Inhibition by galanin of experimental carcinogenesis induced by azaserine in rat pancreas.


:The effects of galanin on pancreatic carcinogenesis induced by azaserine and on the norepinephrine concentration in the pancreas were investigated in male Wistar rats. Rats were given weekly injections of 10 mg/kg body weight of azaserine for 25 weeks and 8 microg/kg body weight of galanin in depot form every other day for 62 weeks. Azaserine-induced pancreatic lesions were examined with hematoxylin and eosin and histochemical techniques. In week 62, quantitative histological examination showed that prolonged administration of galanin significantly reduced the number and size (as percent of parenchyma) of adenosine triphosphatase-positive pancreatic lesions, which are correlated closely with the ultimate development of pancreatic cancer. The number of pancreatic adenocarcinomas in rats treated with galanin was significantly less than in controls. Galanin also significantly decreased the bromodeoxyuridine-labeling index of azaserine-induced pancreatic lesions and the norepinephrine concentration in the pancreas. Our findings indicate that galanin inhibits pancreatic carcinogenesis and that such inhibition may be related to the suppression of sympathetic nervous system activity and subsequently to the inhibition of cell proliferation in neoplastic lesions of the pancreas.


Int J Cancer


Iishi H,Tatsuta M,Baba M,Yano H,Iseki K,Uehara H,Nakaizumi A




Has Abstract


1998-01-30 00:00:00














  • Clinical significance of CXCR3 and CXCR4 expression in primary melanoma.

    abstract::Tumor cell migration involved in metastases is a tightly regulated, nonrandom process. Chemokines have been identified as critical molecules guiding cell migration. We performed a prospective study to analyze a possible association between the expression of chemokine receptors CXCR3 and CXCR4 by primary melanoma and c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Longo-Imedio MI,Longo N,Treviño I,Lázaro P,Sánchez-Mateos P

    更新日期:2005-12-10 00:00:00

  • Increased susceptibility of IFN-gamma-treated neuroblastoma cells to lysis by lymphokine-activated killer cells: participation of ICAM-1 induction on target cells.

    abstract::We have investigated the effect of interferon-gamma (IFN-gamma) treatment of neuroblastoma cells on the susceptibility to lysis by lymphokine-activated killer (LAK) cells and examined the participation of cell-adhesion molecules on the target cells in LAK cell lysis. Untreated neuroblastoma cells expressed lymphocyte-...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Naganuma H,Kiessling R,Patarroyo M,Hansson M,Handgretinger R,Grönberg A

    更新日期:1991-02-20 00:00:00

  • Preserved foods and nasopharyngeal carcinoma: a case-control study among Singapore Chinese.

    abstract::The association between the consumption of preserved foods in infancy, childhood and adulthood and the risk of nasopharyngeal carcinoma was investigated in a case-control study among Singapore Chinese: 200 cases (73% male) were compared with 406 hospital controls (71% male). Significantly increased risks were observed...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lee HP,Gourley L,Duffy SW,Esteve J,Lee J,Day NE

    更新日期:1994-12-01 00:00:00

  • Combined effects of cyclooxygenase-1 and cyclooxygenase-2 selective inhibitors on intestinal tumorigenesis in adenomatous polyposis coli gene knockout mice.

    abstract::As with cyclooxygenase (COX)-2, genetic disruption of COX-1 gene or pharmacologic inhibition of its activity has been shown to decrease the number of intestinal polyps in Apc gene-deficient mice. The present study was designed to investigate the combined effects of COX-1 and COX-2 selective inhibitors on spontaneous p...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kitamura T,Itoh M,Noda T,Matsuura M,Wakabayashi K

    更新日期:2004-04-20 00:00:00

  • Expression of urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 in benign, borderline, malignant primary and metastatic ovarian tumors.

    abstract::Elevated levels of expression of the urokinase-type plasminogen activator (uPA) and its inhibitor PAI-1 have shown to be related to poor prognosis in a variety of cancer types. In the present study, cytosolic levels of uPA and PAI-1 were determined with enzyme-linked immunosorbent assays in cytosols prepared from 244 ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: van der Burg ME,Henzen-Logmans SC,Berns EM,van Putten WL,Klijn JG,Foekens JA

    更新日期:1996-12-20 00:00:00

  • Biallelic mutations of the Tsc2 gene in chemically induced rat renal cell carcinoma.

    abstract::A number of cancer genes have been identified by the study of hereditary human cancers and shown to be involved in sporadic genesis of the same tumors. We have identified a germline mutation in the rat homologue of the human tuberous sclerosis (TSC2) predisposing gene in the Eker rat model. In this study, we searched ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Satake N,Urakami S,Hirayama Y,Izumi K,Hino O

    更新日期:1998-09-11 00:00:00

  • Presence of EBV-DNA sequences in nasopharyngeal cells of individuals without IgA-VCA antibodies.

