abstract：:The predictive effect of circulating tumor DNA (ctDNA) in colorectal cancer (CRC) treatment is still highly discussed. The primary objective of our study was to investigate a possible prognostic/predictive value of ctDNA under regorafenib treatment. This prospective multicenter translational biomarker phase II pilot s...

journal_title：International journal of cancer

authors： Unseld M,Belic J,Pierer K,Zhou Q,Moser T,Bauer R,Piringer G,Gerger A,Siebenhüner A,Speicher M,Heitzer E,Prager GW

更新日期：2021-03-15 00:00:00

abstract：:Cholangiocarcinoma is the second most common primary hepatic cancer, with a rising incidence worldwide. Owing to late diagnosis and limited treatment options, the prognosis for cholangiocarcinoma remains dismal, compelling a search for new treatments. As aspirin exhibits a well-supported chemopreventive effect on comm...

journal_title：International journal of cancer

authors： Shen X,Shen X

更新日期：2021-03-15 00:00:00

abstract：:The Be Clear on Cancer (BCoC) campaigns have run in England since 2010. They aim to raise awareness of possible cancer symptoms, encouraging people to consult a general practice with these symptoms. Our study provides an overview of the impact of 11 national campaigns, for bowel, lung, bladder and kidney, breast and o...

journal_title：International journal of cancer

authors： Lai J,Mak V,Bright CJ,Lyratzopoulos G,Elliss-Brookes L,Gildea C

更新日期：2021-03-01 00:00:00

abstract：:The WHO Classification of Tumours provides the international standards for the classification and diagnosis of tumours. It enables direct comparisons to be made between different countries. In the new fifth edition, the series has gone digital with the launch of a website as well as a series of books, known widely as ...

journal_title：International journal of cancer

authors： Washington MK,Goldberg RM,Chang GJ,Limburg P,Lam AK,Salto-Tellez M,Arends MJ,Nagtegaal ID,Klimstra DS,Rugge M,Schirmacher P,Lazar AJ,Odze RD,Carneiro F,Fukayama M,Cree IA,WHO Classification of Tumours Editorial Board.

更新日期：2021-03-01 00:00:00

abstract：:Limited and inefficient treatment options exist for metastatic relapsed cervical cancer (MRCC), and there are currently no reliable indicators to guide therapeutic selection. We performed deep sequencing analyses targeting 322 cancer-related genes in plasma cell-free DNA and matched white blood cells in 173 serial blo...

journal_title：International journal of cancer

authors： Tian X,Ge D,Zhang F,Zhang B,Bai W,Xu X,Li Z,Cao Y,Li P,Zou K,Zou L

更新日期：2021-02-15 00:00:00

abstract：:The association between breast cancer risk defined by the Tyrer-Cuzick score (TC) and disease prognosis is not well established. Here, we investigated the relationship between 5-year TC and disease aggressiveness and then characterized underlying molecular processes. In a case-only study (n = 2474), we studied the ass...

journal_title：International journal of cancer

authors： Ugalde-Morales E,Grassmann F,Humphreys K,Li J,Eriksson M,Tobin NP,Borg Å,Vallon-Christersson J,Hall P,Czene K

更新日期：2021-02-15 00:00:00

abstract：:The epidemiological literature reports inconsistent associations between consumption or circulating concentrations of micronutrients and breast cancer risk. We investigated associations between genetically predicted concentrations of 11 micronutrients (beta-carotene, calcium, copper, folate, iron, magnesium, phosphoru...

journal_title：International journal of cancer

authors： Papadimitriou N,Dimou N,Gill D,Tzoulaki I,Murphy N,Riboli E,Lewis SJ,Martin RM,Gunter MJ,Tsilidis KK

更新日期：2021-02-01 00:00:00

abstract：:Corpus uteri cancer is the most common gynecological malignancy in most developed countries. The disease is typically diagnosed at an early stage, is of endometrioid histologic subtype, and has a fairly good prognosis. Here, we describe hysterectomy-corrected mortality rates of corpus uteri cancer, overall and stratif...

journal_title：International journal of cancer

authors： Gustafson LW,Booth BB,Kahlert J,Ørtoft G,Mejlgaard E,Clarke MA,Wentzensen N,Rositch AF,Hammer A

更新日期：2021-02-01 00:00:00

abstract：:Biliary tract cancers have dismal prognoses even when cytotoxic chemotherapy is administered. There is an unmet need to develop precision treatment approaches using comprehensive genomic profiling. A total of 121 patients with biliary tract cancers were analyzed for circulating-tumor DNA (ctDNA) and/or tissue-based tu...

