Chitosan hydrogels containing liposomes and cubosomes as particulate sustained release vaccine delivery systems.

abstract：:In this study we successfully entrapped 5-aminolevulinic acid (ALA) in liposome, although it exists as a zwitter ion. A molar ratio of 2:1:2.5 phosphatidyle-thanolamine (PE)/cholesterol/sodium stearate represented the best condition to achieve high entrapment efficiency (29.37 +/- 1.21%), and the average vehicle size ...

journal_title：Journal of liposome research

authors： Fang YP,Wu PC,Tsai YH,Huang YB

更新日期：2008-01-01 00:00:00

abstract：:Cutaneous leishmaniasis is caused by different species of Leishmania parasites and its available treatments have not yet provided a strong consistent result. The weak response of current chemotherapeutics is due to their deficient effects on stealth parasites inside macrophages, rapid clearance from the site of action...

journal_title：Journal of liposome research

authors： Momeni A,Rasoolian M,Momeni A,Navaei A,Emami S,Shaker Z,Mohebali M,Khoshdel A

更新日期：2013-06-01 00:00:00

abstract：:Sonication is a simple method for reducing the size of liposomes. We report the size distributions of liposomes as a function of sonication time using three different techniques. Liposomes, mildly sonicated for just 30 sec, had bimodal distributions when surface-weighted with modes at about 140 and 750 nm. With extend...

journal_title：Journal of liposome research

authors： Woodbury DJ,Richardson ES,Grigg AW,Welling RD,Knudson BH

更新日期：2006-01-01 00:00:00

abstract：:Thermosensitive liposomes are attractive vehicles for the delivery and release of drugs to tumors. To improvethe targeting efficacy for breast cancer treatment, an 8.3-kDa HER2-specific Affibody molecule (Z(HER2:342)-Cys) was conjugated to the surface of liposomes. The effects of this modification on physical characte...

journal_title：Journal of liposome research

authors： Puri A,Kramer-Marek G,Campbell-Massa R,Yavlovich A,Tele SC,Lee SB,Clogston JD,Patri AK,Blumenthal R,Capala J

更新日期：2008-01-01 00:00:00

abstract：:The aim of this study was to establish the mechanisms of action of a novel liposomal nitric oxide (NO) carrier on large-conductance Ca2+-activated channels (BKCa or Maxi-K) expressed in vascular smooth muscle cells (VSMCs) isolated from the rat main pulmonary artery (MPA). Experimental design comprised of both whole-c...

journal_title：Journal of liposome research

authors： Ivanova IV,Melnyk MI,Dryn DO,Prokhorov VV,Zholos AV,Soloviev AI

更新日期：2021-01-08 00:00:00

abstract：:Pulmonary lung targeting finds applications in drug delivery to the lung itself and to other body organs, via blood circulation following transfer across alveolar membranes. Understanding pulmonary drug delivery systems towards improving their efficacy needs identification of particle sizes of relevance and elucidatio...

journal_title：Journal of liposome research

authors： Chattopadhyay S

更新日期：2013-12-01 00:00:00

abstract：:RNA interference is an effective and naturally occurring post-transcriptional gene regulatory mechanism. This mechanism involves the degradation of a target messenger RNA (mRNA) through the introduction of short interfering RNA (siRNA) that is complementary to the target mRNA. The application of siRNA-based therapeuti...

journal_title：Journal of liposome research

authors： Obeid MA,Dufès C,Somani S,Mullen AB,Tate RJ,Ferro VA

更新日期：2019-09-01 00:00:00

abstract：:This work describes the preparation of a PEGylated niosomes-mediated drug delivery systems for Paeonol, thereby improving the bioavailability and chemical stability of Paeonol, prolonging its cellular uptake and enhancing its synergistic anti-cancer effects with 5-Fu. PEGylated niosomes, which are prepared from biocom...

journal_title：Journal of liposome research

authors： He RX,Ye X,Li R,Chen W,Ge T,Huang TQ,Nie XJ,Chen HJ,Peng DY,Chen WD

更新日期：2017-06-01 00:00:00

abstract：:Valsartan (VLT) is a highly selective and orally active antihypertensive drug. However, its oral administration is associated with drawbacks like low bioavailability. The objective of this study was to design and develop a transdermal delivery system for VLT using ethosomal carriers to investigate their enhanced trans...

journal_title：Journal of liposome research

authors： Bhosale SS,Avachat AM

更新日期：2013-06-01 00:00:00

abstract：:The liposomalization and polyethyleneglycol (PEG) modification of antitumor agents prolongs their circulation in the blood and increases their accumulation in the tumor. It is expected that modification of the liposome surface with PEG-Lipid will prevent connection of liposome and tumor cell, so we examined the effect...

