Abstract:
:Surface modification of liposomes with amphiphilic flexible polymers significantly prolongs their circulation time in blood and reduces uptake by cells of the reticuloendothelial system (RES). Several polymers have already been shown to provide steric protection to liposomes. Still more polymers are expected to serve this purpose, thus broadening the variability of properties of long-circulating liposomes. Poly[N-(2-hydroxypropyl)methacrylamide] (poly (HPMA)) seems to have some properties similar to polyethylene glycol (PEG), the most widely used polymer in liposome surface modification, including flexibility, hydrophilicity and low immunogenicity, which suggest that it may also function as an efficient steric protector of liposomes. Semitelechelic poly(HPMA) with single- or double-oleic acid hydrophobic terminus were synthesized and incorporated into the surface of liposomes composed of phosphatidylcholine and cholesterol. These poly(HPMA)-modified liposomes provided strong steric protection for liposomes, increasing their circulation time and decreasing liver accumulation in experimental mice. Poly(HPMA)-modified liposomes may become a useful addition to a family of long-circulating liposomes with potential to be used as a drug delivery system.
journal_name
J Liposome Resjournal_title
Journal of liposome researchauthors
Whiteman KR,Subr V,Ulbrich K,Torchilin VPdoi
10.1081/LPR-100108459subject
Has Abstractpub_date
2001-01-01 00:00:00pages
153-64issue
2-3eissn
0898-2104issn
1532-2394journal_volume
11pub_type
杂志文章abstract::Skin, the largest organ of the body serves as a potential route of drug delivery for local and systemic effects. However, the outermost layer of skin, the stratum corneum (SC) acts as a tough barrier that prevents penetration of hydrophilic and high molecular weight drugs. Ethosomes are a novel phospholipid vesicular ...
journal_title:Journal of liposome research
pub_type: 杂志文章,评审
doi:10.1080/08982104.2018.1517160
更新日期:2019-06-01 00:00:00
abstract::Background and objective: The combination of two or more different mechanisms of drugs in the treatment of cancer has become one of the effective methods. The purpose of this study was to successfully prepare a non-viral delivery system that could efficiently co-delivery siRNA and gambogenic acid (GNA) to improve the ...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2018.1473423
更新日期:2019-12-01 00:00:00
abstract::The current study aimed to deliver minoxidil (2,4-diamino-6-piperidinopyrimidine 3-oxide; MXD), a potent hypertrichotic agent, into the pilosebaceous units, exploring the potential of the liposomal system. MXD-loaded liposomes of different compositions were prepared by a thin-film hydration technique and subsequently ...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982100903161449
更新日期:2010-06-01 00:00:00
abstract::Thermodynamical techniques are applied for determining the thermal stress of medicinal compounds of the excipients as well as their interactions during the formulation process. The physicochemical properties and the stability of the medicinal products could be measured as a function of temperature or time using therma...
journal_title:Journal of liposome research
pub_type: 杂志文章,评审
doi:10.1080/08982100802310261
更新日期:2008-01-01 00:00:00
abstract::The aim of present study was to develop conventional and PEGylated (long circulating), liposomes containing anastrozole (ANS) for effective treatment of breast cancer. ANS is a third-generation non-steroidal aromatase inhibitor of the triazole class used for the treatment of advanced and late-stage breast cancer in po...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2015.1029493
更新日期:2016-01-01 00:00:00
abstract::This study aimed to investigate the influence of the preparation conditions on the performance of an ethosomal formulation for topical delivery of the local anesthetic agent, benzocaine (BZC). Ethosomes were prepared with different techniques, such as thin-layer evaporation, freezing and thawing, reverse-phase evapora...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982100902788408
更新日期:2009-01-01 00:00:00
abstract::Sonication is a simple method for reducing the size of liposomes. We report the size distributions of liposomes as a function of sonication time using three different techniques. Liposomes, mildly sonicated for just 30 sec, had bimodal distributions when surface-weighted with modes at about 140 and 750 nm. With extend...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982100500528842
更新日期:2006-01-01 00:00:00
abstract:CONTEXT:Ropivacaine (RVC) is an aminoamide local anesthetic widely used in surgical procedures. Studies with RVC encapsulated in liposomes and complexed in cyclodextrins have shown good results, but in order to use RVC for lengthy procedures and during the postoperative period, a still more prolonged anesthetic effect ...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2015.1022555
更新日期:2016-01-01 00:00:00
abstract::Adsorption of serum proteins to the liposomal surface plays a critical role in the clearance of liposomes from the blood circulation. In this review, we will discuss the role of the liposomal opsonins proposed so far in liposome clearance. Additional, related topics that will be addressed are the cell-surface receptor...
