The international classification of childhood cancer.

abstract：:O6-alkylguanine-DNA alkyltransferase (MGMT) represents the first line of defense against the toxic, mutagenic and carcinogenic effects of O6-alkylguanine adducts in DNA. These adducts mediate the biological activity from a series of alkylating agents, such as the tobacco-specific nitrosamines, believed to contribute t...

journal_title：International journal of cancer

authors： Povey AC,O'Donnell P,Barber P,Watson M,Margison GP,Santibáñez Koref MF

更新日期：2006-07-15 00:00:00

abstract：:Previous studies have shown that the in vitro-selected adriamycin-resistant human small-cell lung-carcinoma cell line GLC4-ADR150 displays multidrug resistance as the result of 3-fold decreased DNA-topoisomerase II (topo II) activity and a 6-fold reduction in adriamycin accumulation. Not the MDR1 gene, but the MRP gen...

journal_title：International journal of cancer

authors： Versantvoort CH,Withoff S,Broxterman HJ,Kuiper CM,Scheper RJ,Mulder NH,de Vries EG

更新日期：1995-05-04 00:00:00

abstract：:The U.S. Preventive Services Task Force (USPSTF) recently updated their national lung screening guidelines and recommended low-dose computed tomography (LDCT) for lung cancer (LC) screening through age 80. However, the risk of overdiagnosis among older populations is a concern. Using four comparative models from the C...

journal_title：International journal of cancer

authors： Han SS,Ten Haaf K,Hazelton WD,Munshi VN,Jeon J,Erdogan SA,Johanson C,McMahon PM,Meza R,Kong CY,Feuer EJ,de Koning HJ,Plevritis SK

更新日期：2017-06-01 00:00:00

abstract：:The present experiments were performed to investigate the possibility of inhibiting tumor growth in vivo with syngeneic lymphocytes sensitized in vitro on monolayers of the tumor under test, and to study the effect of a thymic humoral factor (THF) in this sensitization process. Monolayers of fibrosarcoma cells were us...

journal_title：International journal of cancer

authors： Small M,Trainin N

更新日期：1975-06-15 00:00:00

abstract：:We have shown in the preceding paper that AKR mice are highly resistant to M-MSV tumor development, and that resistance is transmitted as a dominant character. In the present studies the tumor-response pattern of F1 hybrids between resistant AKR and susceptible strains (C57Bl/6, BALB/c and B10BR) following injection w...

journal_title：International journal of cancer

authors： Colombatti A,Collavo D,Biasi G,Chieco-Bianchi L

更新日期：1975-09-15 00:00:00

abstract：:We quantified the expression of survivin, both as mRNA in real-time PCR and protein in immunohistochemistry, in tumor samples of 112 patients with esophageal cancer (56 squamous cell carcinomas and 56 adenocarcinomas). Overall survival of squamous cell carcinoma patients with high survivin mRNA levels was significantl...

journal_title：International journal of cancer

authors： Rosato A,Pivetta M,Parenti A,Iaderosa GA,Zoso A,Milan G,Mandruzzato S,Del Bianco P,Ruol A,Zaninotto G,Zanovello P

更新日期：2006-10-01 00:00:00

abstract：:We examined pp60c-src protein kinase activity in human gastric carcinoma cell lines and gastric carcinoma tissues as well as normal mucosa. pp60c-src kinase activity was detected in all 5 carcinoma cell lines at various levels. Of 16 gastric carcinoma tissues, 8 showed higher pp60c-src kinase activity in tumor tissues...

journal_title：International journal of cancer

authors： Takekura N,Yasui W,Yoshida K,Tsujino T,Nakayama H,Kameda T,Yokozaki H,Nishimura Y,Ito H,Tahara E

更新日期：1990-05-15 00:00:00

abstract：:In a previous study, human ZNF312b was identified as a cell proliferation-associated oncogene via the K-ras/extracellular signal-regulated kinase cascade in gastric cancer. However, the mechanism concerning its transcriptional activation remains unknown. Here, we show that DNA methylation and histone acetylation of th...

