peptide (CPP), we have prepared liposomes simultaneously be...

journal_title：Journal of liposome research

authors： Kale AA,Torchilin VP

更新日期：2007-01-01 00:00:00

abstract：:Andrographis paniculata is a medicinal herb used extensively for various ailments and contains therapeutically active phytoconstituent, andrographolide (AN). Although hepatoprotective activity of AN is established, but their bioavailability is restricted due to its rapid clearance. The aim of this study, therefore, wa...

journal_title：Journal of liposome research

authors： Jain PK,Khurana N,Pounikar Y,Gajbhiye A,Kharya MD

更新日期：2013-06-01 00:00:00

abstract：:The present study is envisaged to develop nanoethosomal formulation for enhanced topical delivery of amphotericin B (AmB) for the treatment of cutaneous fungal infections. AmB encapsulated nanoethosomes were prepared using mechanical dispersion method in a strength of 0.1% w/w similar to the strength of marketed topic...

journal_title：Journal of liposome research

authors： Kaur L,Jain SK,Manhas RK,Sharma D

更新日期：2015-01-01 00:00:00

abstract：:The luciferase gene expression of lipoplexes, a liposome containing luciferase plasmid (pCMVLuc), in HeLa cell lines, was investigated. Cationic liposomes were prepared by the chloroform film method with sonication. The lipoplex was formed by loading the liposome with pCMVLuc. The lipoplex with an optimal weight ratio...

journal_title：Journal of liposome research

authors： Manosroi A,Thathang K,Manosroi J,Werner RG,Schubert R,Peschka-Süss R

更新日期：2009-01-01 00:00:00

abstract：:Intravenous injection of some liposomal drugs, diagnostic agents, micelles and other lipid-based nanoparticles can cause acute hypersensitivity reactions (HSRs) in a high percentage (up to 45%) of patients, with hemodynamic, respiratory and cutaneous manifestations. The phenomenon can be explained with activation of t...

journal_title：Journal of liposome research

authors： Szebeni J,Alving CR,Rosivall L,Bünger R,Baranyi L,Bedöcs P,Tóth M,Barenholz Y

更新日期：2007-01-01 00:00:00

abstract：:Sustained release depot systems have been widely investigated for their potential to improve the efficacy of subunit vaccines and reduce the requirement for boosting. The present study aimed to further enhance the immunogenicity of a sustained release vaccine by combining a depot formulation with a particulate antigen...

journal_title：Journal of liposome research

authors： Gordon S,Young K,Wilson R,Rizwan S,Kemp R,Rades T,Hook S

更新日期：2012-09-01 00:00:00

abstract：:Mefenamic acid (MA) is a BCS II class NSAID drug. It is available only in the form of tablets, capsules, and pediatric suspensions. Oral administration of MA is associated with severe gastrointestinal side effects. The aim of this study was to develop a convenient and low-cost transdermal drug delivery system for MA u...

journal_title：Journal of liposome research

authors： Wen MM,Farid RM,Kassem AA

更新日期：2014-12-01 00:00:00

abstract：:The imaging of sentinel lymph nodes (SLN) has been researched for its role in assessing cancer progression and postsurgical lymphedema. Indocyanine green (ICG) is a near-infrared (NIR) optical dye that has been approved by the Food and Drug Administration. It is known that liposome-encapsulated ICG (LP-ICG) has improv...

journal_title：Journal of liposome research

authors： Jeong HS,Lee CM,Cheong SJ,Kim EM,Hwang H,Na KS,Lim ST,Sohn MH,Jeong HJ

更新日期：2013-12-01 00:00:00

abstract：:Valsartan (VLT) is a highly selective and orally active antihypertensive drug. However, its oral administration is associated with drawbacks like low bioavailability. The objective of this study was to design and develop a transdermal delivery system for VLT using ethosomal carriers to investigate their enhanced trans...

