Abstract:
:The influence of esters based on gamma-aminobutyric acid (GABA) and mono-/bicyclic terpenoids on membrane structure was investigated. The mechanism of action for terpenoid esters on phospholipids of artificial membranes and lipids isolated from the rat stratum corneum was studied by fluorescence and FT-IR spectroscopy. We report here, that inclusion of monocyclic terpenoid esters in phospholipid liposomes leads to growth of excimer to monomer ratio (IE/IM) indicating a decrease of membrane microviscosity. Another mechanism of influence on biomembranes was proposed for ester of bicyclic borneol - in this case a high ratio of vibronic peak intensities (I1/I3) was revealed. The addition of terpenoid esters appears in the FT-IR spectra as intensity reduction of absorption bands associated with C = O, P = O and P-O-С groups of lecithin phospholipids. Similar results were obtained after esters addition to lipids isolated from stratum corneum indicating a decrease of hydrogen bonds number between polar groups of lipids. Thus, the influence of terpenoid esters on molecular organization of the lipid matrix substantiates the feasibility of their use after transdermal delivery in vivo.
journal_name
J Liposome Resjournal_title
Journal of liposome researchauthors
Nesterkina M,Smola S,Kravchenko Idoi
10.1080/08982104.2018.1538238subject
Has Abstractpub_date
2019-09-01 00:00:00pages
239-246issue
3eissn
0898-2104issn
1532-2394journal_volume
29pub_type
杂志文章abstract::Skin, the largest organ of the body serves as a potential route of drug delivery for local and systemic effects. However, the outermost layer of skin, the stratum corneum (SC) acts as a tough barrier that prevents penetration of hydrophilic and high molecular weight drugs. Ethosomes are a novel phospholipid vesicular ...
journal_title:Journal of liposome research
pub_type: 杂志文章,评审
doi:10.1080/08982104.2018.1517160
更新日期:2019-06-01 00:00:00
abstract:CONTEXT:The stability of liposomes in the form of dispersion is a major concern due to drug leakage and fusion or aggregation. The stability can be improved by lyophilization, but the stress induced by the lyophilization process can affect the integrity of liposomes. OBJECTIVE:The objective of this study was to evalua...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2014.992023
更新日期:2015-01-01 00:00:00
abstract:CONTEXT:Ropivacaine (RVC) is an aminoamide local anesthetic widely used in surgical procedures. Studies with RVC encapsulated in liposomes and complexed in cyclodextrins have shown good results, but in order to use RVC for lengthy procedures and during the postoperative period, a still more prolonged anesthetic effect ...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2015.1022555
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abstract::The use of arsenic-containing compounds in cancer therapy is currently being re-considered, after the recent approval of arsenic trioxide (Trisenox) for the treatment of relapsed promyelocytic leukemia (PML). In an attempt to prepare a carrier system to minimize the toxicity of this drug, the aim of this study is to p...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1081/lpr-120039661
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abstract::A simple strategy for designing a cancer immunotherapeutic system involves modification of tumor cells from tumor-bearing animals in vivo in such a way that the host can evoke a specific immune response against them. We have expressed allogeneic class I major histocompatibility complex (MHC) molecules on tumor cells, ...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982109409018623
更新日期:1994-01-01 00:00:00
abstract::Vesicular phospholipid gels (VPGs) represent semi-solid phospholipid dispersions. Their morphology is truly vesicular with aqueous compartments both within the core of the vesicles and in-between the vesicles. VPGs are suited to carry both hydrophilic, amphiphilic and lipophilic drugs. Their drug load is stable since ...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982100601186490
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abstract::Mefenamic acid (MA) is a BCS II class NSAID drug. It is available only in the form of tablets, capsules, and pediatric suspensions. Oral administration of MA is associated with severe gastrointestinal side effects. The aim of this study was to develop a convenient and low-cost transdermal drug delivery system for MA u...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2014.911313
更新日期:2014-12-01 00:00:00
abstract::In this study, the electron spin resonance (ESR) method was used to examine the effect of Amphotericin B (AmB) molecules on the fluidity of model membranes made of dipalmitoylphosphatidylcholine (DPPC). The changes occurring under increased AmB concentrations in the spectroscopic parameters of spin probes placed in li...
