Development and characterization of minoxidil-loaded liposomal system for delivery to pilosebaceous units.

abstract：:Adsorption of serum proteins to the liposomal surface plays a critical role in the clearance of liposomes from the blood circulation. In this review, we will discuss the role of the liposomal opsonins proposed so far in liposome clearance. Additional, related topics that will be addressed are the cell-surface receptor...

journal_title：Journal of liposome research

authors： Yan X,Scherphof GL,Kamps JA

更新日期：2005-01-01 00:00:00

abstract：:Adenosine triphosphate (ATP)-binding cassette (ABC) transporters play a key role in the development of multidrug resistance (MDR) in cancer cells. P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) are important proteins in this superfamily which are widely expressed on the membranes of multidr...

journal_title：Journal of liposome research

authors： Gao M,Xu Y,Qiu L

更新日期：2017-06-01 00:00:00

abstract：:Surface modification of liposomes with amphiphilic flexible polymers significantly prolongs their circulation time in blood and reduces uptake by cells of the reticuloendothelial system (RES). Several polymers have already been shown to provide steric protection to liposomes. Still more polymers are expected to serve ...

journal_title：Journal of liposome research

authors： Whiteman KR,Subr V,Ulbrich K,Torchilin VP

更新日期：2001-01-01 00:00:00

abstract：:The evidence in this communication indicate that, unlike resident Kupffer cells, newly recruited liver macrophages (following monocyte migration from the blood to the liver) use complement receptors to recognize and internalize stearylamine-incorporated liposomes. Within two weeks of hepatic residency complement recep...

journal_title：Journal of liposome research

authors： Moghimi SM

更新日期：2002-02-01 00:00:00

abstract：:Vesicular phospholipid gels (VPGs) represent semi-solid phospholipid dispersions. Their morphology is truly vesicular with aqueous compartments both within the core of the vesicles and in-between the vesicles. VPGs are suited to carry both hydrophilic, amphiphilic and lipophilic drugs. Their drug load is stable since ...

journal_title：Journal of liposome research

authors： Brandl M

更新日期：2007-01-01 00:00:00

abstract：:The influence of the lipid composition of arsonoliposomes on their membrane integrity was investigated to evaluate whether it is possible to combine their action with drugs that can be encapsulated in their aqueous interior. This was investigated by measuring the retention of vesicle-encapsulated calcein (100 mM) duri...

journal_title：Journal of liposome research

authors： Piperoudi S,Ioannou PV,Frederik P,Antimisiaris SG

更新日期：2005-01-01 00:00:00

abstract：:This work describes the preparation of a PEGylated niosomes-mediated drug delivery systems for Paeonol, thereby improving the bioavailability and chemical stability of Paeonol, prolonging its cellular uptake and enhancing its synergistic anti-cancer effects with 5-Fu. PEGylated niosomes, which are prepared from biocom...

journal_title：Journal of liposome research

authors： He RX,Ye X,Li R,Chen W,Ge T,Huang TQ,Nie XJ,Chen HJ,Peng DY,Chen WD

更新日期：2017-06-01 00:00:00

abstract：:Skin is considered the most accessible organ of the body because of its underlying capillary network. However, stratum corneum (SC), the upper most layer of skin, represents major diffusional barrier for most drugs. Hence, the use of edge activators (EAs) in designing novel elastic vesicles is hypothesized to impart t...

journal_title：Journal of liposome research

authors： Aziz DE,Abdelbary AA,Elassasy AI

更新日期：2019-03-01 00:00:00

abstract：:A simple strategy for designing a cancer immunotherapeutic system involves modification of tumor cells from tumor-bearing animals in vivo in such a way that the host can evoke a specific immune response against them. We have expressed allogeneic class I major histocompatibility complex (MHC) molecules on tumor cells, ...

journal_title：Journal of liposome research

authors： Hui KM,Sabapathy TK,Oei AA,Singhal A,Huang L

更新日期：1994-01-01 00:00:00

abstract：:Valsartan (VLT) is a highly selective and orally active antihypertensive drug. However, its oral administration is associated with drawbacks like low bioavailability. The objective of this study was to design and develop a transdermal delivery system for VLT using ethosomal carriers to investigate their enhanced trans...

journal_title：Journal of liposome research

authors： Bhosale SS,Avachat AM

更新日期：2013-06-01 00:00:00

abstract：:Mefenamic acid (MA) is a BCS II class NSAID drug. It is available only in the form of tablets, capsules, and pediatric suspensions. Oral administration of MA is associated with severe gastrointestinal side effects. The aim of this study was to develop a convenient and low-cost transdermal drug delivery system for MA u...

