Radiomics predicts response of individual HER2-amplified colorectal cancer liver metastases in patients treated with HER2-targeted therapy.


:The aim of our study was to develop and validate a machine learning algorithm to predict response of individual HER2-amplified colorectal cancer liver metastases (lmCRC) undergoing dual HER2-targeted therapy. Twenty-four radiomics features were extracted after 3D manual segmentation of 141 lmCRC on pretreatment portal CT scans of a cohort including 38 HER2-amplified patients; feature selection was then performed using genetic algorithms. lmCRC were classified as nonresponders (R-), if their largest diameter increased more than 10% at a CT scan performed after 3 months of treatment, responders (R+) otherwise. Sensitivity, specificity, negative (NPV) and positive (PPV) predictive values in correctly classifying individual lesion and overall patient response were assessed on a training dataset and then validated on a second dataset using a Gaussian naïve Bayesian classifier. Per-lesion sensitivity, specificity, NPV and PPV were 89%, 85%, 93%, 78% and 90%, 42%, 73%, 71% respectively in the testing and validation datasets. Per-patient sensitivity and specificity were 92% and 86%. Heterogeneous response was observed in 9 of 38 patients (24%). Five of nine patients were carriers of nonresponder lesions correctly classified as such by our radiomics signature, including four of seven harboring only one nonresponder lesion. The developed method has been proven effective in predicting behavior of individual metastases to targeted treatment in a cohort of HER2 amplified patients. The model accurately detects responder lesions and identifies nonresponder lesions in patients with heterogeneous response, potentially paving the way to multimodal treatment in selected patients. Further validation will be needed to confirm our findings.


Int J Cancer


Giannini V,Rosati S,Defeudis A,Balestra G,Vassallo L,Cappello G,Mazzetti S,De Mattia C,Rizzetto F,Torresin A,Sartore-Bianchi A,Siena S,Vanzulli A,Leone F,Zagonel V,Marsoni S,Regge D




Has Abstract


2020-12-01 00:00:00












  • Dynamic analysis of circulating tumor DNA to predict prognosis and monitor therapeutic response in metastatic relapsed cervical cancer.

    abstract::Limited and inefficient treatment options exist for metastatic relapsed cervical cancer (MRCC), and there are currently no reliable indicators to guide therapeutic selection. We performed deep sequencing analyses targeting 322 cancer-related genes in plasma cell-free DNA and matched white blood cells in 173 serial blo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tian X,Ge D,Zhang F,Zhang B,Bai W,Xu X,Li Z,Cao Y,Li P,Zou K,Zou L

    更新日期:2021-02-15 00:00:00

  • Spontaneous in vitro malignant transformation in a xeroderma pigmentosum fibroblast line.

    abstract::This paper deals with a spontaneous malignant transformation in one of our XP fibroblast lines. This cell line, designated XP29MA, was derived from a 14-year-old boy who did not show skin tumors or precancerous alterations either at the time of clinical examination or when the biopsy was taken. We have compared the fo...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Thielmann HW,Fischer E,Dzarlieva RT,Komitowski D,Popanda O,Edler L

    更新日期:1983-06-15 00:00:00

  • Quantitative changes in cytoskeletal and nuclear actins during cellular transformation.

    abstract::Actin, a highly conserved protein comprising cell stress fibers and other cellular structures, is found in both the cytoplasm and nucleus of cells and responds to both epigenetic signals and altered gene expression occurring during tumorigenesis. We have previously shown that changes in the cytoplasmic F- and G-actin ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rao JY,Bonner RB,Hurst RE,Liang YY,Reznikoff CA,Hemstreet GP 3rd

    更新日期:1997-02-07 00:00:00

  • Increased plasma MMP9 in integrin alpha1-null mice enhances lung metastasis of colon carcinoma cells.

