Suppression of Friend leukemia virus by Bacillus Calmette-Guérin and a streptococcal preparation, OK-432.


:OK-432, a streptococcal preparation, and BCG effectively inhibited splenomegaly in Friend leukemia virus (FLV)-infected mice. Divided drug dosage resulted in stronger inhibition than single administration. When the second dose was fixed at the 3rd pre-infection day, the best timing for the first dose was approximately 30 days before infection. The optimal dosages were 100--600 KE/kg for OK-432 and 25--100 mg/kg for BCG. Transfer of peritoneal exudate cells (PEC) from immunomodulator-treated mice, but not PEC from untreated mice, conferred resistance against FLV which was highest when PEC were transferred 1 day before FLV infection. The transfer of PEC on the day of or one day after infection had no protective effect. Inactivation also occurred when FLV was incubated in the presence of PEC from immunomodulator-treated mice, however, no significant effect was observed for PEC from untreated mice.


Int J Cancer


Tsuruo T,Iida H,Tsukagoshi S,Sakurai Y




Has Abstract


1980-01-15 00:00:00












  • A selective retinoid with high activity against an androgen-resistant prostate cancer cell type.

    abstract::Retinoic acid (RA) and its natural and synthetic analogs, the retinoids, regulate many biological processes, including development, differentiation, cell growth, morphogenesis, metabolism and homeostasis. Retinoid effects are mediated by specific nuclear receptors, the RARs and RXRs. Because of their ability to contro...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lu XP,Fanjul A,Picard N,Shroot B,Pfahl M

    更新日期:1999-01-18 00:00:00

  • SMAD4: a predictive marker of PDAC cell permissiveness for oncolytic infection with parvovirus H-1PV.

    abstract::Pancreatic ductal adenocarcinoma (PDAC) represents the eighth frequent solid tumor and fourth leading cause of cancer death. Because current treatments against PDAC are still unsatisfactory, new anticancer strategies are required, including oncolytic viruses. Among these, autonomous parvoviruses (PV), like MVMp (minut...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dempe S,Stroh-Dege AY,Schwarz E,Rommelaere J,Dinsart C

    更新日期:2010-06-15 00:00:00

  • Relationship of SNCG, S100A4, S100A9 and LCN2 gene expression and DNA methylation in bladder cancer.

    abstract::Microarray analysis of paired cultures of normal and cancerous urothelial cells revealed differences in cytokeratin and adhesion gene expression. Normal cells expressed autocrine growth factor genes more strongly whereas carcinoma cells were distinguished by concomitant expression of urothelial and epidermal different...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dokun OY,Florl AR,Seifert HH,Wolff I,Schulz WA

    更新日期:2008-12-15 00:00:00

  • Hand-spinning chrysotile exposure and risk of malignant mesothelioma: A case-control study in Southeastern China.

    abstract::While chrysotile has been commonly used by Chinese textile industry for many years, investigations on the association of chrysotile exposure with risk of mesothelioma in China are scarce. We conducted a case-control study in a county located at Southeastern China, including 46 cases and 230 individually matched contro...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jiang Z,Chen T,Chen J,Ying S,Gao Z,He X,Miao C,Yu M,Feng L,Xia H,Wu W,Chen R,Morinaga K,Lou J,Zhang X

    更新日期:2018-02-01 00:00:00

  • Reversibility of the transformed and neoplastic phenotype. IV. Effects of long-term interferon treatment of C3H/10T1/2 cells transformed by methylcholanthrene and SV40 virus.

    abstract::The effects of long-term treatment with mouse interferon on the phenotype of untransformed C3H/10T1/2 cells and cloned derivatives transformed by methylcholanthrene (MCA) and Simian virus 40 (SV40) were investigated. Continuous presence of interferon induced morphologic reversion, with the development of thick, submem...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Brouty-Boyé D,Wybier-Franqui J,Calvo C,Feunteun J,Gresser I

    更新日期:1984-07-15 00:00:00

  • Interleukin-33/ST2 axis promotes breast cancer growth and metastases by facilitating intratumoral accumulation of immunosuppressive and innate lymphoid cells.

    abstract::The role of IL-33/ST2 pathway in antitumor immunity is unclear. Using 4T1 breast cancer model we demonstrate time-dependent increase of endogenous IL-33 at both the mRNA and protein levels in primary tumors and metastatic lungs during cancer progression. Administration of IL-33 accelerated tumor growth and development...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jovanovic IP,Pejnovic NN,Radosavljevic GD,Pantic JM,Milovanovic MZ,Arsenijevic NN,Lukic ML

    更新日期:2014-04-01 00:00:00

  • Early life risk factors in cancer: the relation of birth weight to adult obesity.