journal_title：International journal of cancer

authors： Song IS,Ha GH,Kim JM,Jeong SY,Lee HC,Kim YS,Kim YJ,Kwon TK,Kim NS

更新日期：2011-11-01 00:00:00

abstract：:The ability of endogenously synthesized protoporphyrin IX (PpIX) to damage Chinese hamster lung fibroblasts of the line V79 by exposure to light was examined. This treatment induced reduction of cellular ATP, GTP, of the NADH/NAD+ ratio and of oxygen consumption. The present results indicate a close relationship betwe...

journal_title：International journal of cancer

authors： Shevchuk I,Chekulayev V,Moan J,Berg K

更新日期：1996-09-17 00:00:00

abstract：:Mesothelin is a glycosylphosphatidylinositol-anchored glycoprotein that is highly expressed on the cell surface of mesothelioma, ovarian cancer and other malignant tumors. The interaction between mesothelin and CA125 (also called MUC16) may facilitate the implantation and metastasis of tumors in the peritoneal cavity....

journal_title：International journal of cancer

authors： Ho M,Feng M,Fisher RJ,Rader C,Pastan I

更新日期：2011-05-01 00:00:00

abstract：:Our study explored the drug interaction of all-trans retinoic acid (ATRA) and RAD001 (everolimus), the inhibitor of mammalian target of rapamycin complex 1 (mTORC1), in acute myelogenous leukemia (AML) NB4 and HL60 cells. RAD001 (10 nM) significantly enhanced the ATRA-induced growth arrest and differentiation of these...

journal_title：International journal of cancer

authors： Nishioka C,Ikezoe T,Yang J,Gery S,Koeffler HP,Yokoyama A

更新日期：2009-10-01 00:00:00

abstract：:The role of retinoic acid receptor (RAR) expression in sensitivity to N-(4-hydroxyphenyl)retinamide (4HPR or fenretinide) as well as on the tumorigenicity of human ovarian carcinoma cells was examined. Two human ovarian cancer cell lines, A2780 and IGROV-1, with a 10-fold difference in sensitivity to 4HPR were chosen ...

journal_title：International journal of cancer

authors： Pergolizzi R,Appierto V,Crosti M,Cavadini E,Cleris L,Guffanti A,Formelli F

更新日期：1999-05-31 00:00:00

abstract：:Immunosuppressed patients who develop non-Hodgkin's lymphoma (NHL) have abnormal antibody responses against the Epstein-Barr virus (EBV) prior to the diagnosis of malignancy. To see if this is also true of "spontaneous" cases in the general population, we undertook a collaborative serologic case-control study. From 4 ...

journal_title：International journal of cancer

authors： Mueller N,Mohar A,Evans A,Harris NL,Comstock GW,Jellum E,Magnus K,Orentreich N,Polk BF,Vogelman J

更新日期：1991-09-30 00:00:00

abstract：:Transmission routes of Kaposi's sarcoma-associated herpesvirus (KSHV) in the general population are poorly understood. Whereas sexual transmission appears to be common in homosexual men, the evidence for heterosexual transmission is less convincing. In our study, prevalence of KSHV infection was examined among women i...

journal_title：International journal of cancer

authors： de Sanjosé S,Marshall V,Solà J,Palacio V,Almirall R,Goedert JJ,Bosch FX,Whitby D

更新日期：2002-03-01 00:00:00

abstract：:The modulation of DNA topology by topoisomerase II plays a crucial role during chromosome condensation and segregation in mitosis and has thus become a highly attractive target for chemotherapeutic drugs. However, these drugs are highly toxic, and so new approaches are required. One such strategy is to target topoisom...

journal_title：International journal of cancer

authors： Barker CR,Hamlett J,Pennington SR,Burrows F,Lundgren K,Lough R,Watson AJ,Jenkins JR

