Resistance to verapamil sensitization of multidrug-resistant cells grown as multicellular spheroids.

abstract：:We have previously shown that AEV infection of leukosis-free chickens provokes an erythroleukemia in the infected birds, and that the target cell for virus transformation is most likely an early pro-erythroblast comparable to the BFU-E. The virus infection correlates with a block in differentiation which was studied a...

journal_title：International journal of cancer

authors： Therwath A,Scherrer K

更新日期：1982-05-15 00:00:00

abstract：:We screened 29 human esophageal squamous cell carcinoma (ESC) cell lines for mutations of the p53 gene through all coding exons and exon-intron junctions. Mutations were found in 22 cell lines (76%), consisting of 20 single-base substitutions, 2 small deletions and 1 single-base insertion. Out of 20 single-base substi...

journal_title：International journal of cancer

authors： Tanaka H,Shibagaki I,Shimada Y,Wagata T,Imamura M,Ishizaki K

更新日期：1996-01-26 00:00:00

abstract：:One hundred patients with Ph1-chromosome-positive chronic myelogenous leukemia (CML) with t(9;22) are included in the present investigation. The position of the Ph1 chromosome in relation to the normal as well as the abnormal chromosomes 9 was localized at metaphase in 1,000 bone-marrow cells. Our study suggests that ...

journal_title：International journal of cancer

authors： Verma RS,Thomas S,Coleman M,Silver RT

更新日期：1988-06-15 00:00:00

abstract：:Approximately 80% of bladder tumors are urothelial superficial papillary carcinomas (USPC). Despite a generally good prognosis, these tumors have a strong propensity to recur and about 1/3 of them compared to disease progression. Histological assessment of these superficial tumors is not sufficiently discriminator in ...

journal_title：International journal of cancer

authors： Santos L,Amaro T,Costa C,Pereira S,Bento MJ,Lopes P,Oliveira J,Criado B,Lopes C

更新日期：2003-06-10 00:00:00

abstract：:Hooded rats bearing a syngeneic methylcholanthrene-induced tumour were evaluated for extent of in vivo host immunity and this was correlated by in vitro techniques with the levels of circulating tumour antigen and specific antibody. Early tumour growth was associated with detectable immunity, as measured by the capaci...

journal_title：International journal of cancer

authors： Thomson DM

更新日期：1975-06-15 00:00:00

abstract：:A mammographic breast cancer screening programme has been ongoing in the Florence District (Italy) since 1970 and a favourable impact of screening on breast cancer mortality of women aged 50-70 has been shown by means of a case-control study. Two hundred and eleven screen- and 116 interval-detected cancers in the peri...

journal_title：International journal of cancer

authors： Paci E,Ciatto S,Buiatti E,Cecchini S,Palli D,Rosselli del Turco M

更新日期：1990-08-15 00:00:00

abstract：:MAGE genes are frequently expressed in several types of human malignancy and code for antigens recognized by cytotoxic T lymphocytes. We have previously described a monoclonal antibody (MAb), named 6C1, that recognizes the MAGE-1 protein and cross-reacts with a 72-kDa protein present in lysates of melanoma cells such ...

journal_title：International journal of cancer

authors： Rimoldi D,Salvi S,Reed D,Coulie P,Jongeneel VC,De Plaen E,Brasseur F,Rodriguez AM,Boon T,Cerottini JC

更新日期：1999-09-09 00:00:00

abstract：:The relationship between the biomarker of vitamin D status, 25(OH)D, and the risk for colorectal neoplasia is suggestive but equivocal. Questions remain regarding whether there are differential associations between 25(OH)D and colorectal adenoma by gender, colorectal subsite or features of baseline and recurrent adeno...

journal_title：International journal of cancer

authors： Jacobs ET,Hibler EA,Lance P,Sardo CL,Jurutka PW

更新日期：2013-12-15 00:00:00

abstract：:Production of interleukin-6 (IL-6) by human pancreatic carcinoma cells inversely correlates with potentials for blood-borne metastasis to the liver in nude mice. IL-6 cDNA was transfected to PCI-43, one of our cultured pancreatic carcinoma cell lines that does not produce IL-6 and generates numerous metastases to the ...

journal_title：International journal of cancer

authors： Saito K,Ishikura H,Kishimoto T,Kawarada Y,Yano T,Takahashi T,Kato H,Yoshiki T

更新日期：1998-01-19 00:00:00

abstract：:Target-specific acute myeloid leukemia (AML) immunotherapy requires selective cell-surface antigens on AML blast cells. CD64 is a promising candidate antigen because it is abundantly expressed on monocytoid differentiated AML subtypes. In previous studies, a chemically linked full-length anti-CD64 immunotoxin based on...

journal_title：International journal of cancer

authors： Tur MK,Huhn M,Jost E,Thepen T,Brümmendorf TH,Barth S

更新日期：2011-09-01 00:00:00

abstract：:This study investigates the role of tumor nitric oxide (NO) and vascular regulation in tumor ulceration following high-dose tumor necrosis factor-alpha (TNF) treatment. Using TNF-responsive (MethA) and nonresponsive (LL2) mouse tumors, tumor NO concentration was measured with an electrochemical sensor and tumor blood ...

