Abstract:
:A study was conducted in northern Iran in areas of very high, high and moderately low incidence of oesophageal cancer. Morphine metabolites in urine as an indicator of opium use, and a variety of nutritional and biochemical measures, including salivary antipyrine half-life, were determined in households with a case of oesophageal cancer and in control households. Results on 1,590 individuals showed that the prevalence of appreciable levels (greater than or equal to 1 microgram/ml) of urinary morphine metabolites was much higher in areas of high and very high incidence of oesophageal cancer than in low-incidence areas, particularly for those under age 50 years in both sexes, where a 6-fold difference was seen. Members of households with a case of oesophageal cancer had a higher prevalence of positive urinary morphine metabolite findings than members of control households from the same village. Salivary anti-pyrine half-life (AP-T1/2), as a measure of hepatic drug metabolizing capacity, was estimated in 120 subjects. No relationship was seen with use of opium, region of residence, case-control status of household, age or sex. Experimental studies have meanwhile identified mutagenic substances with carcinogenic potential in opium pipe scrapings, used widely in the study region, opium pyrolysates and morphine pyrolysates. Our data give additional support to the hypothesis that opium use, in the form of its pyrolysates, is one of the factors involved in the aetiology of oesophageal cancer in the region.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Ghadirian P,Stein GF,Gorodetzky C,Roberfroid MB,Mahon GA,Bartsch H,Day NEdoi
10.1002/ijc.2910350505subject
Has Abstractpub_date
1985-05-15 00:00:00pages
593-7issue
5eissn
0020-7136issn
1097-0215journal_volume
35pub_type
杂志文章abstract::Tumor infiltrating T cells are a predictor of patient outcome in patients with colorectal cancer (CRC). However, many T cell populations have been associated with both poor and positive patient prognoses, indicating a need to further understand the role of different T cell subsets in CRC. In this study, the T cell inf...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31598
更新日期:2018-10-15 00:00:00
abstract::Little is known about age-dependent variation in outcomes of cervical cytology with modern technologies. This population-based study evaluated age-dependent changes after routine implementation of ThinPrep and SurePath technology in two independent laboratories, and controlled for time trends in a third laboratory usi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28532
更新日期:2014-05-01 00:00:00
abstract::A new cell line from a sporadic Wilms' tumor was established and extensively characterized. In nude mice, the tumor cells rapidly formed tumors which, in histological characteristics and extracellular-matrix (ECM) composition resembled sarcomatoid Wilms' tumor. The tumor cells produced B chains of laminin, but no A ch...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910540524
更新日期:1993-07-09 00:00:00
abstract::RAGE is a central driver of tumorigenesis by sustaining an inflammatory tumor microenvironment. This study links the soluble forms of RAGE (sRAGE and esRAGE) with clinical outcome of melanoma patients. Moreover, tissue expression of RAGE was analyzed using immunohistochemistry on two independent tissue microarrays (TM...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29619
更新日期:2015-12-01 00:00:00
abstract::Two metastatic cell lines, mouse B16-Fl melanoma and human Hs939 melanoma, were examined for their abilities to adhere to confluent vascular endothelial cell monolayers and to the underlying endothelial extracellular matrix. Tumor cells attacked slowly to the endothelial cell monolayers while they adhered rapidly to i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910260516
更新日期:1980-11-15 00:00:00
abstract::Human papillomavirus (HPV)-associated penile lesions in men may increase the risk of HPV transmission to their female partners. Risk factor data on HPV-associated penile lesions are needed from regions with a high burden of cervical cancer. Visual inspection of the penis was conducted using a colposcope at the 24-mont...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26196
更新日期:2012-04-15 00:00:00
abstract::The involvement of 12-lipoxygenase (12-LOX) expression and function in tumor metastasis has been demonstrated in several murine tumor cell lines. In addition, 12-LOX expression was detected in human prostatic tumors and correlated to the clinical stage of disease. Here we provide data that human prostate cancer cell l...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20000701)87:1<37::aid-ijc6>3.0.c
更新日期:2000-07-01 00:00:00
