Abstract：
:In this prospective study, the relationship between energy and fat consumption and the risk of breast cancer was examined. Between 1977 and 1983, 31,209 Norwegian women, 20 to 54 years of age attended a health screening. The attendees were given a food-frequency questionnaire to be completed at home, and this was returned by 25,892 (83%). During the 7 to 13 years of follow-up, 248 cases of breast cancer were identified for analysis by linkage to the Norwegian Cancer Registry. The relative risk of women who ate meat more than 5 times a week, as compared with those who consumed meat twice or less than twice a week, was 2.44. Consumers of 0.75 litres or more of full-fat milk daily had a relative risk of 2.91 compared with those who consumed 0.15 litres or less. A positive relationship was found between those reporting the highest quartile of mono-unsaturated fat consumption and the risk of breast cancer. The main foods contributing to the mono-unsaturated fat index were edible fats, meat and milk.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Gaard M,Tretli S,Løken EBdoi
10.1002/ijc.2910630104subject
Has Abstractpub_date
1995-09-27 00:00:00pages
13-7issue
1eissn
0020-7136issn
1097-0215journal_volume
63pub_type
杂志文章abstract：:The human bowel contains a large and dynamic bacterial population that is not only essential for intestinal health, but also critical for the development of diseases such as cancer. In this respect, the Gram-positive bacterium Streptococcus bovis has been associated with colon cancer for many years. To investigate the...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22116
更新日期：2006-11-01 00:00:00
abstract：:Cell lines established from T-cell leukemias have recently been reported to exhibit a chromosome translocation t(8;14) involving proto-oncogene c-myc and the gene of the T-cell receptor alpha-chain(TcR-alpha). In this work, we have studied a case of T-cell leukemia presenting a t(8;14)(q24;q11) translocation that was ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910380609
更新日期：1986-12-15 00:00:00
abstract：:The human surface antigen CD24 is over-expressed in small-cell lung cancer. Here we describe the isolation, sequencing and functional characterization of the 5'-flanking region of the human CD24 gene. A sequence (accession number: Y14692) of 3.4 kb regulates the activity of a luciferase reporter gene in CD24-expressin...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19981109)78:4<496::aid-ijc
更新日期：1998-11-09 00:00:00
abstract：:In 1927 Otto Warburg established that tumours derive energy primarily from the conversion of glucose to lactic acid and only partially through cellular respiration involving oxygen. In the 1950s he proposed that all causes of cancer reflected different mechanisms of disabling cellular respiration in favour of fermenta...
journal_title：International journal of cancer
pub_type： 杂志文章,评审
doi：10.1002/ijc.29012
更新日期：2015-10-01 00:00:00
abstract：:The EBV-encoded membrane protein (LMP) and the nuclear antigen EBNA-1 were compared for their capacity to induce rejection of transfected murine mammary carcinoma cells in syngeneic hosts. The tumorigenic potential of stable LMP and EBNA-1 expressing sublines of the ACA (H-2f)-derived mammary carcinoma line S6C was te...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910480527
更新日期：1991-07-09 00:00:00
abstract：:LAF-4, which encodes a nuclear protein with transactivation potential, is fused to the MLL gene in acute lymphoblastic leukemia (ALL). We identified LAF-4 as a gene that is transcriptionally deregulated in breast tumors and thus may have a pathological role in mammary tumorigenesis. In line with the previous finding t...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.20881
更新日期：2005-07-01 00:00:00
abstract：:Marfe, G., Pucci, B., De Martino, L., Fiorito, F., Di Stefano, C., Indelicato, M., Aventaggiato, M., Russo, M. A. and Tafani, M. (2009), Heat-shock pretreatment inhibits sorbitol-induced apoptosis in K562, U937 and HeLa cells. Int. J. Cancer, 125: 2077-2085. doi: 10.1002/ijc.24572 The above article, published online o...
