Tissue pharmacokinetics and pharmacodynamics of AmBisome® (L-AmBis) in uninfected and infected animals and their effects on dosing regimens.

abstract：:Background and objective: The combination of two or more different mechanisms of drugs in the treatment of cancer has become one of the effective methods. The purpose of this study was to successfully prepare a non-viral delivery system that could efficiently co-delivery siRNA and gambogenic acid (GNA) to improve the ...

journal_title：Journal of liposome research

authors： Yu Q,Zhang B,Zhou Y,Ge Q,Chang J,Chen Y,Zhang K,Peng D,Chen W

更新日期：2019-12-01 00:00:00

abstract：:To engineer drug carriers capable of spontaneous accumulation in tumors and ischemic areas via the enhanced permeability and retention (EPR) effect and further penetration and drug delivery inside tumor or ischemic cells via the action of the cell-penetrating peptide (CPP), we have prepared liposomes simultaneously be...

journal_title：Journal of liposome research

authors： Kale AA,Torchilin VP

更新日期：2007-01-01 00:00:00

abstract：:The present study is envisaged to develop nanoethosomal formulation for enhanced topical delivery of amphotericin B (AmB) for the treatment of cutaneous fungal infections. AmB encapsulated nanoethosomes were prepared using mechanical dispersion method in a strength of 0.1% w/w similar to the strength of marketed topic...

journal_title：Journal of liposome research

authors： Kaur L,Jain SK,Manhas RK,Sharma D

更新日期：2015-01-01 00:00:00

abstract：:Sonication is a simple method for reducing the size of liposomes. We report the size distributions of liposomes as a function of sonication time using three different techniques. Liposomes, mildly sonicated for just 30 sec, had bimodal distributions when surface-weighted with modes at about 140 and 750 nm. With extend...

journal_title：Journal of liposome research

authors： Woodbury DJ,Richardson ES,Grigg AW,Welling RD,Knudson BH

更新日期：2006-01-01 00:00:00

abstract：:Naturally occurring antibodies to phospholipids and cholesterol are widespread; they occur commonly during the course of acute infections; they are not causally related to the anti-phospholipid syndrome; they have been associated with other clinical entities only as an epiphenomenon; and they have not been implicated ...

journal_title：Journal of liposome research

authors： Alving CR

更新日期：2006-01-01 00:00:00

abstract：:Methotrexate (MTX) is indicated in the symptomatic control of severe, recalcitrant, and disabling psoriasis. The oral or parenteral route of administration causes systemic toxicity. The topical route of delivery, though, reduces systemic toxicity and has limited applicability due to restricted permeability. Liposomal ...

journal_title：Journal of liposome research

authors： Nagle A,Goyal AK,Kesarla R,Murthy RR

更新日期：2011-06-01 00:00:00

abstract：:RNA interference is an effective and naturally occurring post-transcriptional gene regulatory mechanism. This mechanism involves the degradation of a target messenger RNA (mRNA) through the introduction of short interfering RNA (siRNA) that is complementary to the target mRNA. The application of siRNA-based therapeuti...

journal_title：Journal of liposome research

authors： Obeid MA,Dufès C,Somani S,Mullen AB,Tate RJ,Ferro VA

更新日期：2019-09-01 00:00:00

abstract：CONTEXT:The stability of liposomes in the form of dispersion is a major concern due to drug leakage and fusion or aggregation. The stability can be improved by lyophilization, but the stress induced by the lyophilization process can affect the integrity of liposomes. OBJECTIVE:The objective of this study was to evalua...

journal_title：Journal of liposome research

authors： Kannan V,Balabathula P,Thoma LA,Wood GC

更新日期：2015-01-01 00:00:00

abstract：:Thermodynamical techniques are applied for determining the thermal stress of medicinal compounds of the excipients as well as their interactions during the formulation process. The physicochemical properties and the stability of the medicinal products could be measured as a function of temperature or time using therma...

journal_title：Journal of liposome research

authors： Demetzos C

更新日期：2008-01-01 00:00:00

abstract：:In this study, the electron spin resonance (ESR) method was used to examine the effect of Amphotericin B (AmB) molecules on the fluidity of model membranes made of dipalmitoylphosphatidylcholine (DPPC). The changes occurring under increased AmB concentrations in the spectroscopic parameters of spin probes placed in li...

journal_title：Journal of liposome research

authors： Man D,Olchawa R

更新日期：2013-12-01 00:00:00

abstract：:The use of arsenic-containing compounds in cancer therapy is currently being re-considered, after the recent approval of arsenic trioxide (Trisenox) for the treatment of relapsed promyelocytic leukemia (PML). In an attempt to prepare a carrier system to minimize the toxicity of this drug, the aim of this study is to p...