journal_title：International journal of cancer

authors： Okamura R,Kurzrock R,Mallory RJ,Fanta PT,Burgoyne AM,Clary BM,Kato S,Sicklick JK

更新日期：2021-02-01 00:00:00

abstract：:Deletion of chromosome 5q is common in prostate cancer and is linked to aggressive disease. Most previous studies focused on 5q21 where CHD1 is located, but deletion of mapping studies has identified a second deletion hotspot at 5q13. To clarify the prevalence and clinical relevance of 5q13 deletions and to determine ...

journal_title：International journal of cancer

authors： Möller K,Kluth M,Ahmed M,Burkhardt L,Möller-Koop C,Büscheck F,Weidemann S,Tsourlakis MC,Minner S,Heinzer H,Huland H,Graefen M,Sauter G,Schlomm T,Dum D,Simon R

更新日期：2021-02-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) development entails changes in liver metabolism. Current knowledge on metabolic perturbations in HCC is derived mostly from case-control designs, with sparse information from prospective cohorts. Our objective was to apply comprehensive metabolite profiling to detect metabolites whose se...

journal_title：International journal of cancer

authors： Stepien M,Keski-Rahkonen P,Kiss A,Robinot N,Duarte-Salles T,Murphy N,Perlemuter G,Viallon V,Tjønneland A,Rostgaard-Hansen AL,Dahm CC,Overvad K,Boutron-Ruault MC,Mancini FR,Mahamat-Saleh Y,Aleksandrova K,Kaaks R,Kühn T,

更新日期：2021-02-01 00:00:00

abstract：:Androgen deprivation therapy (ADT) remains a key approach in the treatment of prostate cancer (PCa). However, PCa inevitably relapses and becomes ADT resistant. Besides androgens, there is evidence that thyroid hormone thyroxine (T4) and its active form 3,5,3'-triiodo-L-thyronine (T3) are involved in the progression o...

journal_title：International journal of cancer

authors： Aksoy O,Pencik J,Hartenbach M,Moazzami AA,Schlederer M,Balber T,Varady A,Philippe C,Baltzer PA,Mazumder B,Whitchurch JB,Roberts CJ,Haitel A,Herac M,Susani M,Mitterhauser M,Marculescu R,Stangl-Kremser J,Hassler MR,Kr

更新日期：2021-02-01 00:00:00

abstract：:Twin studies suggest a familial aggregation of bladder cancer but elements of this increased familial risk of bladder cancer are not well understood. To characterize familial risk of bladder cancer, we examined the relationship between family history of bladder and other types of cancer among first-degree relatives an...

journal_title：International journal of cancer

authors： Koutros S,Decker KL,Baris D,Pardo LA,Johnson A,Hosain GMM,Rothman N,Karagas MR,Schwenn MR,Silverman DT

更新日期：2021-01-27 00:00:00

abstract：:In children, renal cell carcinoma (RCC) is rare. This study is the first report of pediatric patients with RCC registered by the International Society of Pediatric Oncology-Renal Tumor Study Group (SIOP-RTSG). Pediatric patients with histologically confirmed RCC, registered in SIOP 93-01, 2001 and UK-IMPORT databases,...

journal_title：International journal of cancer

authors： van der Beek JN,Hol JA,Coulomb-l'Hermine A,Graf N,van Tinteren H,Pritchard-Jones K,Houwing ME,de Krijger RR,Vujanic GM,Dzhuma K,Schenk JP,Littooij AS,Ramírez-Villar GL,Murphy D,Ray S,Al-Saadi R,Gessler M,Godzinski J,R

更新日期：2021-01-18 00:00:00

abstract：:Blood lipids have been associated with the development of a range of cancers, including breast, lung and colorectal cancer. For endometrial cancer, observational studies have reported inconsistent associations between blood lipids and cancer risk. To reduce biases from unmeasured confounding, we performed a bidirectio...

journal_title：International journal of cancer

authors： Kho PF,Amant F,Annibali D,Ashton K,Attia J,Auer PL,Beckmann MW,Black A,Brinton L,Buchanan DD,Chanock SJ,Chen C,Chen MM,Cheng THT,Cook LS,Crous-Bous M,Czene K,De Vivo I,Dennis J,Dörk T,Dowdy SC,Dunning AM,Dürst