journal_title：International journal of cancer

authors： Menon C,Bauer TW,Kelley ST,Raz DJ,Bleier JI,Patel K,Steele K,Prabakaran I,Shifrin A,Buerk DG,Sehgal CM,Fraker DL

更新日期：2008-07-15 00:00:00

abstract：:To assess whether there has been a change in histological features and prognostic factors of primary cutaneous malignant melanoma (CMM) in young individuals in Sweden, an unselected, population-based study was undertaken; 177 cases of primary CMM in persons below 20 years of age were reported to the Swedish National C...

journal_title：International journal of cancer

authors： Sander B,Karlsson P,Rosdahl I,Westermark P,Boeryd B

更新日期：1999-03-01 00:00:00

abstract：:Transferrin is required for proliferation of most cells in culture. This effect is presumably mediated by the binding of transferrin to its receptor, a surface glycoprotein which is preferentially expressed by actively growing cells. Here we show that normal human fibroblasts cultured in serum, and other media contain...

journal_title：International journal of cancer

authors： Ekblom P,Thesleff I,Lehto VP,Virtanen I

更新日期：1983-01-15 00:00:00

abstract：:The expression of the Wilms tumor suppressor gene WT1 is largely restricted to elements of the developing urogenital system. In the fetal kidney, WT1 transcripts are present at low levels in the condensing mesenchyme and at much higher levels in differentiating glomerular epithelium and are not detected in other mesen...

journal_title：International journal of cancer

authors： Campbell CE,Kuriyan NP,Rackley RR,Caulfield MJ,Tubbs R,Finke J,Williams BR

更新日期：1998-10-05 00:00:00

abstract：:Subcellular distribution of hexokinase (HK) isoenzymes in 22 human breast cancers (21 primary cancers and 1 axillary metastatic growth) and 7 non-pathological human mammary gland tissue samples was studied with starch gel electrophoresis on isolated cell fractions obtained by differential centrifugation. Fractions use...

journal_title：International journal of cancer

authors： Gudnason V,Ingvarsson S,Jonasdottir A,Andresdottir V,Egilsson V

更新日期：1984-07-15 00:00:00

abstract：:Germline mutation of the folliculin gene (BHD) at chromosome 17p11.2 is associated with the development of multiplex hamartomas of the hair follicles, chromophobe renal cell carcinomas (RCC) and renal oncocytomas (RO). We have analyzed the folliculin gene with sequencing for mutations and the chromosome 17p11.2 with m...

journal_title：International journal of cancer

authors： Nagy A,Zoubakov D,Stupar Z,Kovacs G

更新日期：2004-04-10 00:00:00

abstract：:Head and neck squamous cell carcinoma (HNSCC) is a morbid cancer with poor outcomes. Statins possess anticancer properties such as immunomodulatory and anti-inflammatory effects. The objective of our study is to identify the association between statin use among untreated HNSCC patients and overall death, disease-speci...

journal_title：International journal of cancer

authors： Getz KR,Bellile E,Zarins KR,Rullman C,Chinn SB,Taylor JMG,Rozek LS,Wolf GT,Mondul AM

更新日期：2020-12-15 00:00:00

abstract：:Esophageal cancer is a leading cause of cancer death, especially in developing countries. In high-risk regions, squamous cell carcinoma is the most common type of esophageal cancer, and its etiology remains poorly understood. The purpose of this study was to evaluate the association between human papillomavirus (HPV) ...

journal_title：International journal of cancer

authors： Gao GF,Roth MJ,Wei WQ,Abnet CC,Chen F,Lu N,Zhao FH,Li XQ,Wang GQ,Taylor PR,Pan QJ,Chen W,Dawsey SM,Qiao YL

更新日期：2006-09-15 00:00:00

abstract：:Hybridoma CE7 produces a murine antibody (gamma 1/kappa) which binds to a 190-kDa cell-surface glycoprotein of human neuroblastoma. Because of its tumor specificity, it has been used routinely in clinical pathology to confirm diagnosis of neuroblastoma. We have isolated the gene segments coding for the variable region...

journal_title：International journal of cancer

authors： Amstutz H,Rytz C,Novak-Hofer I,Spycher M,Schubiger PA,Blaser K,Morgenthaler JJ

更新日期：1993-01-02 00:00:00

abstract：:Antibodies directed against idiotypic determinants of the cell-surface IgM of a B lymphoma, 38c, were effective in delaying development of the tumor and in some instances in preventing its growth. The efficacity of the anti-idiotype antibodies was markedly increased when they were injected in combination with anti-neo...

journal_title：International journal of cancer

authors： Hurwitz E,Burowski D,Kashi R,Hollander N,Haimovich J

更新日期：1986-05-15 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC) is rare in most parts of the world, but prevalent in Southern China. Although this disease poses a serious health problem in our population, the genetic alterations that lead to the development of NPC have yet to be defined. In a comparative genomic hybridization (CGH) study on NPC by ou...