    abstract::Inhibitors of matrix metalloproteinases (MMPs) were developed as anticancer agents based on the observation that MMPs facilitate local tumor spread and metastasis by promoting matrix degradation and cell migration. Unfortunately, these inhibitors were unsuccessful in the clinical treatment of several cancers, includin...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Chen X,Su Y,Fingleton B,Acuff H,Matrisian LM,Zent R,Pozzi A

    更新日期:2005-08-10 00:00:00

  • Variations in serum alkaline DNase activity in rats during growth and treatment of tumors sensitive or resistant to therapy.

    abstract::Serum alkaline DNase activity (SADA) was investigated in rats receiving s.c. transplants of tumor cells sensitive or resistant to chemotherapy. Serum samples from each animal were collected before transplantation, during the development of tumors and after therapy. Within a few days after transplantation of both tumor...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Economidou-Karaoglou A,Brasseur F,Lans M,Taper HS,Roberfroid MB

    更新日期:1989-05-15 00:00:00

  • Human peri-tumoral and lung fibroblasts produce paracrine motility factors for recently established human sarcoma cell strains.

    abstract::Paracrine motogenic cytokines secreted by normal cells can stimulate metastatic cell invasion. For example, human fibroblasts secrete hepatocyte growth factor/scatter factor (HGF/SF), which stimulates paracrine migration of epithelial and certain carcinoma cells, and migration-stimulating factor (MSF), which stimulate...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hu M,Pollock RE,Nakamura T,Nicolson GL

    更新日期:1995-09-04 00:00:00

  • Cervical carcinoma: detection of herpes simplex virus RNA in cells undergoing neoplastic change.

    abstract::3H-HSV-2 DNA has been hybridized in situ to frozen sectioned tissue from human cervical biopsies. RNA complementary to the virus-specific probe was detected in cells undergoing pre-malignant changes, but not in the cells of the fully developed squamous-cell cancer. ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: McDougall JK,Galloway DA,Fenoglio CM

    更新日期:1980-01-15 00:00:00

  • Binding of some metastatic tumor cell lines to fibrous elastin and elastin peptides.

    abstract::Recent suggestions that tumor-cell targeting of elastin-rich tissues (e.g., lung) correlates with the presence of surface elastin receptors have been investigated. Receptors for insoluble (fibrous) elastin and for soluble elastin peptides have been implemented in these correlations. A rapid assay for binding of insolu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Svitkina TM,Parsons DF

    更新日期:1993-03-12 00:00:00

  • Farnesyl thiosalicylic acid inhibits the growth of melanoma cells through a combination of cytostatic and pro-apoptotic effects.

    abstract::Novel classes of drug that interfere with the signalling of the small G-protein Ras, the so-called Ras antagonists, are showing much promise as novel anti-cancer agents. In this study, we demonstrate that the novel Ras antagonist farnesylthiosalicylic acid (FTS) inhibits the growth of Colo 853 melanoma cells through a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Smalley KS,Eisen TG

    更新日期:2002-04-01 00:00:00

  • Azacytidine impairs NK cell reactivity while decitabine augments NK cell responsiveness toward stimulation.

    abstract::Azacytidine and decitabine are approved for treatment of acute myeloid leukemias and myelodysplastic syndromes. While clinical responses are attributed to epigenetic effects and induction of apoptosis in malignant cells, these azanucleosides also affect antitumor immune responses. NK cells as components of innate immu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Schmiedel BJ,Arélin V,Gruenebach F,Krusch M,Schmidt SM,Salih HR

    更新日期:2011-06-15 00:00:00

  • Isotype-specific inhibitors of the glycolytic key regulator pyruvate kinase subtype M2 moderately decelerate tumor cell proliferation.

    abstract::Tumor cells express the glycolytic regulator pyruvate kinase subtype M2 (M2-PK), which can occur in a tetrameric form with high affinity to its substrate phosphoenolpyruvate (PEP) and a dimeric form with a low PEP affinity. The transition between both conformations contributes to the control of glycolysis and is impor...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Spoden GA,Mazurek S,Morandell D,Bacher N,Ausserlechner MJ,Jansen-Dürr P,Eigenbrodt E,Zwerschke W

