Arsonoliposomes: effect of lipid composition on their stability and morphology.

abstract：:Drug-in-CD-in-liposome (DCL) systems which encapsulate the drug/CD inclusion complexes into inner aqueous phase of liposomes have been applied as a novel strategy to improve efficacy of lipophilic antitumor drugs. The aim of this work was to assess the role of transferrin (Tf) modification and phosphatidylcholine (PC)...

journal_title：Journal of liposome research

authors： Chen J,Yao J,Ma Z,Peng P,Lu S,Hu Y,Xu F,Yang Y,Yang X

更新日期：2017-03-01 00:00:00

abstract：:The current investigation aims to develop and evaluate novel ocular proniosomal gels of lomefloxacin HCl (LXN); in order to improve its ocular bioavailability for the management of bacterial conjunctivitis. Proniosomes were prepared using different types of nonionic surfactants solely and as mixtures with Span 60. The...

journal_title：Journal of liposome research

authors： Khalil RM,Abdelbary GA,Basha M,Awad GE,El-Hashemy HA

更新日期：2017-06-01 00:00:00

abstract：:Pulmonary lung targeting finds applications in drug delivery to the lung itself and to other body organs, via blood circulation following transfer across alveolar membranes. Understanding pulmonary drug delivery systems towards improving their efficacy needs identification of particle sizes of relevance and elucidatio...

journal_title：Journal of liposome research

authors： Chattopadhyay S

更新日期：2013-12-01 00:00:00

abstract：:Thermosensitive liposomes are attractive vehicles for the delivery and release of drugs to tumors. To improvethe targeting efficacy for breast cancer treatment, an 8.3-kDa HER2-specific Affibody molecule (Z(HER2:342)-Cys) was conjugated to the surface of liposomes. The effects of this modification on physical characte...

journal_title：Journal of liposome research

authors： Puri A,Kramer-Marek G,Campbell-Massa R,Yavlovich A,Tele SC,Lee SB,Clogston JD,Patri AK,Blumenthal R,Capala J

更新日期：2008-01-01 00:00:00

abstract：:Skin, the largest organ of the body serves as a potential route of drug delivery for local and systemic effects. However, the outermost layer of skin, the stratum corneum (SC) acts as a tough barrier that prevents penetration of hydrophilic and high molecular weight drugs. Ethosomes are a novel phospholipid vesicular ...

journal_title：Journal of liposome research

authors： Nainwal N,Jawla S,Singh R,Saharan VA

更新日期：2019-06-01 00:00:00

abstract：:Sustained release depot systems have been widely investigated for their potential to improve the efficacy of subunit vaccines and reduce the requirement for boosting. The present study aimed to further enhance the immunogenicity of a sustained release vaccine by combining a depot formulation with a particulate antigen...

journal_title：Journal of liposome research

authors： Gordon S,Young K,Wilson R,Rizwan S,Kemp R,Rades T,Hook S

更新日期：2012-09-01 00:00:00

abstract：:Dopamine delivery to the central nervous system (CNS) undergoes the permeability limitations of the blood-brain barrier (BBB). Condensation of dopamine with neutral amino acids could afford potential prodrugs able to interact with the BBB endogenous transporters and easily enter the brain. To improve the bioavailabili...

journal_title：Journal of liposome research

authors： Carafa M,Marianecci C,Di Marzio L,De Caro V,Giandalia G,Giannola LI,Santucci E

更新日期：2010-09-01 00:00:00

abstract：:A novel scalable liposome preparation technique for pharmaceutical application is presented. Previous experiments have shown that the concept of continuous crossflow injection is a promising approach. For the characterization of the process, we focus on the influencing parameters like the lipid concentration, the inje...

journal_title：Journal of liposome research

authors： Wagner A,Vorauer-Uhl K,Kreismayr G,Katinger H

更新日期：2002-01-01 00:00:00

abstract：:Andrographis paniculata is a medicinal herb used extensively for various ailments and contains therapeutically active phytoconstituent, andrographolide (AN). Although hepatoprotective activity of AN is established, but their bioavailability is restricted due to its rapid clearance. The aim of this study, therefore, wa...

journal_title：Journal of liposome research

authors： Jain PK,Khurana N,Pounikar Y,Gajbhiye A,Kharya MD

更新日期：2013-06-01 00:00:00

abstract：:Hepatic carcinoma (HC) is one of the most prevalent cancers, ranked as the second most common cause of cancer-related deaths worldwide. Silymarin (SYL) has been reported for its anticarcinogenic activity against various types of cancer such as prostate, breast, ovary, colon, lung, bladder and liver. Due to poor solubi...