journal_title:Journal of liposome research
pub_type: 杂志文章,评审
doi:10.1081/lpr-64971
更新日期:2005-01-01 00:00:00
abstract::Intravenous injection of some liposomal drugs, diagnostic agents, micelles and other lipid-based nanoparticles can cause acute hypersensitivity reactions (HSRs) in a high percentage (up to 45%) of patients, with hemodynamic, respiratory and cutaneous manifestations. The phenomenon can be explained with activation of t...
journal_title:Journal of liposome research
pub_type: 杂志文章,评审
doi:10.1080/08982100701375118
更新日期:2007-01-01 00:00:00
abstract::In the present work, we show that we obtained nanometric structures made of water, 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC), cholesterol (Chol), and a mixture of ethoxylated and non-ethoxylated sorbitan fatty acid esters (Tween 20, Span 20, Tween 80, and Span 80) by mixing all of them near the cloud poi...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2016.1174944
更新日期:2017-06-01 00:00:00
abstract::The aim of this study was to establish the mechanisms of action of a novel liposomal nitric oxide (NO) carrier on large-conductance Ca2+-activated channels (BKCa or Maxi-K) expressed in vascular smooth muscle cells (VSMCs) isolated from the rat main pulmonary artery (MPA). Experimental design comprised of both whole-c...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2020.1863424
更新日期:2021-01-08 00:00:00
abstract::The present study is envisaged to develop nanoethosomal formulation for enhanced topical delivery of amphotericin B (AmB) for the treatment of cutaneous fungal infections. AmB encapsulated nanoethosomes were prepared using mechanical dispersion method in a strength of 0.1% w/w similar to the strength of marketed topic...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2014.995670
更新日期:2015-01-01 00:00:00
abstract::The aim of the present study was to characterize a liposome-based benzocaine (BZC) formulation designed for topical use on the oral mucosa and to evaluate its in vitro retention and permeation using the Franz-type diffusion cells through pig esophagus mucosa. To predict the effectiveness of new designed formulations d...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2012.742536
更新日期:2013-03-01 00:00:00
abstract::Dopamine delivery to the central nervous system (CNS) undergoes the permeability limitations of the blood-brain barrier (BBB). Condensation of dopamine with neutral amino acids could afford potential prodrugs able to interact with the BBB endogenous transporters and easily enter the brain. To improve the bioavailabili...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982100903384129
更新日期:2010-09-01 00:00:00
abstract::In this study we successfully entrapped 5-aminolevulinic acid (ALA) in liposome, although it exists as a zwitter ion. A molar ratio of 2:1:2.5 phosphatidyle-thanolamine (PE)/cholesterol/sodium stearate represented the best condition to achieve high entrapment efficiency (29.37 +/- 1.21%), and the average vehicle size ...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982100801893952
更新日期:2008-01-01 00:00:00
abstract::Co-delivery of chemotherapeutic agents using nanocarriers is a promising strategy for enhancing therapeutic efficacy of anticancer agents. The aim of this work was to develop tamoxifen and imatinib dual drug loaded temperature-sensitive liposomes to treat breast cancer. Liposomes were prepared using 1, 2-dipalmitoyl-s...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2018.1502315
更新日期:2019-06-01 00:00:00
abstract::Andrographis paniculata is a medicinal herb used extensively for various ailments and contains therapeutically active phytoconstituent, andrographolide (AN). Although hepatoprotective activity of AN is established, but their bioavailability is restricted due to its rapid clearance. The aim of this study, therefore, wa...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2012.753456
更新日期:2013-06-01 00:00:00
abstract::The liposomalization and polyethyleneglycol (PEG) modification of antitumor agents prolongs their circulation in the blood and increases their accumulation in the tumor. It is expected that modification of the liposome surface with PEG-Lipid will prevent connection of liposome and tumor cell, so we examined the effect...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1081/lpr-120020318
更新日期:2003-05-01 00:00:00