更新日期：2006-06-01 00:00:00

abstract：:High epidermal growth factor (EGF) concentration (10(-8) M) induces inhibition of A431 cell proliferation, resulting in part from an apoptotic process. For some cells escaping this process, proliferation was associated with a decrease in apoptosis. Moreover, these surviving cells displayed marked morphological changes...

journal_title：International journal of cancer

authors： Smida Rezgui S,Honore S,Rognoni JB,Martin PM,Penel C

更新日期：2000-08-01 00:00:00

abstract：:Non-small-cell lung cancers (NSCLC) are often infiltrated by T lymphocytes. It is postulated that the presence of tumor-infiltrating lymphocytes (TIL) reflects a local host immune response against autologous tumors. To identify the nature of NSCLC TIL, we have characterized the molecular structure of the TCRbeta chain...

journal_title：International journal of cancer

authors： Echchakir H,Asselin-Paturel C,Dorothee G,Vergnon I,Grunenwald D,Chouaib S,Mami-Chouaib F

更新日期：1999-04-12 00:00:00

abstract：:Using nationwide Danish registries we examined the long-term risk of cervical cancer in women diagnosed with cervical intraepithelial neoplasia grade 3 (CIN3) (including adenocarcinoma in situ (AIS)) on the cone compared to women with a normal cytology test. Initially, we identified women born 1918-1990, who were reco...

journal_title：International journal of cancer

authors： Sand FL,Frederiksen K,Munk C,Jensen SM,Kjaer SK

更新日期：2018-05-01 00:00:00

abstract：:In a series of 87 primary breast tumors, somatostatin receptor (SSR) expression was detected by in vitro autoradiography in 58 tumors. In 41 tumors the SSR expression was homogeneous and in 17 it was heterogeneous. Although the tumors were not selected by the investigators upon entry in the study, examination of the t...

journal_title：International journal of cancer

authors： Bootsma AH,van Eijck C,Schouten KK,Reubi JC,Waser B,Foekens JA,van Pel R,Zwarthoff EC,Lamberts SW,de Klein A

更新日期：1993-05-28 00:00:00

abstract：:Akt is a promising therapeutic target for cancer treatment. In our study, we have identified that 7-deoxynarciclasine (7-DONCS) is a potential inhibitor of Akt, which results in the repression of multiple oncogenic processes in hepatocellular carcinoma (HCC). We have found that 7-DONCS suppresses the growth of HCC by ...

journal_title：International journal of cancer

authors： Yin S,Qiu Y,Jin C,Wang R,Wu S,Liu H,Koo S,Han L,Zhang Y,Gao X,Pang X,Wang T,Yu H

更新日期：2019-12-15 00:00:00

abstract：:We examined the expression of tumor-suppressor protein p53 in a variety of laryngeal carcinomas from 43 patients (25 primary, 13 metastatic and 5 recurrent cases), 13 normal laryngeal tissues and 7 benign laryngeal nodule biopsy specimens, using the polyclonal antibody CM-1. Previously we have reported a high incidenc...

journal_title：International journal of cancer

authors： Anwar K,Nakakuki K,Imai H,Naiki H,Inuzuka M

更新日期：1993-04-01 00:00:00

abstract：:We have recently shown that an adenovirus carrying REIC/Dkk-3 (Ad-REIC) exhibits a potent tumor-specific cell-killing function for various human cancers. It has also become evident that some human cancers are resistant to Ad-REIC-induced apoptosis. The aim of the present study was to determine the molecular mechanisms...

journal_title：International journal of cancer

authors： Tanimoto R,Sakaguchi M,Abarzua F,Kataoka K,Kurose K,Murata H,Nasu Y,Kumon H,Huh NH

更新日期：2010-04-01 00:00:00

abstract：:The cis-2a,3-diol and the trans-4,5-, trans-7,8-, trans-9,10- and trans-11,12-dihydrodiols of 3-methylcholanthrene and the trans-3,4, trans-5,6-, trans-8,9. and trans-10,11- dihydrodiols of 7,12-dimethylbenz[a]anthrancene have been tested, in comparison with the parent hydrocarbons, for their abilities to initiate sk...

