Abstract:
:Propylthiouracil, a lyophobic drug with an antiproliferative activity, was formulated into niosomes using various classes of nonionic surfactants. Feasibility of vesicle formation by the sonication method was evaluated. Size and size distribution was measured by laser diffraction. Entrapment and drug release over 24 h were monitored by UV spectrophotometric method at 275 nm. The results revealed that niosomes readily formed from various compositions of nonionic surfactant and cholesterol, with or without a stabilizer. Entrapment of PTU in niosomes depended on bilayer composition. The release of PTU from all niosomal formulations studied was retarded and followed the first-order kinetics. Degree of slow release had a negative correlation with drug entrapment. The release rate also depended on the physical state of the bilayer. The results of this study indicate that PTU niosomes were able to control the release of PTU and might be of value to develop further into topical formulations.
journal_name
J Liposome Resjournal_title
Journal of liposome researchauthors
Suwakul W,Ongpipattanakul B,Vardhanabhuti Ndoi
10.1080/08982100600992542subject
Has Abstractpub_date
2006-01-01 00:00:00pages
391-401issue
4eissn
0898-2104issn
1532-2394pii
W354UW51U5M450K4journal_volume
16pub_type
杂志文章abstract:CONTEXT:Asenapine maleate (ASPM) is an antipsychotic drug for the treatment of schizophrenia and bipolar disorder. Extensive metabolism makes the oral route inconvenient for ASPM. OBJECTIVE:The objective of this study is to increase ASPM bioavailability via transdermal route by improving the skin permeation using comb...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2015.1098659
更新日期:2016-09-01 00:00:00
abstract::In the current research work, rivastigmine (RV)-loaded in situ gelling nanostructured lipid carriers (NLCs) were developed for nose to brain delivery. NLCs were fabricated by ethanol injection method using glyceryl monosterate, Capmul MCM C8, Lecithin and Tween 80. NLCs showed average particle size of 123.2 ± 2.3 nm w...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2014.954129
更新日期:2015-01-01 00:00:00
abstract::The evidence in this communication indicate that, unlike resident Kupffer cells, newly recruited liver macrophages (following monocyte migration from the blood to the liver) use complement receptors to recognize and internalize stearylamine-incorporated liposomes. Within two weeks of hepatic residency complement recep...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1081/lpr-120004778
更新日期:2002-02-01 00:00:00
abstract::Intravenous injection of some liposomal drugs, diagnostic agents, micelles and other lipid-based nanoparticles can cause acute hypersensitivity reactions (HSRs) in a high percentage (up to 45%) of patients, with hemodynamic, respiratory and cutaneous manifestations. The phenomenon can be explained with activation of t...
journal_title:Journal of liposome research
pub_type: 杂志文章,评审
doi:10.1080/08982100701375118
更新日期:2007-01-01 00:00:00
abstract::Sustained release depot systems have been widely investigated for their potential to improve the efficacy of subunit vaccines and reduce the requirement for boosting. The present study aimed to further enhance the immunogenicity of a sustained release vaccine by combining a depot formulation with a particulate antigen...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2011.637502
更新日期:2012-09-01 00:00:00
abstract::The influence of esters based on gamma-aminobutyric acid (GABA) and mono-/bicyclic terpenoids on membrane structure was investigated. The mechanism of action for terpenoid esters on phospholipids of artificial membranes and lipids isolated from the rat stratum corneum was studied by fluorescence and FT-IR spectroscopy...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2018.1538238
更新日期:2019-09-01 00:00:00
abstract::Thermodynamical techniques are applied for determining the thermal stress of medicinal compounds of the excipients as well as their interactions during the formulation process. The physicochemical properties and the stability of the medicinal products could be measured as a function of temperature or time using therma...