abstract:CONTEXT:The stability of liposomes in the form of dispersion is a major concern due to drug leakage and fusion or aggregation. The stability can be improved by lyophilization, but the stress induced by the lyophilization process can affect the integrity of liposomes. OBJECTIVE:The objective of this study was to evalua...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2014.992023
更新日期:2015-01-01 00:00:00
abstract::The influence of the lipid composition of arsonoliposomes on their membrane integrity was investigated to evaluate whether it is possible to combine their action with drugs that can be encapsulated in their aqueous interior. This was investigated by measuring the retention of vesicle-encapsulated calcein (100 mM) duri...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982100500364263
更新日期:2005-01-01 00:00:00
abstract::In this study, the electron spin resonance (ESR) method was used to examine the effect of Amphotericin B (AmB) molecules on the fluidity of model membranes made of dipalmitoylphosphatidylcholine (DPPC). The changes occurring under increased AmB concentrations in the spectroscopic parameters of spin probes placed in li...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2013.814139
更新日期:2013-12-01 00:00:00
abstract::To engineer drug carriers capable of spontaneous accumulation in tumors and ischemic areas via the enhanced permeability and retention (EPR) effect and further penetration and drug delivery inside tumor or ischemic cells via the action of the cell-penetrating peptide (CPP), we have prepared liposomes simultaneously be...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982100701525035
更新日期:2007-01-01 00:00:00
abstract::The luciferase gene expression of lipoplexes, a liposome containing luciferase plasmid (pCMVLuc), in HeLa cell lines, was investigated. Cationic liposomes were prepared by the chloroform film method with sonication. The lipoplex was formed by loading the liposome with pCMVLuc. The lipoplex with an optimal weight ratio...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982100802642457
更新日期:2009-01-01 00:00:00
abstract::Ag:Au alloy nanoparticles were successfully synthesized through the new route using co-reduction method with silver nitrate, chloroauric acid, cetyl trimethyl ammonium bromide (CTAB) and sodium borohydride at room temperature. The Ag:Au alloy nanoparticles were then loaded within the phosphatidylcholine (97%) liposome...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2014.926917
更新日期:2015-03-01 00:00:00
abstract::Drug-in-CD-in-liposome (DCL) systems which encapsulate the drug/CD inclusion complexes into inner aqueous phase of liposomes have been applied as a novel strategy to improve efficacy of lipophilic antitumor drugs. The aim of this work was to assess the role of transferrin (Tf) modification and phosphatidylcholine (PC)...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2016.1140184
更新日期:2017-03-01 00:00:00
abstract::Amphotericin B (AmB) liposome formulations are very successful in the treatment of fungal infections and leishmaniasis. But higher cost limits its widespread use among people in developing countries. Therefore, we have developed a modified ethanol-injection method for the preparation of AmB liposomes. Two liposomal fo...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2011.584317
更新日期:2012-03-01 00:00:00
abstract::RNA interference is an effective and naturally occurring post-transcriptional gene regulatory mechanism. This mechanism involves the degradation of a target messenger RNA (mRNA) through the introduction of short interfering RNA (siRNA) that is complementary to the target mRNA. The application of siRNA-based therapeuti...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2018.1531424
更新日期:2019-09-01 00:00:00
abstract::Leishmaniasis is a parasitic disease treatable and curable, however, the chemotherapeutic agents for their treatment are limited. In South American countries, pentavalent antimonials are still the first line of treatment for cutaneous leishmaniasis with an efficacy of about 75%, but the toxicity of the drug causes ser...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2020.1749067
更新日期:2020-04-13 00:00:00
abstract::The poor selectivity of anticancer drugs often leads to their multiplicate dose-limiting toxicities in humans, which severely restricts their clinical application. In this study, a novel liposomal formulation of zedoary turmeric oil (ZTO) targeting the insulin receptor (IR) was prepared by covalently conjugating insul...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982100903015017
更新日期:2010-03-01 00:00:00