journal_title：Journal of liposome research

authors： Kallinteri P,Fatouros D,Klepetsanis P,Antimisiaris SG

更新日期：2004-01-01 00:00:00

abstract：:A novel scalable liposome preparation technique for pharmaceutical application is presented. Previous experiments have shown that the concept of continuous crossflow injection is a promising approach. For the characterization of the process, we focus on the influencing parameters like the lipid concentration, the inje...

journal_title：Journal of liposome research

authors： Wagner A,Vorauer-Uhl K,Kreismayr G,Katinger H

更新日期：2002-01-01 00:00:00

abstract：:Liposomal vinorelbine formulation is desirable, as it might improve the therapeutic activity of vinorelbine. However, because of its lipophilic and membrane-permeable properties, vinorelbine is hard to be formulated into liposomes using conventional drug-loading technologies. To improve vinorelbine retention, ammonium...

journal_title：Journal of liposome research

authors： Li C,Cui J,Wang C,Cao J,Zhang L,Li Y,Liang M,Xiu X,Li Y,Wei N,Deng C

更新日期：2012-03-01 00:00:00

abstract：:Leishmaniasis is a parasitic disease treatable and curable, however, the chemotherapeutic agents for their treatment are limited. In South American countries, pentavalent antimonials are still the first line of treatment for cutaneous leishmaniasis with an efficacy of about 75%, but the toxicity of the drug causes ser...

journal_title：Journal of liposome research

authors： Téllez J,Echeverry MC,Romero I,Guatibonza A,Santos Ramos G,Borges De Oliveira AC,Frézard F,Demicheli C

更新日期：2020-04-13 00:00:00

abstract：:Andrographis paniculata is a medicinal herb used extensively for various ailments and contains therapeutically active phytoconstituent, andrographolide (AN). Although hepatoprotective activity of AN is established, but their bioavailability is restricted due to its rapid clearance. The aim of this study, therefore, wa...

journal_title：Journal of liposome research

authors： Jain PK,Khurana N,Pounikar Y,Gajbhiye A,Kharya MD

更新日期：2013-06-01 00:00:00

abstract：:Simvastatin (SIM) is a lipophilic statin that has potential benefits for prevention and treatment of several types of malignancies. However, its low water solubility and the toxicity associated with administration of high doses recommend it for encapsulation in carriers able to deliver the therapeutic dose in the tumo...

journal_title：Journal of liposome research

authors： Porfire A,Tomuta I,Muntean D,Luca L,Licarete E,Alupei MC,Achim M,Vlase L,Banciu M

更新日期：2015-01-01 00:00:00

abstract：:This multicenter study investigated the possibility of reducing mortality rate by administering natural lung surfactant additional to standard therapy to treat patients after cardiac surgery who developed an acute respiratory failure (ARDS/ALI).A total of 78 patients (1998-2002) diagnosed with ALI or ARDS were enrolle...

journal_title：Journal of liposome research

authors： Bautin A,Khubulava G,Kozlov I,Poptzov V,Osovskikh V,Seiliev A,Volchkov V,Rosenberg O

更新日期：2006-01-01 00:00:00

abstract：:The influence of esters based on gamma-aminobutyric acid (GABA) and mono-/bicyclic terpenoids on membrane structure was investigated. The mechanism of action for terpenoid esters on phospholipids of artificial membranes and lipids isolated from the rat stratum corneum was studied by fluorescence and FT-IR spectroscopy...

journal_title：Journal of liposome research

authors： Nesterkina M,Smola S,Kravchenko I

更新日期：2019-09-01 00:00:00

abstract：:In this study we successfully entrapped 5-aminolevulinic acid (ALA) in liposome, although it exists as a zwitter ion. A molar ratio of 2:1:2.5 phosphatidyle-thanolamine (PE)/cholesterol/sodium stearate represented the best condition to achieve high entrapment efficiency (29.37 +/- 1.21%), and the average vehicle size ...

journal_title：Journal of liposome research

authors： Fang YP,Wu PC,Tsai YH,Huang YB

更新日期：2008-01-01 00:00:00

abstract：:A simple strategy for designing a cancer immunotherapeutic system involves modification of tumor cells from tumor-bearing animals in vivo in such a way that the host can evoke a specific immune response against them. We have expressed allogeneic class I major histocompatibility complex (MHC) molecules on tumor cells, ...

journal_title：Journal of liposome research

authors： Hui KM,Sabapathy TK,Oei AA,Singhal A,Huang L

更新日期：1994-01-01 00:00:00

abstract：:Internal wool lipids (IWLs) are rich in cholesterol, free fatty acids, cholesteryl sulfate, and, mainly, ceramides. The repairing effect of these lipids structured as liposomes was demonstrated by reinforcing the skin-barrier integrity and increasing the water-holding capacity when applied onto the skin. This work was...

