COX-2 and p53 in human sinonasal cancer: COX-2 expression is associated with adenocarcinoma histology and wood-dust exposure.


:The causal role of wood-dust exposure in sinonasal cancer (SNC) has been established in epidemiological studies, but the mechanisms of SNC carcinogenesis are still largely unknown. Increased amounts of COX-2 are found in both premalignant and malignant tissues, and experimental evidence link COX-2 to development of cancer. Many signals that activate COX-2 also induce tumor suppressor p53, a transcription factor central in cellular stress response. We investigated COX-2 and p53 expressions by immunohistochemistry in 50 SNCs (23 adenocarcinomas, and 27 squamous cell carcinomas (SCC); 48 analyzed for COX-2; 41 for p53). Occupational histories and smoking habits were available for majority of the cases. Most of the adenocarcinoma cases with exposure history data had been exposed to wood dust at work in the past (88%, 14/16). For smokers, 63% (12/19) presented with SSC, whereas 64% (7/11) of nonsmokers displayed adenocarcinoma. COX-2 was expressed at higher levels in adenocarcinoma as compared to SSC (p < 0.001). COX-2 expression showed significant association with occupational exposure to wood dust (p = 0.024), and with nonsmoking status (p = 0.001). No statistically significant associations between the exposures and p53 accumulation were found; however, the p53 accumulation pattern (p = 0.062 for wood dust exposure) resembled that of COX-2 expression. In summary, our findings show increased COX-2 expression in SNC adenocarcinoma with wood dust exposure, suggesting a role for inflammatory components in the carcinogenesis process. In contrast, SCCs predominated among smokers and expressed COX-2 rarely; this may suggest at least partially different molecular mechanisms.


Int J Cancer


Holmila R,Cyr D,Luce D,Heikkilä P,Dictor M,Steiniche T,Stjernvall T,Bornholdt J,Wallin H,Wolff H,Husgafvel-Pursiainen K




Has Abstract


2008-05-01 00:00:00












  • Age- and sex-specific cumulative rate and risk of ATLL for HTLV-I carriers.

    abstract::We have surveyed the incidence of adult T-cell leukemia/lymphoma (ATLL) in an endemic area of 290,464 inhabitants for 7 years. We now revise our previous results on the basis of additional findings and estimate the age- and sex-specific cumulative rate for HTLV-I carriers, the adoption of which is recommended by curre...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kondo T,Kono H,Miyamoto N,Yoshida R,Toki H,Matsumoto I,Hara M,Inoue H,Inatsuki A,Funatsu T

    更新日期:1989-06-15 00:00:00

  • OTX2 directly activates cell cycle genes and inhibits differentiation in medulloblastoma cells.

    abstract::The transcription factor OTX2 has been implicated as an oncogene in medulloblastoma, which is the most common malignant brain tumor in children. It is highly expressed in most medulloblastomas and amplified in a subset of them. To study the role OTX2 has in medulloblastoma we investigated the downstream pathway of OTX...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bunt J,Hasselt NE,Zwijnenburg DA,Hamdi M,Koster J,Versteeg R,Kool M

    更新日期:2012-07-15 00:00:00

  • Delayed primary excision with subsequent modification of radiotherapy dose for intermediate-risk rhabdomyosarcoma: a report from the Children's Oncology Group Soft Tissue Sarcoma Committee.

    abstract::The majority of intermediate-risk rhabdomyosarcoma (RMS) patients have gross residual disease (Group III) after their first operative procedure. It is currently not known if local control rates can be maintained when, following induction chemotherapy, the radiation therapy (RT) dose is decreased after a delayed primar...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rodeberg DA,Wharam MD,Lyden ER,Stoner JA,Brown K,Wolden SL,Paidas CN,Donaldson SS,Hawkins DS,Spunt SL,Arndt CA

    更新日期:2015-07-01 00:00:00

  • Inhibition by lymphoblastoid interferon of growth of cells derived from the human breast.

