Abstract：
:Transferrin is required for proliferation of most cells in culture. This effect is presumably mediated by the binding of transferrin to its receptor, a surface glycoprotein which is preferentially expressed by actively growing cells. Here we show that normal human fibroblasts cultured in serum, and other media containing transferrin express transferrin receptors in a distinctly non-random way; punctate foci of the receptor were seen only at the leading lamellae of the cells, whereas cells grown without serum, or in transferrin-depleted serum showed a random distribution of the receptor. In contrast, malignant fibrosarcoma cells showed the receptor uniformly throughout the cell surface in all media tested, including those containing transferrin. The data suggest that the ligand causes a directional lateral movement of the receptor in normal but not in malignant cells. Application of the receptor antibody caused a rapid internalization of the receptor in both cell types.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Ekblom P,Thesleff I,Lehto VP,Virtanen Idoi
10.1002/ijc.2910310118subject
Has Abstractpub_date
1983-01-15 00:00:00pages
111-7issue
1eissn
0020-7136issn
1097-0215journal_volume
31pub_type
杂志文章abstract：:We have examined the effect of various cell monolayers on the ability of mouse spleen cells to lyse tumor cell targets (natural cytotoxicity reaction). Natural killer (NK) cell activity was reduced by as much as 75% depending on the cell substrate, with the greatest protection afforded by endothelial cells. Cell adhes...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910410612
更新日期：1988-06-15 00:00:00
abstract：:Two distinct cell lines (OPM-1 and OPM-2) were established from the peripheral blood of a 56-year-old female myeloma patient at the stage of terminal leukemic evolution associated with loss of cytoplasmic immunoglobulin heavy chain (G lambda----lambda). The lines grew in suspension with a doubling time of 36-42 hr and...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910360217
更新日期：1985-08-15 00:00:00
abstract：:Vascular endothelial growth factor (VEGF) is a major inducer of angiogenesis in tumors. Basic fibroblast growth factor (bFGF) and epidermal growth factor (EGF) have both been shown to interact with VEGF. The involvement of VEGF, bFGF, and EGF in melanoma angiogenesis was investigated here. Four human melanoma cell lin...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19980610)76:6<836::aid-ijc
更新日期：1998-06-10 00:00:00
abstract：:Interleukin-10 (IL-10) is an inhibitory cytokine produced by various cell types. It exhibits strong sequence homology to BCRF-1 (viral IL-10, vIL-10), an open reading frame in the Epstein-Barr-virus (EBV) genome. Using in situ hybridization (ISH), polymerase chain reaction (PCR) and immunohistochemistry, we checked 41...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19970729)72:3<398::aid-ijc
更新日期：1997-07-29 00:00:00
abstract：:These studies were designed to examine the role of neutrophils in transplantation immunity to syngeneic rat tumors. We have earlier reported that specific transplantation immunity to syngeneic transplanted tumors is abrogated by selective depletion of peripheral-blood neutrophils by administration of a monoclonal anti...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910540121
更新日期：1993-04-22 00:00:00
abstract：:The incidence of tonsillar cancer and the proportion of human papillomavirus (HPV) positive tonsillar cancer cases have increased in the last decades. In parallel, treatment for tonsillar cancer has been intensified e.g., by accelerated radiotherapy, and chemotherapy, resulting in more side effects. Patients with HPV-...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.26490
更新日期：2012-09-01 00:00:00
abstract：:Esophageal squamous-cell neoplasia (ESCN) is a common second primary neoplasia found in patients with head-and-neck squamous-cell carcinoma (HNSCC). This study sought to identify the risk factors for synchronous ESCN and how they influence survival in HNSCC patient. Eight hundred and fifteen incident HNSCC patients we...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.30911
更新日期：2017-11-15 00:00:00
abstract：:The human tumor line LOX was established as an s.c. xenograft in nude mice from a lymph-node metastasis of a patient with malignant melanoma. I.v. injection into adult nude mice of single-cell suspensions prepared from xenografts resulted in progressively growing lung tumor colonies that killed the animals. No differe...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910410322
更新日期：1988-03-15 00:00:00
