Lifestyle factors, autoimmune disease and family history in prognosis of non-hodgkin lymphoma overall and subtypes.


:Lifestyle factors and medical history are known to influence risk of non-Hodgkin lymphoma (NHL). Whether these factors affect the prognosis of NHL, especially its subtypes, is unclear. To investigate this, the association between these factors and all-cause and lymphoma-related mortality was assessed in a population-based cohort of 1,523 Swedish NHL patients included in the Scandinavian Lymphoma Etiology study in 1999-2002. Participants contributed time from NHL diagnosis until death or October 1, 2010, with virtually complete follow-up through linkage to the Swedish Cause of Death Register. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using stratified and multivariable-adjusted Cox regression models. During a median follow-up of 8.8 years, 670 patients (44%) died, with the majority of deaths attributed to lymphoma (86%). Current versus never smoking at diagnosis was associated with increased rate of all-cause death for all NHL (HR = 1.5, 1.2-1.8) and diffuse large B-cell lymphoma (HR = 1.8, 1.2-2.7). Low educational level (HR = 1.3, 1.1-1.7, <9 vs. >12 years) and NHL risk-associated autoimmune disease (HR = 1.4, 1.0-1.8) were associated with death for all NHL combined. However, evidence of an association with lymphoma-related death was limited. Body mass index, recent sunbathing and family history of hematopoietic malignancy were not consistently associated with death after NHL or its specific subtypes. These results add to the evidence that cigarette smoking, socioeconomic status and certain autoimmune diseases affect survival after NHL. Further investigations are needed to determine how these factors should be incorporated into clinical prognostic assessment.


Int J Cancer


Simard JF,Baecklund F,Chang ET,Baecklund E,Hjalgrim H,-Olov Adami H,Glimelius B,Smedby KE




Has Abstract


2013-06-01 00:00:00












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    pub_type: 杂志文章


    authors: König J,Hartel M,Nies AT,Martignoni ME,Guo J,Büchler MW,Friess H,Keppler D

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    authors: Vuk-Pavlović S,Bozikov V,Pavelić K

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    pub_type: 杂志文章


    authors: Chang CP,Siwakoti B,Sapkota A,Gautam DK,Lee YA,Monroe M,Hashibe M

    更新日期:2020-08-01 00:00:00

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    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Mantovani A,Tagliabue A,Dean JH,Jerrells TR,Herberman RB

    更新日期:1979-01-15 00:00:00

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    abstract::A pilot case-control study on bladder cancer, with population-based controls matched for each of 74 cases, has been conducted in two industrial areas of Southern Belgium in order to analyze the influence of tobacco use and occupation. Observed bladder cancer risk for smokers is more than 5 times higher than that for n...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Schifflers E,Jamart J,Renard V

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  • By inhibiting PFKFB3, aspirin overcomes sorafenib resistance in hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is one of the few cancers with a continuous increase in incidence and mortality. Drug resistance is a major problem in the treatment of HCC. In this study, two sorafenib-resistant HCC cell lines and a nude mouse subcutaneously tumor model were used to explore the possible mechanisms lead...

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    pub_type: 杂志文章


    authors: Li S,Dai W,Mo W,Li J,Feng J,Wu L,Liu T,Yu Q,Xu S,Wang W,Lu X,Zhang Q,Chen K,Xia Y,Lu J,Zhou Y,Fan X,Xu L,Guo C

    更新日期:2017-12-15 00:00:00

  • Synchronous multiple primary gastrointestinal cancer exhibits frequent microsatellite instability.

    abstract::Colorectal (CRC) and gastric cancers (GC), the most common gastrointestinal malignancies, have been known to develop occasionally in a same patient. Previous studies have focused on the etiology of patients with multiple primary gastric and colorectal cancer (MPGCC); however, the carcinogenic process of MPGCC remains ...