    abstract::Exfoliated nasopharyngeal (NP) cells from 62 normal Cantonese Chinese having IgA/VCA antibodies for more than a year and from 39 similar persons without IgA/VCA antibodies, were tested for the presence of EBV/DNA sequences by spot followed by blot hybridization tests, using the cloned internal repeat of B95-8 viral DN...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Desgranges C,Pi GH,Bornkamm GW,Legrand C,Zeng Y,de-Thé G

    更新日期:1983-11-15 00:00:00

  • Inhibition of CXCR4/CXCL12 signaling axis by ursolic acid leads to suppression of metastasis in transgenic adenocarcinoma of mouse prostate model.

    abstract::Increasing evidences indicate that CXCR4/CXCL12 signaling pathway plays a pivotal role in the process of distant site metastasis that accounts for more than 90% of prostate cancer related deaths in patients. Thus, novel drugs that can downregulate CXCR4/CXCL12 axis have a great potential in the treatment of metastatic...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Shanmugam MK,Manu KA,Ong TH,Ramachandran L,Surana R,Bist P,Lim LH,Kumar AP,Hui KM,Sethi G

    更新日期:2011-10-01 00:00:00

  • Distinct molecular landscapes between endometrioid and nonendometrioid uterine carcinomas.

    abstract::Endometrial carcinoma (EC) is traditionally characterized as endometrioid and nonendometrioid based on histopathologic phenotypes. Molecular-based classifications have been proposed, but are not widely implemented. Herein we examine molecular profiles between EC histologic subtypes. 3133 ECs were submitted between Mar...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jones NL,Xiu J,Chatterjee-Paer S,Buckley de Meritens A,Burke WM,Tergas AI,Wright JD,Hou JY

    更新日期:2017-03-15 00:00:00

  • Identification of genomic aberrations associated with shorter overall survival in patients with oligodendroglial tumors.

    abstract::Deletions on chromosomes 1p and 19q are associated with favorable prognosis in patients with oligodendroglial tumors. The aim of our study was to identify additional genomic aberrations linked to patient survival. We performed a genome-wide screen for genomic imbalances by comparative genomic hybridization on tumors f...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Trost D,Ehrler M,Fimmers R,Felsberg J,Sabel MC,Kirsch L,Schramm J,Wiestler OD,Reifenberger G,Weber RG

    更新日期:2007-06-01 00:00:00

  • KSHV viral load and Interleukin-6 in HIV-associated pediatric Kaposi sarcoma-Exploring the role of lytic activation in driving the unique clinical features seen in endemic regions.

    abstract::Kaposi sarcoma (KS) is among the most common childhood malignancies in central, eastern, and southern Africa. Although its unique clinical features have been established, biological mechanisms related to the causative agent, KS-associated herpes-virus (KSHV), have yet to be explored in children. We performed a prospec...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: El-Mallawany NK,Mehta PS,Kamiyango W,Villiera J,Peckham-Gregory EC,Kampani C,Krysiak R,Sanders MK,Caro-Vegas C,Eason AB,Ahmed S,Schutze GE,Martin SC,Kazembe PN,Scheurer ME,Dittmer DP

    更新日期:2019-01-01 00:00:00

  • Frequent inactivation of SPARC by promoter hypermethylation in colon cancers.

    abstract::Epigenetic modification of gene expression plays an important role in the development of human cancers. The inactivation of SPARC through CpG island methylation was studied in colon cancers using oligonucleotide microarray analysis and methylation specific PCR (MSP). Gene expression of 7 colon cancer cell lines was ev...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yang E,Kang HJ,Koh KH,Rhee H,Kim NK,Kim H

    更新日期:2007-08-01 00:00:00

  • Ganglioside GM2 expression on human melanoma cells correlates with sensitivity to lymphokine-activated killer cells.

    abstract::Ganglioside GM2 is expressed on cell surface membranes of a variety of human malignant cells and has been demonstrated to be immunogenic in humans. We have assessed the role of the antigen GM2 on melanoma cells as a recognition structure for lymphokine-activated killer (LAK) cells. LAK cells were generated by stimulat...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hoon DS,Ando I,Sviland G,Tsuchida T,Okun E,Morton DL,Irie RF

    更新日期:1989-05-15 00:00:00

  • DNA ploidy and clonal selection in ras + myc-induced mouse prostate cancer.

    abstract::An important goal in prostate cancer research is to define specific molecular and cellular alterations that are associated with malignant progression. The mouse prostate reconstitution model is a relevant and useful system as it allows the study of early events in cancer progression under conditions where oncogene-ini...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Greene DR,Taylor SR,Aihara M,Yoshida K,Egawa S,Park SH,Timme TL,Yang G,Scardino PT,Thompson TC

