Abstract:
:A subline of the murine P815 mastocytoma passaged for a long period of time in histoincompatible hosts was found to be deficient in surface MHC class-I antigens by serological and biochemical methods. In agreement with the lack of restriction elements, this variant cell line was no longer susceptible to killing by cytotoxic T cells stimulated by and directed against the parental tumor cell line in syngeneic DBA-2 hosts. We did not observe the appearance of susceptibility to NK killing concomitantly with H-2 loss. We thus could not confirm the hypothesis of a regulatory function of H-2 structures in NK recognition/killing. Both cell lines were also resistant to lysis by mouse macrophages. The parental cell line was sensitive to rat macrophage killing, whereas the variant line had lost such sensitivity. In spite of resistance in vitro to various defense mechanisms, the variant H-2 loss tumor cell line was less tumorigenic in syngeneic hosts and exhibited a lower metastatic capacity than the parental cell line. We propose that in the H-2 loss subline, survival of cells in vivo is impeded since positive signals mediated by H-2 structures are missing, which are necessary for cell-cell contact and survival.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Bertschmann M,Käsermann D,Keller Rdoi
10.1002/ijc.2910460431subject
Has Abstractpub_date
1990-10-15 00:00:00pages
739-44issue
4eissn
0020-7136issn
1097-0215journal_volume
46pub_type
杂志文章abstract::The next-generation antiandrogen MDV3100 prolongs overall survival of patients with metastatic castration-resistant prostate cancer (CRPC). However, patient responses are variable, and survival benefit remains relatively small. Developing effective modality to improve MDV3100 efficacy is urgently needed. Recent eviden...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28202
更新日期:2013-11-01 00:00:00
abstract::The growth of a spontaneous adenocarcinoma (ADK-1t) of BALB/c mice (H-2d, MIsb) induces progressive hyporesponsiveness of spleen cells stimulated with PHA or irradiated leukocytes from DBA/2 strain (H-2d, MIsa) in mixed leukocyte culture. This hyporesponsiveness is due to the suppressor activity of macrophage-like cel...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910290616
更新日期:1982-06-15 00:00:00
abstract::Monoclonal antibodies (MAbs) reactive with the ganglioside fucosyl GM1 (Fuc-GM1), an antigen associated with small-cell carcinoma of the lung (SCLC), were tested for their ability to mediate tumor-cell killing in vitro in conjunction with humoral and cellular effectors and to inhibit tumor engraftment in nude mice in ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910490619
更新日期:1991-12-02 00:00:00
abstract::HNPCC is an autosomal dominantly inherited cancer-susceptibility syndrome that confers an increased risk for colorectal cancer and endometrial cancer at a young age. It also entails an increased risk of a variety of other tumors, such as ovarian, gastric, uroepithelial and biliary tract cancers. The underlying pathoge...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10240
更新日期:2002-04-10 00:00:00
abstract::A hospital-based case-control study of renal-cell carcinoma was conducted in France from 1987 to 1991. A total of 196 histologically confirmed cases (138 males and 58 females) and 347 controls (235 males and 112 females), matched for sex, age at interview, hospital and interviewer, were included. The risk of renal-cel...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910550107
更新日期:1993-08-19 00:00:00
abstract::Regular aspirin and non-aspirin nonsteroidal anti-inflammatory drug (NSAID) use is associated with a reduced risk of colorectal cancer. The effect of NSAIDs on the risk of other cancers remains unclear. To evaluate whether use of aspirin or other specific NSAIDs protects against lung cancer, we conducted a case-contro...