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    pub_type: 杂志文章


    authors: Ohtani H,Yashiro M,Onoda N,Nishioka N,Kato Y,Yamamoto S,Fukushima S,Hirakawa-Ys Chung K

    更新日期:2000-06-01 00:00:00

  • Effect of synthetic matrix-metalloproteinase inhibitors on invasive capacity and proliferation of human malignant gliomas in vitro.

    abstract::Glioma invasion into the surrounding brain tissue is still a major obstacle for any therapeutical approach. As in other solid tumors, matrix-metalloproteases (MMPs) have been suggested as being involved. The aim of this study was to evaluate whether the use of MMP inhibitors to target the protease-mediated invasion pr...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Tonn JC,Kerkau S,Hanke A,Bouterfa H,Mueller JG,Wagner S,Vince GH,Roosen K

    更新日期:1999-03-01 00:00:00

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    abstract::Increased levels of hypoxia and hypoxia-inducible factor 1α (HIF-1α) in human sarcomas correlate with tumor progression and radiation resistance. Prolonged antiangiogenic therapy of tumors not only delays tumor growth but may also increase hypoxia and HIF-1α activity. In our recent clinical trial, treatment with the v...

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    authors: Kim YJ,Lee HJ,Kim TM,Eisinger-Mathason TS,Zhang AY,Schmidt B,Karl DL,Nakazawa MS,Park PJ,Simon MC,Yoon SS

    更新日期:2013-01-01 00:00:00

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    abstract::Epigenetic modification of gene expression plays an important role in the development of human cancers. The inactivation of SPARC through CpG island methylation was studied in colon cancers using oligonucleotide microarray analysis and methylation specific PCR (MSP). Gene expression of 7 colon cancer cell lines was ev...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Yang E,Kang HJ,Koh KH,Rhee H,Kim NK,Kim H

    更新日期:2007-08-01 00:00:00

  • Lifetime and baseline alcohol intake and risk of cancer of the upper aero-digestive tract in the European Prospective Investigation into Cancer and Nutrition (EPIC) study.

    abstract::Recent alcohol consumption is an established risk factor for squamous cell carcinoma (SCC) of the upper aero-digestive tract. In contrast, the role of lifetime exposure to alcohol with regard to risk of SCC is not well established. Historical data on alcohol use are available in 271,253 participants of the European Pr...

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    pub_type: 杂志文章


    authors: Weikert C,Dietrich T,Boeing H,Bergmann MM,Boutron-Ruault MC,Clavel-Chapelon F,Allen N,Key T,Lund E,Olsen A,Tjønneland A,Overvad K,Rohrmann S,Linseisen J,Pischon T,Trichopoulou A,Weinehall L,Johansson I,Sánchez MJ,Ag

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    abstract::A single treatment of chick embryo fibroblasts with DNA recovered from chick embryo fibroblasts productively infected and transformed with four different strains of RSV, or productively infected with two different strains of RAV, resulted in virus production and cell transformation (in the case of RSV) two or three p...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Vigier P,Montagnier L

    更新日期:1975-01-15 00:00:00

  • Postdiagnosis weight change is associated with poorer survival in breast cancer survivors: A prospective population-based patient cohort study.

    abstract::More women are surviving after breast cancer due to early detection and modern treatment strategies. Body weight also influences survival. We aimed to characterize associations between postdiagnosis weight change and prognosis in postmenopausal long-term breast cancer survivors. We used data from a prospective populat...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Jung AY,Hüsing A,Behrens S,Krzykalla J,Obi N,Becher H,Chang-Claude J

    更新日期:2021-01-01 00:00:00

  • Modulation of intra-epithelial expansion of human T24 bladder-carcinoma cells in murine urothelium by growth factors and extracellular-matrix components.

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    authors: Rebel JM,Thijssen CD,Vermey M,Zwarthoff EC,Van der Kwast TH

    更新日期:1995-03-03 00:00:00

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    abstract::Target-specific acute myeloid leukemia (AML) immunotherapy requires selective cell-surface antigens on AML blast cells. CD64 is a promising candidate antigen because it is abundantly expressed on monocytoid differentiated AML subtypes. In previous studies, a chemically linked full-length anti-CD64 immunotoxin based on...

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    authors: Tur MK,Huhn M,Jost E,Thepen T,Brümmendorf TH,Barth S

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    abstract::Endostatin, the proteolytic fragment of collagen XVIII, is an inhibitor of angiogenesis and tumor growth. Interestingly, elevated circulating endostatin levels have been found to correlate with poor patients' prognosis in several cancers. The aim of this study was to assess the prognostic value of endostatin in bladde...