    更新日期:1995-01-27 00:00:00

  • Loss of heterozygosity and tumor suppressor activity of Bin1 in prostate carcinoma.

    abstract::The genetic events underlying the development of prostate cancer are poorly defined. c-Myc is often activated in tumors that have progressed to metastatic status, so events that promote this process may be important. Bin1 is a nucleocytoplasmic adaptor protein with features of a tumor suppressor that was identified th...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ge K,Minhas F,Duhadaway J,Mao NC,Wilson D,Buccafusca R,Sakamuro D,Nelson P,Malkowicz SB,Tomaszewski J,Prendergast GC

    更新日期:2000-04-15 00:00:00

  • Promiscuous survivin peptide induces robust CD4+ T-cell responses in the majority of vaccinated cancer patients.

    abstract::CD4(+) T cells have been shown to be crucial for the induction and maintenance of cytotoxic T cell responses and to be also capable of mediating direct tumor rejection. Therefore, the anticancer therapeutic efficacy of peptide-based vaccines may be improved by addition of HLA class II epitopes to stimulate T helper c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Widenmeyer M,Griesemann H,Stevanović S,Feyerabend S,Klein R,Attig S,Hennenlotter J,Wernet D,Kuprash DV,Sazykin AY,Pascolo S,Stenzl A,Gouttefangeas C,Rammensee HG

    更新日期:2012-07-01 00:00:00

  • Focal amplifications are associated with high grade and recurrences in stage Ta bladder carcinoma.

    abstract::Urinary bladder cancer is a heterogeneous disease with tumors ranging from papillary noninvasive (stage Ta) to solid muscle infiltrating tumors (stage T2+). The risk of progression and death for the most frequent diagnosed type, Ta, is low, but the high incidence of recurrences has a significant effect on the patients...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nord H,Segersten U,Sandgren J,Wester K,Busch C,Menzel U,Komorowski J,Dumanski JP,Malmström PU,Díaz de Ståhl T

    更新日期:2010-03-15 00:00:00

  • Marker profile of mesothelial cells versus ovarian carcinoma cells.

    abstract::We investigated the marker profile of human ascitic and cultured mesothelial cells, and compared it to that of ovarian carcinoma cells which are related in terms of their histogenesis, unrelated colon carcinomas being used as reference. Mesothelial and ovarian carcinoma cells could not be distinguished by (intermediat...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: van Niekerk CC,Jap PH,Thomas CM,Smeets DF,Ramaekers FC,Poels LG

    更新日期:1989-06-15 00:00:00

  • Prenatal diethylstilbestrol exposure and mammographic density.

    abstract::In a prospective cohort study of the health effects associated with prenatal Diethylstilbestrol (DES) exposure, DES was associated with an increased breast cancer risk after 40 years of age. It is unknown whether it is associated with greater mammographic density, which strongly predicts breast cancer risk. A cohort o...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Strohsnitter WC,Bertrand KA,Troisi R,Scott CG,Cheville AL,Hoover RN,Palmer JR,Vachon CM

    更新日期:2018-09-15 00:00:00

  • Prevalence of Kaposi's sarcoma-associated herpesvirus infection in sex workers and women from the general population in Spain.

    abstract::Transmission routes of Kaposi's sarcoma-associated herpesvirus (KSHV) in the general population are poorly understood. Whereas sexual transmission appears to be common in homosexual men, the evidence for heterosexual transmission is less convincing. In our study, prevalence of KSHV infection was examined among women i...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: de Sanjosé S,Marshall V,Solà J,Palacio V,Almirall R,Goedert JJ,Bosch FX,Whitby D

    更新日期:2002-03-01 00:00:00

  • Tumour growth fraction measured by immunohistochemical staining of Ki67 is an independent prognostic factor in preoperative prostate biopsies with small-volume or low-grade prostate cancer.

    abstract::Accurate prognostic parameters in prostate biopsies are needed to better counsel individual patients with prostate cancer. We evaluated the prognostic impact of morphologic and immunohistochemical parameters in preoperative prostate cancer biopsies. A consecutive series of prostate biopsies of 279 men (72% with clinic...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zellweger T,Günther S,Zlobec I,Savic S,Sauter G,Moch H,Mattarelli G,Eichenberger T,Curschellas E,Rüfenacht H,Bachmann A,Gasser TC,Mihatsch MJ,Bubendorf L

    更新日期:2009-05-01 00:00:00

  • Tumor production of angiostatin is enhanced after exposure to TNF-alpha.

    abstract::Infection of tumors with an adenoviral vector expressing a chimeric gene composed of the CArG elements of the Egr-1 promoter and a cDNA encoding TNF-alpha (Ad.Egr-TNF) has previously been shown to result in the production of high intratumoral levels of TNF-alpha and thereby tumor regression. The antitumor effects of T...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mauceri HJ,Seetharam S,Beckett MA,Lee JY,Gupta VK,Gately S,Stack MS,Brown CK,Swedberg K,Kufe DW,Weichselbaum RR

