Use of liposomal nanoformulations in antileishmania therapy: challenges and perspectives.

abstract：:This study aimed to investigate the influence of the preparation conditions on the performance of an ethosomal formulation for topical delivery of the local anesthetic agent, benzocaine (BZC). Ethosomes were prepared with different techniques, such as thin-layer evaporation, freezing and thawing, reverse-phase evapora...

journal_title：Journal of liposome research

authors： Maestrelli F,Capasso G,González-Rodríguez ML,Rabasco AM,Ghelardini C,Mura P

更新日期：2009-01-01 00:00:00

abstract：:The influence of esters based on gamma-aminobutyric acid (GABA) and mono-/bicyclic terpenoids on membrane structure was investigated. The mechanism of action for terpenoid esters on phospholipids of artificial membranes and lipids isolated from the rat stratum corneum was studied by fluorescence and FT-IR spectroscopy...

journal_title：Journal of liposome research

authors： Nesterkina M,Smola S,Kravchenko I

更新日期：2019-09-01 00:00:00

abstract：:The aim of this study was to design and optimize a transdermal liposomes gel formulation for paeonol (PAE). A three-factor, three-level Box-Behnken design was used to derive a second-order polynomial equation to construct three-dimensional (3-D) contour plots for prediction of responses. Independent variables studied ...

journal_title：Journal of liposome research

authors： Shi J,Ma F,Wang X,Wang F,Liao H

更新日期：2012-12-01 00:00:00

abstract：:This work describes the preparation of a PEGylated niosomes-mediated drug delivery systems for Paeonol, thereby improving the bioavailability and chemical stability of Paeonol, prolonging its cellular uptake and enhancing its synergistic anti-cancer effects with 5-Fu. PEGylated niosomes, which are prepared from biocom...

journal_title：Journal of liposome research

authors： He RX,Ye X,Li R,Chen W,Ge T,Huang TQ,Nie XJ,Chen HJ,Peng DY,Chen WD

更新日期：2017-06-01 00:00:00

abstract：:Naturally occurring antibodies to phospholipids and cholesterol are widespread; they occur commonly during the course of acute infections; they are not causally related to the anti-phospholipid syndrome; they have been associated with other clinical entities only as an epiphenomenon; and they have not been implicated ...

journal_title：Journal of liposome research

authors： Alving CR

更新日期：2006-01-01 00:00:00

abstract：:Thermosensitive liposomes are attractive vehicles for the delivery and release of drugs to tumors. To improvethe targeting efficacy for breast cancer treatment, an 8.3-kDa HER2-specific Affibody molecule (Z(HER2:342)-Cys) was conjugated to the surface of liposomes. The effects of this modification on physical characte...

journal_title：Journal of liposome research

authors： Puri A,Kramer-Marek G,Campbell-Massa R,Yavlovich A,Tele SC,Lee SB,Clogston JD,Patri AK,Blumenthal R,Capala J

更新日期：2008-01-01 00:00:00

abstract：:The current study aimed to deliver minoxidil (2,4-diamino-6-piperidinopyrimidine 3-oxide; MXD), a potent hypertrichotic agent, into the pilosebaceous units, exploring the potential of the liposomal system. MXD-loaded liposomes of different compositions were prepared by a thin-film hydration technique and subsequently ...

journal_title：Journal of liposome research

authors： Jain B,Singh B,Katare OP,Vyas SP

更新日期：2010-06-01 00:00:00

abstract：:Andrographis paniculata is a medicinal herb used extensively for various ailments and contains therapeutically active phytoconstituent, andrographolide (AN). Although hepatoprotective activity of AN is established, but their bioavailability is restricted due to its rapid clearance. The aim of this study, therefore, wa...

journal_title：Journal of liposome research

authors： Jain PK,Khurana N,Pounikar Y,Gajbhiye A,Kharya MD

更新日期：2013-06-01 00:00:00

abstract：:The evidence in this communication indicate that, unlike resident Kupffer cells, newly recruited liver macrophages (following monocyte migration from the blood to the liver) use complement receptors to recognize and internalize stearylamine-incorporated liposomes. Within two weeks of hepatic residency complement recep...

journal_title：Journal of liposome research

authors： Moghimi SM

更新日期：2002-02-01 00:00:00

abstract：:Liposomal vinorelbine formulation is desirable, as it might improve the therapeutic activity of vinorelbine. However, because of its lipophilic and membrane-permeable properties, vinorelbine is hard to be formulated into liposomes using conventional drug-loading technologies. To improve vinorelbine retention, ammonium...

