Abstract:
:We quantified the expression of survivin, both as mRNA in real-time PCR and protein in immunohistochemistry, in tumor samples of 112 patients with esophageal cancer (56 squamous cell carcinomas and 56 adenocarcinomas). Overall survival of squamous cell carcinoma patients with high survivin mRNA levels was significantly less than that of patients with low survivin mRNA levels (p = 0.0033). Distribution pattern of survivin (nuclear vs. cytoplasmic or mixed) was not correlated to survival, while the extent of immunostaining was significantly correlated to survivin mRNA values (p = 0.016) and had prognostic relevance in univariate analysis (p = 0.0012). Cox's proportional-hazard regression model showed that tumor survivin expression in esophageal squamous cell carcinoma was the most important prognostic factor, independent of tumor stage and other histopathological factors, both as mRNA relative value (p = 0.0259) and protein immunostaining (p = 0.0147). In esophageal adenocarcinoma, survivin expression and pattern of distribution had no prognostic relevance. Thus, quantifying survivin expression provides a prognostic marker only for esophageal squamous tumors.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Rosato A,Pivetta M,Parenti A,Iaderosa GA,Zoso A,Milan G,Mandruzzato S,Del Bianco P,Ruol A,Zaninotto G,Zanovello Pdoi
10.1002/ijc.21923subject
Has Abstractpub_date
2006-10-01 00:00:00pages
1717-22issue
7eissn
0020-7136issn
1097-0215journal_volume
119pub_type
杂志文章abstract::Microsatellite instability (MSI) has been reported to occur in a wide variety of sporadic tumours, such as colorectal and gastric cancers. MSI positivity has been associated with a particular clinico-pathologic profile, including the presence of abundant lymphoid infiltration, poor differentiation and a relatively goo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990827)82:5<644::aid-ijc
更新日期:1999-08-27 00:00:00
abstract::Apurinic/apyrimidinic (AP) sites are common mutagenic and cytotoxic DNA lesions that arise from the loss of normal bases. APE1, the major AP endonuclease of human cells, plays a central role in the repair of AP sites through both its endonuclease and phosphodiesterase activities. A common APE1 polymorphism, a T-->G tr...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.21768
更新日期:2006-06-15 00:00:00
abstract::A critical requirement for cancer vaccines is that they stimulate CD8+ T cell responses. In this study, we tested the ability of a polyvalent melanoma vaccine to induce CD8+ T cell responses to the melanoma associated antigens MAGE-3 and Melan A/MART-1. Fifteen HLA-A2+ patients with resected malignant melanoma were im...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章
doi:10.1002/(sici)1097-0215(19970917)72:6<972::aid-ijc
更新日期:1997-09-17 00:00:00
abstract::A population-based case-control study of esophageal cancer was conducted in urban Shanghai involving interviews with 902 cases and 1,552 controls. Risk of esophageal cancer was increased among tobacco smokers and alcohol drinkers. Odds ratios (OR) for smoking were 2.1 and 1.6 for men and women, respectively, and incre...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910580208
更新日期:1994-07-15 00:00:00
abstract::XIAP directly inhibits executor caspases, making it the most downstream antiapoptotic molecule. Here, we examined the expression and function of XIAP in normal urothelium and TCC. We also examined the therapeutic effect of xiap AS PODN on the cell cycle and apoptosis of multidrug-resistant T24 bladder cancer cells. XI...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10776
更新日期:2003-01-01 00:00:00
abstract::Thrombin is now recognized as an important factor in many cancers. Here, we examined the expression and role of the recently discovered thrombin receptor PAR4, in human colon cancer cells. PAR4 mRNA was found in 10 out of 14 (71%) human colon cancer cell lines tested but not in epithelial cells isolated from normal hu...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24070
更新日期:2009-04-01 00:00:00
abstract::Transferrin is required for proliferation of most cells in culture. This effect is presumably mediated by the binding of transferrin to its receptor, a surface glycoprotein which is preferentially expressed by actively growing cells. Here we show that normal human fibroblasts cultured in serum, and other media contain...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910310118
更新日期:1983-01-15 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the most common type of primary tumor in the liver and is a leading cause of cancer-related death worldwide. Activated hepatic stellate cells (HSCs) are key components of the HCC microenvironment and play an important role in the onset and progression of HCC through the secretion of g...