    abstract::The intrauterine environment appears to play a role in the development of adult diseases, including several prominent cancers. Our study aims to characterize the relationship between birth weight, a measure of the intrauterine environment, and adult obesity. A population-based sample of women aged 50-79, living in the...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Leong NM,Mignone LI,Newcomb PA,Titus-Ernstoff L,Baron JA,Trentham-Dietz A,Stampfer MJ,Willett WC,Egan KM

    更新日期:2003-03-01 00:00:00

  • A-kinase anchoring protein 3 messenger RNA expression in ovarian cancer and its implication on prognosis.

    abstract::A-kinase anchoring protein 3 (AKAP3) is a sperm protein and its expression appears to be restricted to the testis in normal adult tissues. We investigated AKAP3 mRNA expression in 20 normal ovaries and 54 ovarian cancers of different histological types, grades and stages by reverse transcription-polymerase chain react...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hasegawa K,Ono T,Matsushita H,Shimono M,Noguchi Y,Mizutani Y,Kodama J,Kudo T,Nakayama E

    更新日期:2004-01-01 00:00:00

  • Sex-specificity in lung cancer risk.

    abstract::Smoking is indisputably linked to lung cancer, yet only a small fraction of smokers develops this disease. Although previously tobacco-derived carcinogens and enzyme polymorphisms have been identified to increase the risk for smokers, recent epidemiological data suggest even sex-specificity as a new and additional fac...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Stapelfeld C,Dammann C,Maser E

    更新日期:2020-05-01 00:00:00

  • Attenuation by cyclic phosphatidic acid of peritoneal metastasis of azoxymethane-induced intestinal cancers in Wistar rats.

    abstract::The effect of cyclic phosphatidic acid, a unique analogue of lysophosphatidic acid, on the induction of bombesin-enhanced peritoneal metastases from intestinal adenocarcinomas induced by azoxymethane was investigated in male Wistar rats. Rats were given 10 weekly injections of azoxymethane (7.4 mg/kg body weight, s.c....

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ishihara R,Tatsuta M,Iishi H,Baba M,Uedo N,Higashino K,Mukai M,Ishiguro S,Kobayashi S,Murakami-Murofushi K

    更新日期:2004-06-10 00:00:00

  • Body mass and stage of breast cancer at diagnosis.

    abstract::Obesity is a well-known risk factor for postmenopausal breast cancer. In contrast, the relationship between obesity and stage of breast cancer at diagnosis is less clear. We hypothesized that increased breast size in obese women may delay discovery of breast tumors. Thus, the purpose of our study was to examine whethe...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Cui Y,Whiteman MK,Flaws JA,Langenberg P,Tkaczuk KH,Bush TL

    更新日期:2002-03-10 00:00:00

  • Laminin-gamma2 overexpression in head-and-neck squamous cell carcinoma.

    abstract::To identify molecular markers for the progression of head-and-neck squamous cell carcinoma (HNSCC), we used RNA arbitrarily primed (RAP) PCR to determine the qualitative and quantitative differences in gene expression between normal epithelial cells, those derived from dysplastic oral mucosa and invasive and metastati...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Patel V,Aldridge K,Ensley JF,Odell E,Boyd A,Jones J,Gutkind JS,Yeudall WA

    更新日期:2002-06-01 00:00:00

  • Longitudinal quality of life data can provide insights on the impact of adjuvant treatment for pancreatic cancer-Subset analysis of the ESPAC-1 data.

    abstract::The European Study Group for Pancreatic Cancer (ESPAC-1) study is the largest study of adjuvant treatment for pancreatic ductal adenocarcinoma to date and confirmed a survival advantage for adjuvant chemotherapy but not for chemoradiation. The importance of parallel evaluation of survival and quality of life (QoL) has...

    journal_title:International journal of cancer

    pub_type: 杂志文章,随机对照试验


    authors: Carter R,Stocken DD,Ghaneh P,Bramhall SR,Olah A,Kelemen D,Bassi C,Friess H,Dervenis C,Spry N,Büchler MW,Neoptolemos JP,European Study Group for Pancreatic Cancer (ESPAC).

