DNA adducts in urothelial cells: relationship with biomarkers of exposure to arylamines and polycyclic aromatic hydrocarbons from tobacco smoke.


:Markers of exposure to polycyclic aromatic hydrocarbons (urinary 1-hydroxypyrene-glucuronide) and aromatic amines (4-aminobiphenyl-hemoglobin adducts), as well as urinary mutagenicity, were measured in 47 healthy smokers and 50 nonsmokers. DNA adducts were determined by P32-postlabeling in the exfoliated bladder cells of 39 healthy subjects. Both 1-hydroxypyrene-glucuronide (1-OHPG) and 4-aminobiphenyl adducts (4-ABP-Hb) were associated with smoking habits, but only 4-ABP-Hb adducts were associated with consumption of black, air-cured tobacco. The levels of 2 DNA adducts (numbers 2 and 4) in urothelial cells were clearly associated with 4-ABP-Hb adducts, in all subjects and in smokers. Levels of one of these DNA adducts (number 2) were also associated with 1-hydroxypyrene-glucuronide in urines, but in smokers the association was not statistically significant. Overall, these observations constitute further evidence of a role of arylamines in tobacco-induced bladder cancer.


Int J Cancer


Vineis P,Talaska G,Malaveille C,Bartsch H,Martone T,Sithisarankul P,Strickland P




Has Abstract


1996-01-26 00:00:00














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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Snaebjornsson P,Jonasson L,Olafsdottir EJ,van Grieken NCT,Moller PH,Theodors A,Jonsson T,Meijer GA,Jonasson JG

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    authors: Culine S,Olofsson B,Gosselin S,Honore N,Tavitian A

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    journal_title:International journal of cancer

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    authors: Prudovsky IA,Gumeniuk RR,Yegorov YE,Zelenin AV

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    journal_title:International journal of cancer

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lang K,Niggemann B,Zanker KS,Entschladen F

    更新日期:2002-06-10 00:00:00

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Croce M,Corrias MV,Orengo AM,Brizzolara A,Carlini B,Borghi M,Rigo V,Pistoia V,Ferrini S

    更新日期:2010-09-01 00:00:00

  • Effects of an inducible anti-sense c-myc gene transfer in a drug-resistant human small-cell-lung-carcinoma cell line.

    abstract::Small-cell-lung-cancer (SCLC) is characterized by rapid development of resistance to cytotoxic agents, such as cisplatin (cDDP) and anthracyclines. c-myc over-expression is one of the reported genetic alterations in this tumor. Amplification of the c-myc gene in this and other cancers is often correlated with poor pro...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Van Waardenburg RC,Meijer C,Burger H,Nooter K,De Vries EG,Mulder NH,De Jong S

    更新日期:1997-11-14 00:00:00