journal_title：Journal of liposome research

authors： Wen MM,Farid RM,Kassem AA

更新日期：2014-12-01 00:00:00

abstract：:Liposomal vinorelbine formulation is desirable, as it might improve the therapeutic activity of vinorelbine. However, because of its lipophilic and membrane-permeable properties, vinorelbine is hard to be formulated into liposomes using conventional drug-loading technologies. To improve vinorelbine retention, ammonium...

journal_title：Journal of liposome research

authors： Li C,Cui J,Wang C,Cao J,Zhang L,Li Y,Liang M,Xiu X,Li Y,Wei N,Deng C

更新日期：2012-03-01 00:00:00

abstract：:Andrographis paniculata is a medicinal herb used extensively for various ailments and contains therapeutically active phytoconstituent, andrographolide (AN). Although hepatoprotective activity of AN is established, but their bioavailability is restricted due to its rapid clearance. The aim of this study, therefore, wa...

journal_title：Journal of liposome research

authors： Jain PK,Khurana N,Pounikar Y,Gajbhiye A,Kharya MD

更新日期：2013-06-01 00:00:00

abstract：:The aim of this study was to design and optimize a transdermal liposomes gel formulation for paeonol (PAE). A three-factor, three-level Box-Behnken design was used to derive a second-order polynomial equation to construct three-dimensional (3-D) contour plots for prediction of responses. Independent variables studied ...

journal_title：Journal of liposome research

authors： Shi J,Ma F,Wang X,Wang F,Liao H

更新日期：2012-12-01 00:00:00

abstract：:The poor selectivity of anticancer drugs often leads to their multiplicate dose-limiting toxicities in humans, which severely restricts their clinical application. In this study, a novel liposomal formulation of zedoary turmeric oil (ZTO) targeting the insulin receptor (IR) was prepared by covalently conjugating insul...

journal_title：Journal of liposome research

authors： Yang Z,Fu D,Zhu L,Yang M,Cheng Q

更新日期：2010-03-01 00:00:00

abstract：:The current investigation aims to develop and evaluate novel ocular proniosomal gels of lomefloxacin HCl (LXN); in order to improve its ocular bioavailability for the management of bacterial conjunctivitis. Proniosomes were prepared using different types of nonionic surfactants solely and as mixtures with Span 60. The...

journal_title：Journal of liposome research

authors： Khalil RM,Abdelbary GA,Basha M,Awad GE,El-Hashemy HA

更新日期：2017-06-01 00:00:00

abstract：:Background and objective: The combination of two or more different mechanisms of drugs in the treatment of cancer has become one of the effective methods. The purpose of this study was to successfully prepare a non-viral delivery system that could efficiently co-delivery siRNA and gambogenic acid (GNA) to improve the ...

journal_title：Journal of liposome research

authors： Yu Q,Zhang B,Zhou Y,Ge Q,Chang J,Chen Y,Zhang K,Peng D,Chen W

更新日期：2019-12-01 00:00:00

abstract：:Naturally occurring antibodies to phospholipids and cholesterol are widespread; they occur commonly during the course of acute infections; they are not causally related to the anti-phospholipid syndrome; they have been associated with other clinical entities only as an epiphenomenon; and they have not been implicated ...

journal_title：Journal of liposome research

authors： Alving CR

更新日期：2006-01-01 00:00:00

abstract：:RNA interference is an effective and naturally occurring post-transcriptional gene regulatory mechanism. This mechanism involves the degradation of a target messenger RNA (mRNA) through the introduction of short interfering RNA (siRNA) that is complementary to the target mRNA. The application of siRNA-based therapeuti...

journal_title：Journal of liposome research

authors： Obeid MA,Dufès C,Somani S,Mullen AB,Tate RJ,Ferro VA

更新日期：2019-09-01 00:00:00

abstract：:A novel scalable liposome preparation technique for pharmaceutical application is presented. Previous experiments have shown that the concept of continuous crossflow injection is a promising approach. For the characterization of the process, we focus on the influencing parameters like the lipid concentration, the inje...

journal_title：Journal of liposome research

authors： Wagner A,Vorauer-Uhl K,Kreismayr G,Katinger H

更新日期：2002-01-01 00:00:00

abstract：:The liposomalization and polyethyleneglycol (PEG) modification of antitumor agents prolongs their circulation in the blood and increases their accumulation in the tumor. It is expected that modification of the liposome surface with PEG-Lipid will prevent connection of liposome and tumor cell, so we examined the effect...