    更新日期:2009-06-15 00:00:00

  • Population dynamics of serologically identified coinfections with human papillomavirus types 11, 16, 18 and 31 in fertile-aged Finnish women.

    abstract::Licensed human papillomavirus (HPV) vaccines are expected to prevent high-risk (hr) HPV-infections (most notably types 16 and 18). Whether HPV vaccination will change the distribution of hrHPVs at the population level is open, since competition between HPV types is not well understood. Two stratified random subcohorts...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kaasila M,Koskela P,Kirnbauer R,Pukkala E,Surcel HM,Lehtinen M

    更新日期:2009-11-01 00:00:00

  • Effect of aspirin on cell proliferation and differentiation of colon adenocarcinoma Caco-2 cells.

    abstract::Several lines of evidence suggest that long-term treatment with non-steroidal anti-inflammatory drugs may reduce the risk of colon cancer and the size and number of colonic polyps in patients with familial adenomatous polyposis. Aspirin has also been shown to inhibit cell proliferation in human tumor cell lines and to...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ricchi P,Pignata S,Di Popolo A,Memoli A,Apicella A,Zarrilli R,Acquaviva AM

    更新日期:1997-12-10 00:00:00

  • Multiple births and risk of breast cancer.

    abstract::Data from a large, multicenter, population-based case-control study were analyzed to investigate the relation between multiple birth pregnancies and subsequent breast-cancer risk in the gravidas. Women less than 75 years old who had breast cancer were identified from statewide tumor registries in Wisconsin, western Ma...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Dietz AT,Newcomb PA,Storer BE,Longnecker MP,Mittendorf R

    更新日期:1995-07-17 00:00:00

  • Non-Hodgkin's lymphoma and skin malignancies--shared etiology?

    abstract::The Stockholm-Gotland Cancer Register was used to evaluate the clinical observation that patients with non-Hodgkin's lymphoma (NHL) had an increased risk of malignant melanoma or squamous-cell carcinoma of the skin (SCCS) and vice versa. During 1958-1992, NHL was diagnosed in a total of 6,176 patients. Of these patien...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hall P,Rosendahl I,Mattsson A,Einhorn S

    更新日期:1995-09-04 00:00:00

  • Family history of breast or ovarian cancer modifies the risk of secondary leukemia after breast cancer: results from a population-based study.

    abstract::We evaluated the impact of a family history of breast/ovarian cancer on the risk of secondary leukemia following breast cancer. At the Geneva cancer registry, we identified 4,397 patients diagnosed with invasive breast cancer between 1990 and 2004. Patients were followed up for leukemia until the end of 2005. Family h...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Verkooijen HM,Fioretta G,Rapiti E,Vlastos G,Neyroud-Caspar I,Chappuis PO,Bouchardy C

    更新日期:2008-03-01 00:00:00

  • The association of hormonal contraceptive use and HPV prevalence.

    abstract::Women diagnosed with cervical cancer report longer duration and more recent use of combined oral contraceptives (COCs). It is unclear whether COC use is associated with upstream events of human papillomavirus (HPV) infection prior to development of clinical disease. The objective of our study was to assess the associa...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Marks M,Gravitt PE,Gupta SB,Liaw KL,Kim E,Tadesse A,Phongnarisorn C,Wootipoom V,Yuenyao P,Vipupinyo C,Rugpao S,Sriplienchan S,Celentano DD

    更新日期:2011-06-15 00:00:00

  • Cross-sectional study of Opisthorchis viverrini infection and cholangiocarcinoma in communities within a high-risk area in northeast Thailand.

    abstract::We describe an innovative strategy to quantify risk of cancer associated with varying levels of exposure to chronic parasitic infection through the identification of asymptomatic cases of cholangiocarcinoma within a population-based survey of Opisthorchis viverrini infection. Stool samples from 12,311 adults over age ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Haswell-Elkins MR,Mairiang E,Mairiang P,Chaiyakum J,Chamadol N,Loapaiboon V,Sithithaworn P,Elkins DB

    更新日期:1994-11-15 00:00:00

  • In vivo growth inhibition of L1210 leukemia by 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A), a new inhibitor of S-adenosylmethionine decarboxylase.

    abstract::We studied the in vivo growth-inhibitory effect of the new S-adenosylmethionine decarboxylase inhibitor 4-amidinoindan-1-one 2'-amidinohydrazone (CGP 48664A). L1210-bearing DBA-2 mice were treated with increasing CGP 48664A doses from 1 day after i.p. L1210 cell inoculation. Treatment was continued for 4 days, after w...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Dorhout B,Te Velde RJ,Ferwerda H,Kingma AW,De Hoog E,Muskiet FA

    更新日期:1995-04-10 00:00:00

  • The association between markers of tumour cell metabolism, the tumour microenvironment and outcomes in patients with colorectal cancer.

    abstract::Tumour cell anaerobic metabolism has been reported to be a prognostic factor in colorectal cancer. The present study investigated the association between monocarboxylate transporter (MCT) 1, MCT 2, lactate dehydrogenase (LDH) 1 and LDH 5, the tumour microenvironment, and outcome in patients with colorectal cancer. A c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Roseweir AK,Clark J,McSorley ST,vanWyk HC,Quinn JA,Horgan PG,McMillan DC,Park JH,Edwards J