journal_title：Journal of liposome research

authors： Li C,Cui J,Wang C,Cao J,Zhang L,Li Y,Liang M,Xiu X,Li Y,Wei N,Deng C

更新日期：2012-03-01 00:00:00

abstract：:Sustained release depot systems have been widely investigated for their potential to improve the efficacy of subunit vaccines and reduce the requirement for boosting. The present study aimed to further enhance the immunogenicity of a sustained release vaccine by combining a depot formulation with a particulate antigen...

journal_title：Journal of liposome research

authors： Gordon S,Young K,Wilson R,Rizwan S,Kemp R,Rades T,Hook S

更新日期：2012-09-01 00:00:00

abstract：:Drug-in-CD-in-liposome (DCL) systems which encapsulate the drug/CD inclusion complexes into inner aqueous phase of liposomes have been applied as a novel strategy to improve efficacy of lipophilic antitumor drugs. The aim of this work was to assess the role of transferrin (Tf) modification and phosphatidylcholine (PC)...

journal_title：Journal of liposome research

authors： Chen J,Yao J,Ma Z,Peng P,Lu S,Hu Y,Xu F,Yang Y,Yang X

更新日期：2017-03-01 00:00:00

abstract：:The liposomalization and polyethyleneglycol (PEG) modification of antitumor agents prolongs their circulation in the blood and increases their accumulation in the tumor. It is expected that modification of the liposome surface with PEG-Lipid will prevent connection of liposome and tumor cell, so we examined the effect...

journal_title：Journal of liposome research

authors： Sadzuka Y,Kishi K,Hirota S,Sonobe T

更新日期：2003-05-01 00:00:00

abstract：:Liposomes have the capacity to be used as efficient, biodegradable and nontoxic carriers of bioactive molecules and are able to better control their delivery at the site of interest. The objective of this study was to obtain and characterize an appropriate liposomal formulation of the bioactive molecule chondroitin su...

journal_title：Journal of liposome research

authors： Craciunescu O,Moldovan L,Moisei M,Trif M

更新日期：2013-06-01 00:00:00

abstract：:Mefenamic acid (MA) is a BCS II class NSAID drug. It is available only in the form of tablets, capsules, and pediatric suspensions. Oral administration of MA is associated with severe gastrointestinal side effects. The aim of this study was to develop a convenient and low-cost transdermal drug delivery system for MA u...

journal_title：Journal of liposome research

authors： Wen MM,Farid RM,Kassem AA

更新日期：2014-12-01 00:00:00

abstract：:A simple strategy for designing a cancer immunotherapeutic system involves modification of tumor cells from tumor-bearing animals in vivo in such a way that the host can evoke a specific immune response against them. We have expressed allogeneic class I major histocompatibility complex (MHC) molecules on tumor cells, ...

journal_title：Journal of liposome research

authors： Hui KM,Sabapathy TK,Oei AA,Singhal A,Huang L

更新日期：1994-01-01 00:00:00

abstract：:The aim of this study was to investigate the application of ultrasonic gas-filled liposomes in enhancing transfer for breast cancer-related antisense oligonucleotides in vitro. An antisense oligodeoxynucleotide (AS-ODN) sequence, HA2741, modified with luciferase reporter plasmid, was used in evaluating the enhancing e...

journal_title：Journal of liposome research

authors： Luo YK,Zhao YZ,Lu CT,Tang J,Li XK

更新日期：2008-01-01 00:00:00

abstract：:This multicenter study investigated the possibility of reducing mortality rate by administering natural lung surfactant additional to standard therapy to treat patients after cardiac surgery who developed an acute respiratory failure (ARDS/ALI).A total of 78 patients (1998-2002) diagnosed with ALI or ARDS were enrolle...

journal_title：Journal of liposome research

authors： Bautin A,Khubulava G,Kozlov I,Poptzov V,Osovskikh V,Seiliev A,Volchkov V,Rosenberg O

更新日期：2006-01-01 00:00:00

abstract：:Skin is considered the most accessible organ of the body because of its underlying capillary network. However, stratum corneum (SC), the upper most layer of skin, represents major diffusional barrier for most drugs. Hence, the use of edge activators (EAs) in designing novel elastic vesicles is hypothesized to impart t...

journal_title：Journal of liposome research

authors： Aziz DE,Abdelbary AA,Elassasy AI

更新日期：2019-03-01 00:00:00

abstract：:Doxorubicin, as a widely used chemotherapeutic, always causes multidrug resistance in human cancer cells. To circumvent drug resistance, we developed a novel formulation where doxorubicin hydrochloride (DOX) and chloroquine phosphate (CQ) were simultaneously loaded into liposomes by a pH-gradient method where CQ playe...