journal_title：Journal of liposome research

authors： Parashar P,Rana P,Dwivedi M,Saraf SA

更新日期：2019-09-01 00:00:00

abstract：:Doxorubicin, as a widely used chemotherapeutic, always causes multidrug resistance in human cancer cells. To circumvent drug resistance, we developed a novel formulation where doxorubicin hydrochloride (DOX) and chloroquine phosphate (CQ) were simultaneously loaded into liposomes by a pH-gradient method where CQ playe...

journal_title：Journal of liposome research

authors： Qiu L,Yao M,Gao M,Zhao Q

更新日期：2012-09-01 00:00:00

abstract：:The influence of esters based on gamma-aminobutyric acid (GABA) and mono-/bicyclic terpenoids on membrane structure was investigated. The mechanism of action for terpenoid esters on phospholipids of artificial membranes and lipids isolated from the rat stratum corneum was studied by fluorescence and FT-IR spectroscopy...

journal_title：Journal of liposome research

authors： Nesterkina M,Smola S,Kravchenko I

更新日期：2019-09-01 00:00:00

abstract：:Mefenamic acid (MA) is a BCS II class NSAID drug. It is available only in the form of tablets, capsules, and pediatric suspensions. Oral administration of MA is associated with severe gastrointestinal side effects. The aim of this study was to develop a convenient and low-cost transdermal drug delivery system for MA u...

journal_title：Journal of liposome research

authors： Wen MM,Farid RM,Kassem AA

更新日期：2014-12-01 00:00:00

abstract：:The poor selectivity of anticancer drugs often leads to their multiplicate dose-limiting toxicities in humans, which severely restricts their clinical application. In this study, a novel liposomal formulation of zedoary turmeric oil (ZTO) targeting the insulin receptor (IR) was prepared by covalently conjugating insul...

journal_title：Journal of liposome research

authors： Yang Z,Fu D,Zhu L,Yang M,Cheng Q

更新日期：2010-03-01 00:00:00

abstract：:Leishmaniasis is a parasitic disease treatable and curable, however, the chemotherapeutic agents for their treatment are limited. In South American countries, pentavalent antimonials are still the first line of treatment for cutaneous leishmaniasis with an efficacy of about 75%, but the toxicity of the drug causes ser...

journal_title：Journal of liposome research

authors： Téllez J,Echeverry MC,Romero I,Guatibonza A,Santos Ramos G,Borges De Oliveira AC,Frézard F,Demicheli C

更新日期：2020-04-13 00:00:00

abstract：:Adenosine triphosphate (ATP)-binding cassette (ABC) transporters play a key role in the development of multidrug resistance (MDR) in cancer cells. P-glycoprotein (P-gp) and multidrug resistance-associated protein 1 (MRP1) are important proteins in this superfamily which are widely expressed on the membranes of multidr...

journal_title：Journal of liposome research

authors： Gao M,Xu Y,Qiu L

更新日期：2017-06-01 00:00:00

abstract：:The luciferase gene expression of lipoplexes, a liposome containing luciferase plasmid (pCMVLuc), in HeLa cell lines, was investigated. Cationic liposomes were prepared by the chloroform film method with sonication. The lipoplex was formed by loading the liposome with pCMVLuc. The lipoplex with an optimal weight ratio...

journal_title：Journal of liposome research

authors： Manosroi A,Thathang K,Manosroi J,Werner RG,Schubert R,Peschka-Süss R

更新日期：2009-01-01 00:00:00

abstract：:The aim of the present study was to characterize a liposome-based benzocaine (BZC) formulation designed for topical use on the oral mucosa and to evaluate its in vitro retention and permeation using the Franz-type diffusion cells through pig esophagus mucosa. To predict the effectiveness of new designed formulations d...

journal_title：Journal of liposome research

authors： Franz-Montan M,Cereda CM,Gaspari A,da Silva CM,de Araújo DR,Padula C,Santi P,Narvaes E,Novaes PD,Groppo FC,de Paula E

更新日期：2013-03-01 00:00:00

abstract：:Simvastatin (SIM) is a lipophilic statin that has potential benefits for prevention and treatment of several types of malignancies. However, its low water solubility and the toxicity associated with administration of high doses recommend it for encapsulation in carriers able to deliver the therapeutic dose in the tumo...

journal_title：Journal of liposome research

authors： Porfire A,Tomuta I,Muntean D,Luca L,Licarete E,Alupei MC,Achim M,Vlase L,Banciu M

更新日期：2015-01-01 00:00:00

abstract：:The effect of liposomal inclusion on the stability and in vitro antiherpetic activity of Santolina insularis essential oil was investigated. In order to study the influence of vesicle structure on the liposome properties, multilamellar and unilamellar vesicles were prepared by the film method and sonication, respectiv...