journal_title：Journal of liposome research

authors： Bhosale SS,Avachat AM

更新日期：2013-06-01 00:00:00

abstract：CONTEXT:Asenapine maleate (ASPM) is an antipsychotic drug for the treatment of schizophrenia and bipolar disorder. Extensive metabolism makes the oral route inconvenient for ASPM. OBJECTIVE:The objective of this study is to increase ASPM bioavailability via transdermal route by improving the skin permeation using comb...

journal_title：Journal of liposome research

authors： Shreya AB,Managuli RS,Menon J,Kondapalli L,Hegde AR,Avadhani K,Shetty PK,Amirthalingam M,Kalthur G,Mutalik S

更新日期：2016-09-01 00:00:00

abstract：:Naturally occurring antibodies to phospholipids and cholesterol are widespread; they occur commonly during the course of acute infections; they are not causally related to the anti-phospholipid syndrome; they have been associated with other clinical entities only as an epiphenomenon; and they have not been implicated ...

journal_title：Journal of liposome research

authors： Alving CR

更新日期：2006-01-01 00:00:00

abstract：:Sonication is a simple method for reducing the size of liposomes. We report the size distributions of liposomes as a function of sonication time using three different techniques. Liposomes, mildly sonicated for just 30 sec, had bimodal distributions when surface-weighted with modes at about 140 and 750 nm. With extend...

journal_title：Journal of liposome research

authors： Woodbury DJ,Richardson ES,Grigg AW,Welling RD,Knudson BH

更新日期：2006-01-01 00:00:00

abstract：:The current study aimed to deliver minoxidil (2,4-diamino-6-piperidinopyrimidine 3-oxide; MXD), a potent hypertrichotic agent, into the pilosebaceous units, exploring the potential of the liposomal system. MXD-loaded liposomes of different compositions were prepared by a thin-film hydration technique and subsequently ...

journal_title：Journal of liposome research

authors： Jain B,Singh B,Katare OP,Vyas SP

更新日期：2010-06-01 00:00:00

abstract：CONTEXT:The stability of liposomes in the form of dispersion is a major concern due to drug leakage and fusion or aggregation. The stability can be improved by lyophilization, but the stress induced by the lyophilization process can affect the integrity of liposomes. OBJECTIVE:The objective of this study was to evalua...

journal_title：Journal of liposome research

authors： Kannan V,Balabathula P,Thoma LA,Wood GC

更新日期：2015-01-01 00:00:00

abstract：:The effect of liposomal inclusion on the stability and in vitro antiherpetic activity of Santolina insularis essential oil was investigated. In order to study the influence of vesicle structure on the liposome properties, multilamellar and unilamellar vesicles were prepared by the film method and sonication, respectiv...

journal_title：Journal of liposome research

authors： Valenti D,De Logu A,Loy G,Sinico C,Bonsignore L,Cottiglia F,Garau D,Fadda AM

更新日期：2001-01-01 00:00:00

abstract：:The aim of the present study was to characterize a liposome-based benzocaine (BZC) formulation designed for topical use on the oral mucosa and to evaluate its in vitro retention and permeation using the Franz-type diffusion cells through pig esophagus mucosa. To predict the effectiveness of new designed formulations d...

journal_title：Journal of liposome research

authors： Franz-Montan M,Cereda CM,Gaspari A,da Silva CM,de Araújo DR,Padula C,Santi P,Narvaes E,Novaes PD,Groppo FC,de Paula E

更新日期：2013-03-01 00:00:00

abstract：:Drug-in-CD-in-liposome (DCL) systems which encapsulate the drug/CD inclusion complexes into inner aqueous phase of liposomes have been applied as a novel strategy to improve efficacy of lipophilic antitumor drugs. The aim of this work was to assess the role of transferrin (Tf) modification and phosphatidylcholine (PC)...

journal_title：Journal of liposome research

authors： Chen J,Yao J,Ma Z,Peng P,Lu S,Hu Y,Xu F,Yang Y,Yang X

更新日期：2017-03-01 00:00:00

abstract：:Thermosensitive liposomes are attractive vehicles for the delivery and release of drugs to tumors. To improvethe targeting efficacy for breast cancer treatment, an 8.3-kDa HER2-specific Affibody molecule (Z(HER2:342)-Cys) was conjugated to the surface of liposomes. The effects of this modification on physical characte...