journal_title：International journal of cancer

authors： Tsang YS,Lo KW,Leung SF,Choi PH,Fong Y,Lee JC,Huang DP

更新日期：1999-10-29 00:00:00

abstract：:The antigen recognized by the MOv18 MAb (Ca-MOv18) was recently shown to be a glycosylphosphatidylinositol (GPI)-linked protein. In this report we show that GPI-anchorage is not limited to IGROVI cells nor to other ovary carcinoma cell lines, but Ca-MOv18 was also found to be sensitive to phosphatidylinositol-specific...

journal_title：International journal of cancer

authors： Miotti S,Alberti S,Facheris P,Mantovani L,Fornaro M,Stella M,Ménard S,Canevari S,Colnaghi MI

更新日期：1992-05-28 00:00:00

abstract：:A human ovarian adenocarcinoma cell line (PE04) has been established as a xenograft in nude mice. In vitro, this cell line is estrogen receptor (ER)-positive and its growth is stimulated by 17 beta-estradiol at concentrations between 10(-12) and 10(-6) M. When xenografted, PE04 cells remain ER-positive and also posses...

journal_title：International journal of cancer

authors： Langdon SP,Ritchie A,Young K,Crew AJ,Sweeting V,Bramley T,Hillier S,Hawkins RA,Tesdale AL,Smyth JF

更新日期：1993-09-30 00:00:00

abstract：:Estimates of the worldwide incidence and mortality from 36 cancers and for all cancers combined for the year 2018 are now available in the GLOBOCAN 2018 database, compiled and disseminated by the International Agency for Research on Cancer (IARC). This paper reviews the sources and methods used in compiling the cancer...

journal_title：International journal of cancer

authors： Ferlay J,Colombet M,Soerjomataram I,Mathers C,Parkin DM,Piñeros M,Znaor A,Bray F

更新日期：2019-04-15 00:00:00

abstract：:The second most common target of prostate-cancer metastasis is bone, and the phenomenon of skeletal metastasis represents the incurable stage of disease. Histologically, skeletal metastasis from prostate cancer is distinctive due to its osteoblastic nature. The osteoblastic bone metastasis shows extensive new bone for...

journal_title：International journal of cancer

authors： Thomas R,True LD,Lange PH,Vessella RL

更新日期：2001-07-01 00:00:00

abstract：:A case of epidermodysplasia verruciformis in a patient from Upper-Volta is described. Slightly elevated, flat warts were observed on hands, feet, arms and legs, and pityriasis versicolor-like lesions were found mainly on the trunk. The patient showed no malignant tumors. Histological examination revealed hyperkeratosi...

journal_title：International journal of cancer

authors： Pfister H,Nürnberger F,Gissmann L,zur Hausen H

更新日期：1981-05-15 00:00:00

abstract：:It has been suggested that phytoestrogens protect against hormone-dependent cancers. Lignans are the main class of phytoestrogens in Western diets. We conducted a prospective study of endometrial cancer and circulating levels of the main human lignan, enterolactone. The design was a case-control study nested within 3 ...

journal_title：International journal of cancer

authors： Zeleniuch-Jacquotte A,Lundin E,Micheli A,Koenig KL,Lenner P,Muti P,Shore RE,Johansson I,Krogh V,Lukanova A,Stattin P,Afanasyeva Y,Rinaldi S,Arslan AA,Kaaks R,Berrino F,Hallmans G,Toniolo P,Adlercreutz H

更新日期：2006-11-15 00:00:00

abstract：:Although early detection and systemic therapies have improved the diagnosis and clinical cure rate of breast cancer, breast cancer remains the most frequently occurring malignant cancer in women due to a lack of sufficiently effective treatments. Thus, to develop potential targeted therapies and thus benefit more pati...

journal_title：International journal of cancer

authors： Liu ZH,Chen ML,Zhang Q,Zhang Y,An X,Luo YL,Liu XM,Liu SX,Liu Q,Yang T,Liu YM,Liu BL,Zhou AJ,Li MZ,Liu YJ,Liu ZX,Zhong Q

更新日期：2020-07-15 00:00:00

abstract：:A novel intra-operative chemotherapy nude mouse model for human hepatocellular carcinoma (HCC) has been developed. Intra-peritoneal (i.p.) administration of 5-fluorouracil (5-FU) was begun 2 hr before hepatic resection of HCC and then continued post-operatively for 4 consecutive days. This regime, termed intra-hepatec...

journal_title：International journal of cancer

authors： Rashidi B,An Z,Sun FX,Li X,Tang ZY,Moossa AR,Hoffman RM

更新日期：2001-01-15 00:00:00

abstract：:Pancreatic adenocarcinoma (PDAC) is known to have a poor prognosis partly because of lack of effective biomarkers. In the test set, we investigated dysbindin (DTNBP1) as a potential biomarker for PDAC by comparing preoperative and postoperative serum mass spectrometry (MS) proteomic profilings. Of the included 50 PDAC...

journal_title：International journal of cancer

authors： Guo X,Lv X,Fang C,Lv X,Wang F,Wang D,Zhao J,Ma Y,Xue Y,Bai Q,Yao X,Chen Y

更新日期：2016-10-15 00:00:00