更新日期：2021-01-15 00:00:00

abstract：:Most breast cancer patients in sub-Saharan Africa are diagnosed at advanced stages after prolonged symptomatic periods. In the multicountry African Breast Cancer-Disparities in Outcomes cohort, we dissected the diagnostic journey to inform downstaging interventions. At hospital presentation for breast cancer, women re...

journal_title：International journal of cancer

authors： Foerster M,McKenzie F,Zietsman A,Galukande M,Anele A,Adisa C,Parham G,Pinder L,Schüz J,McCormack V,Dos-Santos-Silva I

更新日期：2021-01-15 00:00:00

abstract：:Peptidylarginine deiminases (PADs) catalyze the conversion of arginine residues to citrulline residues on target proteins in the presence of calcium ions. This elaborate type of posttranslational modification is termed citrullination. PADs may regulate gene transcriptional activity via histone citrullination. There ha...

journal_title：International journal of cancer

authors： Wang Y,Chen R,Gan Y,Ying S

更新日期：2021-01-15 00:00:00

abstract：:A 30-kb deletion that eliminates the coding region of APOBEC3B (A3B) is >5 times more common in women of Asian compared to European descent. This polymorphism creates a chimera with the APOBEC3A (A3A) coding region and A3B 3'UTR, and is associated with an increased risk for breast cancer in Asian women. Here, we explo...

journal_title：International journal of cancer

authors： Pan JW,Zabidi MMA,Chong BK,Meng MY,Ng PS,Hasan SN,Sandey B,Bahnu S,Rajadurai P,Yip CH,Rueda OM,Caldas C,Chin SF,Teo SH

更新日期：2021-01-07 00:00:00

abstract：:Pseudomyxoma peritonei (PMP) is a rare disorder with unique pathological and genetic changes. Although several studies have reported the clinical features and mutational changes of PMP that originates from the appendix, few studies on PMP originating from the ovary have been reported due to its extreme rarity. In orde...

journal_title：International journal of cancer

authors： Wang B,Yao J,Ma R,Liu D,Lu Y,Shi G,An L,Xia A,Chen F,Pang S,Zhai X,Liu G,Chen S,Xu M,Song L,Xu H

更新日期：2021-01-05 00:00:00

abstract：:Cancer is well established as an age-associated disease, and there is substantial overlap in the molecular, cellular and physiological changes observed with both ageing and the progression of cancer. Age-specific declines in resilience mechanisms such as DNA repair or epigenetic maintenance may contribute to the devel...

journal_title：International journal of cancer

authors： Lau CE,Robinson O

更新日期：2021-01-04 00:00:00

abstract：:More women are surviving after breast cancer due to early detection and modern treatment strategies. Body weight also influences survival. We aimed to characterize associations between postdiagnosis weight change and prognosis in postmenopausal long-term breast cancer survivors. We used data from a prospective populat...

journal_title：International journal of cancer

authors： Jung AY,Hüsing A,Behrens S,Krzykalla J,Obi N,Becher H,Chang-Claude J

更新日期：2021-01-01 00:00:00

abstract：:The influence of polyunsaturated fatty acids (PUFAs) on risk of colorectal cancer precursors remains largely unknown. We examined the associations of erythrocyte PUFAs, including n-3 and n-6 PUFAs, with risk of colorectal conventional adenomas and serrated polyps in 4517 participants from three US prospective cohorts ...

journal_title：International journal of cancer

authors： Wang L,Hang D,He X,Lo CH,Wu K,Chan AT,Ogino S,Giovannucci EL,Song M

更新日期：2021-01-01 00:00:00

abstract：:RAS, TP53 (p53) and MYC are among the most frequently altered driver genes in cancer. Thus, RAS is the most frequently mutated oncogene, MYC the most frequently amplified gene and TP53 the most frequently mutated tumor suppressor gene and overall the most frequently mutated gene in cancer. Theoretically, therefore, th...

journal_title：International journal of cancer

authors： Duffy MJ,Crown J

更新日期：2021-01-01 00:00:00

abstract：:Trilaciclib is an intravenous CDK4/6 inhibitor administered prior to chemotherapy to preserve haematopoietic stem and progenitor cells and immune system function from chemotherapy-induced damage (myelopreservation). The effects of administering trilaciclib prior to carboplatin, etoposide and atezolizumab (E/P/A) were ...