journal_title:International journal of cancer
pub_type: 杂志文章,评审
doi:10.1002/ijc.32899
更新日期:2020-09-15 00:00:00
abstract::The Swedish Family-Cancer Database was used to analyze second cancers after oral, esophageal, rectal, cervical, genital and skin (squamous cell carcinoma) cancers. A strong and consistent association of second cancers was observed at all these sites, in men and women. As a novel finding, an association of rectal cance...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1319
更新日期:2001-07-15 00:00:00
abstract::Fibronectin in human solid tumors was studied by indirect immunofluorescence staining of biopsy material. Altogether 73 tumors were examined, comprising 12 sarcomas, 3 melanomas 1 reticulum cell sarcoma, 39 carcinomas, 6 benign soft-tissue tumors and 12 benign epithelial tumors. In all sarcomas the individual tumor ce...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270403
更新日期:1981-01-01 00:00:00
abstract::Membrane-type metalloproteinase-1 (MT1-MMP) is a transmembrane metalloproteinase overexpressed in tumors, which plays a major role in the first step of pro-MMP-2 activation, leading to the generation of an intermediate 62 kDa species. The second step of MMP-2 activation that yields to the mature form is less understoo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10134
更新日期:2002-03-01 00:00:00
abstract::A reanalysis of the Women's Health Initiative (WHI) randomized clinical trial found a significant interaction between supplementation with vitamin D/calcium and estrogen therapy and the risk of colorectal cancer risk, with reduced risks from supplementation limited to the placebo arms of the estrogen trials. To explor...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24903
更新日期:2010-04-15 00:00:00
abstract::MicroRNAs (mirs) are small noncoding RNA molecules (~22 nucleotides) that regulate posttranscriptional gene expression. Currently, there has not been a comprehensive study of their role in primary head and neck squamous cell carcinoma (HNSCC). To determine the role of mirs in HNSCC, we screened for altered microRNA ex...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23831
更新日期:2008-12-15 00:00:00
abstract::In mice as well as humans, cytotoxic T lymphocytes (CTL) specific for wild-type-sequence (wt) p53 peptides have been shown to react against a wide range of tumors, but not normal cells. As such, they are attractive candidates for developing broadly applicable cancer vaccines. Of particular interest is the potential of...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20686
更新日期:2005-03-01 00:00:00
abstract::OK-432, a streptococcal preparation, and BCG effectively inhibited splenomegaly in Friend leukemia virus (FLV)-infected mice. Divided drug dosage resulted in stronger inhibition than single administration. When the second dose was fixed at the 3rd pre-infection day, the best timing for the first dose was approximately...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910250117
更新日期:1980-01-15 00:00:00
abstract::In chronic lymphocytic leukemia (CLL) cells, both interleukin-6 (IL-6) and the B-cell receptor (BCR) activate Janus kinase 2 (JAK2) and induce the phosphorylation of signal transduction and activator of transcription 3 (STAT3) on tyrosine 705 residues. However, whereas IL-6 phosphorylates STAT3 within 15 min, stimulat...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30892
更新日期:2017-11-15 00:00:00
abstract::We present a pilot study that aims to examine the possibility to easily and noninvasively detect and discriminate females with ovarian cancer (OC) from females that have no tumor(s) and from females that have benign genital tract neoplasia, using exhaled breath samples. The study is based on clinical samples and data ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29166
更新日期:2015-03-15 00:00:00
abstract::Transforming growth factor-beta (TGF-beta) inhibits epithelial cell proliferation. Inactivation of the TGF-beta signaling pathway is thought to play a role in tumorigenesis. Our purpose was to clarify the correlation between TGF-beta receptors or TGF-beta 1 expression and the clinicopathologic characteristics of patie...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10929
更新日期:2003-03-20 00:00:00
abstract::Chromosome 17 is a frequent target during breast-cancer formation and progression. It has been shown to be affected by allele losses at multiple sites, as well as by DNA amplification. Our aim was to delineate a map of the genetic alterations on chromosome 17 in a given set of breast tumors. To this end we analyzed 15...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910560208
