Optimizing long-circulating liposomes for delivery of simvastatin to C26 colon carcinoma cells.

abstract：:Valsartan (VLT) is a highly selective and orally active antihypertensive drug. However, its oral administration is associated with drawbacks like low bioavailability. The objective of this study was to design and develop a transdermal delivery system for VLT using ethosomal carriers to investigate their enhanced trans...

journal_title：Journal of liposome research

authors： Bhosale SS,Avachat AM

更新日期：2013-06-01 00:00:00

abstract：:The aim of this study was to establish the mechanisms of action of a novel liposomal nitric oxide (NO) carrier on large-conductance Ca2+-activated channels (BKCa or Maxi-K) expressed in vascular smooth muscle cells (VSMCs) isolated from the rat main pulmonary artery (MPA). Experimental design comprised of both whole-c...

journal_title：Journal of liposome research

authors： Ivanova IV,Melnyk MI,Dryn DO,Prokhorov VV,Zholos AV,Soloviev AI

更新日期：2021-01-08 00:00:00

abstract：:The aim of the present study was to characterize a liposome-based benzocaine (BZC) formulation designed for topical use on the oral mucosa and to evaluate its in vitro retention and permeation using the Franz-type diffusion cells through pig esophagus mucosa. To predict the effectiveness of new designed formulations d...

journal_title：Journal of liposome research

authors： Franz-Montan M,Cereda CM,Gaspari A,da Silva CM,de Araújo DR,Padula C,Santi P,Narvaes E,Novaes PD,Groppo FC,de Paula E

更新日期：2013-03-01 00:00:00

abstract：:The influence of esters based on gamma-aminobutyric acid (GABA) and mono-/bicyclic terpenoids on membrane structure was investigated. The mechanism of action for terpenoid esters on phospholipids of artificial membranes and lipids isolated from the rat stratum corneum was studied by fluorescence and FT-IR spectroscopy...

journal_title：Journal of liposome research

authors： Nesterkina M,Smola S,Kravchenko I

更新日期：2019-09-01 00:00:00

abstract：:Mefenamic acid (MA) is a BCS II class NSAID drug. It is available only in the form of tablets, capsules, and pediatric suspensions. Oral administration of MA is associated with severe gastrointestinal side effects. The aim of this study was to develop a convenient and low-cost transdermal drug delivery system for MA u...

journal_title：Journal of liposome research

authors： Wen MM,Farid RM,Kassem AA

更新日期：2014-12-01 00:00:00

abstract：:Leishmaniasis is a parasitic disease treatable and curable, however, the chemotherapeutic agents for their treatment are limited. In South American countries, pentavalent antimonials are still the first line of treatment for cutaneous leishmaniasis with an efficacy of about 75%, but the toxicity of the drug causes ser...

journal_title：Journal of liposome research

authors： Téllez J,Echeverry MC,Romero I,Guatibonza A,Santos Ramos G,Borges De Oliveira AC,Frézard F,Demicheli C

更新日期：2020-04-13 00:00:00

abstract：:Archaeosomes, liposomes prepared from the polar ether lipids extracted from Archaea, demonstrate great potential as immunomodulating carriers of soluble antigens, promoting humoral and cell mediated immunity in the vaccinated host. The safety of unilamellar archaeosomes prepared from the total polar lipids (TPL) of Ha...

journal_title：Journal of liposome research

authors： Patel GB,Omri A,Deschatelets L,Sprott GD

更新日期：2002-11-01 00:00:00

abstract：:Amphotericin B (AmB) liposome formulations are very successful in the treatment of fungal infections and leishmaniasis. But higher cost limits its widespread use among people in developing countries. Therefore, we have developed a modified ethanol-injection method for the preparation of AmB liposomes. Two liposomal fo...

journal_title：Journal of liposome research

authors： Singodia D,Verma A,Khare P,Dube A,Mitra K,Mishra PR

更新日期：2012-03-01 00:00:00

abstract：:In the present work, we show that we obtained nanometric structures made of water, 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC), cholesterol (Chol), and a mixture of ethoxylated and non-ethoxylated sorbitan fatty acid esters (Tween 20, Span 20, Tween 80, and Span 80) by mixing all of them near the cloud poi...

journal_title：Journal of liposome research

authors： Juárez-Osornio C,Gracia-Fadrique J

更新日期：2017-06-01 00:00:00

abstract：CONTEXT:Ropivacaine (RVC) is an aminoamide local anesthetic widely used in surgical procedures. Studies with RVC encapsulated in liposomes and complexed in cyclodextrins have shown good results, but in order to use RVC for lengthy procedures and during the postoperative period, a still more prolonged anesthetic effect ...

journal_title：Journal of liposome research

authors： da Silva CM,Fraceto LF,Franz-Montan M,Couto VM,Casadei BR,Cereda CM,de Paula E