abstract::We conducted a longitudinal cohort study to determine the association of Helicobacter pylori infection and the progression of chronic atrophic gastritis (CAG) with gastric cancer. A cohort of 4655 healthy asymptomatic subjects was followed for a mean period of 7.7 years. H. pylori infection was established by serum sp...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11680
更新日期:2004-03-01 00:00:00
abstract::Using morphometric and immunohistological techniques, we investigated the distribution of T lymphocytes and subsets, B lymphocytes, macrophages and plasma cells in sections of human breast tissue. In normal lobules and ducts, leukocytes were found in greater density in the epithelium than in the stroma. The intra-epit...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910360404
更新日期:1985-10-15 00:00:00
abstract::Aberrant methylation of CpG islands (CGI) not only plays a role in gene silencing, but is also a potential cancer biomarker. To identify more CGI aberrantly methylated in human breast cancers, we carried out a genome-wide search for aberrant methylation, using methylation-sensitive-representational difference analysis...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21054
更新日期:2005-09-01 00:00:00
abstract::The levels of tumour-specific antigen, antibody and specific immune complexes in the sera of rats bearing lung nodules of a chemically induced rat hepatoma, produced by intravenous inoculation of viable tumour cells, have been examined and compared with the levels of serum factors in animals actively immunized by intr...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910170214
更新日期:1976-02-15 00:00:00
abstract::W/Fu rats were injected subcutaneously with low numbers of cells from the Gross leukemia virus-induced lymphoma, (C58NT)D, which induced transient tumor growth and regression (regressors), or with high numbers of tumor cells resulting in progressive tumor growth (progressors). Spleen cells from regressors had a signif...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910160305
更新日期:1975-09-15 00:00:00
abstract::Environmental carcinogens often induce specific mutations in the p53 gene, apparent in tumors. The relation between aflatoxin B1 (AFB1 )-related hepatocellular carcinomas (HCCs) and hot spot at codon 249 of the p53 gene has received a great deal of attention, but its significance is still controversial. To clarify thi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990719)82:2<187::aid-ijc
更新日期:1999-07-19 00:00:00
abstract::Tumor cells express the glycolytic regulator pyruvate kinase subtype M2 (M2-PK), which can occur in a tetrameric form with high affinity to its substrate phosphoenolpyruvate (PEP) and a dimeric form with a low PEP affinity. The transition between both conformations contributes to the control of glycolysis and is impor...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23512
更新日期:2008-07-15 00:00:00
abstract::Two genes encoding the latent membrane protein 1 (LMP1) of the Epstein-Barr virus (EBV) were isolated from a single case of Hodgkin's disease (HD) and were tested for their biological activities. The LMP1 gene from the Reed-Sternberg cells contained point mutations relative to the prototype LMP1 gene, leading to amino...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980413)76:2<194::aid-ijc
更新日期:1998-04-13 00:00:00
abstract::The MDM2 gene encodes a 90-kDa oncoprotein that is overexpressed in several human carcinomas, osteosarcomas, gliomas and soft tissue sarcomas (STSs). This overexpression is the result of several mechanisms, for example, enhanced transcription or translation, gene amplification and alternative splicing. We found that 1...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20010520)95:3<168::aid-ijc1029>3
更新日期:2001-05-20 00:00:00
abstract::Ubiquitin-conjugated proteins in human colorectal cancer tissues were analyzed by the immunoprecipitation with the antibody FK2 against conjugated ubiquitin followed with SDS-PAGE. In these immunoprecipitable proteins, a 38-kDa protein was abundant in the tumor regions but almost absent in the adjacent normal regions ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1524
更新日期:2001-12-01 00:00:00
abstract::Neuroblastoma (NBL), one of the most common childhood solid tumors, has a distinct nature in different prognostic subgroups. However, the precise mechanism underlying this phenomenon remains largely unknown. To understand the molecular and genetic bases of neuroblastoma, we have generated its cDNA libraries and identi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20431
更新日期:2004-11-10 00:00:00
abstract::There is a familial aggregation of prostate cancer, and 5 to 10% of all prostate cancers are estimated to be inherited in an autosomal-dominant mode. A population-based cohort study was performed in order to study familial prostate cancer and associated malignancies. A nation-wide register cohort study was conducted u...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19981029)78:3<293::AID-IJC