journal_title:International journal of cancer
pub_type: 杂志文章,随机对照试验
doi:10.1002/ijc.22514
更新日期:2007-04-01 00:00:00
abstract::5-Fluorouracil (5-FU) is the major chemotherapeutic component for colorectal cancer (CRC) and other types of solid tumours. Resistance of cancer cells to 5-FU is considered the major obstacle for successful chemotherapy. NF-kappaB is a transcription factor. Cancer cells with high NF-kappaB nuclear activity demonstrate...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10972
更新日期:2003-04-20 00:00:00
abstract::The mass screening (MS) of neuroblastoma has been undertaken in Japan by measuring urinary catecholamine metabolites in infants at the age of 6 months. To clarify the biological characteristics of MS-positive (MS+) tumors in infants and MS-negative (MS-)/late-presenting tumors in young children, metaphase cytogenetic ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990105)80:1<54::aid-ijc1
更新日期:1999-01-05 00:00:00
abstract::The effects of androgen manipulation on epidermal growth factor (EGF) receptor, p185erbB-2 and transforming growth factor-alpha (TGF-alpha) levels were examined in prostatic adenocarcinoma. Male nude mice were inoculated with the CWR22 androgen-dependent human prostatic tumor or an androgen-independent (CWR22R) deriva...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990730)82:3<424::aid-ijc
更新日期:1999-07-30 00:00:00
abstract::Apigenin is a plant flavonoid that is thought to play a role in the prevention of carcinogenesis. However, its mechanism of action has not yet been elucidated. Because of the importance of angiogenesis in tumor growth, we investigated the effect of apigenin on endothelial and smooth-muscle cells in an in vitro model. ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(20000301)85:5<691::aid-ijc
更新日期:2000-03-01 00:00:00
abstract::A syngeneic tumor system in DBA/2 mice consisting of a methyl-cholanthrene-induced, weakly metastatic lymphoma, L5178YE (= Eb), its spontaneous strongly metastatic variant, L5178YES (= ESb), and an unrelated, methylcholanthrene-induced, metastasizing tumor, MDAY-D2, were used to study the relationship between metastat...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910360514
更新日期:1985-11-15 00:00:00
abstract::Nasopharyngeal carcinoma (NPC) is an aggressive tumour of multifactorial aetiology that, although rare in most parts of the world, poses a significant mortality problem in its high incidence area of Southern China. Improved therapies are an urgent requirement and, towards this end, immunotherapeutic methods are being ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20001215)88:6<949::aid-ijc18>3.0
更新日期:2000-12-15 00:00:00
abstract::The molecular mechanisms underlying the genesis and progression of oligodendroglial tumors are poorly understood, since only restricted information on loss of heterozygosity from isolated cases is available. The commonest alterations appear to involve deletion of 1p and 19q, while loss of heterozygosity for 9p, chromo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910640311
更新日期:1995-06-22 00:00:00
abstract::The cellular tumor suppressor p16 is strongly overexpressed in cervical cancers and precancers. We have previously demonstrated that infiltrating T lymphocytes reactive against p16 can be found in cervical cancer patients. Here, we analyzed whether p16 induces humoral immune responses. Sera of patients with cervical c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23837
更新日期:2008-12-01 00:00:00
abstract::The independent effects of parity and age at first birth on breast cancer incidence are investigated in a 1% sample of women aged 16 to 59 from the 1971 Census of England and Wales. Over the period 1971-81, 1,003 breast cancer cases occurred in the cohort of 113,263 women who were either married, widowed or divorced a...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910430606
更新日期:1989-06-15 00:00:00
abstract::Alterations in TGF-beta signaling appear to be associated with an altered risk of developing cancer, including breast cancer. We carried out a case-control study on 8 polymorphisms, including 5 in the TGF-beta1 gene (G-800A, C-509T, Leu10-->Pro, Arg25-->Pro and Thr263-->Ile), a polyalanine polymorphism (9A-->6A) in th...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20370
更新日期:2004-10-20 00:00:00
abstract::Fibroblast growth factor 15 (FGF15), FGF19 in humans, is a gut-derived hormone and a key regulator of bile acids and carbohydrate metabolism. FGF15 also participates in liver regeneration after partial hepatectomy inducing hepatocellular proliferation. FGF19 is overexpressed in a significant proportion of human hepato...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29287
更新日期:2015-05-15 00:00:00
abstract::A human tumor clonogenic assay has been used to test the antiproliferative effect of recombinant human leukocyte interferon alpha 2 alone and in combination with each of 8 cytotoxic agents. Cell lines derived from 6 human tumors and primary tumor cells from 13 patients have been used in these clonogenic assay studies....
