Abstract:
:In this study we successfully entrapped 5-aminolevulinic acid (ALA) in liposome, although it exists as a zwitter ion. A molar ratio of 2:1:2.5 phosphatidyle-thanolamine (PE)/cholesterol/sodium stearate represented the best condition to achieve high entrapment efficiency (29.37 +/- 1.21%), and the average vehicle size was 133.6 +/- 2.8 nm. After 32 days of storage, the vehicle sizes of formulations with PE series were still approximately less than 200 nm. The safety of liposomes was tested and ensured both with regard to cellular cytotoxicity and erythrocyte hemolysis. Safety studies showed that liposome formulations did not affect cell viability except when both potassium stearate and sodium oleate were added. Moreover, PE and PE/cholesterol did not damage human erythrocytes in this study. The range of the hemolytic effect caused by liposomes was 5 to 37% and the effect was dependent on the amount of sodium stearate added to the formulation. According to the release rates and skin penetration of ALA liposomes in vitro, PE/cholesterol/sodium stearate liposomes might increase skin penetration, and it was shown that penetration across the stratum-corneum (sc) layer was the rate-limiting process. Images from confocal laser scanning microscopy (CLSM) confirmed the great potency of liposomes for delivering ALA into skin.
journal_name
J Liposome Resjournal_title
Journal of liposome researchauthors
Fang YP,Wu PC,Tsai YH,Huang YBdoi
10.1080/08982100801893952subject
Has Abstractpub_date
2008-01-01 00:00:00pages
31-45issue
1eissn
0898-2104issn
1532-2394pii
791540216journal_volume
18pub_type
杂志文章abstract::The poor selectivity of anticancer drugs often leads to their multiplicate dose-limiting toxicities in humans, which severely restricts their clinical application. In this study, a novel liposomal formulation of zedoary turmeric oil (ZTO) targeting the insulin receptor (IR) was prepared by covalently conjugating insul...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982100903015017
更新日期:2010-03-01 00:00:00
abstract::Sustained release depot systems have been widely investigated for their potential to improve the efficacy of subunit vaccines and reduce the requirement for boosting. The present study aimed to further enhance the immunogenicity of a sustained release vaccine by combining a depot formulation with a particulate antigen...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2011.637502
更新日期:2012-09-01 00:00:00
abstract::Virosomes are reconstituted viral envelopes which lack the genetic material but retain the cell entry and membrane fusion characteristics of the virus they are derived from. Thus, influenza virosomes are taken up by cells via receptor-mediated endocytosis, which directs the particles to the endosomal cell compartment....
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1081/lpr-120004789
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abstract::Doxorubicin, as a widely used chemotherapeutic, always causes multidrug resistance in human cancer cells. To circumvent drug resistance, we developed a novel formulation where doxorubicin hydrochloride (DOX) and chloroquine phosphate (CQ) were simultaneously loaded into liposomes by a pH-gradient method where CQ playe...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2012.684150
更新日期:2012-09-01 00:00:00
abstract::Thermosensitive liposomes are attractive vehicles for the delivery and release of drugs to tumors. To improvethe targeting efficacy for breast cancer treatment, an 8.3-kDa HER2-specific Affibody molecule (Z(HER2:342)-Cys) was conjugated to the surface of liposomes. The effects of this modification on physical characte...
journal_title:Journal of liposome research
pub_type: 杂志文章
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abstract::A simple strategy for designing a cancer immunotherapeutic system involves modification of tumor cells from tumor-bearing animals in vivo in such a way that the host can evoke a specific immune response against them. We have expressed allogeneic class I major histocompatibility complex (MHC) molecules on tumor cells, ...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982109409018623
更新日期:1994-01-01 00:00:00
abstract::Background and objective: The combination of two or more different mechanisms of drugs in the treatment of cancer has become one of the effective methods. The purpose of this study was to successfully prepare a non-viral delivery system that could efficiently co-delivery siRNA and gambogenic acid (GNA) to improve the ...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2018.1473423
更新日期:2019-12-01 00:00:00
abstract::Archaeosomes, liposomes prepared from the polar ether lipids extracted from Archaea, demonstrate great potential as immunomodulating carriers of soluble antigens, promoting humoral and cell mediated immunity in the vaccinated host. The safety of unilamellar archaeosomes prepared from the total polar lipids (TPL) of Ha...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1081/lpr-120016712
更新日期:2002-11-01 00:00:00
abstract::The influence of esters based on gamma-aminobutyric acid (GABA) and mono-/bicyclic terpenoids on membrane structure was investigated. The mechanism of action for terpenoid esters on phospholipids of artificial membranes and lipids isolated from the rat stratum corneum was studied by fluorescence and FT-IR spectroscopy...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2018.1538238
更新日期:2019-09-01 00:00:00
abstract::The evidence in this communication indicate that, unlike resident Kupffer cells, newly recruited liver macrophages (following monocyte migration from the blood to the liver) use complement receptors to recognize and internalize stearylamine-incorporated liposomes. Within two weeks of hepatic residency complement recep...