journal_title：Journal of liposome research

authors： Sadzuka Y,Kishi K,Hirota S,Sonobe T

更新日期：2003-05-01 00:00:00

abstract：:Naturally occurring antibodies to phospholipids and cholesterol are widespread; they occur commonly during the course of acute infections; they are not causally related to the anti-phospholipid syndrome; they have been associated with other clinical entities only as an epiphenomenon; and they have not been implicated ...

journal_title：Journal of liposome research

authors： Alving CR

更新日期：2006-01-01 00:00:00

abstract：:To engineer drug carriers capable of spontaneous accumulation in tumors and ischemic areas via the enhanced permeability and retention (EPR) effect and further penetration and drug delivery inside tumor or ischemic cells via the action of the cell-penetrating peptide (CPP), we have prepared liposomes simultaneously be...

journal_title：Journal of liposome research

authors： Kale AA,Torchilin VP

更新日期：2007-01-01 00:00:00

abstract：:The aim of this study was to design and optimize a transdermal liposomes gel formulation for paeonol (PAE). A three-factor, three-level Box-Behnken design was used to derive a second-order polynomial equation to construct three-dimensional (3-D) contour plots for prediction of responses. Independent variables studied ...

journal_title：Journal of liposome research

authors： Shi J,Ma F,Wang X,Wang F,Liao H

更新日期：2012-12-01 00:00:00

abstract：:Skin is considered the most accessible organ of the body because of its underlying capillary network. However, stratum corneum (SC), the upper most layer of skin, represents major diffusional barrier for most drugs. Hence, the use of edge activators (EAs) in designing novel elastic vesicles is hypothesized to impart t...

journal_title：Journal of liposome research

authors： Aziz DE,Abdelbary AA,Elassasy AI

更新日期：2019-03-01 00:00:00

abstract：:In the current research work, rivastigmine (RV)-loaded in situ gelling nanostructured lipid carriers (NLCs) were developed for nose to brain delivery. NLCs were fabricated by ethanol injection method using glyceryl monosterate, Capmul MCM C8, Lecithin and Tween 80. NLCs showed average particle size of 123.2 ± 2.3 nm w...

journal_title：Journal of liposome research

authors： Wavikar PR,Vavia PR

更新日期：2015-01-01 00:00:00

abstract：:Amphotericin B (AmB) liposome formulations are very successful in the treatment of fungal infections and leishmaniasis. But higher cost limits its widespread use among people in developing countries. Therefore, we have developed a modified ethanol-injection method for the preparation of AmB liposomes. Two liposomal fo...

journal_title：Journal of liposome research

authors： Singodia D,Verma A,Khare P,Dube A,Mitra K,Mishra PR

更新日期：2012-03-01 00:00:00

abstract：CONTEXT:Ropivacaine (RVC) is an aminoamide local anesthetic widely used in surgical procedures. Studies with RVC encapsulated in liposomes and complexed in cyclodextrins have shown good results, but in order to use RVC for lengthy procedures and during the postoperative period, a still more prolonged anesthetic effect ...

journal_title：Journal of liposome research

authors： da Silva CM,Fraceto LF,Franz-Montan M,Couto VM,Casadei BR,Cereda CM,de Paula E

更新日期：2016-01-01 00:00:00

abstract：:Hepatic carcinoma (HC) is one of the most prevalent cancers, ranked as the second most common cause of cancer-related deaths worldwide. Silymarin (SYL) has been reported for its anticarcinogenic activity against various types of cancer such as prostate, breast, ovary, colon, lung, bladder and liver. Due to poor solubi...

journal_title：Journal of liposome research

authors： Parashar P,Rana P,Dwivedi M,Saraf SA

更新日期：2019-09-01 00:00:00

abstract：:Co-delivery of chemotherapeutic agents using nanocarriers is a promising strategy for enhancing therapeutic efficacy of anticancer agents. The aim of this work was to develop tamoxifen and imatinib dual drug loaded temperature-sensitive liposomes to treat breast cancer. Liposomes were prepared using 1, 2-dipalmitoyl-s...

journal_title：Journal of liposome research

authors： Jose A,Ninave KM,Karnam S,Venuganti VVK

更新日期：2019-06-01 00:00:00

abstract：:Intravenous injection of some liposomal drugs, diagnostic agents, micelles and other lipid-based nanoparticles can cause acute hypersensitivity reactions (HSRs) in a high percentage (up to 45%) of patients, with hemodynamic, respiratory and cutaneous manifestations. The phenomenon can be explained with activation of t...

journal_title：Journal of liposome research

authors： Szebeni J,Alving CR,Rosivall L,Bünger R,Baranyi L,Bedöcs P,Tóth M,Barenholz Y

