Transient immunological and clinical effectiveness of treating mice bearing premalignant oral lesions with PD-1 antibodies.

abstract：:Some studies suggest a favorable role of antioxidants on breast cancer risk but this is still inconclusive. The aim of this study was to assess whether overall dietary antioxidant capacity, as assessed by dietary ferric reducing antioxidant potential (FRAP), and individual dietary antioxidant intake were associated wi...

journal_title：International journal of cancer

authors： Pantavos A,Ruiter R,Feskens EF,de Keyser CE,Hofman A,Stricker BH,Franco OH,Kiefte-de Jong JC

更新日期：2015-05-01 00:00:00

abstract：:Markers of exposure to polycyclic aromatic hydrocarbons (urinary 1-hydroxypyrene-glucuronide) and aromatic amines (4-aminobiphenyl-hemoglobin adducts), as well as urinary mutagenicity, were measured in 47 healthy smokers and 50 nonsmokers. DNA adducts were determined by P32-postlabeling in the exfoliated bladder cells...

journal_title：International journal of cancer

authors： Vineis P,Talaska G,Malaveille C,Bartsch H,Martone T,Sithisarankul P,Strickland P

更新日期：1996-01-26 00:00:00

abstract：:Cancer awareness public campaigns aim to shorten the interval between symptom onset and presentation to a doctor (the 'patient interval'). Appreciating variation in promptness of presentation can help to better target awareness campaigns. We explored variation in patient intervals recorded in consultations with genera...

journal_title：International journal of cancer

authors： Keeble S,Abel GA,Saunders CL,McPhail S,Walter FM,Neal RD,Rubin GP,Lyratzopoulos G

更新日期：2014-09-01 00:00:00

abstract：:In STU mice bearing metastasizing SV40-transformed 51A-232B-M tumors, an immune response against a cellular 60kDa protein (p60) developed in about 50% of the tumor-bearing animals, in addition to the response against SV40 large T-antigen and cellular protein p53. The anti-p60 auto-immune response could be observed as ...

journal_title：International journal of cancer

authors： Manneck HE,Pfaff M,Anderer FA

更新日期：1988-12-15 00:00:00

abstract：:Childhood cancers (age at diagnosis: 0-14 years) comprise a variety of malignancies, with incidence varying worldwide by age, sex, ethnicity and geography, that provide insights into cancer etiology. A total of 1,334 childhood cancers registered in population-based cancer registry, Chennai, India, during 1990-2001 and...

journal_title：International journal of cancer

authors： Swaminathan R,Rama R,Shanta V

更新日期：2008-06-01 00:00:00

abstract：:To better understand the role of individual and lifestyle factors in human disease, an exposome-wide association study was performed to investigate within a single-study anthropometry measures and lifestyle factors previously associated with B-cell lymphoma (BCL). Within the European Prospective Investigation into Can...

journal_title：International journal of cancer

authors： Saberi Hosnijeh F,Casabonne D,Nieters A,Solans M,Naudin S,Ferrari P,Mckay JD,Benavente Y,Weiderpass E,Freisling H,Severi G,Boutron Ruault MC,Besson C,Agnoli C,Masala G,Sacerdote C,Tumino R,Huerta JM,Amiano P,Rodrigu

更新日期：2020-10-31 00:00:00

abstract：:Malignant mesothelioma of the pleura (MPM) is a highly aggressive neoplasm with a poor prognosis and limited treatment options. A better understanding of its pathogenesis is essential to developing alternative therapeutic strategies. We previously demonstrated that the Wnt signaling pathway is activated in MPM through...

journal_title：International journal of cancer

authors： Mazieres J,You L,He B,Xu Z,Twogood S,Lee AY,Reguart N,Batra S,Mikami I,Jablons DM

更新日期：2005-11-01 00:00:00

abstract：:CD4(+) Th cells that are restricted by MHC class II molecules play an important role in the induction of antitumor immune responses. We have established a stable CD4(+) Th cell clone (Th35-1A) from the PBMCs of a patient with primary cutaneous melanoma. The Th cell clone is noncytolytic and proliferates specifically i...

journal_title：International journal of cancer

authors： Somasundaram R,Swoboda R,Caputo L,Lee A,Jackson N,Marincola FM,Guerry D,Herlyn D

更新日期：2003-04-10 00:00:00

abstract：:Adequate consumption of folate may reduce the risk of colorectal cancer. We performed a meta-analysis of 7 cohort and 9 case-control studies that examined the association between folate consumption and colorectal cancer risk. In cohort studies, the association between folate consumption and colorectal cancer risk was ...

journal_title：International journal of cancer

authors： Sanjoaquin MA,Allen N,Couto E,Roddam AW,Key TJ

更新日期：2005-02-20 00:00:00

abstract：:The present study was undertaken to determine the role of the metalloproteinase MMP-9 in the invasive phenotype of squamous-cell carcinoma of the oral cavity and the regulation of its expression. Zymographic analysis of conditioned medium from 2 highly invasive squamous-cell-carcinoma cell lines indicated large amount...