journal_title：International journal of cancer

authors： Chouroulinkov I,Gentil A,Tierney B,Grover PL,Sims P

更新日期：1979-10-15 00:00:00

abstract：:A randomized clinical trial designed to compare the effectiveness of cytoxan (CTX) alone versus a combination consisting of CTX, vincristine (Oncovin) and methotrexate (COM) in the treatment of Burkitt's lymphoma (BL) was carried out. Nineteen patients were selected at random to receive CTX alone while 21 received COM...

journal_title：International journal of cancer

authors： Olweny CL,Katongole-Mbidde E,Kaddu-Mukasa A,Atine I,Owor R,Lwanga S,Carswell W,Magrath IT

更新日期：1976-04-15 00:00:00

abstract：:The nature of 15 immortal mouse liver epithelial cell (MLEC) lines established from normal C3H mice was investigated specifically in terms of ras oncogene activation. Neither transforming activity nor point mutation within codon 61 of c-H-ras could be demonstrated in any of the cell lines by DNA transfection in a NIH/...

journal_title：International journal of cancer

authors： Lee GH,Sakai R,Nagao M,Kitagawa T

更新日期：1991-01-02 00:00:00

abstract：:We compared and contrasted intracranial (i.c.) and subcutaneous (s.c.) heterotransplantation of small-cell carcinoma of the lung (SCCL) into athymic nude mice. Fresh human SCCL tumor specimens, tumor colonies grown in soft agarose and continuous cell lines were used. Tumors induced by the three types of specimens were...

journal_title：International journal of cancer

authors： Gazdar AF,Carney DN,Sims HL,Simmons A

更新日期：1981-12-01 00:00:00

abstract：:For patients with brain tumors identification of diagnostic and prognostic markers in easy accessible biological material, such as plasma or cerebrospinal fluid (CSF), would greatly facilitate patient management. MIC-1/GDF15 (growth differentiation factor 15) is a secreted protein of the TGF-beta superfamily and emerg...

journal_title：International journal of cancer

authors： Shnaper S,Desbaillets I,Brown DA,Murat A,Migliavacca E,Schluep M,Ostermann S,Hamou MF,Stupp R,Breit SN,de Tribolet N,Hegi ME

更新日期：2009-12-01 00:00:00

abstract：:Immunochromatographical fecal occult blood tests were shown to have higher sensitivity for detecting colorectal neoplasms than the commonly used guaiac-based test. However, positivity rates, sensitivity and specificity vary widely. We aimed to assess the reasons for this heterogeneity. Six dichotomous (qualitative) im...

journal_title：International journal of cancer

authors： Brenner H,Haug U,Hundt S

更新日期：2010-10-01 00:00:00

abstract：:The purpose of this study was to assess the relationship between progression-free survival (PFS) in patients treated with DFMO + PCV (procarbazine, CCNU, vincristine) chemotherapy for malignant gliomas with tumor cell ornithine decarboxylase (ODC) activity. Formalin-fixed slides were obtained for study patients with a...

journal_title：International journal of cancer

authors： Levin VA,Jochec JL,Shantz LM,Aldape KD

更新日期：2007-11-15 00:00:00

abstract：:Seminomas and control tissues were analyzed for several tumor markers. Very high levels of placental alkaline phosphatase (PLAP)-like enzyme levels were found in all 18 seminomas studied. The majority of the seminomas were of phenotype I, thus differing from palcental PLAP. The mean amount of enzyme protein as measure...

journal_title：International journal of cancer

authors： Yamamoto H,Rudén U,Ljungdahl-Ståhle E,Brehmer-Andersson E,Hirano K,Hisazumi H,Stigbrand T,Wahren B

更新日期：1987-11-15 00:00:00