journal_title:Journal of liposome research
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doi:10.3109/08982104.2013.814139
更新日期:2013-12-01 00:00:00
abstract::Simvastatin (SIM) is a lipophilic statin that has potential benefits for prevention and treatment of several types of malignancies. However, its low water solubility and the toxicity associated with administration of high doses recommend it for encapsulation in carriers able to deliver the therapeutic dose in the tumo...
journal_title:Journal of liposome research
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doi:10.3109/08982104.2014.987787
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journal_title:Journal of liposome research
pub_type: 杂志文章
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abstract::Ag:Au alloy nanoparticles were successfully synthesized through the new route using co-reduction method with silver nitrate, chloroauric acid, cetyl trimethyl ammonium bromide (CTAB) and sodium borohydride at room temperature. The Ag:Au alloy nanoparticles were then loaded within the phosphatidylcholine (97%) liposome...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2014.926917
更新日期:2015-03-01 00:00:00
abstract::The liposomalization and polyethyleneglycol (PEG) modification of antitumor agents prolongs their circulation in the blood and increases their accumulation in the tumor. It is expected that modification of the liposome surface with PEG-Lipid will prevent connection of liposome and tumor cell, so we examined the effect...
journal_title:Journal of liposome research
pub_type: 杂志文章
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abstract::Surface modification of liposomes with amphiphilic flexible polymers significantly prolongs their circulation time in blood and reduces uptake by cells of the reticuloendothelial system (RES). Several polymers have already been shown to provide steric protection to liposomes. Still more polymers are expected to serve ...
journal_title:Journal of liposome research
pub_type: 杂志文章
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abstract::The current study aimed to deliver minoxidil (2,4-diamino-6-piperidinopyrimidine 3-oxide; MXD), a potent hypertrichotic agent, into the pilosebaceous units, exploring the potential of the liposomal system. MXD-loaded liposomes of different compositions were prepared by a thin-film hydration technique and subsequently ...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982100903161449
更新日期:2010-06-01 00:00:00
abstract::Propylthiouracil, a lyophobic drug with an antiproliferative activity, was formulated into niosomes using various classes of nonionic surfactants. Feasibility of vesicle formation by the sonication method was evaluated. Size and size distribution was measured by laser diffraction. Entrapment and drug release over 24 h...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982100600992542
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abstract::Drug-in-CD-in-liposome (DCL) systems which encapsulate the drug/CD inclusion complexes into inner aqueous phase of liposomes have been applied as a novel strategy to improve efficacy of lipophilic antitumor drugs. The aim of this work was to assess the role of transferrin (Tf) modification and phosphatidylcholine (PC)...
journal_title:Journal of liposome research
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doi:10.3109/08982104.2016.1140184
更新日期:2017-03-01 00:00:00
abstract::Virosomes are reconstituted viral envelopes which lack the genetic material but retain the cell entry and membrane fusion characteristics of the virus they are derived from. Thus, influenza virosomes are taken up by cells via receptor-mediated endocytosis, which directs the particles to the endosomal cell compartment....
