Abstract:
:Six oncogenic cell lines were established from primary sarcomas that had been induced in thymectomized, aged, BALB/cSt mice by the injection of 3-methylcholanthrene. Of these lines, three produced B-tropic murine leukemia virus (MuLV), i.e. MuLV that would patently infect fibroblasts of BALB/c origin but not those from NIH Swiss mice. One of these lines, M-138, produced large quantities of virus, permitting the isolation of milligram quantities of B-tropic MuLV. Neonatal BALB/c mice injected with the M-138 MuLV developed high plasma levels of the species-specific virion antigen p30, but during 9 months of observation failed to manifest clinical signs of leukemia. Plasma p30 levels of NIH Swiss mice (non-permissive host) that were inoculated also as neonates with the same virus preparation, remained undetectable by radioimmunoassay. Xenotropic MuLV, i.e. that which infects cells of species other than the species of origin, was released by one of the three remaining cell lines. Two of the six original lines have remained free of detectable oncornavirus production. Our results suggest that cell lines that are stable sources of large quantities of B-tropic MuLV may be easily obtainable by the described manipulations. Equally important, however, is the fact that these data re-emphasize the danger that is inherent in assuming that a cell line is virus-free simply because it was isolated from a chemical carcinogen-induced neoplasm
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Gillespie GY,Jensen FC,Russell SWdoi
10.1002/ijc.2910210216subject
Has Abstractpub_date
1978-02-15 00:00:00pages
234-8issue
2eissn
0020-7136issn
1097-0215journal_volume
21pub_type
杂志文章abstract::Licensed human papillomavirus (HPV) vaccines are expected to prevent high-risk (hr) HPV-infections (most notably types 16 and 18). Whether HPV vaccination will change the distribution of hrHPVs at the population level is open, since competition between HPV types is not well understood. Two stratified random subcohorts...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24539
更新日期:2009-11-01 00:00:00
abstract::Using antisera for two specific basement membrane (b.m.) antigens such as laminin and collagen type-IV, together with electron microscopy, we have shown that fully antigenic b.m. and morphologically typical basal lamina (b.l.) are associated with normal and transformed cells of the melanocyte lineage in different ways...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350408
更新日期:1985-04-15 00:00:00
abstract::Metastasis is a multistep process that involves the dissemination of cells from the primary tumor and colonization of distant secondary organs. Epithelial cells at the invasive front of a carcinoma acquire an enhanced migratory phenotype in a process called epithelial-to-mesenchymal transition (EMT). This cellular pla...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.30039
更新日期:2016-07-15 00:00:00
abstract::The potential role of p16(INK4a) methylation in breast cancer is controversial whereas there are no data on fibroadenoma. To assess if inactivation of p16(INK4a) by promoter hypermethylation occurs in this hyperproliferative benign breast lesion or, on the contrary, it is strictly related to the carcinogenic process, ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20771
更新日期:2005-04-10 00:00:00
abstract::We have examined the effect of various cell monolayers on the ability of mouse spleen cells to lyse tumor cell targets (natural cytotoxicity reaction). Natural killer (NK) cell activity was reduced by as much as 75% depending on the cell substrate, with the greatest protection afforded by endothelial cells. Cell adhes...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910410612
更新日期:1988-06-15 00:00:00
abstract::Previous studies have shown that macrophage cell lines retained the ability to phagocytize, to secrete lysosomal enzymes, and to function as effector cells in antibody-dependent cellular cytoxicity. In this paper, the cytolytic activity of murine macrophage cell lines against tumor target cells was assessed using an 1...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910260110
更新日期:1980-07-15 00:00:00
abstract::Parathyroid hormone-related protein (PTHrP) is a causative factor of humoral hypercalcemia in malignancy. However, it is difficult to explain the mechanism of anorexia/cachexia with PTHrP secretion in detail. Previously, we demonstrated that the expressions of orexigenic peptides increased and anorexigenic peptides de...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25535
更新日期:2011-05-01 00:00:00