更新日期：2016-01-01 00:00:00

abstract：:Co-delivery of chemotherapeutic agents using nanocarriers is a promising strategy for enhancing therapeutic efficacy of anticancer agents. The aim of this work was to develop tamoxifen and imatinib dual drug loaded temperature-sensitive liposomes to treat breast cancer. Liposomes were prepared using 1, 2-dipalmitoyl-s...

journal_title：Journal of liposome research

authors： Jose A,Ninave KM,Karnam S,Venuganti VVK

更新日期：2019-06-01 00:00:00

abstract：:Ag:Au alloy nanoparticles were successfully synthesized through the new route using co-reduction method with silver nitrate, chloroauric acid, cetyl trimethyl ammonium bromide (CTAB) and sodium borohydride at room temperature. The Ag:Au alloy nanoparticles were then loaded within the phosphatidylcholine (97%) liposome...

journal_title：Journal of liposome research

authors： Salehi AH,Montazer M,Toliyat T,Mahmoudi-Rad M

更新日期：2015-03-01 00:00:00

abstract：:By selecting a unique combination of lipids and amphotericin B, the liposome composition for AmBisome® (L-AmBis) has been optimized resulting in a formulation that is minimally toxic, targets to fungal cell walls, and distributes into and remains for days to weeks in various host tissues at drug levels above the MIC f...

journal_title：Journal of liposome research

authors： Adler-Moore JP,Proffitt RT,Olson JA,Jensen GM

更新日期：2017-09-01 00:00:00

abstract：:The use of arsenic-containing compounds in cancer therapy is currently being re-considered, after the recent approval of arsenic trioxide (Trisenox) for the treatment of relapsed promyelocytic leukemia (PML). In an attempt to prepare a carrier system to minimize the toxicity of this drug, the aim of this study is to p...

journal_title：Journal of liposome research

authors： Kallinteri P,Fatouros D,Klepetsanis P,Antimisiaris SG

更新日期：2004-01-01 00:00:00

abstract：:The aim of present study was to develop conventional and PEGylated (long circulating), liposomes containing anastrozole (ANS) for effective treatment of breast cancer. ANS is a third-generation non-steroidal aromatase inhibitor of the triazole class used for the treatment of advanced and late-stage breast cancer in po...

journal_title：Journal of liposome research

authors： Shavi GV,Sreenivasa Reddy M,Raghavendra R,Nayak UY,Kumar AR,Deshpande PB,Udupa N,Behl G,Dave V,Kushwaha K

更新日期：2016-01-01 00:00:00

abstract：:Liposomal vinorelbine formulation is desirable, as it might improve the therapeutic activity of vinorelbine. However, because of its lipophilic and membrane-permeable properties, vinorelbine is hard to be formulated into liposomes using conventional drug-loading technologies. To improve vinorelbine retention, ammonium...

journal_title：Journal of liposome research

authors： Li C,Cui J,Wang C,Cao J,Zhang L,Li Y,Liang M,Xiu X,Li Y,Wei N,Deng C

更新日期：2012-03-01 00:00:00

abstract：:Doxorubicin, as a widely used chemotherapeutic, always causes multidrug resistance in human cancer cells. To circumvent drug resistance, we developed a novel formulation where doxorubicin hydrochloride (DOX) and chloroquine phosphate (CQ) were simultaneously loaded into liposomes by a pH-gradient method where CQ playe...

journal_title：Journal of liposome research

authors： Qiu L,Yao M,Gao M,Zhao Q

更新日期：2012-09-01 00:00:00

abstract：:To engineer drug carriers capable of spontaneous accumulation in tumors and ischemic areas via the enhanced permeability and retention (EPR) effect and further penetration and drug delivery inside tumor or ischemic cells via the action of the cell-penetrating peptide (CPP), we have prepared liposomes simultaneously be...

journal_title：Journal of liposome research

authors： Kale AA,Torchilin VP

更新日期：2007-01-01 00:00:00

abstract：:The evidence in this communication indicate that, unlike resident Kupffer cells, newly recruited liver macrophages (following monocyte migration from the blood to the liver) use complement receptors to recognize and internalize stearylamine-incorporated liposomes. Within two weeks of hepatic residency complement recep...

journal_title：Journal of liposome research

authors： Moghimi SM

更新日期：2002-02-01 00:00:00

abstract：:Dopamine delivery to the central nervous system (CNS) undergoes the permeability limitations of the blood-brain barrier (BBB). Condensation of dopamine with neutral amino acids could afford potential prodrugs able to interact with the BBB endogenous transporters and easily enter the brain. To improve the bioavailabili...

journal_title：Journal of liposome research

authors： Carafa M,Marianecci C,Di Marzio L,De Caro V,Giandalia G,Giannola LI,Santucci E