    更新日期:2008-07-15 00:00:00

  • Expression of CYP1A1, CYP1B1 and CYP3A, and polycyclic aromatic hydrocarbon-DNA adduct formation in bronchoalveolar macrophages of smokers and non-smokers.

    abstract::Variability in the expression of enzymes metabolizing carcinogens derived from cigarette smoke may contribute to individual susceptibility to pulmonary carcinogenesis. This study was designed to determine the effects of smoking and 3 major cytochrome P450 (CYP) enzymes, i.e., CYP1A1, CYP1B1 and CYP3A, which metabolize...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Piipari R,Savela K,Nurminen T,Hukkanen J,Raunio H,Hakkola J,Mäntylä T,Beaune P,Edwards RJ,Boobis AR,Anttila S

    更新日期:2000-06-01 00:00:00

  • Induction of 2.5 OAS gene expression and activity is not sufficient for IFN-gamma-induced neuroblastoma cell differentiation.

    abstract::We showed earlier that interferon-gamma is a powerful inducer of differentiation of human neuroblastoma (NB) cells. Although 2',5' oligo-adenylate synthetase (2,5 OAS) may play a role in mediating the anti-proliferative and/or differentiative effects of interferons (IFNs), direct evidence is lacking. We have investiga...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Corrias MV,Gribaudo G,Guarnaccia F,Ponzoni M

    更新日期:1995-07-17 00:00:00

  • Detection of tumors with fluoromarker-releasing bacteria.

    abstract::Combining the specificity of tumor-targeting bacteria with the sensitivity of biomarker detection would create a screening method able to detect small tumors and metastases. To create this system, we genetically modified an attenuated strain of Salmonella enterica to release a recombinant fluorescent biomarker (or flu...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Panteli JT,Van Dessel N,Forbes NS

    更新日期:2020-01-01 00:00:00

  • Detection of Merkel cell polyomavirus (MCPyV) in Merkel cell carcinoma cell lines: cell morphology and growth phenotype do not reflect presence of the virus.

    abstract::The recently discovered human polyomavirus (MCPyV) is frequently found in Merkel cell carcinoma (MCC) tissue and is believed to be causally linked to MCC pathogenesis. While cell lines established from MCC represent a valuable tool to study the contribution of MCPyV to MCC pathogenesis, hitherto only 1 MCPyV-positive ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fischer N,Brandner J,Fuchs F,Moll I,Grundhoff A

    更新日期:2010-05-01 00:00:00

  • TGF-beta inactivation and TGF-alpha overexpression cooperate in an in vivo mouse model to induce hepatocellular carcinoma that recapitulates molecular features of human liver cancer.

    abstract::Hepatocellular carcinoma (HCC) results from the cumulative effects of deregulated tumor suppressor genes and oncogenes. The tumor suppressor and oncogenes commonly affected include growth factors, receptors and their downstream signaling pathway components. The overexpression of transforming growth factor alpha (TGF-a...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Baek JY,Morris SM,Campbell J,Fausto N,Yeh MM,Grady WM

    更新日期:2010-09-01 00:00:00

  • A functional and quantitative mutational analysis of p53 mutations in yeast indicates strand biases and different roles of mutations in DMBA- and BBN-induced tumors in rats.

    abstract::In order to analyze the mutational events and to understand the biological significance of the p53 gene in chemical carcinogenesis, we applied a new yeast-based p53 functional assay to ovarian tumors induced by 7, 12-dimethylbenz[a]anthracene (DMBA), as well as to transitional cell carcinomas of the urinary bladder in...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yamamoto K,Nakata D,Tada M,Tonoki H,Nishida T,Hirai A,Ba Y,Aoyama T,Hamada J,Furuuchi K,Harada H,Hirai K,Shibahara N,Katsuoka Y,Moriuchi T