abstract::Epithelial ovarian cancer is the most lethal gynecological malignancy and the fifth leading cause of cancer deaths in women in the Western world. ETS transcription factors are known to act as positive or negative regulators of the expression of genes that are involved in various biological processes, including those t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26148
更新日期:2012-04-01 00:00:00
abstract::The impact of the ABC transporters breast cancer resistance protein/mitoxantrone resistance associated transporter (BCRP/MXR), multidrug resistance-associated protein 1 (MRP1) and multidrug resistance gene-1/P-glycoprotein (MDR1/PGP) on the multidrug resistance (MDR) phenotype in chemoresistance and thermoresistance w...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10131
更新日期:2002-02-20 00:00:00
abstract::Polymorphisms in DNA repair genes may be associated with differences in the repair capacity of DNA damage and may thereby influence an individual's susceptibility to smoking-related cancer. We investigated the association between the -93G-->A polymorphism in the hMLH1 gene and the risk of lung cancer in a Korean popul...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20359
更新日期:2004-11-20 00:00:00
abstract::A human papillomavirus (HPV) was cloned from a patient with multiple squamous cell carcinomas (SCCs) and identified as HPV88, recently categorized into a new species within the genus Gamma. The HPV88 viral load in an SCC of the index patient exceeded 1 million copies/cell. By contrast, a survey of 447 skin lesions (79...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23115
更新日期:2008-01-15 00:00:00
abstract::The incidence of esophageal cancer is extremely high in Linxian County and certain other regions of the People's Republic of China. Epidemiologic and laboratory studies suggest that N-nitroso carcinogens and other environmental factors play a causative role. In the present study, employing over 100 DNA samples obtaine...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910420406
更新日期:1988-10-15 00:00:00
abstract::Luteolin is a polyphenolic flavone and has antitumor activity for many cancers. The prostate-derived Ets factor (PDEF), a novel epithelium-specific Ets transcription factor, acts as an androgen-independent transcriptional activator of the prostate-specific antigen (PSA) promoter. We determined the antitumor function o...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26284
更新日期:2012-06-15 00:00:00
abstract::The International Classification of Childhood Cancer (ICCC) updates the widely used Birch and Marsden classification scheme. ICCC is based on the second edition of the International Classification of Diseases for Oncology (ICD-O-2). The purpose of the new classification is to accommodate important changes in recogniti...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/(SICI)1097-0215(19961211)68:6<759::AID-IJC
更新日期:1996-12-11 00:00:00
abstract::In this study, the anticancer effect of prednisolone was investigated using rats with normal endogen adrenaline levels (intact), reduced adrenaline levels (metyrosine-induced) and adrenaline deficiency (adrenalectomized) via gastric adenocarcinoma model. Gastric adenocarcinoma was induced with N-methyl-N'-nitro-N-nitr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24869
更新日期:2010-04-01 00:00:00
abstract::Cancer survival among people with AIDS (PWA) has been described in developed countries, but there is lack of data from developing countries. The aim of this study was to evaluate survival after cancer diagnosis in PWA and compare it with people without AIDS (non-PWA) in São Paulo, Brazil. A probabilistic record linkag...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31081
更新日期:2018-02-01 00:00:00
abstract::Studies of the MLTI were performed in a primary MSV-induced tumor system. Reactivity against mitomycin-C-treated RBL-5 cells could be detected during a limited period at about 14 days after virus injection. The degree of reactivity of MSV 14 spleen cells was quite variable; stimulation indices ranged from 2.2 to 9.4. ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910170313
更新日期:1976-03-15 00:00:00
abstract::This review is one of two complementary reviews that have been prepared in the framework of the Eurogin Roadmap 2015 to evaluate how knowledge about HPV is changing practices in HPV infection and disease control through vaccination and screening. In this review of HPV vaccine knowledge, we present the most significant...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.30063
更新日期:2016-08-01 00:00:00
abstract::In order to establish the role of human papillomavirus (HPV) in carcinogenesis of epidermodysplasia verruciformis (EV), the presence, the molecular characteristics and the physical state of HPV DNA in a benign lesion, a primary carcinoma and a metastatic carcinoma developing in the same EV patient were studied and com...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910430611