更新日期：2007-01-01 00:00:00

abstract：:Simvastatin (SIM) is a lipophilic statin that has potential benefits for prevention and treatment of several types of malignancies. However, its low water solubility and the toxicity associated with administration of high doses recommend it for encapsulation in carriers able to deliver the therapeutic dose in the tumo...

journal_title：Journal of liposome research

authors： Porfire A,Tomuta I,Muntean D,Luca L,Licarete E,Alupei MC,Achim M,Vlase L,Banciu M

更新日期：2015-01-01 00:00:00

abstract：:The influence of esters based on gamma-aminobutyric acid (GABA) and mono-/bicyclic terpenoids on membrane structure was investigated. The mechanism of action for terpenoid esters on phospholipids of artificial membranes and lipids isolated from the rat stratum corneum was studied by fluorescence and FT-IR spectroscopy...

journal_title：Journal of liposome research

authors： Nesterkina M,Smola S,Kravchenko I

更新日期：2019-09-01 00:00:00

abstract：:The influence of the lipid composition of arsonoliposomes on their membrane integrity was investigated to evaluate whether it is possible to combine their action with drugs that can be encapsulated in their aqueous interior. This was investigated by measuring the retention of vesicle-encapsulated calcein (100 mM) duri...

journal_title：Journal of liposome research

authors： Piperoudi S,Ioannou PV,Frederik P,Antimisiaris SG

更新日期：2005-01-01 00:00:00

abstract：:The aim of this study was to investigate the application of ultrasonic gas-filled liposomes in enhancing transfer for breast cancer-related antisense oligonucleotides in vitro. An antisense oligodeoxynucleotide (AS-ODN) sequence, HA2741, modified with luciferase reporter plasmid, was used in evaluating the enhancing e...

journal_title：Journal of liposome research

authors： Luo YK,Zhao YZ,Lu CT,Tang J,Li XK

更新日期：2008-01-01 00:00:00

abstract：:Leishmaniasis is a parasitic disease treatable and curable, however, the chemotherapeutic agents for their treatment are limited. In South American countries, pentavalent antimonials are still the first line of treatment for cutaneous leishmaniasis with an efficacy of about 75%, but the toxicity of the drug causes ser...

journal_title：Journal of liposome research

authors： Téllez J,Echeverry MC,Romero I,Guatibonza A,Santos Ramos G,Borges De Oliveira AC,Frézard F,Demicheli C

更新日期：2020-04-13 00:00:00

abstract：:Skin, the largest organ of the body serves as a potential route of drug delivery for local and systemic effects. However, the outermost layer of skin, the stratum corneum (SC) acts as a tough barrier that prevents penetration of hydrophilic and high molecular weight drugs. Ethosomes are a novel phospholipid vesicular ...

journal_title：Journal of liposome research

authors： Nainwal N,Jawla S,Singh R,Saharan VA

更新日期：2019-06-01 00:00:00

abstract：:By selecting a unique combination of lipids and amphotericin B, the liposome composition for AmBisome® (L-AmBis) has been optimized resulting in a formulation that is minimally toxic, targets to fungal cell walls, and distributes into and remains for days to weeks in various host tissues at drug levels above the MIC f...

journal_title：Journal of liposome research

authors： Adler-Moore JP,Proffitt RT,Olson JA,Jensen GM

更新日期：2017-09-01 00:00:00

abstract：:Vesicular phospholipid gels (VPGs) represent semi-solid phospholipid dispersions. Their morphology is truly vesicular with aqueous compartments both within the core of the vesicles and in-between the vesicles. VPGs are suited to carry both hydrophilic, amphiphilic and lipophilic drugs. Their drug load is stable since ...

journal_title：Journal of liposome research

authors： Brandl M

更新日期：2007-01-01 00:00:00

abstract：:The imaging of sentinel lymph nodes (SLN) has been researched for its role in assessing cancer progression and postsurgical lymphedema. Indocyanine green (ICG) is a near-infrared (NIR) optical dye that has been approved by the Food and Drug Administration. It is known that liposome-encapsulated ICG (LP-ICG) has improv...

journal_title：Journal of liposome research

authors： Jeong HS,Lee CM,Cheong SJ,Kim EM,Hwang H,Na KS,Lim ST,Sohn MH,Jeong HJ

更新日期：2013-12-01 00:00:00

abstract：:Methotrexate (MTX) is indicated in the symptomatic control of severe, recalcitrant, and disabling psoriasis. The oral or parenteral route of administration causes systemic toxicity. The topical route of delivery, though, reduces systemic toxicity and has limited applicability due to restricted permeability. Liposomal ...

journal_title：Journal of liposome research

authors： Nagle A,Goyal AK,Kesarla R,Murthy RR

更新日期：2011-06-01 00:00:00