journal_title:Journal of liposome research
pub_type: 杂志文章,评审
doi:10.1080/08982100802310261
更新日期:2008-01-01 00:00:00
abstract::RNA interference is an effective and naturally occurring post-transcriptional gene regulatory mechanism. This mechanism involves the degradation of a target messenger RNA (mRNA) through the introduction of short interfering RNA (siRNA) that is complementary to the target mRNA. The application of siRNA-based therapeuti...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2018.1531424
更新日期:2019-09-01 00:00:00
abstract::Hepatic carcinoma (HC) is one of the most prevalent cancers, ranked as the second most common cause of cancer-related deaths worldwide. Silymarin (SYL) has been reported for its anticarcinogenic activity against various types of cancer such as prostate, breast, ovary, colon, lung, bladder and liver. Due to poor solubi...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2018.1551408
更新日期:2019-09-01 00:00:00
abstract::Skin, the largest organ of the body serves as a potential route of drug delivery for local and systemic effects. However, the outermost layer of skin, the stratum corneum (SC) acts as a tough barrier that prevents penetration of hydrophilic and high molecular weight drugs. Ethosomes are a novel phospholipid vesicular ...
journal_title:Journal of liposome research
pub_type: 杂志文章,评审
doi:10.1080/08982104.2018.1517160
更新日期:2019-06-01 00:00:00
abstract::The luciferase gene expression of lipoplexes, a liposome containing luciferase plasmid (pCMVLuc), in HeLa cell lines, was investigated. Cationic liposomes were prepared by the chloroform film method with sonication. The lipoplex was formed by loading the liposome with pCMVLuc. The lipoplex with an optimal weight ratio...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982100802642457
更新日期:2009-01-01 00:00:00
abstract::Co-delivery of chemotherapeutic agents using nanocarriers is a promising strategy for enhancing therapeutic efficacy of anticancer agents. The aim of this work was to develop tamoxifen and imatinib dual drug loaded temperature-sensitive liposomes to treat breast cancer. Liposomes were prepared using 1, 2-dipalmitoyl-s...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2018.1502315
更新日期:2019-06-01 00:00:00
abstract:CONTEXT:The stability of liposomes in the form of dispersion is a major concern due to drug leakage and fusion or aggregation. The stability can be improved by lyophilization, but the stress induced by the lyophilization process can affect the integrity of liposomes. OBJECTIVE:The objective of this study was to evalua...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2014.992023
更新日期:2015-01-01 00:00:00
abstract::Ag:Au alloy nanoparticles were successfully synthesized through the new route using co-reduction method with silver nitrate, chloroauric acid, cetyl trimethyl ammonium bromide (CTAB) and sodium borohydride at room temperature. The Ag:Au alloy nanoparticles were then loaded within the phosphatidylcholine (97%) liposome...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2014.926917
更新日期:2015-03-01 00:00:00
abstract::Liposomes have the capacity to be used as efficient, biodegradable and nontoxic carriers of bioactive molecules and are able to better control their delivery at the site of interest. The objective of this study was to obtain and characterize an appropriate liposomal formulation of the bioactive molecule chondroitin su...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2013.770016
更新日期:2013-06-01 00:00:00
abstract::Background and objective: The combination of two or more different mechanisms of drugs in the treatment of cancer has become one of the effective methods. The purpose of this study was to successfully prepare a non-viral delivery system that could efficiently co-delivery siRNA and gambogenic acid (GNA) to improve the ...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2018.1473423
更新日期:2019-12-01 00:00:00
abstract::Pulmonary lung targeting finds applications in drug delivery to the lung itself and to other body organs, via blood circulation following transfer across alveolar membranes. Understanding pulmonary drug delivery systems towards improving their efficacy needs identification of particle sizes of relevance and elucidatio...
