Abstract:
:Ionizing radiation remains a major therapeutic tool against human cancers, especially epithelial tumors, which account for the majority of human malignancies. Although Fas and Fas-L are essential determinants of apoptosis, few data support their role in the cytotoxic effect of ionizing radiation. Epstein-Barr-virus (EBV)-positive nasopharyngeal carcinoma (NPC) were chosen to address this question owing to their known sensitivity to ionizing radiation and their constitutive expression of the Fas-receptor. We here report that, in xenografted NPC cells, Fas-L expression, which was very low in basal conditions, was dramatically increased by tumor irradiation. Both the Fas receptor and the Fas ligand were found to be functional in this model, and a high proportion of irradiated NPC cells underwent apoptosis following tumor irradiation. Induction of Fas-L expression and apoptosis were observed for doses as low as 2 Gy. These data show an increase in Fas-L expression upon irradiation exposure, and strongly suggest that, in some epithelial malignancies, Fas-mediated apoptosis can play a major role in the anti-tumor effect of ionizing radiation, in the range of doses used for therapeutic applications.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Abdulkarim B,Sabri S,Deutsch E,Vaganay S,Marangoni E,Vainchenker W,Bongrand P,Busson P,Bourhis Jdoi
10.1002/(sici)1097-0215(20000415)86:2<229::aid-ijckeywords:
subject
Has Abstractpub_date
2000-04-15 00:00:00pages
229-37issue
2eissn
0020-7136issn
1097-0215pii
10.1002/(SICI)1097-0215(20000415)86:2<229::AID-IJCjournal_volume
86pub_type
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