journal_title：International journal of cancer

authors： Daniel D,Kuchava V,Bondarenko I,Ivashchuk O,Reddy S,Jaal J,Kudaba I,Hart L,Matitashvili A,Pritchett Y,Morris SR,Sorrentino JA,Antal JM,Goldschmidt J

更新日期：2020-12-21 00:00:00

abstract：:Chimeric antigen receptor (CAR) T-cell therapy is a promising immunotherapy with high acquisition costs, and it has raised concerns about affordability and sustainability in many countries. Furthermore, the current centralized production paradigm for the T cells is less than satisfactory. Therefore, several countries ...

journal_title：International journal of cancer

authors： Ran T,Eichmüller SB,Schmidt P,Schlander M

更新日期：2020-12-15 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is a morbid cancer with poor outcomes. Statins possess anticancer properties such as immunomodulatory and anti-inflammatory effects. The objective of our study is to identify the association between statin use among untreated HNSCC patients and overall death, disease-speci...

journal_title：International journal of cancer

authors： Getz KR,Bellile E,Zarins KR,Rullman C,Chinn SB,Taylor JMG,Rozek LS,Wolf GT,Mondul AM

更新日期：2020-12-15 00:00:00

abstract：:Metabolic syndrome (MetS) and its components may link to pancreatic cancer risk; however, current epidemiological evidence is limited, and the potential mechanisms underlying the associations remain unclear. To investigate this, we carried out this prospective cohort study of 474 929 participants without a diagnosis o...

journal_title：International journal of cancer

authors： Xia B,He Q,Pan Y,Gao F,Liu A,Tang Y,Chong C,Teoh AYB,Li F,He Y,Zhang C,Yuan J

更新日期：2020-12-15 00:00:00

abstract：:The underlying molecular mechanisms involved in the pathogenesis of endometrial cancer (EC) are still not well understood. Our goal was to investigate the composition of the endometrial microbiota and the association with inflammatory cytokines in EC. Endometrial microbiota profiles of women with EC (n = 25) and benig...

journal_title：International journal of cancer

authors： Lu W,He F,Lin Z,Liu S,Tang L,Huang Y,Hu Z

更新日期：2020-12-07 00:00:00

abstract：:The cystine/glutamate antiporter, system xc- , is essential for the efficient uptake of cystine into cells. Interest in the mechanisms of system xc- function soared with the recognition that system xc- presents the most upstream node of ferroptosis, a recently described form of regulated necrosis relevant for degenera...

journal_title：International journal of cancer

authors： Sato M,Onuma K,Domon M,Hasegawa S,Suzuki A,Kusumi R,Hino R,Kakihara N,Kanda Y,Osaki M,Hamada J,Bannai S,Feederle R,Buday K,Angeli JPF,Proneth B,Conrad M,Okada F,Sato H

更新日期：2020-12-01 00:00:00

abstract：:In the Japanese atomic bomb survivors, risk of lung cancer has been shown to increase with greater acute exposure to ionizing radiation. Although similar findings have been observed in populations exposed to low-dose, protracted radiation, such studies lack information on cigarette smoking history, a potential confoun...

journal_title：International journal of cancer

authors： Velazquez-Kronen R,Gilbert ES,Linet MS,Moysich KB,Freudenheim JL,Wactawski-Wende J,Simon SL,Cahoon EK,Alexander BH,Doody MM,Kitahara CM

更新日期：2020-12-01 00:00:00

abstract：:The aim of our study was to develop and validate a machine learning algorithm to predict response of individual HER2-amplified colorectal cancer liver metastases (lmCRC) undergoing dual HER2-targeted therapy. Twenty-four radiomics features were extracted after 3D manual segmentation of 141 lmCRC on pretreatment portal...

journal_title：International journal of cancer

authors： Giannini V,Rosati S,Defeudis A,Balestra G,Vassallo L,Cappello G,Mazzetti S,De Mattia C,Rizzetto F,Torresin A,Sartore-Bianchi A,Siena S,Vanzulli A,Leone F,Zagonel V,Marsoni S,Regge D

更新日期：2020-12-01 00:00:00

abstract：:Ovarian cancer is one of the most common gynecological malignancies. The tumor microenvironment plays an important role in regulating the progression of ovarian cancer. Macrophages, which are important immune cells in the tumor microenvironment, participate in the regulation of various biological behaviors and influen...