journal_title：International journal of cancer

authors： Juarez J,Clayman G,Nakajima M,Tanabe KK,Saya H,Nicolson GL,Boyd D

更新日期：1993-08-19 00:00:00

abstract：:Previous studies indicate that the nonclassical class I HLA-G antigen, whose physiologic expression is mainly restricted to placenta, is upregulated in melanoma, renal carcinoma, lung carcinoma, glioblastoma and ovarian carcinoma, where its inhibitory effect on cytotoxic effector cells function is thought to participa...

journal_title：International journal of cancer

authors： Ibrahim EC,Aractingi S,Allory Y,Borrini F,Dupuy A,Duvillard P,Carosella ED,Avril MF,Paul P

更新日期：2004-01-10 00:00:00

abstract：:Homozygous deletion and loss of heterozygosity (LOH) at chromosome 3p21 have been observed in several types of human cancer including lung cancer and breast cancer. In previous work, we cloned and identified the human RAS association domain family 1A gene (RASSF1A) from the lung tumor suppressor locus 3p21.3. The CpG ...

journal_title：International journal of cancer

authors： Yoon JH,Dammann R,Pfeifer GP

更新日期：2001-10-15 00:00:00

abstract：:Quality of life outcomes provide essential information for patients and physicians in oncology care. However, the validity of progression-free survival (PFS) as a surrogate for quality of life, and the inclusion and reporting of quality of life endpoints in clinical trials, is unclear. We performed a retrospective stu...

journal_title：International journal of cancer

authors： Hwang TJ,Gyawali B

更新日期：2019-04-01 00:00:00

abstract：:1D10 is a previously described antibody that binds to cells from a majority of B-cell malignancies. The current studies were designed to further evaluate the antigen specificity of 1D10 and its potential as an immunotherapeutic agent. Studies with transfectants and immunoprecipitation demonstrated that 1D10 recognizes...

journal_title：International journal of cancer

authors： Kostelny SA,Link BK,Tso JY,Vasquez M,Jorgensen BH,Wang H,Hall WC,Weiner GJ

更新日期：2001-08-15 00:00:00

abstract：:The effects of galanin on pancreatic carcinogenesis induced by azaserine and on the norepinephrine concentration in the pancreas were investigated in male Wistar rats. Rats were given weekly injections of 10 mg/kg body weight of azaserine for 25 weeks and 8 microg/kg body weight of galanin in depot form every other da...

journal_title：International journal of cancer

authors： Iishi H,Tatsuta M,Baba M,Yano H,Iseki K,Uehara H,Nakaizumi A

更新日期：1998-01-30 00:00:00

abstract：:EBV-specific cytotoxic T cells (Tc) induced in vitro have continuously proliferated in vitro for over 9 months. The long-term maintenance of the Tc growth was dependent on periodic supplementation of both irrediated EBV-transformed autologous lymphoblastoid cell line (LCL) cels and conditioned medium. The latter was d...

journal_title：International journal of cancer

authors： Sugamura K,Tanaka Y,Hinuma Y

更新日期：1981-08-15 00:00:00

abstract：:In the perspective of in vivo therapeutic applications, the monoclonal antibody (MAb) MOv18 was selected for its restricted reactivity with human ovarian carcinoma. Using the pH 2.8 desorption assay, we found that the antigen recognized by MOv18 had a high stability on the cell membrane and poor internalization. There...

journal_title：International journal of cancer

authors： Mezzanzanica D,Canevari S,Ménard S,Pupa SM,Tagliabue E,Lanzavecchia A,Colnaghi MI

更新日期：1988-04-15 00:00:00

abstract：:Identification of loss of heterozygosity on specific genetic loci is crucial for understanding the pathogenesis of prostate cancer at the molecular level. This is especially important because the deleted regions may contain putative tumor suppressor genes. Chromosome 3p loss appears to be frequently associated with va...

journal_title：International journal of cancer

authors： Dahiya R,McCarville J,Hu W,Lee C,Chui RM,Kaur G,Deng G

更新日期：1997-03-28 00:00:00

abstract：:Metaphase comparative genomic hybridisation (CGH) studies indicate that chromosomes 4, 5, 6, 13, 14, 15 and 18 are frequently deleted in primary ovarian cancers (OCs). Therefore we used microcell-mediated chromosome transfer (MMCT) to establish the functional effects of transferring normal copies of these chromosomes ...

journal_title：International journal of cancer

authors： Dafou D,Ramus SJ,Choi K,Grun B,Trott DA,Newbold RF,Jacobs IJ,Jones C,Gayther SA

更新日期：2009-03-01 00:00:00

abstract：:High BCAR1/p130Cas expression in primary breast tumour cytosol predicts a poor chance of response recurrent disease to tamoxifen treatment in patients with oestrogen receptor (ER)-positive breast carcinomas. In this study, we assessed whether BCAR1/p130Cas expression is altered during acquisition of anti-oestrogen res...

journal_title：International journal of cancer

authors： van der Flier S,Chan CM,Brinkman A,Smid M,Johnston SR,Dorssers LC,Dowsett M