    abstract::Human lymphoblastoid interferon inhibited the growth in vitro of fibroblasts and epithelial cells from normal, hyperplastic and neoplastic human breast tissue. At an interferon concentration of 10(3) inter-national units (IU) per ml, the inhibitory effects on monolayer growth were completely reversible but the growth ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Balkwill F,Watling D,Taylor-Papadimitriou J

    更新日期:1978-09-15 00:00:00

  • Modulation of T leukaemic cell phenotype with phorbol ester.

    abstract::A panel of monoclonal antibodies and other markers (e.g., terminal deoxynucleotidyl transferase, sheep erythrocyte rosettes, peanut agglutinin) have been used in conjunction with flow cytometry and biochemical analysis to monitor the induction of maturation in human thymic (T) leukaemic cell lines by phorbol ester (TP...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Delia D,Greaves MF,Newman RA,Sutherland DR,Minowada J,Kung P,Goldstein G

    更新日期:1982-01-15 00:00:00

  • Hormone sensitivity in vitro and in vivo of v-ras-transfected MCF-7 cell derivatives.

    abstract::Human mammary carcinoma cell lines (MCF-7) were analysed for their hormone sensitivity before and after transfection with a v-Ha-ras oncogene or with a neomycin-resistance gene followed by selection in vitro or in vivo. Our aim was to test how the expression of the ras oncogene would influence the estradiol sensitivit...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Van Roy F,Mareel M,Vleminckx K,Beyaert R,Fiers W,Devleeschouwer N,Muquardt C,Legros N,Bracke M,Leclercq G

    更新日期:1990-09-15 00:00:00

  • Dysbindin as a novel biomarker for pancreatic ductal adenocarcinoma identified by proteomic profiling.

    abstract::Pancreatic adenocarcinoma (PDAC) is known to have a poor prognosis partly because of lack of effective biomarkers. In the test set, we investigated dysbindin (DTNBP1) as a potential biomarker for PDAC by comparing preoperative and postoperative serum mass spectrometry (MS) proteomic profilings. Of the included 50 PDAC...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Guo X,Lv X,Fang C,Lv X,Wang F,Wang D,Zhao J,Ma Y,Xue Y,Bai Q,Yao X,Chen Y

    更新日期:2016-10-15 00:00:00

  • Diabetes mellitus and risk of prostate cancer in the health professionals follow-up study.

    abstract::History of diabetes may be associated with decreased prostate cancer (PCa) risk. Published studies have not always accounted for time since diabetes diagnosis or confounding and effect modification by lifestyle factors. The authors investigated the relationship between diabetes and PCa risk in men in the Health Profes...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kasper JS,Liu Y,Giovannucci E

    更新日期:2009-03-15 00:00:00

  • Smokeless tobacco use and risk of cancer of the pancreas and other organs.

    abstract::Limited data are available on the carcinogenicity of smokeless tobacco products in organs other than the mouth. Snus is a smokeless tobacco product widely used in Norway. We studied 10,136 Norwegian men enrolled since 1966 in a prospective cohort study, 31.7% of whom were exposed to snus. The relative risk of pancreat...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Boffetta P,Aagnes B,Weiderpass E,Andersen A

    更新日期:2005-05-10 00:00:00

  • Uterine carcinosarcoma is derived from a single stem cell: an in vitro study.

    abstract::Expression of intermediate filaments (IFs) has been suggested to be a reliable marker for differentiating epithelial and non-epithelial tumors. Moreover, the c-erbB-2 and p53 genes are considered to be involved relatively early in the process of human carcinogenesis. In order to elucidate the origin of uterine carcino...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Gorai I,Yanagibashi T,Taki A,Udagawa K,Miyagi E,Nakazawa T,Hirahara F,Nagashima Y,Minaguchi H

    更新日期:1997-09-04 00:00:00

  • Oncogenicity of Friend-virus-infected cells: determination of origin of spleen colonies by the H-2 antigens as genetic markers.