journal_title：Journal of liposome research

authors： Ramírez R,Martí M,Cavaco-Paulo A,Silva R,de la Maza A,Parra JL,Coderch L

更新日期：2009-01-01 00:00:00

abstract：:Valsartan (VLT) is a highly selective and orally active antihypertensive drug. However, its oral administration is associated with drawbacks like low bioavailability. The objective of this study was to design and develop a transdermal delivery system for VLT using ethosomal carriers to investigate their enhanced trans...

journal_title：Journal of liposome research

authors： Bhosale SS,Avachat AM

更新日期：2013-06-01 00:00:00

abstract：:The liposomalization and polyethyleneglycol (PEG) modification of antitumor agents prolongs their circulation in the blood and increases their accumulation in the tumor. It is expected that modification of the liposome surface with PEG-Lipid will prevent connection of liposome and tumor cell, so we examined the effect...

journal_title：Journal of liposome research

authors： Sadzuka Y,Kishi K,Hirota S,Sonobe T

更新日期：2003-05-01 00:00:00

abstract：:Intravenous injection of some liposomal drugs, diagnostic agents, micelles and other lipid-based nanoparticles can cause acute hypersensitivity reactions (HSRs) in a high percentage (up to 45%) of patients, with hemodynamic, respiratory and cutaneous manifestations. The phenomenon can be explained with activation of t...

journal_title：Journal of liposome research

authors： Szebeni J,Alving CR,Rosivall L,Bünger R,Baranyi L,Bedöcs P,Tóth M,Barenholz Y

更新日期：2007-01-01 00:00:00

abstract：:This work describes the preparation of a PEGylated niosomes-mediated drug delivery systems for Paeonol, thereby improving the bioavailability and chemical stability of Paeonol, prolonging its cellular uptake and enhancing its synergistic anti-cancer effects with 5-Fu. PEGylated niosomes, which are prepared from biocom...

journal_title：Journal of liposome research

authors： He RX,Ye X,Li R,Chen W,Ge T,Huang TQ,Nie XJ,Chen HJ,Peng DY,Chen WD

更新日期：2017-06-01 00:00:00

abstract：:The luciferase gene expression of lipoplexes, a liposome containing luciferase plasmid (pCMVLuc), in HeLa cell lines, was investigated. Cationic liposomes were prepared by the chloroform film method with sonication. The lipoplex was formed by loading the liposome with pCMVLuc. The lipoplex with an optimal weight ratio...

journal_title：Journal of liposome research

authors： Manosroi A,Thathang K,Manosroi J,Werner RG,Schubert R,Peschka-Süss R

更新日期：2009-01-01 00:00:00

abstract：:The poor selectivity of anticancer drugs often leads to their multiplicate dose-limiting toxicities in humans, which severely restricts their clinical application. In this study, a novel liposomal formulation of zedoary turmeric oil (ZTO) targeting the insulin receptor (IR) was prepared by covalently conjugating insul...

journal_title：Journal of liposome research

authors： Yang Z,Fu D,Zhu L,Yang M,Cheng Q

更新日期：2010-03-01 00:00:00

abstract：:Skin is considered the most accessible organ of the body because of its underlying capillary network. However, stratum corneum (SC), the upper most layer of skin, represents major diffusional barrier for most drugs. Hence, the use of edge activators (EAs) in designing novel elastic vesicles is hypothesized to impart t...

journal_title：Journal of liposome research

authors： Aziz DE,Abdelbary AA,Elassasy AI

更新日期：2019-03-01 00:00:00

abstract：:The imaging of sentinel lymph nodes (SLN) has been researched for its role in assessing cancer progression and postsurgical lymphedema. Indocyanine green (ICG) is a near-infrared (NIR) optical dye that has been approved by the Food and Drug Administration. It is known that liposome-encapsulated ICG (LP-ICG) has improv...

journal_title：Journal of liposome research

authors： Jeong HS,Lee CM,Cheong SJ,Kim EM,Hwang H,Na KS,Lim ST,Sohn MH,Jeong HJ

更新日期：2013-12-01 00:00:00

abstract：CONTEXT:Asenapine maleate (ASPM) is an antipsychotic drug for the treatment of schizophrenia and bipolar disorder. Extensive metabolism makes the oral route inconvenient for ASPM. OBJECTIVE:The objective of this study is to increase ASPM bioavailability via transdermal route by improving the skin permeation using comb...

journal_title：Journal of liposome research

authors： Shreya AB,Managuli RS,Menon J,Kondapalli L,Hegde AR,Avadhani K,Shetty PK,Amirthalingam M,Kalthur G,Mutalik S

更新日期：2016-09-01 00:00:00