Co-delivery of gambogenic acid and VEGF-siRNA with anionic liposome and polyethylenimine complexes to HepG2 cells.

abstract：:Liposomal vinorelbine formulation is desirable, as it might improve the therapeutic activity of vinorelbine. However, because of its lipophilic and membrane-permeable properties, vinorelbine is hard to be formulated into liposomes using conventional drug-loading technologies. To improve vinorelbine retention, ammonium...

journal_title：Journal of liposome research

authors： Li C,Cui J,Wang C,Cao J,Zhang L,Li Y,Liang M,Xiu X,Li Y,Wei N,Deng C

更新日期：2012-03-01 00:00:00

abstract：:RNA interference is an effective and naturally occurring post-transcriptional gene regulatory mechanism. This mechanism involves the degradation of a target messenger RNA (mRNA) through the introduction of short interfering RNA (siRNA) that is complementary to the target mRNA. The application of siRNA-based therapeuti...

journal_title：Journal of liposome research

authors： Obeid MA,Dufès C,Somani S,Mullen AB,Tate RJ,Ferro VA

更新日期：2019-09-01 00:00:00

abstract：:Ag:Au alloy nanoparticles were successfully synthesized through the new route using co-reduction method with silver nitrate, chloroauric acid, cetyl trimethyl ammonium bromide (CTAB) and sodium borohydride at room temperature. The Ag:Au alloy nanoparticles were then loaded within the phosphatidylcholine (97%) liposome...

journal_title：Journal of liposome research

authors： Salehi AH,Montazer M,Toliyat T,Mahmoudi-Rad M

更新日期：2015-03-01 00:00:00

abstract：:Propylthiouracil, a lyophobic drug with an antiproliferative activity, was formulated into niosomes using various classes of nonionic surfactants. Feasibility of vesicle formation by the sonication method was evaluated. Size and size distribution was measured by laser diffraction. Entrapment and drug release over 24 h...

journal_title：Journal of liposome research

authors： Suwakul W,Ongpipattanakul B,Vardhanabhuti N

更新日期：2006-01-01 00:00:00

abstract：CONTEXT:Asenapine maleate (ASPM) is an antipsychotic drug for the treatment of schizophrenia and bipolar disorder. Extensive metabolism makes the oral route inconvenient for ASPM. OBJECTIVE:The objective of this study is to increase ASPM bioavailability via transdermal route by improving the skin permeation using comb...

journal_title：Journal of liposome research

authors： Shreya AB,Managuli RS,Menon J,Kondapalli L,Hegde AR,Avadhani K,Shetty PK,Amirthalingam M,Kalthur G,Mutalik S

更新日期：2016-09-01 00:00:00

abstract：:Naturally occurring antibodies to phospholipids and cholesterol are widespread; they occur commonly during the course of acute infections; they are not causally related to the anti-phospholipid syndrome; they have been associated with other clinical entities only as an epiphenomenon; and they have not been implicated ...

journal_title：Journal of liposome research

authors： Alving CR

更新日期：2006-01-01 00:00:00

abstract：:Thermosensitive liposomes are attractive vehicles for the delivery and release of drugs to tumors. To improvethe targeting efficacy for breast cancer treatment, an 8.3-kDa HER2-specific Affibody molecule (Z(HER2:342)-Cys) was conjugated to the surface of liposomes. The effects of this modification on physical characte...

journal_title：Journal of liposome research

authors： Puri A,Kramer-Marek G,Campbell-Massa R,Yavlovich A,Tele SC,Lee SB,Clogston JD,Patri AK,Blumenthal R,Capala J

更新日期：2008-01-01 00:00:00

abstract：:Virosomes are reconstituted viral envelopes which lack the genetic material but retain the cell entry and membrane fusion characteristics of the virus they are derived from. Thus, influenza virosomes are taken up by cells via receptor-mediated endocytosis, which directs the particles to the endosomal cell compartment....

journal_title：Journal of liposome research

authors： Bungener L,Idema J,ter Veer W,Huckriede A,Daemen T,Wilschut J

更新日期：2002-02-01 00:00:00

abstract：:Intravenous injection of some liposomal drugs, diagnostic agents, micelles and other lipid-based nanoparticles can cause acute hypersensitivity reactions (HSRs) in a high percentage (up to 45%) of patients, with hemodynamic, respiratory and cutaneous manifestations. The phenomenon can be explained with activation of t...

journal_title：Journal of liposome research

authors： Szebeni J,Alving CR,Rosivall L,Bünger R,Baranyi L,Bedöcs P,Tóth M,Barenholz Y