更新日期:1998-10-29 00:00:00
abstract::Malignant glioma is one of the most aggressive cancers. For the development of effective therapeutic strategies against such malignant diseases, elucidation of molecular targets is necessary. We found that inactivated Sendai virus particle (HVJ-E) induced extensive cell death in the human glioblastoma cell line U251MG...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24965
更新日期:2010-04-15 00:00:00
abstract::To determine the relationship between p16MTS1/CDK4I expression, gene inactivation and 9p21 loss of heterozygosity (LOH) in the development of laryngeal carcinomas, we have examined p16MTS1/CDK4I protein and mRNA expression in a series of 7 normal and 36 tumoral tissues, and the presence of gene alterations and 9p21 LO...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990531)81:5<705::aid-ijc
更新日期:1999-05-31 00:00:00
abstract::In order to examine whether or not the expression of the apoptosis-related receptor Fas (CD-95/APO-1) and its ligand (FasL) has relevance for patient survival, immunohistochemistry was used to analyze the proteins of both factors in 164 non-small cell lung carcinomas. Patients with Fas-positive tumors exhibited signif...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990621)84:3<239::aid-ijc
更新日期:1999-06-21 00:00:00
abstract::Women affected by gross cystic disease of the breast have an increased risk of breast cancer. We report here the incidence of breast cancer by cyst type and intracystic epidermal growth factor (EGF) concentration. Our retrospective study included 504 women who had at least 1 cyst aspiration between 1985 and 1993. Cyst...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20010720)95:4<260::aid-ijc1044>3
更新日期:2001-07-20 00:00:00
abstract::Retinoic acid (RA) and its natural and synthetic analogs, the retinoids, regulate many biological processes, including development, differentiation, cell growth, morphogenesis, metabolism and homeostasis. Retinoid effects are mediated by specific nuclear receptors, the RARs and RXRs. Because of their ability to contro...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990118)80:2<272::aid-ijc
更新日期:1999-01-18 00:00:00
abstract::Ninety-eight cases of transitional-cell carcinoma (TCC) of the renal pelvis and ureter, including dysplastic lesions, were studied for tumor incorporation of human papillomavirus (HPV) type-16 and type-18 DNA by in situ hybridization (ISH) with DNA probes for each HPV viral type. Immunohistochemical analysis of p53 ex...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910640503
更新日期:1995-10-20 00:00:00
abstract::Cigarette smoking and alcohol consumption were examined as potential risk factors in a case-control study of primary liver cancer (PLC). A total of 165 PLC cases and 465 matched controls from several US hospitals were studied. A weak but statistically significant (p less than 0.05) dose-response relationship was obser...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910420304
更新日期:1988-09-15 00:00:00
abstract::Salvicine is a diterpenoid quinone derived from a traditional Chinese medication that has been shown to possess potent in vitro and in vivo antitumor effects. This compound, which inhibits the activity of Topoisomerase II, was found to equipotently kill various multidrug-resistant tumor cells and their corresponding p...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20026
更新日期:2004-07-10 00:00:00
abstract::CA 50 is a new tumor marker based on a monoclonal antibody (MAb) against a human colorectal carcinoma cell line. The CA 50 antigen is similar, but not identical, to the tumor marker CA 19-9. The serum concentrations of CA 50 were measured by an immunoradiometric assay (CA 50 IRMA) in 95 patients with pancreatic cancer...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910390412
更新日期:1987-04-15 00:00:00
abstract::Since no large descriptive studies of incident cancers in HIV-infected patients are available in France, the nationwide cross-sectional ONCOVIH study aimed to prospectively report new malignancies diagnosed in HIV-infected patients in cancer centers and HIV/AIDS centers. We estimated the number of cancers in France fo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25903
更新日期:2011-07-15 00:00:00
abstract::Meibomian gland carcinoma (MGC) and basal cell carcinoma (BCC) are common eyelid carcinomas that exhibit highly dissimilar degrees of proliferation and prognoses. We address here the question of the differential mechanisms between these two eyelid cancers that explain their different outcome. A total of 102 confirmed ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29882
更新日期:2016-03-15 00:00:00