abstract：:Non-specific cross-reacting antigens (NCA-95 = CD66b and NCA-50/90 = CD66c) are members of the CEA (carcinoembryonic antigen = CD66e) family. Analysis of mRNA levels of CD66c in colon tumors suggests that this antigen is strongly up-regulated compared to its normal counterpart and could, therefore, be of clinical inte...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910630308
更新日期：1995-11-03 00:00:00
abstract：:Tumors need to acquire an angiogenic phenotype for outgrowth and metastasis formation. Limited information on the angiogenic potential of specific tissues, especially human breast tissues is available. Here we describe an in vivo model, using the dorsal skin fold chamber in immunodeficient nude mice, where various tis...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19980729)77:3<455::aid-ijc
更新日期：1998-07-29 00:00:00
abstract：:It is well known that certain cancers have shown clustering in socioeconomic groups, but limited data are available on recent results and time trends in such clustering. We determined standardized incidence ratios (SIR) for cancer, adjusted for age, period, region, parity and age at first childbirth among men and wome...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.11150
更新日期：2003-07-10 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is one of the most common malignancies worldwide with a very high mortality. Because the success of the conventional therapies is limited, gene therapy may represent an alternative for HCC management. Our earlier study has shown that Bid plays a role in the development of HCC. The aim of...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.22040
更新日期：2006-10-15 00:00:00
abstract：:In addition to the known function in the glycolytic pathway, phosphoglycerate kinase 1 (PGK-1) promotes reduction of plasmin disulfide bonds leading to angiostatin formation and inhibition of tumor angiogenesis. In this study, the effects of PGK-1 on anti- tumor immunity against lung cancer were evaluated using the Te...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.23888
更新日期：2008-12-15 00:00:00
abstract：:The red bone marrow (BM) is an important indicator organ of hematogenous micrometastatic spread of carcinomas. Characterization of biological properties specific for BM micrometastatic cells, however, is technically challenging due to the limited number of target cells usually available for the purpose. This report pr...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.1564
更新日期：2002-01-01 00:00:00
abstract：:We aimed to identify risk factors for Kaposi's sarcoma (KS) among HIV-positive patients and behaviors associated with human Herpesvirus 8 (HHV-8) infection, as well as to assess KS incidence and mortality rates longitudinally. To fulfill the first objective, a European case-control study was designed in the early 1990...
journal_title：International journal of cancer
pub_type： 杂志文章,多中心研究
doi：10.1002/ijc.22281
更新日期：2007-03-01 00:00:00
abstract：:Breast cancer cells frequently metastasize to the skeleton, where they induce OCL formation and activity, resulting in extensive bone destruction. However, the mechanisms by which breast cancer cells mediate increased osteolysis remain unclear. To elucidate this point, we investigated how 3 human breast cancer cell li...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.20056
更新日期：2004-05-01 00:00:00
abstract：:We conducted a retrospective cohort study to investigate the colorectal cancer (CRC) incidence and mortality prevention achievable in clinical practice with an optimized colonoscopy protocol targeting near-complete polyp clearance. The protocol consisted of: (i) telephonic reinforcement of bowel preparation instructio...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.29228
更新日期：2015-03-15 00:00:00
abstract：:By radioimmunoassay (RIA) mammary tumour virus (MTV) antigens were detected in individual milk samples of C3Hf mice, (female BALB/c X male C3Hf)F1 mice and (female C3Hf X male BALB/c)F1 mice; milk samples of BALB/c mice were negative. In the segregating backcross I population, female BALB/c X male (female BALB/c X mal...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910160606
更新日期：1975-12-15 00:00:00
abstract：:Hormonal regulation of mouse mammary tumor virus (MMTV) synthesis was studied in the CCL-51-SF cell subline derived from the Sykes' mammary tumor cell line CCL-51 and adapted to grow in semi-synthetic in vitro conditions. The virus was quantitated by measuring the supernatant reverse transcriptase activity in exogenou...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910190215
