Effect of different platelet agonists on intracellular free Ca++ concentrations in human tumor cells: possible role in tumor growth.


:Modulation of cytoplasmic Ca++ concentration is a mechanism common to signal transduction pathways regulating many cellular phenomena, including the interactions of tumors with the hemostatic system. We have investigated the pro-aggregating and pro-coagulant activities of human tumor cell lines cultured in vitro and the ability of different platelet agonists to induce Ca++ transients in these cells. Cells of a malignant mesothelioma line activated platelets by a thrombin-dependent mechanism; on the contrary, HeLa cells, derived from a uterine cervical cancer, possessed ADP-dependent pro-aggregating activity, and DND-IA melanoma cells did not stimulate platelet aggregation. All cell lines showed a tissue-factor-like procoagulant property, more pronounced in mesothelioma cells. Furthermore, ADP was able to induce a transient increase in cytoplasmic Ca++ concentration in tumor cells from all lines; collagen showed this effect in mesothelioma cells and in HeLa cells, and thrombin was effective only in mesothelioma cells. PAF never induced Ca++ fluxes in any of the cell lines investigated. Finally, the calcium-channel blocker verapamil inhibited agonist-induced Ca++ transients in tumor cells and in vitro tumor-cell growth. These data may help to identify new possible mechanisms of the 2-way interaction of tumors with the hemostatic system.


Int J Cancer


Saporiti A,Brocchieri A,Porta C,Moroni M,Grignani G




Has Abstract


1995-07-28 00:00:00












  • Lymphangiogenesis in colorectal cancer--prognostic and therapeutic aspects.

    abstract::Colorectal cancer (CRC) represents the second most common cause of cancer mortality in the western world. The tumors frequently show metastatic spread which affects different organs such as lymph nodes, liver and lungs. Although the pattern of spread may vary, the initial step usually involves dissemination to regiona...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: Sundlisaeter E,Dicko A,Sakariassen PØ,Sondenaa K,Enger PØ,Bjerkvig R

    更新日期:2007-10-01 00:00:00

  • MicroRNA-31 expression in relation to BRAF mutation, CpG island methylation and colorectal continuum in serrated lesions.

    abstract::The CpG island methylator phenotype (CIMP) is a distinct form of epigenomic instability. Many CIMP-high colorectal cancers (CRCs) with BRAF mutation are considered to arise from serrated pathway. We recently reported that microRNA-31 (miR-31) is associated with BRAF mutation in colorectal tumors. Emerging new approach...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ito M,Mitsuhashi K,Igarashi H,Nosho K,Naito T,Yoshii S,Takahashi H,Fujita M,Sukawa Y,Yamamoto E,Takahashi T,Adachi Y,Nojima M,Sasaki Y,Tokino T,Baba Y,Maruyama R,Suzuki H,Imai K,Yamamoto H,Shinomura Y

    更新日期:2014-12-01 00:00:00

  • Postdiagnosis weight change is associated with poorer survival in breast cancer survivors: A prospective population-based patient cohort study.

    abstract::More women are surviving after breast cancer due to early detection and modern treatment strategies. Body weight also influences survival. We aimed to characterize associations between postdiagnosis weight change and prognosis in postmenopausal long-term breast cancer survivors. We used data from a prospective populat...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jung AY,Hüsing A,Behrens S,Krzykalla J,Obi N,Becher H,Chang-Claude J

    更新日期:2021-01-01 00:00:00

  • Enhancement of colorectal tumor targeting using a novel biparatopic monoclonal antibody against carcinoembryonic antigen in experimental radioimmunoguided surgery.

    abstract::Biparatopic CEA, carcinoembryonic antigen (MAb) was newly designed and tested as to whether it enhanced the accuracy of tumor detection by reducing non-specific binding in experimental radioimmunoguided surgery. Biparatopic MAb was prepared by using cross-linking of reduced Fab' fragments from PR1A3 and T84.66. Fifty-...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kim JC,Roh SA,Koo KH,Ryu JH,Hong HK,Oh SJ,Ryu JS,Kim HJ,Bodmer WF