    abstract::Spleen cells from mice infected with Friend leukemia virus (FLV) inoculated by the intravenous route give rise to macroscopically visible colonies in the spleens of normal F1 histocompatible hybrid hosts. A study of H-2 antigens as generic markers for identification of strains of origin of cells constituting the splee...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wendling F,Tambourin PE

    更新日期:1978-10-15 00:00:00

  • Cotargeting BET proteins overcomes resistance arising from PI3K/mTOR blockade-induced protumorigenic senescence in colorectal cancer.

    abstract::Therapeutics targeting the phosphatidylinositol 3-kinase/mammalian target of rapamycin (PI3K/mTOR) pathway initially produce potent antitumor effects, but resistance frequently occurs. Using a phosphoproteome analysis, we found that colorectal cancer (CRC) cells exhibit resistance against PI3K/mTOR inhibition through ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lee HS,Lee S,Cho KH

    更新日期:2020-11-15 00:00:00

  • Identification of inbred mouse strains harboring genetic modifiers of mammary tumor age of onset and metastatic progression.

    abstract::Metastasis is one of the most important and complex processes in human neoplastic disease. A large number of both positive and negative events must occur to permit a tumor cell to colonize a distant site successfully. To identify mouse strains that harbor dominant genetic modifiers of this process, a strain survey was...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lifsted T,Le Voyer T,Williams M,Muller W,Klein-Szanto A,Buetow KH,Hunter KW

    更新日期:1998-08-12 00:00:00

  • Expression patterns of mitotic and meiotic cell cycle regulators in testicular cancer and development.

    abstract::Mitotic and meiotic cell cycle regulation is essential for normal development and tumor prevention. The underlying molecular mechanisms are not completely characterized. The aim of our analysis was to derive a global expression map of cell cycle regulators in mitosis and meiosis. First, the expression of cyclins, CDKs...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Diederichs S,Bäumer N,Schultz N,Hamra FK,Schrader MG,Sandstede ML,Berdel WE,Serve H,Müller-Tidow C

    更新日期:2005-08-20 00:00:00

  • Risk of developing pancreatic cancer in families with familial atypical multiple mole melanoma associated with a specific 19 deletion of p16 (p16-Leiden).

    abstract::Familial atypical multiple mole melanoma (FAMMM) is an autosomal dominant disease characterized by the familial occurrence of malignant melanoma of the skin and multiple atypical precursor lesions. Germline mutations in the p16 (CDKN2A) gene have been reported in at least a quarter of such families. An association has...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vasen HF,Gruis NA,Frants RR,van Der Velden PA,Hille ET,Bergman W

    更新日期:2000-09-15 00:00:00

  • IGFBP-3 prolongs the p53 response and enhances apoptosis following UV irradiation.

    abstract::Neoplastic transformation is characterised by an imbalance in favour of cell growth over programmed cell death (apoptosis). The tumour-suppressor gene p53, responsible for maintaining cell-cycle control, is mutated in the majority of human cancers. Loss of function of the target genes of p53 are therefore important in...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hollowood AD,Lai T,Perks CM,Newcomb PV,Alderson D,Holly JM

    更新日期:2000-11-01 00:00:00

  • A novel tumor-based epithelial-to-mesenchymal transition score that associates with prognosis and metastasis in patients with Stage II/III colorectal cancer.

    abstract::It is increasingly appreciated that host factors within the tumor center and microenvironment play a key role in dictating colorectal cancer (CRC) outcomes. As a result, the metastatic process has now been defined as a result of epithelial-mesenchymal transition (EMT). Establishment of the role of EMT within the tumor...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Roseweir AK,Kong CY,Park JH,Bennett L,Powell AGMT,Quinn J,van Wyk HC,Horgan PG,McMillan DC,Edwards J,Roxburgh CS

    更新日期:2019-01-01 00:00:00

  • Decreased expression of phosphorylated JNK in breast infiltrating ductal carcinoma is associated with a better overall survival.