journal_title：Journal of liposome research

authors： Valenti D,De Logu A,Loy G,Sinico C,Bonsignore L,Cottiglia F,Garau D,Fadda AM

更新日期：2001-01-01 00:00:00

abstract：:Archaeosomes, liposomes prepared from the polar ether lipids extracted from Archaea, demonstrate great potential as immunomodulating carriers of soluble antigens, promoting humoral and cell mediated immunity in the vaccinated host. The safety of unilamellar archaeosomes prepared from the total polar lipids (TPL) of Ha...

journal_title：Journal of liposome research

authors： Patel GB,Omri A,Deschatelets L,Sprott GD

更新日期：2002-11-01 00:00:00

abstract：:Thermodynamical techniques are applied for determining the thermal stress of medicinal compounds of the excipients as well as their interactions during the formulation process. The physicochemical properties and the stability of the medicinal products could be measured as a function of temperature or time using therma...

journal_title：Journal of liposome research

authors： Demetzos C

更新日期：2008-01-01 00:00:00

abstract：:This study aimed to investigate the influence of the preparation conditions on the performance of an ethosomal formulation for topical delivery of the local anesthetic agent, benzocaine (BZC). Ethosomes were prepared with different techniques, such as thin-layer evaporation, freezing and thawing, reverse-phase evapora...

journal_title：Journal of liposome research

authors： Maestrelli F,Capasso G,González-Rodríguez ML,Rabasco AM,Ghelardini C,Mura P

更新日期：2009-01-01 00:00:00

abstract：:A simple strategy for designing a cancer immunotherapeutic system involves modification of tumor cells from tumor-bearing animals in vivo in such a way that the host can evoke a specific immune response against them. We have expressed allogeneic class I major histocompatibility complex (MHC) molecules on tumor cells, ...

journal_title：Journal of liposome research

authors： Hui KM,Sabapathy TK,Oei AA,Singhal A,Huang L

更新日期：1994-01-01 00:00:00

abstract：CONTEXT:Ropivacaine (RVC) is an aminoamide local anesthetic widely used in surgical procedures. Studies with RVC encapsulated in liposomes and complexed in cyclodextrins have shown good results, but in order to use RVC for lengthy procedures and during the postoperative period, a still more prolonged anesthetic effect ...

journal_title：Journal of liposome research

authors： da Silva CM,Fraceto LF,Franz-Montan M,Couto VM,Casadei BR,Cereda CM,de Paula E

更新日期：2016-01-01 00:00:00

abstract：:Virosomes are reconstituted viral envelopes which lack the genetic material but retain the cell entry and membrane fusion characteristics of the virus they are derived from. Thus, influenza virosomes are taken up by cells via receptor-mediated endocytosis, which directs the particles to the endosomal cell compartment....

journal_title：Journal of liposome research

authors： Bungener L,Idema J,ter Veer W,Huckriede A,Daemen T,Wilschut J

更新日期：2002-02-01 00:00:00

abstract：CONTEXT:The stability of liposomes in the form of dispersion is a major concern due to drug leakage and fusion or aggregation. The stability can be improved by lyophilization, but the stress induced by the lyophilization process can affect the integrity of liposomes. OBJECTIVE:The objective of this study was to evalua...

journal_title：Journal of liposome research

authors： Kannan V,Balabathula P,Thoma LA,Wood GC

更新日期：2015-01-01 00:00:00

abstract：:The liposomalization and polyethyleneglycol (PEG) modification of antitumor agents prolongs their circulation in the blood and increases their accumulation in the tumor. It is expected that modification of the liposome surface with PEG-Lipid will prevent connection of liposome and tumor cell, so we examined the effect...

journal_title：Journal of liposome research

authors： Sadzuka Y,Kishi K,Hirota S,Sonobe T

更新日期：2003-05-01 00:00:00

abstract：:Liposomal vinorelbine formulation is desirable, as it might improve the therapeutic activity of vinorelbine. However, because of its lipophilic and membrane-permeable properties, vinorelbine is hard to be formulated into liposomes using conventional drug-loading technologies. To improve vinorelbine retention, ammonium...

journal_title：Journal of liposome research

authors： Li C,Cui J,Wang C,Cao J,Zhang L,Li Y,Liang M,Xiu X,Li Y,Wei N,Deng C

更新日期：2012-03-01 00:00:00

abstract：:The current study aimed to deliver minoxidil (2,4-diamino-6-piperidinopyrimidine 3-oxide; MXD), a potent hypertrichotic agent, into the pilosebaceous units, exploring the potential of the liposomal system. MXD-loaded liposomes of different compositions were prepared by a thin-film hydration technique and subsequently ...

journal_title：Journal of liposome research

authors： Jain B,Singh B,Katare OP,Vyas SP

更新日期：2010-06-01 00:00:00