更新日期：2010-09-01 00:00:00

abstract：:This work describes the preparation of a PEGylated niosomes-mediated drug delivery systems for Paeonol, thereby improving the bioavailability and chemical stability of Paeonol, prolonging its cellular uptake and enhancing its synergistic anti-cancer effects with 5-Fu. PEGylated niosomes, which are prepared from biocom...

journal_title：Journal of liposome research

authors： He RX,Ye X,Li R,Chen W,Ge T,Huang TQ,Nie XJ,Chen HJ,Peng DY,Chen WD

更新日期：2017-06-01 00:00:00

abstract：:This multicenter study investigated the possibility of reducing mortality rate by administering natural lung surfactant additional to standard therapy to treat patients after cardiac surgery who developed an acute respiratory failure (ARDS/ALI).A total of 78 patients (1998-2002) diagnosed with ALI or ARDS were enrolle...

journal_title：Journal of liposome research

authors： Bautin A,Khubulava G,Kozlov I,Poptzov V,Osovskikh V,Seiliev A,Volchkov V,Rosenberg O

更新日期：2006-01-01 00:00:00

abstract：:The influence of the lipid composition of arsonoliposomes on their membrane integrity was investigated to evaluate whether it is possible to combine their action with drugs that can be encapsulated in their aqueous interior. This was investigated by measuring the retention of vesicle-encapsulated calcein (100 mM) duri...

journal_title：Journal of liposome research

authors： Piperoudi S,Ioannou PV,Frederik P,Antimisiaris SG

更新日期：2005-01-01 00:00:00

abstract：:A simple strategy for designing a cancer immunotherapeutic system involves modification of tumor cells from tumor-bearing animals in vivo in such a way that the host can evoke a specific immune response against them. We have expressed allogeneic class I major histocompatibility complex (MHC) molecules on tumor cells, ...

journal_title：Journal of liposome research

authors： Hui KM,Sabapathy TK,Oei AA,Singhal A,Huang L

更新日期：1994-01-01 00:00:00

abstract：:Sonication is a simple method for reducing the size of liposomes. We report the size distributions of liposomes as a function of sonication time using three different techniques. Liposomes, mildly sonicated for just 30 sec, had bimodal distributions when surface-weighted with modes at about 140 and 750 nm. With extend...

journal_title：Journal of liposome research

authors： Woodbury DJ,Richardson ES,Grigg AW,Welling RD,Knudson BH

更新日期：2006-01-01 00:00:00

abstract：:This study aimed to investigate the influence of the preparation conditions on the performance of an ethosomal formulation for topical delivery of the local anesthetic agent, benzocaine (BZC). Ethosomes were prepared with different techniques, such as thin-layer evaporation, freezing and thawing, reverse-phase evapora...

journal_title：Journal of liposome research

authors： Maestrelli F,Capasso G,González-Rodríguez ML,Rabasco AM,Ghelardini C,Mura P

更新日期：2009-01-01 00:00:00

abstract：:Skin is considered the most accessible organ of the body because of its underlying capillary network. However, stratum corneum (SC), the upper most layer of skin, represents major diffusional barrier for most drugs. Hence, the use of edge activators (EAs) in designing novel elastic vesicles is hypothesized to impart t...

journal_title：Journal of liposome research

authors： Aziz DE,Abdelbary AA,Elassasy AI

更新日期：2019-03-01 00:00:00

abstract：:In the current research work, rivastigmine (RV)-loaded in situ gelling nanostructured lipid carriers (NLCs) were developed for nose to brain delivery. NLCs were fabricated by ethanol injection method using glyceryl monosterate, Capmul MCM C8, Lecithin and Tween 80. NLCs showed average particle size of 123.2 ± 2.3 nm w...

journal_title：Journal of liposome research

authors： Wavikar PR,Vavia PR

更新日期：2015-01-01 00:00:00

abstract：:In this study, the electron spin resonance (ESR) method was used to examine the effect of Amphotericin B (AmB) molecules on the fluidity of model membranes made of dipalmitoylphosphatidylcholine (DPPC). The changes occurring under increased AmB concentrations in the spectroscopic parameters of spin probes placed in li...

journal_title：Journal of liposome research

authors： Man D,Olchawa R

更新日期：2013-12-01 00:00:00

abstract：:Methotrexate (MTX) is indicated in the symptomatic control of severe, recalcitrant, and disabling psoriasis. The oral or parenteral route of administration causes systemic toxicity. The topical route of delivery, though, reduces systemic toxicity and has limited applicability due to restricted permeability. Liposomal ...

journal_title：Journal of liposome research

authors： Nagle A,Goyal AK,Kesarla R,Murthy RR

更新日期：2011-06-01 00:00:00