journal_title:Journal of liposome research
pub_type: 杂志文章,评审
doi:10.3109/08982104.2013.802332
更新日期:2013-12-01 00:00:00
abstract::Vesicular phospholipid gels (VPGs) represent semi-solid phospholipid dispersions. Their morphology is truly vesicular with aqueous compartments both within the core of the vesicles and in-between the vesicles. VPGs are suited to carry both hydrophilic, amphiphilic and lipophilic drugs. Their drug load is stable since ...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982100601186490
更新日期:2007-01-01 00:00:00
abstract::The aim of this study was to investigate the application of ultrasonic gas-filled liposomes in enhancing transfer for breast cancer-related antisense oligonucleotides in vitro. An antisense oligodeoxynucleotide (AS-ODN) sequence, HA2741, modified with luciferase reporter plasmid, was used in evaluating the enhancing e...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/03639040802509868
更新日期:2008-01-01 00:00:00
abstract::Skin is considered the most accessible organ of the body because of its underlying capillary network. However, stratum corneum (SC), the upper most layer of skin, represents major diffusional barrier for most drugs. Hence, the use of edge activators (EAs) in designing novel elastic vesicles is hypothesized to impart t...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2018.1430831
更新日期:2019-03-01 00:00:00
abstract::Leishmaniasis is a parasitic disease treatable and curable, however, the chemotherapeutic agents for their treatment are limited. In South American countries, pentavalent antimonials are still the first line of treatment for cutaneous leishmaniasis with an efficacy of about 75%, but the toxicity of the drug causes ser...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2020.1749067
更新日期:2020-04-13 00:00:00
abstract::By selecting a unique combination of lipids and amphotericin B, the liposome composition for AmBisome® (L-AmBis) has been optimized resulting in a formulation that is minimally toxic, targets to fungal cell walls, and distributes into and remains for days to weeks in various host tissues at drug levels above the MIC f...
journal_title:Journal of liposome research
pub_type: 杂志文章,评审
doi:10.1080/08982104.2017.1327543
更新日期:2017-09-01 00:00:00
abstract::To engineer drug carriers capable of spontaneous accumulation in tumors and ischemic areas via the enhanced permeability and retention (EPR) effect and further penetration and drug delivery inside tumor or ischemic cells via the action of the cell-penetrating peptide (CPP), we have prepared liposomes simultaneously be...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982100701525035
更新日期:2007-01-01 00:00:00
abstract::Virosomes are reconstituted viral envelopes which lack the genetic material but retain the cell entry and membrane fusion characteristics of the virus they are derived from. Thus, influenza virosomes are taken up by cells via receptor-mediated endocytosis, which directs the particles to the endosomal cell compartment....
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1081/lpr-120004789
更新日期:2002-02-01 00:00:00
abstract::The use of arsenic-containing compounds in cancer therapy is currently being re-considered, after the recent approval of arsenic trioxide (Trisenox) for the treatment of relapsed promyelocytic leukemia (PML). In an attempt to prepare a carrier system to minimize the toxicity of this drug, the aim of this study is to p...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1081/lpr-120039661
更新日期:2004-01-01 00:00:00
abstract::The aim of this study was to establish the mechanisms of action of a novel liposomal nitric oxide (NO) carrier on large-conductance Ca2+-activated channels (BKCa or Maxi-K) expressed in vascular smooth muscle cells (VSMCs) isolated from the rat main pulmonary artery (MPA). Experimental design comprised of both whole-c...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2020.1863424
更新日期:2021-01-08 00:00:00
abstract::Cutaneous leishmaniasis is caused by different species of Leishmania parasites and its available treatments have not yet provided a strong consistent result. The weak response of current chemotherapeutics is due to their deficient effects on stealth parasites inside macrophages, rapid clearance from the site of action...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2012.762519
更新日期:2013-06-01 00:00:00
abstract::In the present work, we show that we obtained nanometric structures made of water, 1,2-dipalmitoyl-sn-glycero-3-phosphatidylcholine (DPPC), cholesterol (Chol), and a mixture of ethoxylated and non-ethoxylated sorbitan fatty acid esters (Tween 20, Span 20, Tween 80, and Span 80) by mixing all of them near the cloud poi...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2016.1174944
更新日期:2017-06-01 00:00:00
abstract::Methotrexate (MTX) is indicated in the symptomatic control of severe, recalcitrant, and disabling psoriasis. The oral or parenteral route of administration causes systemic toxicity. The topical route of delivery, though, reduces systemic toxicity and has limited applicability due to restricted permeability. Liposomal ...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2010.492476
更新日期:2011-06-01 00:00:00
abstract::The aim of the present study was to characterize a liposome-based benzocaine (BZC) formulation designed for topical use on the oral mucosa and to evaluate its in vitro retention and permeation using the Franz-type diffusion cells through pig esophagus mucosa. To predict the effectiveness of new designed formulations d...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2012.742536
更新日期:2013-03-01 00:00:00