journal_title：Journal of liposome research

authors： Puri A,Kramer-Marek G,Campbell-Massa R,Yavlovich A,Tele SC,Lee SB,Clogston JD,Patri AK,Blumenthal R,Capala J

更新日期：2008-01-01 00:00:00

abstract：:Dopamine delivery to the central nervous system (CNS) undergoes the permeability limitations of the blood-brain barrier (BBB). Condensation of dopamine with neutral amino acids could afford potential prodrugs able to interact with the BBB endogenous transporters and easily enter the brain. To improve the bioavailabili...

journal_title：Journal of liposome research

authors： Carafa M,Marianecci C,Di Marzio L,De Caro V,Giandalia G,Giannola LI,Santucci E

更新日期：2010-09-01 00:00:00

abstract：:Adenosine triphosphate (ATP)-binding cassette (ABC) transporters play a key role in the development of multidrug resistance (MDR) in cancer cells. P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) are important proteins in this superfamily which are widely expressed on the membranes of multidr...

journal_title：Journal of liposome research

authors： Gao M,Xu Y,Qiu L

更新日期：2017-06-01 00:00:00

abstract：:Liposomes have the capacity to be used as efficient, biodegradable and nontoxic carriers of bioactive molecules and are able to better control their delivery at the site of interest. The objective of this study was to obtain and characterize an appropriate liposomal formulation of the bioactive molecule chondroitin su...

journal_title：Journal of liposome research

authors： Craciunescu O,Moldovan L,Moisei M,Trif M

更新日期：2013-06-01 00:00:00

abstract：:Co-delivery of chemotherapeutic agents using nanocarriers is a promising strategy for enhancing therapeutic efficacy of anticancer agents. The aim of this work was to develop tamoxifen and imatinib dual drug loaded temperature-sensitive liposomes to treat breast cancer. Liposomes were prepared using 1, 2-dipalmitoyl-s...

journal_title：Journal of liposome research

authors： Jose A,Ninave KM,Karnam S,Venuganti VVK

更新日期：2019-06-01 00:00:00

abstract：:Cutaneous leishmaniasis is caused by different species of Leishmania parasites and its available treatments have not yet provided a strong consistent result. The weak response of current chemotherapeutics is due to their deficient effects on stealth parasites inside macrophages, rapid clearance from the site of action...

journal_title：Journal of liposome research

authors： Momeni A,Rasoolian M,Momeni A,Navaei A,Emami S,Shaker Z,Mohebali M,Khoshdel A

更新日期：2013-06-01 00:00:00

abstract：:The aim of this study was to design and optimize a transdermal liposomes gel formulation for paeonol (PAE). A three-factor, three-level Box-Behnken design was used to derive a second-order polynomial equation to construct three-dimensional (3-D) contour plots for prediction of responses. Independent variables studied ...

journal_title：Journal of liposome research

authors： Shi J,Ma F,Wang X,Wang F,Liao H

更新日期：2012-12-01 00:00:00

abstract：:Simvastatin (SIM) is a lipophilic statin that has potential benefits for prevention and treatment of several types of malignancies. However, its low water solubility and the toxicity associated with administration of high doses recommend it for encapsulation in carriers able to deliver the therapeutic dose in the tumo...

journal_title：Journal of liposome research

authors： Porfire A,Tomuta I,Muntean D,Luca L,Licarete E,Alupei MC,Achim M,Vlase L,Banciu M

更新日期：2015-01-01 00:00:00

abstract：:Surface modification of liposomes with amphiphilic flexible polymers significantly prolongs their circulation time in blood and reduces uptake by cells of the reticuloendothelial system (RES). Several polymers have already been shown to provide steric protection to liposomes. Still more polymers are expected to serve ...

journal_title：Journal of liposome research

authors： Whiteman KR,Subr V,Ulbrich K,Torchilin VP

更新日期：2001-01-01 00:00:00