journal_title：Journal of liposome research

authors： Qiu L,Yao M,Gao M,Zhao Q

更新日期：2012-09-01 00:00:00

abstract：:Archaeosomes, liposomes prepared from the polar ether lipids extracted from Archaea, demonstrate great potential as immunomodulating carriers of soluble antigens, promoting humoral and cell mediated immunity in the vaccinated host. The safety of unilamellar archaeosomes prepared from the total polar lipids (TPL) of Ha...

journal_title：Journal of liposome research

authors： Patel GB,Omri A,Deschatelets L,Sprott GD

更新日期：2002-11-01 00:00:00

abstract：CONTEXT:Ropivacaine (RVC) is an aminoamide local anesthetic widely used in surgical procedures. Studies with RVC encapsulated in liposomes and complexed in cyclodextrins have shown good results, but in order to use RVC for lengthy procedures and during the postoperative period, a still more prolonged anesthetic effect ...

journal_title：Journal of liposome research

authors： da Silva CM,Fraceto LF,Franz-Montan M,Couto VM,Casadei BR,Cereda CM,de Paula E

更新日期：2016-01-01 00:00:00

abstract：:The present study is envisaged to develop nanoethosomal formulation for enhanced topical delivery of amphotericin B (AmB) for the treatment of cutaneous fungal infections. AmB encapsulated nanoethosomes were prepared using mechanical dispersion method in a strength of 0.1% w/w similar to the strength of marketed topic...

journal_title：Journal of liposome research

authors： Kaur L,Jain SK,Manhas RK,Sharma D

更新日期：2015-01-01 00:00:00

abstract：:The aim of the present study was to characterize a liposome-based benzocaine (BZC) formulation designed for topical use on the oral mucosa and to evaluate its in vitro retention and permeation using the Franz-type diffusion cells through pig esophagus mucosa. To predict the effectiveness of new designed formulations d...

journal_title：Journal of liposome research

authors： Franz-Montan M,Cereda CM,Gaspari A,da Silva CM,de Araújo DR,Padula C,Santi P,Narvaes E,Novaes PD,Groppo FC,de Paula E

更新日期：2013-03-01 00:00:00

abstract：:Internal wool lipids (IWLs) are rich in cholesterol, free fatty acids, cholesteryl sulfate, and, mainly, ceramides. The repairing effect of these lipids structured as liposomes was demonstrated by reinforcing the skin-barrier integrity and increasing the water-holding capacity when applied onto the skin. This work was...

journal_title：Journal of liposome research

authors： Ramírez R,Martí M,Cavaco-Paulo A,Silva R,de la Maza A,Parra JL,Coderch L

更新日期：2009-01-01 00:00:00

abstract：:Thermodynamical techniques are applied for determining the thermal stress of medicinal compounds of the excipients as well as their interactions during the formulation process. The physicochemical properties and the stability of the medicinal products could be measured as a function of temperature or time using therma...

journal_title：Journal of liposome research

authors： Demetzos C

更新日期：2008-01-01 00:00:00

abstract：:The effect of liposomal inclusion on the stability and in vitro antiherpetic activity of Santolina insularis essential oil was investigated. In order to study the influence of vesicle structure on the liposome properties, multilamellar and unilamellar vesicles were prepared by the film method and sonication, respectiv...

journal_title：Journal of liposome research

authors： Valenti D,De Logu A,Loy G,Sinico C,Bonsignore L,Cottiglia F,Garau D,Fadda AM

更新日期：2001-01-01 00:00:00

abstract：:Methotrexate (MTX) is indicated in the symptomatic control of severe, recalcitrant, and disabling psoriasis. The oral or parenteral route of administration causes systemic toxicity. The topical route of delivery, though, reduces systemic toxicity and has limited applicability due to restricted permeability. Liposomal ...

journal_title：Journal of liposome research

authors： Nagle A,Goyal AK,Kesarla R,Murthy RR

更新日期：2011-06-01 00:00:00

abstract：CONTEXT:The stability of liposomes in the form of dispersion is a major concern due to drug leakage and fusion or aggregation. The stability can be improved by lyophilization, but the stress induced by the lyophilization process can affect the integrity of liposomes. OBJECTIVE:The objective of this study was to evalua...

journal_title：Journal of liposome research

authors： Kannan V,Balabathula P,Thoma LA,Wood GC

更新日期：2015-01-01 00:00:00

abstract：:Intravenous injection of some liposomal drugs, diagnostic agents, micelles and other lipid-based nanoparticles can cause acute hypersensitivity reactions (HSRs) in a high percentage (up to 45%) of patients, with hemodynamic, respiratory and cutaneous manifestations. The phenomenon can be explained with activation of t...

journal_title：Journal of liposome research

authors： Szebeni J,Alving CR,Rosivall L,Bünger R,Baranyi L,Bedöcs P,Tóth M,Barenholz Y

更新日期：2007-01-01 00:00:00