journal_title:Journal of liposome research
pub_type: 杂志文章
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更新日期:2002-02-01 00:00:00
abstract::Skin, the largest organ of the body serves as a potential route of drug delivery for local and systemic effects. However, the outermost layer of skin, the stratum corneum (SC) acts as a tough barrier that prevents penetration of hydrophilic and high molecular weight drugs. Ethosomes are a novel phospholipid vesicular ...
journal_title:Journal of liposome research
pub_type: 杂志文章,评审
doi:10.1080/08982104.2018.1517160
更新日期:2019-06-01 00:00:00
abstract::The aim of present study was to develop conventional and PEGylated (long circulating), liposomes containing anastrozole (ANS) for effective treatment of breast cancer. ANS is a third-generation non-steroidal aromatase inhibitor of the triazole class used for the treatment of advanced and late-stage breast cancer in po...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2015.1029493
更新日期:2016-01-01 00:00:00
abstract::Propylthiouracil, a lyophobic drug with an antiproliferative activity, was formulated into niosomes using various classes of nonionic surfactants. Feasibility of vesicle formation by the sonication method was evaluated. Size and size distribution was measured by laser diffraction. Entrapment and drug release over 24 h...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982100600992542
更新日期:2006-01-01 00:00:00
abstract:CONTEXT:Asenapine maleate (ASPM) is an antipsychotic drug for the treatment of schizophrenia and bipolar disorder. Extensive metabolism makes the oral route inconvenient for ASPM. OBJECTIVE:The objective of this study is to increase ASPM bioavailability via transdermal route by improving the skin permeation using comb...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2015.1098659
更新日期:2016-09-01 00:00:00
abstract::Amphotericin B (AmB) liposome formulations are very successful in the treatment of fungal infections and leishmaniasis. But higher cost limits its widespread use among people in developing countries. Therefore, we have developed a modified ethanol-injection method for the preparation of AmB liposomes. Two liposomal fo...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2011.584317
更新日期:2012-03-01 00:00:00
abstract::This multicenter study investigated the possibility of reducing mortality rate by administering natural lung surfactant additional to standard therapy to treat patients after cardiac surgery who developed an acute respiratory failure (ARDS/ALI).A total of 78 patients (1998-2002) diagnosed with ALI or ARDS were enrolle...
journal_title:Journal of liposome research
pub_type: 杂志文章,多中心研究
doi:10.1080/08982100600850997
更新日期:2006-01-01 00:00:00
abstract::Sonication is a simple method for reducing the size of liposomes. We report the size distributions of liposomes as a function of sonication time using three different techniques. Liposomes, mildly sonicated for just 30 sec, had bimodal distributions when surface-weighted with modes at about 140 and 750 nm. With extend...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982100500528842
更新日期:2006-01-01 00:00:00
abstract::Cutaneous leishmaniasis is caused by different species of Leishmania parasites and its available treatments have not yet provided a strong consistent result. The weak response of current chemotherapeutics is due to their deficient effects on stealth parasites inside macrophages, rapid clearance from the site of action...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2012.762519
更新日期:2013-06-01 00:00:00
abstract:CONTEXT:Ropivacaine (RVC) is an aminoamide local anesthetic widely used in surgical procedures. Studies with RVC encapsulated in liposomes and complexed in cyclodextrins have shown good results, but in order to use RVC for lengthy procedures and during the postoperative period, a still more prolonged anesthetic effect ...