    abstract::Phosphorylation/activation of c-jun NH2-terminal kinase (JNK) has an ambivalent role, pro-proliferation or antiproliferation, in human cancers, which is determined by different cell types and by its crosstalk with other kinases. So far, the role of phosphorylated JNK (p-JNK) in breast cancer is mostly undefined. In th...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yeh YT,Hou MF,Chung YF,Chen YJ,Yang SF,Chen DC,Su JH,Yuan SS

    更新日期:2006-06-01 00:00:00

  • Multiple myeloma: a review of the epidemiologic literature.

    abstract::Multiple myeloma, a neoplasm of plasma cells, accounts for approximately approximately 15% of lymphatohematopoietic cancers (LHC) and 2% of all cancers in the US. Incidence rates increase with age, particularly after age 40, and are higher in men, particularly African American men. The etiology is unknown with no esta...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Alexander DD,Mink PJ,Adami HO,Cole P,Mandel JS,Oken MM,Trichopoulos D

    更新日期:2007-01-01 00:00:00

  • Abrogation of tumor-inhibitory MRC-OX8+ (CD8+) effector T-cell generation in rats by selective depletion of neutrophils in vivo using a monoclonal antibody.

    abstract::These studies were designed to examine the role of neutrophils in transplantation immunity to syngeneic rat tumors. We have earlier reported that specific transplantation immunity to syngeneic transplanted tumors is abrogated by selective depletion of peripheral-blood neutrophils by administration of a monoclonal anti...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tanaka E,Sendo F

    更新日期:1993-04-22 00:00:00

  • Immuno-selection in vivo of H-2D phenotypic variants from a metastatic clone of sarcoma cells results in cell lines of altered metastatic competence.

    abstract::To find out whether manipulation of H-2 expression on metastatic cells could alter their metastatic properties, we immunoselected in vivo H-2 antigen variants from a metastatic clone of the T10 sarcoma [originating in a (C57BL/6J X C3H.eB)FI mouse] and tested their metastatic capacity. The unselected metastatic cells ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Katzav S,Segal S,Feldman M

    更新日期:1984-03-15 00:00:00

  • Permissive expansion and homing of adoptively transferred T cells in tumor-bearing hosts.

    abstract::Activated T cells expressing endogenous or transduced TCRs are two cell types currently used in clinical adoptive T-cell therapy. The ability of these cells to recognize their antigen, expand and traffic to the tumor site are the initial steps necessary for successful therapy. In this study, we used in vivo biolumines...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Perez C,Jukica A,Listopad JJ,Anders K,Kühl AA,Loddenkemper C,Blankenstein T,Charo J

    更新日期:2015-07-15 00:00:00

  • NOTCH, ASCL1, p53 and RB alterations define an alternative pathway driving neuroendocrine and small cell lung carcinomas.

    abstract::Small cell lung cancers (SCLCs) and extrapulmonary small cell cancers (SCCs) are very aggressive tumors arising de novo as primary small cell cancer with characteristic genetic lesions in RB1 and TP53. Based on murine models, neuroendocrine stem cells of the terminal bronchioli have been postulated as the cellular ori...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Meder L,König K,Ozretić L,Schultheis AM,Ueckeroth F,Ade CP,Albus K,Boehm D,Rommerscheidt-Fuss U,Florin A,Buhl T,Hartmann W,Wolf J,Merkelbach-Bruse S,Eilers M,Perner S,Heukamp LC,Buettner R

    更新日期:2016-02-15 00:00:00

  • Menopausal hormone therapy and risk of colorectal cancer in the European Prospective Investigation into Cancer and Nutrition.

    abstract::Menopausal hormone therapy (HT) may influence colorectal cancer risk. A total of 136,275 postmenopausal women from the European Prospective Investigation into Cancer and Nutrition were followed for an average of 9 years, during which time 1,186 colorectal cancers were diagnosed. Hazard ratios (HR) and 95% confidence i...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Tsilidis KK,Allen NE,Key TJ,Sanjoaquin MA,Bakken K,Berrino F,Fournier A,Lund E,Overvad K,Olsen A,Tjønneland A,Byrnes G,Chajes V,Rinaldi S,Boutron-Ruault MC,Clavel-Chapelon F,Chang-Claude J,Kaaks R,Bergmann M,Boeing

