Abstract：
:Experimental studies have consistently shown a protective effect of nonsteroidal antiinflammatory drugs (NSAIDs) against nonmelanoma skin cancers (NMSC). However, little human epidemiological research has been done in this regard. We used data from the Skin Cancer Chemoprevention Study to explore the association of NSAID use and with the risk of basal-cell carcinoma (BCC) and squamous-cell carcinoma (SCC). 1,805 subjects with a recent history of NMSC were randomized to placebo or 50 mg of daily beta-carotene. Participants were asked about their use of over-the-counter and prescription medications at baseline and every 4 months during the trial. Skin follow-up examinations were scheduled annually with a study dermatologist; confirmed lesions were the endpoints in the study. We used a risk set approach to the analysis of grouped times survival data and unconditional logistic regression to compute odds ratios [ORs] for various exposures to NSAIDs. The use of NSAIDs was reported in over 50% of questionnaires. For BCC, NSAIDs exhibited a weak protective effect in crude analyses, which attenuated markedly after adjustment. For SCC, the use of NSAIDs in the year previous to diagnosis reduced the odds by almost 30% (adjusted OR=0.71, 95% CI 0.48-1.04). When we accounted for frequency of use, results for BCC were not striking, and there were inconsistent suggestions of an inverse association with SCC. There were some indications of a modest, nonsignificant reduction on the number of BCCs and SCCs with NSAID use. Our data suggest a weak and inconsistent chemopreventive effect of NSAIDs on BCC and SCC.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Grau MV,Baron JA,Langholz B,Karagas M,Greenberg ER,Stukel TA,Mandel JSdoi
10.1002/ijc.21878keywords:
subject
Has Abstractpub_date
2006-08-01 00:00:00pages
682-6issue
3eissn
0020-7136issn
1097-0215journal_volume
119pub_type
杂志文章abstract：:India has the highest burden of cervical cancer in the world. To estimate the consequences of delaying implementation of organized cervical cancer screening, we projected the avertable burden of disease under different implementation scenarios of a screening program. We used an individual-based microsimulation model o...
journal_title：International journal of cancer
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abstract：:The mechanisms involved in mucosal immune control of cervical human papillomavirus (HPV) infection remain ill defined. Because toll-like receptors (TLRs) are key players in innate immune responses, we investigated the association between TLR expression and viral persistence or clearance in young women with incident in...
journal_title：International journal of cancer
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journal_title：International journal of cancer
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journal_title：International journal of cancer
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journal_title：International journal of cancer
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journal_title：International journal of cancer
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journal_title：International journal of cancer
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更新日期：1980-12-15 00:00:00
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journal_title：International journal of cancer
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更新日期：1998-07-29 00:00:00
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journal_title：International journal of cancer
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journal_title：International journal of cancer
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更新日期：1995-09-15 00:00:00
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更新日期：2001-05-20 00:00:00
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journal_title：International journal of cancer
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journal_title：International journal of cancer
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更新日期：1981-12-01 00:00:00
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