journal_title:Journal of liposome research
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doi:10.3109/08982104.2015.1022555
更新日期:2016-01-01 00:00:00
abstract::The current study aimed to deliver minoxidil (2,4-diamino-6-piperidinopyrimidine 3-oxide; MXD), a potent hypertrichotic agent, into the pilosebaceous units, exploring the potential of the liposomal system. MXD-loaded liposomes of different compositions were prepared by a thin-film hydration technique and subsequently ...
journal_title:Journal of liposome research
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更新日期:2010-06-01 00:00:00
abstract::Vesicular phospholipid gels (VPGs) represent semi-solid phospholipid dispersions. Their morphology is truly vesicular with aqueous compartments both within the core of the vesicles and in-between the vesicles. VPGs are suited to carry both hydrophilic, amphiphilic and lipophilic drugs. Their drug load is stable since ...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982100601186490
更新日期:2007-01-01 00:00:00
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journal_title:Journal of liposome research
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更新日期:2017-06-01 00:00:00
abstract::Pulmonary lung targeting finds applications in drug delivery to the lung itself and to other body organs, via blood circulation following transfer across alveolar membranes. Understanding pulmonary drug delivery systems towards improving their efficacy needs identification of particle sizes of relevance and elucidatio...
journal_title:Journal of liposome research
pub_type: 杂志文章,评审
doi:10.3109/08982104.2013.802332
更新日期:2013-12-01 00:00:00
abstract::RNA interference is an effective and naturally occurring post-transcriptional gene regulatory mechanism. This mechanism involves the degradation of a target messenger RNA (mRNA) through the introduction of short interfering RNA (siRNA) that is complementary to the target mRNA. The application of siRNA-based therapeuti...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982104.2018.1531424
更新日期:2019-09-01 00:00:00
abstract::The effect of liposomal inclusion on the stability and in vitro antiherpetic activity of Santolina insularis essential oil was investigated. In order to study the influence of vesicle structure on the liposome properties, multilamellar and unilamellar vesicles were prepared by the film method and sonication, respectiv...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1081/LPR-100103171
更新日期:2001-01-01 00:00:00
abstract::Liposomal vinorelbine formulation is desirable, as it might improve the therapeutic activity of vinorelbine. However, because of its lipophilic and membrane-permeable properties, vinorelbine is hard to be formulated into liposomes using conventional drug-loading technologies. To improve vinorelbine retention, ammonium...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.3109/08982104.2011.584880
更新日期:2012-03-01 00:00:00
abstract::This study aimed to investigate the influence of the preparation conditions on the performance of an ethosomal formulation for topical delivery of the local anesthetic agent, benzocaine (BZC). Ethosomes were prepared with different techniques, such as thin-layer evaporation, freezing and thawing, reverse-phase evapora...
journal_title:Journal of liposome research
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doi:10.3109/08982100902788408
更新日期:2009-01-01 00:00:00
abstract::The aim of this study was to design and optimize a transdermal liposomes gel formulation for paeonol (PAE). A three-factor, three-level Box-Behnken design was used to derive a second-order polynomial equation to construct three-dimensional (3-D) contour plots for prediction of responses. Independent variables studied ...
journal_title:Journal of liposome research
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doi:10.3109/08982104.2012.690159
更新日期:2012-12-01 00:00:00
abstract::Thermodynamical techniques are applied for determining the thermal stress of medicinal compounds of the excipients as well as their interactions during the formulation process. The physicochemical properties and the stability of the medicinal products could be measured as a function of temperature or time using therma...
journal_title:Journal of liposome research
pub_type: 杂志文章,评审
doi:10.1080/08982100802310261
更新日期:2008-01-01 00:00:00
abstract::The influence of the lipid composition of arsonoliposomes on their membrane integrity was investigated to evaluate whether it is possible to combine their action with drugs that can be encapsulated in their aqueous interior. This was investigated by measuring the retention of vesicle-encapsulated calcein (100 mM) duri...
journal_title:Journal of liposome research
pub_type: 杂志文章
doi:10.1080/08982100500364263
更新日期:2005-01-01 00:00:00