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910350605
更新日期:1985-06-15 00:00:00
abstract::Imatinib mesylate has become an effective agent for the treatment of chronic myeloid leukemia (CML). However, the development of drug resistance has led to examination of combination therapies. In this study, we investigated the effects of combining imatinib with immunotherapy against a murine bcr-abl(+) leukemia, 12B...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20115
更新日期:2004-06-10 00:00:00
abstract::A case of epidermodysplasia verruciformis in a patient from Upper-Volta is described. Slightly elevated, flat warts were observed on hands, feet, arms and legs, and pityriasis versicolor-like lesions were found mainly on the trunk. The patient showed no malignant tumors. Histological examination revealed hyperkeratosi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910270511
更新日期:1981-05-15 00:00:00
abstract::The EMS1 gene encodes an 80/85 kDa c-src substrate and localises with the CCND1 gene to chromosome 11q13. This locus is amplified in approximately 13% of human breast cancers. EMS1 gene amplification and expression were characterised in a panel of human breast cancer cell lines to determine at what levels expression i...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(SICI)1097-0215(19961115)68:4<485::AID-IJC
更新日期:1996-11-15 00:00:00
abstract::DNA-dependent protein kinase (DNA-PK) has been intensively investigated for its roles in the nonhomologous end-joining (NHEJ) pathway of DNA double-strand break repair and maintenance of genomic stability. Its catalytic subunit, DNA-PKcs, a serine/threonine protein kinase, has recently been reported to be overexpresse...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21093
更新日期:2005-11-20 00:00:00
abstract::LAF-4, which encodes a nuclear protein with transactivation potential, is fused to the MLL gene in acute lymphoblastic leukemia (ALL). We identified LAF-4 as a gene that is transcriptionally deregulated in breast tumors and thus may have a pathological role in mammary tumorigenesis. In line with the previous finding t...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.20881
更新日期:2005-07-01 00:00:00
abstract::A case-control study of prostate cancer (PC) was undertaken in Athens, Greece. Cases were 320 patients with histologically confirmed incident disease, whereas controls were 246 patients without history or symptomatology of benign prostatic hyperplasia, treated in the same hospitals as the cases for minor diseases or c...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/(sici)1097-0215(19990301)80:5<699::aid-ijc
更新日期:1999-03-01 00:00:00
abstract::Cervical mucosal expression of cytokines involved in mediating cellular immunity is believed to influence the persistence of human papillomavirus (HPV) infection, a necessary prerequisite for the development of cervical intraepithelial neoplasia (CIN). Additionally, regulatory T (Treg) cells are increasingly understoo...
journal_title:International journal of cancer
pub_type: 杂志文章,多中心研究
doi:10.1002/ijc.24117
更新日期:2009-03-15 00:00:00
abstract::CD4(+) T cells have been shown to be crucial for the induction and maintenance of cytotoxic T cell responses and to be also capable of mediating direct tumor rejection. Therefore, the anticancer therapeutic efficacy of peptide-based vaccines may be improved by addition of HLA class II epitopes to stimulate T helper c...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26365
更新日期:2012-07-01 00:00:00
abstract::Regional lymph-node (LN) lymphocytes may constitute an important defence against the spread of human melanoma beyond regional LNs. The present study was directed to clonal analysis of lymphocytes cultured either directly from the LNs or after stimulation in cultures with autologous melanoma (MLTC). T-cell clones deriv...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910510209
更新日期:1992-05-08 00:00:00
abstract::Patients with head-and-neck cancer commonly have immune defects. It was reported that these patients have raised serum IgA levels. We investigated whether IgA-anti-Fab autoantibodies, which occur in association with immune dysfunction, are present in patients with head-and-neck cancer. Sera of 101 patients with squamo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910570109
更新日期:1994-04-01 00:00:00
abstract::The cystine/glutamate antiporter, system xc- , is essential for the efficient uptake of cystine into cells. Interest in the mechanisms of system xc- function soared with the recognition that system xc- presents the most upstream node of ferroptosis, a recently described form of regulated necrosis relevant for degenera...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33262
更新日期:2020-12-01 00:00:00
abstract::We have investigated the effect of interferon-gamma (IFN-gamma) treatment of neuroblastoma cells on the susceptibility to lysis by lymphokine-activated killer (LAK) cells and examined the participation of cell-adhesion molecules on the target cells in LAK cell lysis. Untreated neuroblastoma cells expressed lymphocyte-...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910470410
更新日期:1991-02-20 00:00:00