Abstract:
:The liposomalization and polyethyleneglycol (PEG) modification of antitumor agents prolongs their circulation in the blood and increases their accumulation in the tumor. It is expected that modification of the liposome surface with PEG-Lipid will prevent connection of liposome and tumor cell, so we examined the effect of PEG chain length and anchor length on liposome uptake into the tumor cell. It was obvious that modification of the liposome surface with PEG-Lipid did not prevent liposome uptake into tumor cells, but rather, promoted it. It was suggested that the increase in liposome uptake into the tumor cell was induced by modification of PEG-lipids with apparent stability. In other words, PEG 2,000-DPG, which had a high rate of residual PEG-Lipid on liposomal membrane depending on the re-uptake to liposomal membrane, met to this requirement.
journal_name
J Liposome Resjournal_title
Journal of liposome researchauthors
Sadzuka Y,Kishi K,Hirota S,Sonobe Tdoi
10.1081/lpr-120020318subject
Has Abstractpub_date
2003-05-01 00:00:00pages
157-72issue
2eissn
0898-2104issn
1532-2394pii
120020318journal_volume
13pub_type
杂志文章abstract::The current study aimed to deliver minoxidil (2,4-diamino-6-piperidinopyrimidine 3-oxide; MXD), a potent hypertrichotic agent, into the pilosebaceous units, exploring the potential of the liposomal system. MXD-loaded liposomes of different compositions were prepared by a thin-film hydration technique and subsequently ...
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