    更新日期:1999-11-26 00:00:00

  • Cytotoxicity against the K562 erythroleukemia cell line by human natural killer (NK) cells which do not bear free Fc receptors for IgG.

    abstract::When Fc receptors (FcR) on normal human peripheral blood lymphocytes were induced to modulate by overnight (18 h) incubation in the presence of soluble or particulate immune complexes, the natural killer (NK) activity of the effector lymphocyte suspension, as measured against the K562 erythroleukemia cell line, was si...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kay HD,Fagnani R,Bonnard GD

    更新日期:1979-08-01 00:00:00

  • p16(INK4a) promoter methylation and protein expression in breast fibroadenoma and carcinoma.

    abstract::The potential role of p16(INK4a) methylation in breast cancer is controversial whereas there are no data on fibroadenoma. To assess if inactivation of p16(INK4a) by promoter hypermethylation occurs in this hyperproliferative benign breast lesion or, on the contrary, it is strictly related to the carcinogenic process, ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Di Vinci A,Perdelli L,Banelli B,Salvi S,Casciano I,Gelvi I,Allemanni G,Margallo E,Gatteschi B,Romani M

    更新日期:2005-04-10 00:00:00

  • Down-regulation of protein and mRNA expression for transforming growth factor-beta (TGF-beta1) type I and type II receptors in human prostate cancer.

    abstract::Transforming growth factor-beta (TGF-beta1) is a potent negative regulator of cell growth that transduces signals through interactions with type I and II receptors. Abnormal expression and mutational alterations of these receptors have been observed in several human malignancies. In this study, we investigated the exp...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Guo Y,Jacobs SC,Kyprianou N

    更新日期:1997-05-16 00:00:00

  • Gene silencing of the BDNF/TrkB axis in multiple myeloma blocks bone destruction and tumor burden in vitro and in vivo.

    abstract::Osteolytic bone diseases are a prominent feature of multiple myeloma (MM), resulting from aberrant osteoclastic bone resorption that is uncoupled from osteoblastic bone formation. Myeloma stimulates osteoclastogenesis, which is largely dependent on an increase in receptor activator of NF-κB ligand (RANKL) and a decrea...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ai LS,Sun CY,Wang YD,Zhang L,Chu ZB,Qin Y,Gao F,Yan H,Guo T,Chen L,Yang D,Hu Y

    更新日期:2013-09-01 00:00:00

  • Fruit consumption and the risk of bladder cancer: A pooled analysis by the Bladder Cancer Epidemiology and Nutritional Determinants Study.

    abstract::While the association between fruit consumption and bladder cancer risk has been extensively reported, studies have had inadequate statistical power to investigate associations between types of fruit and bladder cancer risk satisfactorily. Fruit consumption in relation to bladder cancer risk was investigated by poolin...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jochems SHJ,Reulen RC,van Osch FHM,Witlox WJA,Goossens ME,Brinkman M,Giles GG,Milne RL,van den Brandt PA,White E,Weiderpass E,Huybrechts I,Hémon B,Agudo A,Bueno-de-Mesquita B,Cheng KK,van Schooten FJ,Bryan RT,Wesseliu

    更新日期:2020-10-15 00:00:00

  • HIPEC ROC I: a phase I study of cisplatin administered as hyperthermic intraoperative intraperitoneal chemoperfusion followed by postoperative intravenous platinum-based chemotherapy in patients with platinum-sensitive recurrent epithelial ovarian cancer.

    abstract::This phase I study tested the safety, feasibility, pharmacokinetics and pharmacodynamics of cisplatin administered as hyperthermic intraoperative intraperitoneal chemoperfusion (HIPEC) in patients with platinum-sensitive recurrent epithelial ovarian cancer (EOC) undergoing secondary cytoreductive surgery followed by p...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zivanovic O,Abramian A,Kullmann M,Fuhrmann C,Coch C,Hoeller T,Ruehs H,Keyver-Paik MD,Rudlowski C,Weber S,Kiefer N,Poelcher ML,Thiesler T,Rostamzadeh B,Mallmann M,Schaefer N,Permantier M,Latten S,Kalff J,Thomale J,