更新日期：2007-01-01 00:00:00

abstract：CONTEXT:The stability of liposomes in the form of dispersion is a major concern due to drug leakage and fusion or aggregation. The stability can be improved by lyophilization, but the stress induced by the lyophilization process can affect the integrity of liposomes. OBJECTIVE:The objective of this study was to evalua...

journal_title：Journal of liposome research

authors： Kannan V,Balabathula P,Thoma LA,Wood GC

更新日期：2015-01-01 00:00:00

abstract：:The present study is envisaged to develop nanoethosomal formulation for enhanced topical delivery of amphotericin B (AmB) for the treatment of cutaneous fungal infections. AmB encapsulated nanoethosomes were prepared using mechanical dispersion method in a strength of 0.1% w/w similar to the strength of marketed topic...

journal_title：Journal of liposome research

authors： Kaur L,Jain SK,Manhas RK,Sharma D

更新日期：2015-01-01 00:00:00

abstract：:Adenosine triphosphate (ATP)-binding cassette (ABC) transporters play a key role in the development of multidrug resistance (MDR) in cancer cells. P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) are important proteins in this superfamily which are widely expressed on the membranes of multidr...

journal_title：Journal of liposome research

authors： Gao M,Xu Y,Qiu L

更新日期：2017-06-01 00:00:00

abstract：:Thermodynamical techniques are applied for determining the thermal stress of medicinal compounds of the excipients as well as their interactions during the formulation process. The physicochemical properties and the stability of the medicinal products could be measured as a function of temperature or time using therma...

journal_title：Journal of liposome research

authors： Demetzos C

更新日期：2008-01-01 00:00:00

abstract：:By selecting a unique combination of lipids and amphotericin B, the liposome composition for AmBisome® (L-AmBis) has been optimized resulting in a formulation that is minimally toxic, targets to fungal cell walls, and distributes into and remains for days to weeks in various host tissues at drug levels above the MIC f...

journal_title：Journal of liposome research

authors： Adler-Moore JP,Proffitt RT,Olson JA,Jensen GM

更新日期：2017-09-01 00:00:00

abstract：:The luciferase gene expression of lipoplexes, a liposome containing luciferase plasmid (pCMVLuc), in HeLa cell lines, was investigated. Cationic liposomes were prepared by the chloroform film method with sonication. The lipoplex was formed by loading the liposome with pCMVLuc. The lipoplex with an optimal weight ratio...

journal_title：Journal of liposome research

authors： Manosroi A,Thathang K,Manosroi J,Werner RG,Schubert R,Peschka-Süss R

更新日期：2009-01-01 00:00:00

abstract：:In this study, the electron spin resonance (ESR) method was used to examine the effect of Amphotericin B (AmB) molecules on the fluidity of model membranes made of dipalmitoylphosphatidylcholine (DPPC). The changes occurring under increased AmB concentrations in the spectroscopic parameters of spin probes placed in li...

journal_title：Journal of liposome research

authors： Man D,Olchawa R

更新日期：2013-12-01 00:00:00

abstract：:Cutaneous leishmaniasis is caused by different species of Leishmania parasites and its available treatments have not yet provided a strong consistent result. The weak response of current chemotherapeutics is due to their deficient effects on stealth parasites inside macrophages, rapid clearance from the site of action...

journal_title：Journal of liposome research

authors： Momeni A,Rasoolian M,Momeni A,Navaei A,Emami S,Shaker Z,Mohebali M,Khoshdel A

更新日期：2013-06-01 00:00:00

abstract：:The aim of this study was to design and optimize a transdermal liposomes gel formulation for paeonol (PAE). A three-factor, three-level Box-Behnken design was used to derive a second-order polynomial equation to construct three-dimensional (3-D) contour plots for prediction of responses. Independent variables studied ...

journal_title：Journal of liposome research

authors： Shi J,Ma F,Wang X,Wang F,Liao H

更新日期：2012-12-01 00:00:00

abstract：:Surface modification of liposomes with amphiphilic flexible polymers significantly prolongs their circulation time in blood and reduces uptake by cells of the reticuloendothelial system (RES). Several polymers have already been shown to provide steric protection to liposomes. Still more polymers are expected to serve ...

journal_title：Journal of liposome research

authors： Whiteman KR,Subr V,Ulbrich K,Torchilin VP

更新日期：2001-01-01 00:00:00

abstract：:A novel scalable liposome preparation technique for pharmaceutical application is presented. Previous experiments have shown that the concept of continuous crossflow injection is a promising approach. For the characterization of the process, we focus on the influencing parameters like the lipid concentration, the inje...