更新日期:1994-01-15 00:00:00
abstract::Professional antigen-presenting cells (APC), e.g. dendritic cells, express immuno-proteasome components and process proteins for MHC presentation differently from non-immune cells. Thus, they induce reactivities against sets of peptides that do not overlap with those generated by non-professional APC, i.e., tumor cell...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10616
更新日期:2002-10-01 00:00:00
abstract::Expression of intermediate filaments (IFs) has been suggested to be a reliable marker for differentiating epithelial and non-epithelial tumors. Moreover, the c-erbB-2 and p53 genes are considered to be involved relatively early in the process of human carcinogenesis. In order to elucidate the origin of uterine carcino...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19970904)72:5<821::aid-ijc
更新日期:1997-09-04 00:00:00
abstract::We have shown that the loss of p53 function contributed to resistance of tumor cells to TNF-induced cytotoxicity. In the present study, we evaluated the effect of wild-type p53 (wt-p53) expression on TNF sensitivity, by introducing wt-p53 into MCF7/Adr cells in which p53 was deleted, via a recombinant adenovirus encod...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000101)85:1<93::aid-ijc1
更新日期:2000-01-01 00:00:00
abstract::With an increasing cancer rate worldwide, there is an urgent quest for the improvement of anticancer drugs. One of the main problems of present chemotherapy in treatment of tumor patients is the toxicity of drugs. Most of the existent anticancer drugs, unfortunately, attack also proliferating normal cells. In recent y...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22883
更新日期:2007-10-15 00:00:00
abstract::DNA-dependent protein kinase (DNA-PK) has been intensively investigated for its roles in the nonhomologous end-joining (NHEJ) pathway of DNA double-strand break repair and maintenance of genomic stability. Its catalytic subunit, DNA-PKcs, a serine/threonine protein kinase, has recently been reported to be overexpresse...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21093
更新日期:2005-11-20 00:00:00
abstract::Current evidence suggests poor identification and referral of Lynch syndrome patients. This study evaluated the strategies by which patients with endometrial cancer were referred to genetics services. Data from clinic-based patients with endometrial cancer enrolled through the Australian National Endometrial Cancer po...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27978
更新日期:2013-06-15 00:00:00
abstract::In a cohort of 11,663 participants in a breast-cancer screening program, height, weight, waist circumference and hip circumference were measured, and information about menstrual and reproductive history was obtained by questionnaire. After exclusion of 83 women with unclear menopausal status, the subjects were divided...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19980529)76:5<647::aid-ijc
更新日期:1998-05-29 00:00:00
abstract::Angiogenesis and inflammation are the 2 major stroma reactions in colorectal carcinoma (CRC). Guanylate binding protein-1 (GBP-1) is a key mediator of angiostatic effects of inflammation. Therefore, we hypothesized that GBP-1 may be a biomarker of intrinsic angiostasis associated with an improved outcome in CRC patien...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23764
更新日期:2008-11-01 00:00:00
abstract::Although the existence of a humoral response against tumor-associated antigens is well appreciated, a systematic analysis of its possible induction by the tumor remains missing. We compared the specific IgG response of Stage IV melanoma patients during vaccination. Patients had been treated within 2 clinical trials wi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.11537
更新日期:2004-01-10 00:00:00
abstract::We have investigated the effect of pre-treatment with the anti-cancer drugs cisplatin and etoposide on the susceptibility of P815 murine mastocytoma cells to lysis by murine spleen-derived anti-CD3-activated killer-T (AK-T) cells. A 20 hr pre-treatment with cisplatin (0.2-2 microg/ml) or etoposide (0.01-1 microg/ml) r...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19971104)73:3<416::aid-ijc
更新日期:1997-11-04 00:00:00
abstract::We report here side population (SP) cells, a cancer stem cell enriched fraction from pancreatic cancer cell line, have enormous superior potential of the epithelial to mesenchymal transition (EMT), invasion, and metastasis. In an isolated SP cell culture, the cells rapidly expressed and up-regulated E-cadherin, an epi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.24349
更新日期:2009-06-15 00:00:00