journal_title：Journal of liposome research

authors： Sadzuka Y,Kishi K,Hirota S,Sonobe T

更新日期：2003-05-01 00:00:00

abstract：:Thermosensitive liposomes are attractive vehicles for the delivery and release of drugs to tumors. To improvethe targeting efficacy for breast cancer treatment, an 8.3-kDa HER2-specific Affibody molecule (Z(HER2:342)-Cys) was conjugated to the surface of liposomes. The effects of this modification on physical characte...

journal_title：Journal of liposome research

authors： Puri A,Kramer-Marek G,Campbell-Massa R,Yavlovich A,Tele SC,Lee SB,Clogston JD,Patri AK,Blumenthal R,Capala J

更新日期：2008-01-01 00:00:00

abstract：:The aim of the present study was to characterize a liposome-based benzocaine (BZC) formulation designed for topical use on the oral mucosa and to evaluate its in vitro retention and permeation using the Franz-type diffusion cells through pig esophagus mucosa. To predict the effectiveness of new designed formulations d...

journal_title：Journal of liposome research

authors： Franz-Montan M,Cereda CM,Gaspari A,da Silva CM,de Araújo DR,Padula C,Santi P,Narvaes E,Novaes PD,Groppo FC,de Paula E

更新日期：2013-03-01 00:00:00

abstract：:Thermodynamical techniques are applied for determining the thermal stress of medicinal compounds of the excipients as well as their interactions during the formulation process. The physicochemical properties and the stability of the medicinal products could be measured as a function of temperature or time using therma...

journal_title：Journal of liposome research

authors： Demetzos C

更新日期：2008-01-01 00:00:00

abstract：:Dopamine delivery to the central nervous system (CNS) undergoes the permeability limitations of the blood-brain barrier (BBB). Condensation of dopamine with neutral amino acids could afford potential prodrugs able to interact with the BBB endogenous transporters and easily enter the brain. To improve the bioavailabili...

journal_title：Journal of liposome research

authors： Carafa M,Marianecci C,Di Marzio L,De Caro V,Giandalia G,Giannola LI,Santucci E

更新日期：2010-09-01 00:00:00

abstract：:Ag:Au alloy nanoparticles were successfully synthesized through the new route using co-reduction method with silver nitrate, chloroauric acid, cetyl trimethyl ammonium bromide (CTAB) and sodium borohydride at room temperature. The Ag:Au alloy nanoparticles were then loaded within the phosphatidylcholine (97%) liposome...

journal_title：Journal of liposome research

authors： Salehi AH,Montazer M,Toliyat T,Mahmoudi-Rad M

更新日期：2015-03-01 00:00:00

abstract：:Skin, the largest organ of the body serves as a potential route of drug delivery for local and systemic effects. However, the outermost layer of skin, the stratum corneum (SC) acts as a tough barrier that prevents penetration of hydrophilic and high molecular weight drugs. Ethosomes are a novel phospholipid vesicular ...

journal_title：Journal of liposome research

authors： Nainwal N,Jawla S,Singh R,Saharan VA

更新日期：2019-06-01 00:00:00

abstract：CONTEXT:Ropivacaine (RVC) is an aminoamide local anesthetic widely used in surgical procedures. Studies with RVC encapsulated in liposomes and complexed in cyclodextrins have shown good results, but in order to use RVC for lengthy procedures and during the postoperative period, a still more prolonged anesthetic effect ...

journal_title：Journal of liposome research

authors： da Silva CM,Fraceto LF,Franz-Montan M,Couto VM,Casadei BR,Cereda CM,de Paula E

更新日期：2016-01-01 00:00:00

abstract：:In this study we successfully entrapped 5-aminolevulinic acid (ALA) in liposome, although it exists as a zwitter ion. A molar ratio of 2:1:2.5 phosphatidyle-thanolamine (PE)/cholesterol/sodium stearate represented the best condition to achieve high entrapment efficiency (29.37 +/- 1.21%), and the average vehicle size ...

journal_title：Journal of liposome research

authors： Fang YP,Wu PC,Tsai YH,Huang YB

更新日期：2008-01-01 00:00:00

abstract：:Simvastatin (SIM) is a lipophilic statin that has potential benefits for prevention and treatment of several types of malignancies. However, its low water solubility and the toxicity associated with administration of high doses recommend it for encapsulation in carriers able to deliver the therapeutic dose in the tumo...

journal_title：Journal of liposome research

authors： Porfire A,Tomuta I,Muntean D,Luca L,Licarete E,Alupei MC,Achim M,Vlase L,Banciu M

更新日期：2015-01-01 00:00:00