journal_title：Journal of liposome research

authors： Wagner A,Vorauer-Uhl K,Kreismayr G,Katinger H

更新日期：2002-01-01 00:00:00

abstract：:In this study we successfully entrapped 5-aminolevulinic acid (ALA) in liposome, although it exists as a zwitter ion. A molar ratio of 2:1:2.5 phosphatidyle-thanolamine (PE)/cholesterol/sodium stearate represented the best condition to achieve high entrapment efficiency (29.37 +/- 1.21%), and the average vehicle size ...

journal_title：Journal of liposome research

authors： Fang YP,Wu PC,Tsai YH,Huang YB

更新日期：2008-01-01 00:00:00

abstract：:Methotrexate (MTX) is indicated in the symptomatic control of severe, recalcitrant, and disabling psoriasis. The oral or parenteral route of administration causes systemic toxicity. The topical route of delivery, though, reduces systemic toxicity and has limited applicability due to restricted permeability. Liposomal ...

journal_title：Journal of liposome research

authors： Nagle A,Goyal AK,Kesarla R,Murthy RR

更新日期：2011-06-01 00:00:00

abstract：:The aim of the present study was to characterize a liposome-based benzocaine (BZC) formulation designed for topical use on the oral mucosa and to evaluate its in vitro retention and permeation using the Franz-type diffusion cells through pig esophagus mucosa. To predict the effectiveness of new designed formulations d...

journal_title：Journal of liposome research

authors： Franz-Montan M,Cereda CM,Gaspari A,da Silva CM,de Araújo DR,Padula C,Santi P,Narvaes E,Novaes PD,Groppo FC,de Paula E

更新日期：2013-03-01 00:00:00

abstract：:Sustained release depot systems have been widely investigated for their potential to improve the efficacy of subunit vaccines and reduce the requirement for boosting. The present study aimed to further enhance the immunogenicity of a sustained release vaccine by combining a depot formulation with a particulate antigen...

journal_title：Journal of liposome research

authors： Gordon S,Young K,Wilson R,Rizwan S,Kemp R,Rades T,Hook S

更新日期：2012-09-01 00:00:00

abstract：:Pulmonary lung targeting finds applications in drug delivery to the lung itself and to other body organs, via blood circulation following transfer across alveolar membranes. Understanding pulmonary drug delivery systems towards improving their efficacy needs identification of particle sizes of relevance and elucidatio...

journal_title：Journal of liposome research

authors： Chattopadhyay S

更新日期：2013-12-01 00:00:00

abstract：CONTEXT:Ropivacaine (RVC) is an aminoamide local anesthetic widely used in surgical procedures. Studies with RVC encapsulated in liposomes and complexed in cyclodextrins have shown good results, but in order to use RVC for lengthy procedures and during the postoperative period, a still more prolonged anesthetic effect ...

journal_title：Journal of liposome research

authors： da Silva CM,Fraceto LF,Franz-Montan M,Couto VM,Casadei BR,Cereda CM,de Paula E

更新日期：2016-01-01 00:00:00

abstract：:In the present work, we show that we obtained nanometric structures made of water, 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC), cholesterol (Chol), and a mixture of ethoxylated and non-ethoxylated sorbitan fatty acid esters (Tween 20, Span 20, Tween 80, and Span 80) by mixing all of them near the cloud poi...

journal_title：Journal of liposome research

authors： Juárez-Osornio C,Gracia-Fadrique J

更新日期：2017-06-01 00:00:00

abstract：:The current investigation aims to develop and evaluate novel ocular proniosomal gels of lomefloxacin HCl (LXN); in order to improve its ocular bioavailability for the management of bacterial conjunctivitis. Proniosomes were prepared using different types of nonionic surfactants solely and as mixtures with Span 60. The...

journal_title：Journal of liposome research

authors： Khalil RM,Abdelbary GA,Basha M,Awad GE,El-Hashemy HA

更新日期：2017-06-01 00:00:00

abstract：:The aim of present study was to develop conventional and PEGylated (long circulating), liposomes containing anastrozole (ANS) for effective treatment of breast cancer. ANS is a third-generation non-steroidal aromatase inhibitor of the triazole class used for the treatment of advanced and late-stage breast cancer in po...

journal_title：Journal of liposome research

authors： Shavi GV,Sreenivasa Reddy M,Raghavendra R,Nayak UY,Kumar AR,Deshpande PB,Udupa N,Behl G,Dave V,Kushwaha K

更新日期：2016-01-01 00:00:00

abstract：:A simple strategy for designing a cancer immunotherapeutic system involves modification of tumor cells from tumor-bearing animals in vivo in such a way that the host can evoke a specific immune response against them. We have expressed allogeneic class I major histocompatibility complex (MHC) molecules on tumor cells, ...

journal_title：Journal of liposome research

authors： Hui KM,Sabapathy TK,Oei AA,Singhal A,Huang L

更新日期：1994-01-01 00:00:00