    更新日期:2002-02-01 00:00:00

  • Transient immunological and clinical effectiveness of treating mice bearing premalignant oral lesions with PD-1 antibodies.

    abstract::A carcinogen-induced premalignant oral lesion model that progresses to oral cancer was used to examine the impact of blocking PD-1 on cytokine expression and on progression of lesions to cancer. The results of this study show increased production of IL-2 and the inflammatory cytokines IL-6, IL-17 and TNF-α by spleen c...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Levingston CA,Young MR

    更新日期:2017-04-01 00:00:00

  • Leukemic progenitor cells are susceptible to targeting by stimulated cytotoxic T cells against immunogenic leukemia-associated antigens.

    abstract::Leukemic stem cells (LSC) might be the source for leukemic disease self-renewal and account for disease relapse after treatment, which makes them a critical target for further therapeutic options. We investigated the role of cytotoxic T-lymphocytes (CTL) counteracting and recognizing LSC. Leukemia-associated antigens ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Schneider V,Zhang L,Rojewski M,Fekete N,Schrezenmeier H,Erle A,Bullinger L,Hofmann S,Götz M,Döhner K,Ihme S,Döhner H,Buske C,Feuring-Buske M,Greiner J

    更新日期:2015-11-01 00:00:00

  • Detection of integrated papillomavirus sequences by ligation-mediated PCR (DIPS-PCR) and molecular characterization in cervical cancer cells.

    abstract::Human papillomavirus (HPV) genomes usually persist as episomal molecules in HPV associated preneoplastic lesions whereas they are frequently integrated into the host cell genome in HPV-related cancers cells. This suggests that malignant conversion of HPV-infected epithelia is linked to recombination of cellular and vi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Luft F,Klaes R,Nees M,Dürst M,Heilmann V,Melsheimer P,von Knebel Doeberitz M

    更新日期:2001-04-01 00:00:00

  • A novel EGR-1 dependent mechanism for YB-1 modulation of paclitaxel response in a triple negative breast cancer cell line.

    abstract::Chemotherapy with taxanes such as paclitaxel (PTX) is a key component of triple negative breast cancer (TNBC) treatment. PTX is used in combination with other drugs in both the adjuvant setting and in advanced breast cancer. Because a proportion of patients respond poorly to PTX or relapse after its use, a greater und...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lasham A,Mehta SY,Fitzgerald SJ,Woolley AG,Hearn JI,Hurley DG,Ruza I,Algie M,Shelling AN,Braithwaite AW,Print CG

    更新日期:2016-09-01 00:00:00

  • COX-2 and p53 in human sinonasal cancer: COX-2 expression is associated with adenocarcinoma histology and wood-dust exposure.

    abstract::The causal role of wood-dust exposure in sinonasal cancer (SNC) has been established in epidemiological studies, but the mechanisms of SNC carcinogenesis are still largely unknown. Increased amounts of COX-2 are found in both premalignant and malignant tissues, and experimental evidence link COX-2 to development of ca...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Holmila R,Cyr D,Luce D,Heikkilä P,Dictor M,Steiniche T,Stjernvall T,Bornholdt J,Wallin H,Wolff H,Husgafvel-Pursiainen K

    更新日期:2008-05-01 00:00:00

  • Toward a real liquid biopsy in metastatic breast and prostate cancer: Diagnostic LeukApheresis increases CTC yields in a European prospective multicenter study (CTCTrap).

    abstract::Frequently, the number of circulating tumor cells (CTC) isolated in 7.5 mL of blood is too small to reliably determine tumor heterogeneity and to be representative as a "liquid biopsy". In the EU FP7 program CTCTrap, we aimed to validate and optimize the recently introduced Diagnostic LeukApheresis (DLA) to screen lit...

    journal_title:International journal of cancer

    pub_type: 杂志文章,多中心研究


    authors: Andree KC,Mentink A,Zeune LL,Terstappen LWMM,Stoecklein NH,Neves RP,Driemel C,Lampignano R,Yang L,Neubauer H,Fehm T,Fischer JC,Rossi E,Manicone M,Basso U,Marson P,Zamarchi R,Loriot Y,Lapierre V,Faugeroux V,Oulhen

