Abstract:
:The independent effects of parity and age at first birth on breast cancer incidence are investigated in a 1% sample of women aged 16 to 59 from the 1971 Census of England and Wales. Over the period 1971-81, 1,003 breast cancer cases occurred in the cohort of 113,263 women who were either married, widowed or divorced at the time of Census. Age at first birth was positively related to breast cancer risk, women giving birth to their first child after 35 years being at greater risk than nulliparous women. This effect remained, after adjustment for number of live-born children. Breast cancer risk showed a statistically significant decline with increasing parity even after adjustment for age at first birth. These results are consistent with other published evidence which suggests that other births subsequent to the first have an independent effect on breast cancer risk.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Leon DAdoi
10.1002/ijc.2910430606subject
Has Abstractpub_date
1989-06-15 00:00:00pages
986-91issue
6eissn
0020-7136issn
1097-0215journal_volume
43pub_type
杂志文章abstract::The U.S. Preventive Services Task Force (USPSTF) recently updated their national lung screening guidelines and recommended low-dose computed tomography (LDCT) for lung cancer (LC) screening through age 80. However, the risk of overdiagnosis among older populations is a concern. Using four comparative models from the C...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.30602
更新日期:2017-06-01 00:00:00
abstract::Intraductal papillary-mucinous carcinoma (IPMC) of the pancreas, a new entity of pancreatic cancer with a favorable prognosis, has shown a gradual increase in the number of reported cases. Patients with high-frequency microsatellite instability (MSI-H) tumors have been shown to survive longer than those with low-frequ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.10771
更新日期:2002-12-20 00:00:00
abstract::While chrysotile has been commonly used by Chinese textile industry for many years, investigations on the association of chrysotile exposure with risk of mesothelioma in China are scarce. We conducted a case-control study in a county located at Southeastern China, including 46 cases and 230 individually matched contro...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.31077
更新日期:2018-02-01 00:00:00
abstract::Most breast cancer patients in sub-Saharan Africa are diagnosed at advanced stages after prolonged symptomatic periods. In the multicountry African Breast Cancer-Disparities in Outcomes cohort, we dissected the diagnostic journey to inform downstaging interventions. At hospital presentation for breast cancer, women re...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33209
更新日期:2021-01-15 00:00:00
abstract::We studied plasmin receptors on 3 MCF-7 sublines: MCF7, MCF7R which was derived by transfection with v-Ha-ras oncogene, and MCF7MF which has been studied for the secretion of procathepsin D in the presence of estrogen. All 3 sublines bound plasmin (Pli) with a much higher affinity than plasminogen (Pg). The number of ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910460432
更新日期:1990-10-15 00:00:00
abstract::A population-based case-control study was conducted to evaluate risk of developing multiple myeloma (MM) associated with personal history of autoimmune diseases and occurrence of autoimmune and selected hematologic disorders in first-degree relatives. Data were obtained for all (n = 8,406) MM cases diagnosed in Sweden...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21745
更新日期:2006-06-15 00:00:00
abstract::Increased levels of hypoxia and hypoxia-inducible factor 1α (HIF-1α) in human sarcomas correlate with tumor progression and radiation resistance. Prolonged antiangiogenic therapy of tumors not only delays tumor growth but may also increase hypoxia and HIF-1α activity. In our recent clinical trial, treatment with the v...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.27666
更新日期:2013-01-01 00:00:00
abstract::Environmental carcinogens often induce specific mutations in the p53 gene, apparent in tumors. The relation between aflatoxin B1 (AFB1 )-related hepatocellular carcinomas (HCCs) and hot spot at codon 249 of the p53 gene has received a great deal of attention, but its significance is still controversial. To clarify thi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990719)82:2<187::aid-ijc
更新日期:1999-07-19 00:00:00
abstract::The causal role of wood-dust exposure in sinonasal cancer (SNC) has been established in epidemiological studies, but the mechanisms of SNC carcinogenesis are still largely unknown. Increased amounts of COX-2 are found in both premalignant and malignant tissues, and experimental evidence link COX-2 to development of ca...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23360
更新日期:2008-05-01 00:00:00
abstract::Osteolytic bone diseases are a prominent feature of multiple myeloma (MM), resulting from aberrant osteoclastic bone resorption that is uncoupled from osteoblastic bone formation. Myeloma stimulates osteoclastogenesis, which is largely dependent on an increase in receptor activator of NF-κB ligand (RANKL) and a decrea...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.28116
更新日期:2013-09-01 00:00:00
abstract::Using immunohistochemical methods, we analyzed the association between nuclear p53 overexpression and various clinicopathological parameters in patients with endometrial cancers. Formalin-fixed and paraffin-embedded tissue sections from 139 cases of endometrial cancer (endometrioid type, 126; serous papillary type, 12...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910580104
更新日期:1994-07-01 00:00:00
abstract::Marked variation in phenotypic expression among BRCA1 and BRCA2 mutation carriers may be partly explained by modifier genes that influence mutation penetrance. Variation in CAG/CAA repeat lengths coding for stretches of glutamines in the C-terminus of the AIB1 protein (amplified in breast cancer 1, a steroid receptor ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.21176
更新日期:2005-11-01 00:00:00
abstract::Our group has conducted two previous studies on the association between vitamin D binding protein (DBP) and renal cell carcinoma (RCC), the most common form of kidney cancer, finding strong inverse associations. We undertook the current analysis to replicate our findings in a different study population that included w...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.32758
更新日期:2020-08-01 00:00:00
abstract::Immortalized and cancer cells maintain their telomeres by activation of a telomere maintenance mechanism (TMM). In approximately 85% of cancers telomerase is activated (TA) but in some tumours, in particular sarcomas, an alternative lengthening of telomeres (ALT) pathway is used. Liposarcomas are the most common soft-...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.23412
更新日期:2008-06-01 00:00:00
abstract::In order to study the mechanisms responsible for resistance to CDDP, 5 human tumor cell lines were made resistant to CDDP by repeated in vitro exposures. After cloning it was found that the cell lines developed were between 3.3-fold and 17-fold more resistant to CDDP than the parental cell lines at the IC90. These lin...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910470214
更新日期:1991-01-21 00:00:00
abstract::In 1979, a hypothesis-generating, population-based case-control study was undertaken in Montreal, Canada, to explore the association between occupational exposure to 294 substances, 130 occupations and industries, and various cancers. Interviews were carried out with 3, 630 histologically confirmed cancer cases, of wh...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/1097-0215(20000915)87:6<874::aid-ijc18>3.0
更新日期:2000-09-15 00:00:00
abstract::A multi-national, hospital-based, case-control study was conducted to evaluate the possible relationships of steroid contraceptives to 6 neoplasms. Based on data from 122 newly diagnosed cases of primary liver cancer and 802 matched controls, the relative risk of liver cancer in women who had ever used combined oral c...