更新日期：1977-02-15 00:00:00
abstract：:The REGb tumor cell line is a cloned variant of the DHD-K12 cell line, established from a colon carcinoma chemically induced in the rat. Unlike the parent DHD-K12 cell line, or other clones, which give progressive tumors when inoculated to the syngeneic rat, REGb cells produce tumors which regress in 3 to 5 weeks and ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910400518
更新日期：1987-11-15 00:00:00
abstract：:High-grade serous epithelial ovarian cancer (HGS-EOC) is a systemic disease, with marked intra and interpatient tumor heterogeneity. The issue of spatial and temporal heterogeneity has long been overlooked, hampering the possibility to identify those genomic alterations that persist, before and after therapy, in the g...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.32288
更新日期：2019-11-15 00:00:00
abstract：:Survival rates for osteosarcoma, the most common primary bone cancer, have changed little over the past three decades and are particularly low for patients with metastatic disease. We conducted a multi-institutional genome-wide association study (GWAS) to identify germline genetic variants associated with overall surv...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.31195
更新日期：2018-04-15 00:00:00
abstract：:Dietary factors in the aetiology of stomach cancer were investigated using data from a case-control study conducted in Northern Italy on 206 histologically confirmed carcinomas and 474 control subjects in hospital for acute, non-digestive conditions, unrelated to any of the potential risk factors for gastric cancer. D...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910400409
更新日期：1987-10-15 00:00:00
abstract：:Interleukin (IL)-2 has been approved for treatment of metastatic renal cancer and malignant melanoma. However, its unfavorable pharmacologic properties, severe side effects and the negative role of IL-2 in maintaining T regulatory cells are severe drawbacks. It has been shown that immunocomplexes of IL-2 and certain a...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.25859
更新日期：2011-10-15 00:00:00
abstract：:The recently identified cell adhesion regulator (CAR) modulates the process of integrin-mediated cell adhesion. The CAR gene is located on 16q, a locus at which high levels of allelic losses have been demonstrated in advanced human hepatocellular carcinoma (HCC). We studied the possible involvement of the CAR gene in ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19970620)74:3<251::aid-ijc
更新日期：1997-06-20 00:00:00
abstract：:Stage 4 neuroblastoma (NB) is a devastating childhood cancer whose poor outcome has remained essentially unchanged in the last 20 years. Receptor tyrosine kinases have important roles in the control of proliferation, differentiation and apoptosis of NB cells. Thus, we tested the activity of second-generation tyrosine ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.24606
更新日期：2009-12-01 00:00:00
abstract：:Six oncogenic cell lines were established from primary sarcomas that had been induced in thymectomized, aged, BALB/cSt mice by the injection of 3-methylcholanthrene. Of these lines, three produced B-tropic murine leukemia virus (MuLV), i.e. MuLV that would patently infect fibroblasts of BALB/c origin but not those fro...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910210216
更新日期：1978-02-15 00:00:00
abstract：:Some ovarian cancer cells in vivo are in a reversible quiescent state where they can contribute to cancer spread under favorable growth conditions. The serine/threonine kinase Mirk/dyrk1B was expressed in each of seven ovarian cancer cell lines and in 21 of 28 resected human ovarian cancers, and upregulated in 60% of ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.25692
更新日期：2011-07-15 00:00:00
abstract：:The Stockholm-Gotland Cancer Register was used to evaluate the clinical observation that patients with non-Hodgkin's lymphoma (NHL) had an increased risk of malignant melanoma or squamous-cell carcinoma of the skin (SCCS) and vice versa. During 1958-1992, NHL was diagnosed in a total of 6,176 patients. Of these patien...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910620505
更新日期：1995-09-04 00:00:00
abstract：:In order to identify regulatory genes involved in the development of an apoptosis-resistant phenotype in patients with chemotherapy refractory B-cell chronic lymphocytic leukemia (B-CLL) expression of apoptosis-regulating genes in B-CLL cells was quantified using cDNA arrays and RT-PCR. Data were obtained from and com...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.20614
更新日期：2005-02-20 00:00:00