journal_title：International journal of cancer

authors： An Y,Yang Q

更新日期：2020-11-24 00:00:00

abstract：:We examined the geospatial dimension of delays to diagnosis of breast cancer in a prospective study of 1541 women newly diagnosed in the African Breast Cancer - Disparities in Outcomes (ABC-DO) Study. Women were recruited at cancer treatment facilities in Namibia, Nigeria, Uganda, and Zambia. The baseline interview in...

journal_title：International journal of cancer

authors： Togawa K,Anderson BO,Foerster M,Galukande M,Zietsman A,Pontac J,Anele A,Adisa C,Parham G,Pinder LF,McKenzie F,Schüz J,Dos-Santos-Silva I,McCormack V

更新日期：2020-11-16 00:00:00

abstract：:HPV35 has been found in only ∼2% of invasive cervical cancers (ICC) worldwide but up to 10% in Sub-Saharan Africa, warranting further investigation and consideration of impact on preventive strategies. We studied HPV35 and ethnicity, in relation to the known steps in cervical carcinogenesis, using multiple large epide...

journal_title：International journal of cancer

authors： Pinheiro M,Gage JC,Clifford GM,Demarco M,Cheung LC,Chen Z,Yeager M,Cullen M,Boland JF,Chen X,Raine-Bennett T,Steinberg M,Bass S,Befano B,Xiao Y,Tenet V,Walker J,Zuna R,Poitras NE,Gold MA,Dunn T,Yu K,Zhu B,Bu

更新日期：2020-11-15 00:00:00

abstract：:Therapeutics targeting the phosphatidylinositol 3-kinase/mammalian target of rapamycin (PI3K/mTOR) pathway initially produce potent antitumor effects, but resistance frequently occurs. Using a phosphoproteome analysis, we found that colorectal cancer (CRC) cells exhibit resistance against PI3K/mTOR inhibition through ...

journal_title：International journal of cancer

authors： Lee HS,Lee S,Cho KH

更新日期：2020-11-15 00:00:00

abstract：:With the improvement of treatments, a growing number of survivors with childhood or adolescent central nervous system (CNS) tumor are parenting their own children. We aimed to explore the risk of somatic diseases among children of these survivors compared to population controls. Children of survivors with CNS tumor be...

journal_title：International journal of cancer

authors： Huang W,Sundquist K,Sundquist J,Ji J

更新日期：2020-11-13 00:00:00

abstract：:EGFR is an oncogene with a high frequency of activating mutations in nonsmall cell lung cancer (NSCLC). EGFR inhibitors have been FDA-approved for NSCLC and have shown efficacy in patients with certain EGFR mutations. However, only 9% to 26% of these patients achieve objective responses. In our study, we developed an ...

journal_title：International journal of cancer

authors： Cheng C,Zhao Y,Schaafsma E,Weng YL,Amos C

更新日期：2020-11-01 00:00:00

abstract：:Smoking and second-hand smoke (SHS) exposure have been recently linked to a higher risk of breast cancer in women. The aim of this work is to estimate the number of deaths and disability-adjusted life years (DALYs) from breast cancer attributable to these two risk factors in the European Union (EU-28) in 2017. The com...

journal_title：International journal of cancer

authors： Carreras G,Lachi A,Boffi R,Clancy L,Gallus S,Fernández E,López MJ,Soriano JB,López Nicolás Á,Semple S,Behrakis P,Gorini G,TackSHS Project Investigators.

更新日期：2020-11-01 00:00:00

abstract：:To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Can...

journal_title：International journal of cancer

authors： Saberi Hosnijeh F,Casabonne D,Nieters A,Solans M,Naudin S,Ferrari P,Mckay JD,Benavente Y,Weiderpass E,Freisling H,Severi G,Boutron Ruault MC,Besson C,Agnoli C,Masala G,Sacerdote C,Tumino R,Huerta JM,Amiano P,Rodrigu

更新日期：2020-10-31 00:00:00

abstract：:There is limited research on the effect of dietary quality on hepatocellular carcinoma (HCC) risk in populations with relatively high risk of HCC. Using data from Singapore Chinese Health Study, a prospective cohort study, of 63 257 Chinese aged 45 to 74, we assessed four diet-quality index (DQI) scores: the Alternati...

journal_title：International journal of cancer

authors： Luu HN,Neelakantan N,Geng TT,Wang R,Goh GB,Clemente JC,Jin A,van Dam RM,Jia W,Behari J,Koh WP,Yuan JM

更新日期：2020-10-31 00:00:00