    更新日期:2019-05-01 00:00:00

  • Downregulation of c-myc protein by siRNA-mediated silencing of DNA-PKcs in HeLa cells.

    abstract::DNA-dependent protein kinase (DNA-PK) has been intensively investigated for its roles in the nonhomologous end-joining (NHEJ) pathway of DNA double-strand break repair and maintenance of genomic stability. Its catalytic subunit, DNA-PKcs, a serine/threonine protein kinase, has recently been reported to be overexpresse...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: An J,Xu QZ,Sui JL,Bai B,Zhou PK

    更新日期:2005-11-20 00:00:00

  • TP53 mutations in breast cancer tumors of patients from Rio de Janeiro, Brazil: association with risk factors and tumor characteristics.

    abstract::Somatic mutations in the TP53 gene are the most frequently observed genetic alterations in human malignancies, including breast cancer, which is one of the leading causes of death among women in Brazil. In our study, we determined the frequency and the pattern of TP53 mutations in malignant breast tumors from 120 pati...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Simão TA,Ribeiro FS,Amorim LM,Albano RM,Andrada-Serpa MJ,Cardoso LE,Mendonça GA,de Moura-Gallo CV

    更新日期:2002-09-01 00:00:00

  • Early detection of tumor-specific antibodies to mammary carcinoma.

    abstract::BALB/cfC3H female mice which develop mammary tumor virus (MTV)-induced mammary tumors possess not only serun antibodies directed against virus-associated antigens which are expressed on mammary tumor cells but also antibodies directed against antigenic specificities which are unique to each tumor. The possible range o...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Blair PB,Lane ML

    更新日期:1978-04-15 00:00:00

  • Interleukin-2-stimulated natural killer activity against malignant and benign endometrium.

    abstract::Natural cell-mediated immunity against autologous tumor cells, autologous endometrial epithelium, and allogeneic epidermoid carcinoma cell line HeLa was tested in 8 patients with endometrial carcinoma and one patient with endometrial stromal sarcoma. The average cytotoxicity of unstimulated peripheral blood lymphocyte...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Timonen T,Lehtovirta P,Saksela E

    更新日期:1987-10-15 00:00:00

  • Contrasting effects of 17 beta-estradiol on the growth of human ovarian carcinoma cells in vitro and in vivo.

    abstract::A human ovarian adenocarcinoma cell line (PE04) has been established as a xenograft in nude mice. In vitro, this cell line is estrogen receptor (ER)-positive and its growth is stimulated by 17 beta-estradiol at concentrations between 10(-12) and 10(-6) M. When xenografted, PE04 cells remain ER-positive and also posses...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Langdon SP,Ritchie A,Young K,Crew AJ,Sweeting V,Bramley T,Hillier S,Hawkins RA,Tesdale AL,Smyth JF

    更新日期:1993-09-30 00:00:00

  • Increased plasma DNA integrity index in head and neck cancer patients.

    abstract::Analysis of the length of circulating DNA in plasma has been reported as a marker for solid tumor detection. We assessed the sensitivity and specificity of increased plasma DNA length to identify patients with head and neck squamous cell carcinoma (HNSCC) and monitor posttreatment disease status. Fifty-eight HNSCC pat...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jiang WW,Zahurak M,Goldenberg D,Milman Y,Park HL,Westra WH,Koch W,Sidransky D,Califano J

    更新日期:2006-12-01 00:00:00

  • HER3 is required for the maintenance of neuregulin-dependent and -independent attributes of malignant progression in prostate cancer cells.

    abstract::HER3 (ERBB3) is a catalytically inactive pseudokinase of the HER receptor tyrosine kinase family, frequently overexpressed in prostate and other cancers. Aberrant expression and mutations of 2 other members of the family, EGFR and HER2, are key carcinogenic events in several types of tumors, and both are well- validat...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Soler M,Mancini F,Meca-Cortés O,Sánchez-Cid L,Rubio N,López-Fernández S,Lozano JJ,Blanco J,Fernández PL,Thomson TM

    更新日期:2009-12-01 00:00:00

  • Transcription of biliary glycoprotein I gene in malignant and non-malignant human liver tissues.

    abstract::Biliary glycoprotein I (BGP I) is a member of carcinoembryonic antigen (CEA) gene family consisting of at least 11 related genes. The transcription of BGP I gene was analysed in malignant and non-malignant human liver tissues with a 396-bp 3'-untranslated region probe from a cDNA clone 4-13 which was newly isolated fr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hinoda Y,Imai K,Nakagawa N,Ibayashi Y,Nakano T,Paxton RJ,Shively JE,Yachi A

    更新日期:1990-05-15 00:00:00