    更新日期:2011-04-15 00:00:00

  • Activation of PPARalpha inhibits IGF-I-mediated growth and survival responses in medulloblastoma cell lines.

    abstract::Recent studies suggest a potential role of lipid lowering drugs, fibrates and statins, in anticancer treatment. One candidate for tumor chemoprevention is fenofibrate, which is a potent agonist of peroxisome proliferator activated receptor alpha (PPARalpha). Our results demonstrate elevated expression of PPARalpha in ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Urbanska K,Pannizzo P,Grabacka M,Croul S,Del Valle L,Khalili K,Reiss K

    更新日期:2008-09-01 00:00:00

  • Immunohistochemical analysis of p16INK4a, p14ARF, p18INK4c, p21CIP1, p27KIP1 and p73 expression in 271 meningiomas correlation with tumor grade and clinical outcome.

    abstract::Routine pathological examination cannot distinctively predict the clinical course of meningiomas because even histologically benign tumors may recur after gross total resection. Numerous efforts have been made for the evaluation of different immunohistochemical assays in meningioma prognosis. We investigated the progn...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Korshunov A,Shishkina L,Golanov A

    更新日期:2003-05-10 00:00:00

  • Mammary tumor latency is increased in mice lacking the inducible nitric oxide synthase.

    abstract::Nitric oxide (NO) and its metabolites are implicated in carcinogenesis and metastasis. Both stimulatory and inhibitory effects of NO have been reported in relation to breast cancer and its role in the development of malignancies and metastasis remains uncertain. We have used the polyomavirus middle T antigen (PyV-mT) ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ellies LG,Fishman M,Hardison J,Kleeman J,Maglione JE,Manner CK,Cardiff RD,MacLeod CL

    更新日期:2003-08-10 00:00:00

  • Cancer registration and healthcare access in West Bank, Palestine: a GIS analysis of childhood cancer, 1998-2007.

    abstract::In low and middle income countries (LMIC), high-quality disease registration is difficult to achieve in the setting of inadequate healthcare infrastructure and political or economical instability. In this article, we explore the potential of geographic information systems (GIS) to add value to the understanding of chi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Bailony MR,Hararah MK,Salhab AR,Ghannam I,Abdeen Z,Ghannam J

    更新日期:2011-09-01 00:00:00

  • The relationship between blood IL-12p40 level and melanoma progression.

    abstract::Cytokines such as Interleukin (IL)-12p70 ("IL-12") and IL-23 can influence tumor progression. We tested the hypothesis that blood levels of IL-12p40, the common subunit of both cytokines, are associated with melanoma progression. Blood from 2,048 white melanoma patients were collected at a single institution between M...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Fang S,Wang Y,Chun YS,Liu H,Ross MI,Gershenwald JE,Cormier JN,Royal RE,Lucci A,Schacherer CW,Reveille JD,Sui D,Bassett RL Jr,Wang LE,Wei Q,Amos CI,Lee JE

    更新日期:2015-04-15 00:00:00

  • HS3ST2 modulates breast cancer cell invasiveness via MAP kinase- and Tcf4 (Tcf7l2)-dependent regulation of protease and cadherin expression.

    abstract::Heparan sulfate 3-O-sulfotransferase 2 (HS3ST2), an enzyme mediating 3-O-sulfation of heparan sulfate (HS), is silenced by hypermethylation in breast cancer. As HS has an important co-receptor function for numerous signal transduction pathways, the phenotypical changes due to HS3ST2 reexpression were investigated in v...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vijaya Kumar A,Salem Gassar E,Spillmann D,Stock C,Sen YP,Zhang T,Van Kuppevelt TH,Hülsewig C,Koszlowski EO,Pavao MS,Ibrahim SA,Poeter M,Rescher U,Kiesel L,Koduru S,Yip GW,Götte M

    更新日期:2014-12-01 00:00:00