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1081/lpr-120004789
更新日期:2002-02-01 00:00:00
abstract::Liposomes have the capacity to be used as efficient, biodegradable and nontoxic carriers of bioactive molecules and are able to better control their delivery at the site of interest. The objective of this study was to obtain and characterize an appropriate liposomal formulation of the bioactive molecule chondroitin su...
journal_title:Journal of liposome research
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doi:10.3109/08982104.2013.770016
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abstract::Pulmonary lung targeting finds applications in drug delivery to the lung itself and to other body organs, via blood circulation following transfer across alveolar membranes. Understanding pulmonary drug delivery systems towards improving their efficacy needs identification of particle sizes of relevance and elucidatio...
journal_title:Journal of liposome research
pub_type: 杂志文章,评审
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abstract::By selecting a unique combination of lipids and amphotericin B, the liposome composition for AmBisome® (L-AmBis) has been optimized resulting in a formulation that is minimally toxic, targets to fungal cell walls, and distributes into and remains for days to weeks in various host tissues at drug levels above the MIC f...
journal_title:Journal of liposome research
pub_type: 杂志文章,评审
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abstract::Skin is considered the most accessible organ of the body because of its underlying capillary network. However, stratum corneum (SC), the upper most layer of skin, represents major diffusional barrier for most drugs. Hence, the use of edge activators (EAs) in designing novel elastic vesicles is hypothesized to impart t...
journal_title:Journal of liposome research
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journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2012.753456
更新日期:2013-06-01 00:00:00
abstract::Valsartan (VLT) is a highly selective and orally active antihypertensive drug. However, its oral administration is associated with drawbacks like low bioavailability. The objective of this study was to design and develop a transdermal delivery system for VLT using ethosomal carriers to investigate their enhanced trans...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2012.753457
更新日期:2013-06-01 00:00:00
abstract::To engineer drug carriers capable of spontaneous accumulation in tumors and ischemic areas via the enhanced permeability and retention (EPR) effect and further penetration and drug delivery inside tumor or ischemic cells via the action of the cell-penetrating peptide (CPP), we have prepared liposomes simultaneously be...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982100701525035
更新日期:2007-01-01 00:00:00
abstract::The aim of this study was to establish the mechanisms of action of a novel liposomal nitric oxide (NO) carrier on large-conductance Ca2+-activated channels (BKCa or Maxi-K) expressed in vascular smooth muscle cells (VSMCs) isolated from the rat main pulmonary artery (MPA). Experimental design comprised of both whole-c...
journal_title:Journal of liposome research
pub_type: 杂志文章
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更新日期:2021-01-08 00:00:00
abstract::The evidence in this communication indicate that, unlike resident Kupffer cells, newly recruited liver macrophages (following monocyte migration from the blood to the liver) use complement receptors to recognize and internalize stearylamine-incorporated liposomes. Within two weeks of hepatic residency complement recep...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1081/lpr-120004778
更新日期:2002-02-01 00:00:00
abstract::Thermosensitive liposomes are attractive vehicles for the delivery and release of drugs to tumors. To improvethe targeting efficacy for breast cancer treatment, an 8.3-kDa HER2-specific Affibody molecule (Z(HER2:342)-Cys) was conjugated to the surface of liposomes. The effects of this modification on physical characte...
journal_title:Journal of liposome research
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更新日期:2008-01-01 00:00:00
abstract::This study aimed to investigate the influence of the preparation conditions on the performance of an ethosomal formulation for topical delivery of the local anesthetic agent, benzocaine (BZC). Ethosomes were prepared with different techniques, such as thin-layer evaporation, freezing and thawing, reverse-phase evapora...
journal_title:Journal of liposome research
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abstract::Archaeosomes, liposomes prepared from the polar ether lipids extracted from Archaea, demonstrate great potential as immunomodulating carriers of soluble antigens, promoting humoral and cell mediated immunity in the vaccinated host. The safety of unilamellar archaeosomes prepared from the total polar lipids (TPL) of Ha...
journal_title:Journal of liposome research
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更新日期:2002-11-01 00:00:00
abstract::The current investigation aims to develop and evaluate novel ocular proniosomal gels of lomefloxacin HCl (LXN); in order to improve its ocular bioavailability for the management of bacterial conjunctivitis. Proniosomes were prepared using different types of nonionic surfactants solely and as mixtures with Span 60. The...
journal_title:Journal of liposome research
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doi:10.3109/08982104.2016.1167737
更新日期:2017-06-01 00:00:00