Abstract:
:Loss of heterozygosity (LOH) on chromosome 13 and the age of patients at operation were studied in 46 cases of retinoblastoma (RB) tumors, of which 25 were hereditary and 21 were non-hereditary. The frequency of LOH was 70% for all informative tumors, but significantly higher in non-hereditary tumors (90%) than in hereditary ones (52%). Our results suggest that LOH might be involved in the initial somatic events in non-hereditary tumors. Age at operation of patients with hereditary tumors was significantly lower than that of patients with non-hereditary tumors. Even when tumors associated with a family history were omitted from among the hereditary cases, the difference was still significant. In the case of hereditary tumors, age at operation of LOH-negative patients was significantly lower than that of LOH-positive patients. When tumors associated with a family history were omitted, the difference was still significant. The delay in development of LOH-positive tumors suggests that LOH for one chromosome 13 may be disadvantageous with respect to growth of RB tumors.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Kato MV,Ishizaki K,Ejima Y,Kaneko A,Tanooka H,Sasaki MSdoi
10.1002/ijc.2910540609subject
Has Abstractpub_date
1993-07-30 00:00:00pages
922-6issue
6eissn
0020-7136issn
1097-0215journal_volume
54pub_type
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