Abstract:
:In the current research work, rivastigmine (RV)-loaded in situ gelling nanostructured lipid carriers (NLCs) were developed for nose to brain delivery. NLCs were fabricated by ethanol injection method using glyceryl monosterate, Capmul MCM C8, Lecithin and Tween 80. NLCs showed average particle size of 123.2 ± 2.3 nm with entrapment efficiency of 68.34 ± 3.4%. DSC, XRD and IR studies showed complete amorphization and incorporation of the drug into nanoparticles. NLCs were incorporated into an in situ gelling system using 0.8% gellan gum and 15% Lutrol F 127. RV in situ gel showed excellent elasticity, rheology, mucoadhesion and adhesiveness to facilitate its adhesion to the upper nasal mucosa. NLC-based in situ gel showed a 2-fold increase in nasal permeation of the drug over plain RV solution. In situ gelling NLCs showed a 3-fold increase in enzyme inhibition efficacy.
journal_name
J Liposome Resjournal_title
Journal of liposome researchauthors
Wavikar PR,Vavia PRdoi
10.3109/08982104.2014.954129subject
Has Abstractpub_date
2015-01-01 00:00:00pages
141-9issue
2eissn
0898-2104issn
1532-2394journal_volume
25pub_type
杂志文章abstract::The current study aimed to deliver minoxidil (2,4-diamino-6-piperidinopyrimidine 3-oxide; MXD), a potent hypertrichotic agent, into the pilosebaceous units, exploring the potential of the liposomal system. MXD-loaded liposomes of different compositions were prepared by a thin-film hydration technique and subsequently ...
journal_title:Journal of liposome research
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journal_title:Journal of liposome research
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journal_title:Journal of liposome research
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journal_title:Journal of liposome research
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journal_title:Journal of liposome research
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journal_title:Journal of liposome research
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journal_title:Journal of liposome research
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journal_title:Journal of liposome research
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journal_title:Journal of liposome research
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journal_title:Journal of liposome research
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journal_title:Journal of liposome research
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journal_title:Journal of liposome research
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更新日期:2013-06-01 00:00:00
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journal_title:Journal of liposome research
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