更新日期:1989-06-15 00:00:00
abstract::Low ionic strength (50 to 100 mM NaCl) and pH 6.0 were found to be optimal conditions for in vitro conversion of Epstein-Barr virus (EBV)-determined nuclear antigen (EBNA)-negative nuclei to EBNA-positive nuclei by addition of the complement-fixing (CF) antigen extracted from Raji cells. In vitro conversion of nuclei ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910220505
更新日期:1978-11-15 00:00:00
abstract::The prognostic impact of distinct KRAS mutations in colorectal carcinomas is not fully characterized. We hypothesized that the prognostic impact of KRAS mutations is modulated by KRAS mutant allele-specific imbalance (MASI). KRAS MASI was assessed by sequencing electropherograms in KRAS-mutated colorectal carcinomas (...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27461
更新日期:2012-10-15 00:00:00
abstract::In a prospective study with a median follow-up of 13 months on a series of 71 breast cancer patients, 9 developed haematogenous metastases. The neu protein was found on the cell membranes in 27 of the 71 carcinomas (38%) by an immunohistochemical technique using a monoclonal antibody (MAb). Eight of the 9 patients wit...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910450112
更新日期:1990-01-15 00:00:00
abstract::A study was conducted in northern Iran in areas of very high, high and moderately low incidence of oesophageal cancer. Morphine metabolites in urine as an indicator of opium use, and a variety of nutritional and biochemical measures, including salivary antipyrine half-life, were determined in households with a case of...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350505
更新日期:1985-05-15 00:00:00
abstract::Spreading is a critical process involved in motility and growth of tumor cells during the metastatic cascade. Focal adhesion kinase, src-proteins and PKC have been reported to participate in the regulation of cytoskeleton organization in both normal and transformed cells during spreading. The role of other signaling e...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970529)71:5<881::aid-ijc
更新日期:1997-05-29 00:00:00
abstract::Hyaluronan (HA) has been shown to play important roles in the growth, invasion and metastasis of malignant tumors. Our previous study showing that high HA expression in malignant peripheral nerve sheath tumors (MPNST) is predictive of poor patient prognosis, prompted us to speculate that inhibition of HA synthesis in ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30460
更新日期:2017-01-15 00:00:00
abstract::There are approximately 100 genes which when mutated are known to predispose to one or more forms of cancer. Currently, genetic testing is offered for many of these, either as single genes or as multi-gene panels. Features of hereditary cancer include a positive family history of cancer, early age of onset and the app...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.28988
更新日期:2014-10-15 00:00:00
abstract::Women affected by gross cystic disease of the breast have an increased risk of breast cancer. We report here the incidence of breast cancer by cyst type and intracystic epidermal growth factor (EGF) concentration. Our retrospective study included 504 women who had at least 1 cyst aspiration between 1985 and 1993. Cyst...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20010720)95:4<260::aid-ijc1044>3
更新日期:2001-07-20 00:00:00
abstract::Oral microbiome may play an important role in cancer pathogenesis. However, no study has prospectively investigated the association of the oral microbiome with subsequent risk of developing colorectal cancer (CRC). We conducted a nested case-control study including 231 incident CRC cases and 462 controls within the So...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31941
更新日期:2019-05-15 00:00:00
abstract::The effects of DL-alpha-difluoromethylornithine (DFMO), a specific irreversible inhibitor of ornithine decarboxylase, on the growth of experimental mouse B16-F10 melanoma cells were investigated. DFMO (3%) in drinking water was administered to B16-F10 melanoma-bearing mice. At 24 days, B16-F10 melanomas in DFMO-fed mi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910390220
更新日期:1987-02-15 00:00:00
abstract::Effects of therapeutic and supratherapeutic concentrations of bosutinib, a dual Src/Abl tyrosine kinase inhibitor, on the corrected QT interval (QTc) in 60 healthy adults were assessed, according to ICH-E14 guidelines, in this 2-part, randomized, single-dose, double-blind, crossover, placebo- and open-label moxifloxac...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1002/ijc.27348
更新日期:2012-08-01 00:00:00