    更新日期:2002-02-01 00:00:00

  • Changes in lung-cancer mortality trends in Spain.

    abstract::Several changes in smoking patterns over the past decades in Spain can be expected to result in a shift in lung-cancer mortality rates. We examined time trends in lung-cancer mortality from 1973-1997 using a log-linear Poisson age-period-cohort model. The standardized lung-cancer mortality rate for men almost doubled,...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Franco J,Pérez-Hoyos S,Plaza P

    更新日期:2002-01-01 00:00:00

  • The prevalence and concordance of human papillomavirus infection in different anogenital sites among men and women in Liuzhou, China: A population-based study.

    abstract::Human papillomavirus (HPV) infection is the pathogenesis of anogenital cancers and genital warts in both men and women, whereas there is a scarcity of large studies focused on HPV prevalence in different anogenital sites of both sexes in the same population. From May to July 2014, 2,309 men and 2,378 women aged 18-55 ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wei F,Li M,Wu X,Yin K,Lan J,Sheng W,Guo M,Huang S,Wang Y,Li Y,Li R,Su Y,Wu T,Zhang J,Xia N

    更新日期:2018-03-15 00:00:00

  • Cancer prevention by adult-onset calorie restriction after infant exposure to ionizing radiation in B6C3F1 male mice.

    abstract::Children are especially sensitive to ionizing radiation and chemical carcinogens, and limiting their cancer risk is of great public concern. Calorie restriction (CR) is a potent intervention for suppressing cancer. However, CR is generally not appropriate for children. This study, therefore, examined to see if adult-o...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Shang Y,Kakinuma S,Yamauchi K,Morioka T,Kokubo T,Tani S,Takabatake T,Kataoka Y,Shimada Y

    更新日期:2014-09-01 00:00:00

  • An estimate of the proportion of colo-rectal and stomach cancers which might be prevented by certain changes in dietary habits.

    abstract::The colo-rectum and stomach are the 2 sites for which the role of diet in the etiology of cancer is most heavily implicated. Quantitative estimates as to the proportion of cancer deaths attributable to diet vary considerably. This may be partially due to the application of the concept of population attributable risk w...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wahrendorf J

    更新日期:1987-11-15 00:00:00

  • An immunohistological study of leukocyte localization in benign and malignant breast tissue.

    abstract::Using morphometric and immunohistological techniques, we investigated the distribution of T lymphocytes and subsets, B lymphocytes, macrophages and plasma cells in sections of human breast tissue. In normal lobules and ducts, leukocytes were found in greater density in the epithelium than in the stroma. The intra-epit...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lwin KY,Zuccarini O,Sloane JP,Beverley PC

    更新日期:1985-10-15 00:00:00

  • Medical radiation exposure and breast cancer risk: findings from the Breast Cancer Family Registry.

    abstract::Moderate to high-dose radiotherapy is known to increase the risk of breast cancer. Uncertainties remain about the effects of low-dose chest X-rays, particularly in individuals at increased genetic risk. We analyzed case-control data from the Breast Cancer Family Registry. Self-reported data on therapeutic and diagnost...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: John EM,Phipps AI,Knight JA,Milne RL,Dite GS,Hopper JL,Andrulis IL,Southey M,Giles GG,West DW,Whittemore AS

    更新日期:2007-07-15 00:00:00

  • A randomized, crossover, placebo- and moxifloxacin-controlled study to evaluate the effects of bosutinib (SKI-606), a dual Src/Abl tyrosine kinase inhibitor, on cardiac repolarization in healthy adult subjects.

    abstract::Effects of therapeutic and supratherapeutic concentrations of bosutinib, a dual Src/Abl tyrosine kinase inhibitor, on the corrected QT interval (QTc) in 60 healthy adults were assessed, according to ICH-E14 guidelines, in this 2-part, randomized, single-dose, double-blind, crossover, placebo- and open-label moxifloxac...

    journal_title:International journal of cancer

    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Abbas R,Hug BA,Leister C,Sonnichsen D

    更新日期:2012-08-01 00:00:00

  • Immunohistologic expression of blood-group antigens in normal human gastrointestinal tract and colonic carcinoma.

    abstract::A panel of 7 mouse monoclonal antibodies and the lectin from Ulex europeus, detecting blood-group-related antigens of the ABH and Lewis systems, have been used to define the distribution of these antigenic structures within the human gastrointestinal tract, and to characterize their expression and modulation in colore...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cordon-Cardo C,Lloyd KO,Sakamoto J,McGroarty ME,Old LJ,Melamed MR

    更新日期:1986-05-15 00:00:00