    更新日期:2018-11-15 00:00:00

  • Cervical nitric oxide release and persistence of high-risk human papillomavirus in women.

    abstract::Nitric oxide may serve as one cofactor for human papillomavirus (HPV)-induced development of cervical cancer. Therefore, we first assessed the levels of cervical fluid nitric oxide metabolite (NOx) in 283 women with and without high-risk (hr) HPV. The NOx level in women with hr HPV (48.4 μmol/L [95% CI: 39.4-56.6], n ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rahkola P,Väisänen-Tommiska M,Tuomikoski P,Ylikorkala O,Mikkola TS

    更新日期:2011-06-15 00:00:00

  • Antitumor effects of 4-methylumbelliferone, a hyaluronan synthesis inhibitor, on malignant peripheral nerve sheath tumor.

    abstract::Hyaluronan (HA) has been shown to play important roles in the growth, invasion and metastasis of malignant tumors. Our previous study showing that high HA expression in malignant peripheral nerve sheath tumors (MPNST) is predictive of poor patient prognosis, prompted us to speculate that inhibition of HA synthesis in ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Ikuta K,Ota T,Zhuo L,Urakawa H,Kozawa E,Hamada S,Kimata K,Ishiguro N,Nishida Y

    更新日期:2017-01-15 00:00:00

  • Statin use and mortality among ovarian cancer patients: A population-based cohort study.

    abstract::Statin use has been suggested to improve prognosis in cancer patients, however, for ovarian cancer, the evidence is sparse. From the Danish Cancer Registry, we identified patients aged 30-84 years with a histologically verified first diagnosis of epithelial ovarian cancer between 2000 and 2013. Data on filled prescrip...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Verdoodt F,Kjaer Hansen M,Kjaer SK,Pottegård A,Friis S,Dehlendorff C

    更新日期:2017-07-15 00:00:00

  • Methylselenol prodrug enhances MDV3100 efficacy for treatment of castration-resistant prostate cancer.

    abstract::The next-generation antiandrogen MDV3100 prolongs overall survival of patients with metastatic castration-resistant prostate cancer (CRPC). However, patient responses are variable, and survival benefit remains relatively small. Developing effective modality to improve MDV3100 efficacy is urgently needed. Recent eviden...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Zhan Y,Cao B,Qi Y,Liu S,Zhang Q,Zhou W,Xu D,Lu H,Sartor O,Kong W,Zhang H,Dong Y

    更新日期:2013-11-01 00:00:00

  • Delayed primary excision with subsequent modification of radiotherapy dose for intermediate-risk rhabdomyosarcoma: a report from the Children's Oncology Group Soft Tissue Sarcoma Committee.

    abstract::The majority of intermediate-risk rhabdomyosarcoma (RMS) patients have gross residual disease (Group III) after their first operative procedure. It is currently not known if local control rates can be maintained when, following induction chemotherapy, the radiation therapy (RT) dose is decreased after a delayed primar...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Rodeberg DA,Wharam MD,Lyden ER,Stoner JA,Brown K,Wolden SL,Paidas CN,Donaldson SS,Hawkins DS,Spunt SL,Arndt CA

    更新日期:2015-07-01 00:00:00

  • Tumor-associated macrophage-targeted therapeutics in ovarian cancer.

    abstract::Ovarian cancer is one of the most common gynecological malignancies. The tumor microenvironment plays an important role in regulating the progression of ovarian cancer. Macrophages, which are important immune cells in the tumor microenvironment, participate in the regulation of various biological behaviors and influen...

    journal_title:International journal of cancer

    pub_type: 杂志文章,评审


    authors: An Y,Yang Q

    更新日期:2020-11-24 00:00:00

  • Enzymatic oxidation products of spermine induce greater cytotoxic effects on human multidrug-resistant colon carcinoma cells (LoVo) than on their wild-type counterparts.