journal_title：International journal of cancer
pub_type： 撤回出版物
doi：10.1002/ijc.32281
更新日期：2019-08-15 00:00:00
abstract：:Previous studies indicate that the nonclassical class I HLA-G antigen, whose physiologic expression is mainly restricted to placenta, is upregulated in melanoma, renal carcinoma, lung carcinoma, glioblastoma and ovarian carcinoma, where its inhibitory effect on cytotoxic effector cells function is thought to participa...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.11456
更新日期：2004-01-10 00:00:00
abstract：:Small-cell-lung-cancer (SCLC) is characterized by rapid development of resistance to cytotoxic agents, such as cisplatin (cDDP) and anthracyclines. c-myc over-expression is one of the reported genetic alterations in this tumor. Amplification of the c-myc gene in this and other cancers is often correlated with poor pro...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19971114)73:4<544::aid-ijc
更新日期：1997-11-14 00:00:00
abstract：:The myxobacterial agent archazolid inhibits the vacuolar proton pump V-ATPase. V-ATPases are ubiquitously expressed ATP-dependent proton pumps, which are known to regulate the pH in endomembrane systems and thus play a crucial role in endo- and exocytotic processes of the cell. As cancer cells depend on a highly activ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.28562
更新日期：2014-05-15 00:00:00
abstract：:Colon cancer tissues display an increased activity of beta-galactoside alpha2,6 sialyltransferase (ST6Gal.I) and an increased reactivity with the lectin from Sambucus nigra (SNA), specific for alpha2,6-sialyl-linkages. Experimental and clinical studies indicate a contribution of these alterations to tumor progression,...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/1097-0215(20001001)88:1<58::aid-ijc9>3.0.c
更新日期：2000-10-01 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with a very high mortality. Because the success of the conventional therapies is limited, gene therapy may represent an alternative for HCC management. Our earlier study has shown that Bid plays a role in the development of HCC. The aim of...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22040
更新日期：2006-10-15 00:00:00
abstract：:Increased exposure to estrogen is a risk factor for postmenopausal breast cancer, and dietary factors can influence estrogen metabolism. However, studies of diet and breast cancer have been inconclusive. We developed a dietary pattern associated with levels of unconjugated estradiol and the ratio of 2- and 16-hydroxyl...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.31387
更新日期：2018-08-01 00:00:00
abstract：:Controlling adverse events (AEs) through dose reduction can enhance drug adherence and treatment response. Currently, there is no guide for sorafenib dosing. The aim of this study was to evaluate whether sorafenib dosing could affect treatment outcomes. A total of 782 hepatocellular carcinoma (HCC) patients treated wi...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.32964
更新日期：2020-10-01 00:00:00
abstract：:A carcinogen-induced premalignant oral lesion model that progresses to oral cancer was used to examine the impact of blocking PD-1 on cytokine expression and on progression of lesions to cancer. The results of this study show increased production of IL-2 and the inflammatory cytokines IL-6, IL-17 and TNF-α by spleen c...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.30543
更新日期：2017-04-01 00:00:00
abstract：:Telomerase activity is considered to be a diagnostic marker of malignancy since most malignant cells express this activity and most somatic cells do not. However, the detection of telomerase activity is rather complicated and is affected by many factors. Recently, human telomerase components were cloned and found to c...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19990105)80:1<1::aid-ijc1>
更新日期：1999-01-05 00:00:00
abstract：:Loss of heterozygosity (LOH) at the site of the retinoblastoma (RB1) gene, at 13q14, has been shown to occur in a high proportion of ovarian cancer patients. Based on this, RB1 gene inactivation was studied in primary tumor cells from 15 patients with ovarian cancer. Structural changes as well as expression of the RB1...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910580508
更新日期：1994-09-01 00:00:00
abstract：:Activity of Janus kinase 2 (JAK2) in the JAK2/STAT5 signaling pathway is critically controlled by suppressor of cytokine signaling-1 (SOCS-1). We have previously shown that SOCS-1 is biallelically mutated in the primary mediastinal B-cell lymphoma (PMBL) cell line MedB-1, resulting in impaired JAK2 degradation and sus...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.21485
更新日期：2006-04-15 00:00:00
abstract：:We have used differential-display PCR (DD-PCR) to compare renal-cell carcinoma (RCC) and normal kidney gene expression with the aim of identifying genes specifically associated with RCC. Using a modified DD-PCR approach, which was non-radioactive, quicker and simpler than the conventional method, 24 cDNA samples were ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/1097-0215(20001201)88:5<726::aid-ijc7>3.0.