    更新日期:2015-02-01 00:00:00

  • Lung cancer risk prediction: a tool for early detection.

    abstract::Although 45% of men and 39% of women will be diagnosed with cancer in their lifetime, it is difficult to predict which individuals will be affected. For some cancers, substantial progress in individual risk estimation has already been made. However, relatively few models have been developed to predict lung cancer risk...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Cassidy A,Duffy SW,Myles JP,Liloglou T,Field JK

    更新日期:2007-01-01 00:00:00

  • International trends in prostatic cancer.

    abstract::The most recent data available demonstrate a 120-fold difference between the lowest and highest incidence rates of prostatic cancer, the disease being very common in North America, particularly among Blacks, and in Scandinavia, while it is rare in Japan and other oriental countries. The highest mortality for prostatic...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zaridze DG,Boyle P,Smans M

    更新日期:1984-02-15 00:00:00

  • MGMT CpG island is invariably methylated in adult astrocytic and oligodendroglial tumors with IDH1 or IDH2 mutations.

    abstract::We have previously identified a region containing 16 CpGs within the MGMT CpG islands which is critical for the transcriptional control of MGMT (Malley, Acta Neuropathol 2011). To investigate the patterns and incidence of MGMT methylation in astrocytic and oligodendroglial tumors, we quantitatively assessed methylatio...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mulholland S,Pearson DM,Hamoudi RA,Malley DS,Smith CM,Weaver JM,Jones DT,Kocialkowski S,Bäcklund LM,Collins VP,Ichimura K

    更新日期:2012-09-01 00:00:00

  • Detergent extraction and characterization of tumor hemolytic factor from plasma membranes of oncogene transformed fibroblasts.

    abstract::Cancer cells have the capacity to lyse erythrocytes by a cell-contact-requiring phenomenon. Subcellular fractionation procedures have revealed that the hemolytic principle resides in the cancer cell plasma membrane. In this study we report the detergent extraction of a potent hemolytic factor from the plasma membranes...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zucker S,DiMassimo BI,Lysik RM,Vuaridel-Bonanomi E

    更新日期:1991-01-21 00:00:00

  • Two distinct regions of deletion on chromosome 13q in primary nasopharyngeal carcinoma.

    abstract::Nasopharyngeal carcinoma (NPC) is rare in most parts of the world, but prevalent in Southern China. Although this disease poses a serious health problem in our population, the genetic alterations that lead to the development of NPC have yet to be defined. In a comparative genomic hybridization (CGH) study on NPC by ou...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tsang YS,Lo KW,Leung SF,Choi PH,Fong Y,Lee JC,Huang DP

    更新日期:1999-10-29 00:00:00

  • Histo-blotting: hybridization in situ detection of specific RNAs on tissue sections transferred on nitrocellulose.

    abstract::A simple and rapid variant of in situ hybridization on tissue sections (histo-blotting) usable for detection of specific RNA distribution among tissues is proposed. Tissue sections prepared with a cryostatic microtome are placed on nitrocellulose and these "histo-blots" are hybridized with labelled DNA or RNA probes u...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gudkov AV,Kashkin KN,Zaitsevskaya TE,Troyanovsky SM

    更新日期:1989-12-15 00:00:00

  • Biological effects induced by insulin-like growth factor binding protein 3 (IGFBP-3) in malignant melanoma.

    abstract::The insulin like growth factor (IGF) signaling pathway has been shown to contribute to melanoma progression, but little is known about the role of the IGF binding protein 3 (IGFBP-3) in melanoma biology. The aim of the present study was to characterize expression, function and regulation of IGFBP-3 in malignant melano...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Oy GF,Slipicevic A,Davidson B,Solberg Faye R,Maelandsmo GM,Flørenes VA

    更新日期:2010-01-15 00:00:00