    abstract::The occurrence of resistance to cytotoxic agents in tumor cells, associated with several phenotypic alterations, is one of the major obstacles to successful anticancer chemotherapy. A new strategy to overcome MDR of human cancer cells was studied, using BSAO, which generates cytotoxic products from spermine, H(2)O(2) ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Calcabrini A,Arancia G,Marra M,Crateri P,Befani O,Martone A,Agostinelli E

    更新日期:2002-05-01 00:00:00

  • Parity, age at first birth and the risk of carcinoma in situ of the breast.

    abstract::Epidemiological studies of in situ breast cancer are sparse, and the role of reproductive history, an established risk modifier for invasive breast cancer, remains incompletely investigated. To examine possible associations with parity and age at first birth, we undertook a case-control study nested in a nationwide co...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Lambe M,Hsieh CC,Tsaih SW,Ekbom A,Trichopoulos D,Adami HO

    更新日期:1998-07-29 00:00:00

  • HER2-positive patients receiving trastuzumab treatment have a comparable prognosis with HER2-negative advanced gastric cancer patients: a prospective cohort observation.

    abstract::The monoclonal antibody trastuzumab has brought survival benefit to patients with advanced gastric cancer (AGC) that have human epidermal growth factor receptor 2 (HER2) over expression or amplification. This study was designed to compare the clinical outcomes of HER2-negative and HER2-positive AGC patients with or wi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Qiu MZ,Li Q,Wang ZQ,Liu TS,Liu Q,Wei XL,Jin Y,Wang DS,Ren C,Bai L,Zhang DS,Wang FH,Li YH,Xu RH

    更新日期:2014-05-15 00:00:00

  • Suppression of pancreatic cancer growth and metastasis by HMP19 identified through genome-wide shRNA screen.

    abstract::Therapeutic effectiveness against metastatic or even locally advanced pancreatic ductal adenocarcinoma (PDAC) is dismal, with 5-year survival less than 5%. Even in patients who undergo potentially curative resection, most patients' tumors recur in the liver. Improving therapies targeting or preventing liver metastases...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Kurahara H,Bohl C,Natsugoe S,Nishizono Y,Harihar S,Sharma R,Iwakuma T,Welch DR

    更新日期:2016-08-01 00:00:00

  • How many cervical cancers are prevented by treatment of screen-detected disease in young women?

    abstract::Others have argued that as many as a third of women treated for high-grade cervical intraepithelial neoplasia (CIN) would have developed cervical cancer in the absence of screening and treatment. Under various assumptions and using past data on CIN grade 3 (CIN3) registrations in England and Scotland, we estimate what...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Sasieni P,Castanon A,Parkin DM

    更新日期:2009-01-15 00:00:00

  • Seroreactivity to HPV16 virus-like particles as a marker for cervical cancer risk in high-risk populations.

    abstract::Sexually transmitted genital human papillomavirus (HPV) infection, most often HPV 16, is considered the major etiologic determinant of cervical cancer. However, some studies have found relatively low prevalences of genital tract HPV DNA in some geographical areas, such as Greenland, that have high rates of cervical ca...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nonnenmacher B,Kruger Kjaer S,Svare EI,Scott JD,Hubbert NL,van den Brule AJ,Kirnbauer R,Walboomers JM,Lowy DR,Schiller JT

    更新日期:1996-12-11 00:00:00

  • Effectiveness of sorafenib dose modifications on treatment outcome of hepatocellular carcinoma: Analysis in real-life settings.

    abstract::Controlling adverse events (AEs) through dose reduction can enhance drug adherence and treatment response. Currently, there is no guide for sorafenib dosing. The aim of this study was to evaluate whether sorafenib dosing could affect treatment outcomes. A total of 782 hepatocellular carcinoma (HCC) patients treated wi...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tak KY,Nam HC,Choi JY,Yoon SK,Kim CW,Kim HY,Lee SW,Lee HL,Chang UI,Song DS,Yang JM,Kwon JH,Yoo SH,Sung PS,Choi SW,Song MJ,Kim SH,Jang JW

    更新日期:2020-10-01 00:00:00

  • Pronounced antitumor efficacy of doxorubicin when given as the prodrug DOX-GA3 in combination with a monoclonal antibody beta-glucuronidase conjugate.