更新日期：2000-12-01 00:00:00
abstract：:Cancer blood vessels consist of two interacting types of cells: inner lining endothelial cells (ECs) and surrounding perivascular cells (pericytes, vascular smooth muscle cells or mural cells). PDGFRbeta(CD140b)+ progenitor perivascular cells (PPC) can differentiate into pericytes and regulate vessel stability and vas...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.25816
更新日期：2011-09-15 00:00:00
abstract：:Interleukin-11(rhIL-11) is a cytokine that has been shown to enhance the recovery of bone marrow and intestinal crypt cells after cytotoxic insult with radiation or anticancer drugs. The current study examined the effects of rhIL-11 on the response of CEM human lymphoblastic leukemia cells and on the EMT-6 murine mamm...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(SICI)1097-0215(19960917)67:6<864::AID-IJC
更新日期：1996-09-17 00:00:00
abstract：:One hundred patients with Ph1-chromosome-positive chronic myelogenous leukemia (CML) with t(9;22) are included in the present investigation. The position of the Ph1 chromosome in relation to the normal as well as the abnormal chromosomes 9 was localized at metaphase in 1,000 bone-marrow cells. Our study suggests that ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910410609
更新日期：1988-06-15 00:00:00
abstract：:Specific types of human papillomaviruses (HPV) are associated with most cases of pre-invasive and invasive neoplasia of the uterine cervix. HLA phenotype influences susceptibility and resistance to viral infections and may therefore influence the course of HPV-associated tumors. Some data suggest that specific HLA cla...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(SICI)1097-0215(19960621)69:3<159::AID-IJC
更新日期：1996-06-21 00:00:00
abstract：:Expression levels of hTERT mRNA were investigated by RT-PCR in tissue specimens of patients with (Group A) and without (Group B) clinically overt bronchial carcinoma, respectively. Bronchial carcinoma (n = 9) and distant normal (n = 9) specimens were analyzed in Group A. The chance of carcinoma seemed to increase with...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.11732
更新日期：2004-04-10 00:00:00
abstract：:Cultured tumor cell lines, tumor xenografts grown in athymic nude mice, and a murine experimental metastasis model were used to assess the in vitro and in vivo anti-tumor activity of the potent IMP dehydrogenase (IMPDH) inhibitor, mycophenolic acid (MPA), and its morpholinoethyl ester pro-drug, mycophenolate mofetil (...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910570421
更新日期：1994-05-15 00:00:00
abstract：:Since the investigation, at an individual level, of lifetime sun exposure remains difficult the site distribution of different types of skin cancer can be an important source of aetiological clues. The present report deals with 1,149 cases of cutaneous malignant melanoma (CMM), 7,685 of basal-cell carcinoma (BCC) and ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(SICI)1097-0215(19960703)67:1<24::AID-IJC6
更新日期：1996-07-03 00:00:00
abstract：:Duodenogastric reflux (DGR) causes glandular stomach carcinogenesis in rats without carcinogens. We aimed to investigate how this carcinogenesis might be prevented by a selective COX-2 inhibitor, meloxicam. A series of 188 Fisher 344 rats underwent a surgical DGR procedure and were divided into 2 groups. One group was...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.23742
更新日期：2008-10-01 00:00:00
abstract：:We have previously produced a monoclonal antibody (MAb) against TMK-1 cells, a poorly differentiated stomach-cancer cell line, and designated the antigen as 9A3. Immunohistochemical analysis of various tumor tissues revealed that the expression of 9A3 antigen is specific for human adenocarcinoma. In the present study,...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910480115
更新日期：1991-04-22 00:00:00
abstract：:High BMI is a well-known risk factor for postmenopausal breast cancer. There have been some reports of excess risk in association with weight gain and WHR, but little is known about the influence of body fatness per se. Using data from the Malmö Diet and Cancer Study, a prospective cohort study, 12,159 postmenopausal ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.10799
更新日期：2003-01-10 00:00:00
abstract：:A Kunitz-type protease inhibitor, bikunin, downregulates expression of uPA and its receptor uPAR at the mRNA and protein levels in several types of tumor cells. Our recent work showed that, using a cDNA microarray analysis, pregnancy-associated plasma protein-A (PAPP-A) is a candidate bikunin target gene. To clarify h...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.11700
更新日期：2004-04-10 00:00:00