journal_title:International journal of cancer
pub_type: 临床试验,杂志文章,多中心研究
doi:
更新日期:1989-02-15 00:00:00
abstract::Organochlorine insecticides have been studied extensively in relation to breast cancer incidence, and results from two meta-analyses have been null for late-life residues, possibly due to measurement error. Whether these compounds influence survival remains to be fully explored. We examined associations between organo...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29806
更新日期:2016-02-01 00:00:00
abstract::Powerful analytical tools are vital for characterizing the complex molecular changes underlying oncogenesis and cancer treatment. This is particularly true, if information is to be collected in vivo by noninvasive approaches. In the recent past, hyperpolarized (13)C magnetic resonance (MR) spectroscopy has been employ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.25072
更新日期:2010-08-01 00:00:00
abstract::In order to define technical limitations of conventional external beam irradiation for clinically localized prostate cancer, we evaluated the impact of several reduced-field treatment factors, such as reduced-field (RF) irradiated volume, RF technique, photon energy of treatment, and dose on survival endpoints and loc...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:
更新日期:2000-10-20 00:00:00
abstract::The application of dendritic cells (DC) to the active immunotherapy of cancer currently relies on the generation of potent DC capable of presenting tumor antigens such as carcinoembryonic antigen (CEA). It is unknown whether the T cells of patients with advanced malignancies can be reliably stimulated against tumor an...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/(sici)1097-0215(19990702)82:1<121::aid-ijc
更新日期:1999-07-02 00:00:00
abstract::The tumor-suppressor genes p14(ARF), p16(INK4a) and Tp53 are commonly inactivated in many tumors. We investigated their role in the pathogenesis of 9 bile tract cancer cell lines and 21 primary sporadic extrahepatic bile duct carcinomas. p53 and p16 protein expression was examined by Western blot analysis and immunohi...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.1639
更新日期:2002-02-01 00:00:00
abstract::Female residents of six counties in Washington and Utah in whom a diagnosis of ovarian cancer was made during 1975-79 were interviewed concerning prior use of oral contraceptives. Interviews with a random sample of women drawn from these same counties were obtained for comparison. A smaller proportion of women with ep...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910280602
更新日期:1981-12-01 00:00:00
abstract::A new human cell line, designated Ty-82, was established from the pleural effusion of a 22-year-old woman with undifferentiated thymic carcinoma. This cell line consisted of primitive cells that were positive for alpha-naphthyl butyrate esterase and acid phosphatase. The cells were shown to express epithelial membrane...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910500216
更新日期:1992-01-21 00:00:00
abstract::Cervical cancer is the second most common malignancy in women worldwide, with high risk subtypes of human papillomavirus (HPV) constituting the major etiological agent. However, only a small percentage of women infected by the virus develop disease, suggesting that additional host genetic alterations are necessary for...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22335
更新日期:2007-01-15 00:00:00
abstract::Tumor-induced immunosuppression remains a major challenge for immunotherapy of cancer patients. To further elucidate why an allogeneic gene-modified [interleukin-7 (IL-7)/CD80-cotransfected] renal cell cancer (RCC) vaccine failed to induce clinically relevant TH-1-polarized immune responses, peripheral blood mononucle...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.29230
更新日期:2015-04-15 00:00:00
abstract::In light of recent, strong inverse findings between lifetime red wine consumption and prostate cancer among younger men, we revisited our previous cohort analysis to more thoroughly investigate red wine consumption and prostate cancer in the Health Professionals Follow-up Study (HPFS). In 1986, HPFS participants repor...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.22498
更新日期:2007-04-01 00:00:00
abstract::EBNA-positive lymphoblast cells were detected in 0.1 to 0.9% of the T-cell-depleted lymphocytes obtained from peripheral blood samples of five patients with infectious mononucleosis (IM). The same blood specimens from four of the five patients contained cells that formed EBNA-positive colonies in soft agar containing ...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.2910230603
更新日期:1979-06-15 00:00:00
abstract::Estrogen signaling plays an important role in breast carcinogenesis. An increased understanding of estrogen gene targets and their effects will allow for more directed and effective therapies for individuals with breast cancer, particularly those with estrogen receptor positive tumors resistant to tamoxifen therapy. H...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.26239
更新日期:2012-05-15 00:00:00
abstract::With the improvement of treatments, a growing number of survivors with childhood or adolescent central nervous system (CNS) tumor are parenting their own children. We aimed to explore the risk of somatic diseases among children of these survivors compared to population controls. Children of survivors with CNS tumor be...
journal_title:International journal of cancer
pub_type: 杂志文章
doi:10.1002/ijc.33394
更新日期:2020-11-13 00:00:00