    abstract::A glucuronide doxorubicin prodrug N-[4-doxorubicin-N-carbonyl (oxymethyl) phenyl] O-beta-glucuronyl carbamate (DOX-GA3) has been developed to improve the antitumor effects of doxorubicin (DOX). The prodrug was originally designed to be activated into drug by human beta-glucuronidase (GUS) released from tumor cells in ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Houba PH,Boven E,van der Meulen-Muileman IH,Leenders RG,Scheeren JW,Pinedo HM,Haisma HJ

    更新日期:2001-02-15 00:00:00

  • Induction of carcinoembryonic antigen (CEA)-specific cytotoxic T-lymphocyte responses in vitro using autologous dendritic cells loaded with CEA peptide or CEA RNA in patients with metastatic malignancies expressing CEA.

    abstract::The application of dendritic cells (DC) to the active immunotherapy of cancer currently relies on the generation of potent DC capable of presenting tumor antigens such as carcinoembryonic antigen (CEA). It is unknown whether the T cells of patients with advanced malignancies can be reliably stimulated against tumor an...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Nair SK,Hull S,Coleman D,Gilboa E,Lyerly HK,Morse MA

    更新日期:1999-07-02 00:00:00

  • Expression profiling reveals that methylation of TIMP3 is involved in uveal melanoma development.

    abstract::Uveal melanoma is associated with a high tumor-related mortality due to the propensity to develop metastases. The mechanisms that are responsible for malignant dissemination are largely unknown and need to be explored to facilitate diagnosis and treatment of metastases. To identify molecules involved in dissemination,...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: van der Velden PA,Zuidervaart W,Hurks MH,Pavey S,Ksander BR,Krijgsman E,Frants RR,Tensen CP,Willemze R,Jager MJ,Gruis NA

    更新日期:2003-09-10 00:00:00

  • Site distribution of different types of skin cancer: new aetiological clues.

    abstract::Since the investigation, at an individual level, of lifetime sun exposure remains difficult the site distribution of different types of skin cancer can be an important source of aetiological clues. The present report deals with 1,149 cases of cutaneous malignant melanoma (CMM), 7,685 of basal-cell carcinoma (BCC) and ...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Franceschi S,Levi F,Randimbison L,La Vecchia C

    更新日期:1996-07-03 00:00:00

  • Recovery of leukocyte function after super-high-dose chemotherapy with peripheral blood stem cell transplantation in testicular cancer patients.

    abstract::Leukocyte functions (superoxide production and phagocytosis) were evaluated in patients with testicular cancer who had undergone super-high-dose chemotherapy (SHDT) with peripheral blood stem cell transplantation (PBSCT). In 5 patients with advanced or relapsed testicular cancer who received 8 cycles of SHDT with PBSC...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yamada Y,Hara I,Gohji K,Okada H,Arakawa S,Kamidono S

    更新日期:1997-07-03 00:00:00

  • Effect of synthetic matrix-metalloproteinase inhibitors on invasive capacity and proliferation of human malignant gliomas in vitro.

    abstract::Glioma invasion into the surrounding brain tissue is still a major obstacle for any therapeutical approach. As in other solid tumors, matrix-metalloproteases (MMPs) have been suggested as being involved. The aim of this study was to evaluate whether the use of MMP inhibitors to target the protease-mediated invasion pr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tonn JC,Kerkau S,Hanke A,Bouterfa H,Mueller JG,Wagner S,Vince GH,Roosen K

    更新日期:1999-03-01 00:00:00

  • The mutational landscape and prognostic indicators of pseudomyxoma peritonei originating from the ovary.

    abstract::Pseudomyxoma peritonei (PMP) is a rare disorder with unique pathological and genetic changes. Although several studies have reported the clinical features and mutational changes of PMP that originates from the appendix, few studies on PMP originating from the ovary have been reported due to its extreme rarity. In orde...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Wang B,Yao J,Ma R,Liu D,Lu Y,Shi G,An L,Xia A,Chen F,Pang S,Zhai X,Liu G,Chen S,Xu M,Song L,Xu H

    更新日期:2021-01-05 00:00:00