更新日期：2000-09-20 00:00:00

abstract：:Aberrant DNA methylation is considered a major mechanism for silencing tumor suppressor genes in gastric cancer. We used CpG microarray and differential methylation hybridization strategies to identify potential tumor suppressor genes and recovered glutamate receptor, ionotropic, kainate 2 (GRIK2) as a novel epigeneti...

journal_title：International journal of cancer

authors： Wu CS,Lu YJ,Li HP,Hsueh C,Lu CY,Leu YW,Liu HP,Lin KH,Hui-Ming Huang T,Chang YS

更新日期：2010-06-01 00:00:00

abstract：:Androgen receptor (AR) mutations that modify both the ligand binding and the transactivation capacities of the AR represent one of the mechanisms involved in the transition of prostate cancer (PCa) from androgen-dependent to androgen-independent growth. We use a yeast-based functional assay to detect and analyze mutan...

journal_title：International journal of cancer

authors： Céraline J,Cruchant MD,Erdmann E,Erbs P,Kurtz JE,Duclos B,Jacqmin D,Chopin D,Bergerat JP

更新日期：2004-01-01 00:00:00

abstract：:Liquid-based cytology (LBC) has replaced conventional cytology (CC) for cervical cancer screening in some countries. However, it remains unclear whether LBC is superior to CC. A randomized controlled trial was conducted between August 2007 and March 2009 in Germany to compare LBC, alone and in combination with compute...

journal_title：International journal of cancer

authors： Klug SJ,Neis KJ,Harlfinger W,Malter A,König J,Spieth S,Brinkmann-Smetanay F,Kommoss F,Weyer V,Ikenberg H

更新日期：2013-06-15 00:00:00

abstract：:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. These tumors span a wide clinical spectrum from benign to malignant and have long been recognized for their nearly absolute resistance to chemotherapy and radiation treatment. We reviewed the worldwide experience on ...

journal_title：International journal of cancer

authors： Rossi CR,Mocellin S,Mencarelli R,Foletto M,Pilati P,Nitti D,Lise M

更新日期：2003-11-01 00:00:00

abstract：:The antitumor activity of highly purified tumor necrosis factor (TNF) was tested against eight kinds of murine tumor and five kinds of human tumor heterotransplanted into nude mice. Mice were treated by intravenous or intratumoral injection of TNF, commencing when the tumors were well established. TNF showed an excell...

journal_title：International journal of cancer

authors： Haranaka K,Satomi N,Sakurai A

更新日期：1984-08-15 00:00:00

abstract：:Ewing sarcoma (EWS) is the second most common and aggressive type of metastatic bone tumor in adolescents and young adults. There is unmet medical need to develop and test novel pharmacological targets and novel therapies to treat EWS. Here, we found that EWS expresses high levels of a p53 isoform, delta133p53. We fur...

journal_title：International journal of cancer

authors： Charan M,Dravid P,Cam M,Audino A,Gross AC,Arnold MA,Roberts RD,Cripe TP,Pertsemlidis A,Houghton PJ,Cam H

更新日期：2020-06-01 00:00:00

abstract：:We have obtained a novel multidrug resistant cell line, derived from HT29 G(+) human colon carcinoma cells, by selection with gradually increasing concentrations of the anti-mitotic, microtubule-disrupting agent colchicine. This HT29(col) cell line displayed a 25-fold increase in colchicine resistance and exhibited cr...

journal_title：International journal of cancer

authors： Kok JW,Veldman RJ,Klappe K,Koning H,Filipeanu CM,Müller M

更新日期：2000-07-15 00:00:00

abstract：:In order to establish the role of human papillomavirus (HPV) in carcinogenesis of epidermodysplasia verruciformis (EV), the presence, the molecular characteristics and the physical state of HPV DNA in a benign lesion, a primary carcinoma and a metastatic carcinoma developing in the same EV patient were studied and com...

journal_title：International journal of cancer

authors： Yabe Y,Tanimura Y,Sakai A,Hitsumoto T,Nohara N

更新日期：1989-06-15 00:00:00

abstract：:Leukocyte migration inhibition (LMI) assays were performed using 3 M KCI extracts to detect cell-mediated immune reactions against tumor-associated antigens (TAA) of swine melanoma. Positive LMI reactivity was 70% or greater in melanoma-bearing swine compared to 10% reactivity or less in normal swine tested with extra...

journal_title：International journal of cancer

authors： Hook RR Jr,Hamby CV,Millikan LE,Berkelhammer J,Stills HF Jr,Oxenhandler RW

更新日期：1983-05-15 00:00:00

abstract：:To identify CTL-directed antigens in gastrointestinal cancer, we have investigated antigens recognized by the HLA-A2-restricted CTL line established from T cells infiltrating into colon cancer and report herein cleavage and polyadenylation specificity factor (CPSF) as a potent antigen holding peptides capable of induc...

journal_title：International journal of cancer

authors： Maeda Y,Ito M,Harashima N,Nakatsura T,Hida N,Imai N,Sato Y,Shichijo S,Todo S,Itoh K

更新日期：2002-05-20 00:00:00