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    authors: Szarvas T,László V,Vom Dorp F,Reis H,Szendröi A,Romics I,Tilki D,Rübben H,Ergün S

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    abstract::Since no large descriptive studies of incident cancers in HIV-infected patients are available in France, the nationwide cross-sectional ONCOVIH study aimed to prospectively report new malignancies diagnosed in HIV-infected patients in cancer centers and HIV/AIDS centers. We estimated the number of cancers in France fo...

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    authors: Lanoy E,Spano JP,Bonnet F,Guiguet M,Boué F,Cadranel J,Carcelain G,Couderc LJ,Frange P,Girard PM,Oksenhendler E,Poizot-Martin I,Semaille C,Agut H,Katlama C,Costagliola D,ONCOVIH study group.

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    abstract::Lethal phenotypes of human prostate cancer are characterized by progression to androgen-independence and metastasis. For want of a clinically relevant animal model, mechanisms behind this progression remain unclear. Our study used an in vivo model of androgen-sensitive LNCaP human prostate cancer cell xenografts in ma...

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    authors: Zhou JR,Yu L,Zerbini LF,Libermann TA,Blackburn GL

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  • Anti-tumor activity of mycophenolate mofetil against human and mouse tumors in vivo.

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    authors: Tressler RJ,Garvin LJ,Slate DL

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    abstract::Tumorigenesis of head and neck squamous cell carcinomas (HNSCC) is associated with various genetic changes such as loss of heterozygosity (LOH) on human chromosome 18q21. This chromosomal region maps a gene cluster coding for a family of intracellular serine protease inhibitors (serpins), including SERPINB13. As SERPI...

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    authors: de Koning PJ,Bovenschen N,Leusink FK,Broekhuizen R,Quadir R,van Gemert JT,Hordijk GJ,Chang WS,van der Tweel I,Tilanus MG,Kummer JA

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  • Adoptive transfer of human natural killer cells in mice with severe combined immunodeficiency inhibits growth of Hsp70-expressing tumors.

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    authors: Multhoff G,Pfister K,Botzler C,Jordan A,Scholz R,Schmetzer H,Burgstahler R,Hiddemann W

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  • Isothiocyanates, glutathione S-transferase M1 and T1 polymorphisms and gastric cancer risk: a prospective study of men in Shanghai, China.

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    authors: Moy KA,Yuan JM,Chung FL,Wang XL,Van Den Berg D,Wang R,Gao YT,Yu MC

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    authors: Boccardo F,Marenghi C,Ghione G,Pepe A,Parodi S,Rubagotti A

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    abstract::Chemotherapy-induced gastrointestinal toxicity (CIGT) occurs in up to 80% of all patients undergoing cancer treatment, and leads to symptoms such as diarrhoea, abdominal bleeding and pain. There is currently limited understanding of how to predict an individual patient's risk of CIGT. It is believed the gut microbiome...

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    authors: Secombe KR,Coller JK,Gibson RJ,Wardill HR,Bowen JM

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    abstract::The p16INK4a gene product acts as a negative regulator of the cell cycle by binding to cyclin-dependent kinases (CDKs) 4 and 6, thereby inhibiting the formation of an active CDK/cyclin D complex. Deletion of the p16 locus has been observed in tumor cell lines and, less frequently, in primary human neoplasms. We analyz...

    journal_title:International journal of cancer

    pub_type: 杂志文章


    authors: Hegi ME,zur Hausen A,Rüedi D,Malin G,Kleihues P

    更新日期:1997-09-26 00:00:00

  • Comparison of 131I-labelled anti-episialin 139H2 with cisplatin, cyclophosphamide or external-beam radiation for anti-tumor efficacy in human ovarian cancer xenografts.

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    pub_type: 杂志文章


    authors: Molthoff CF,Pinedo HM,Schlüper HM,Rutgers DH,Boven E

    更新日期:1992-04-22 00:00:00

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    pub_type: 杂志文章


    authors: Ohshima K,Karube K,Hamasaki M,Suefuji H,Tutiya T,Yamaguchi T,Suzumiya J,Kikuchi M

    更新日期:2003-09-20 00:00:00

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    pub_type: 杂志文章


    authors: Isakov N,Segal S,Hollander N,Feldman M

    更新日期:1978-10-15 00:00:00

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    abstract::A population-based study was conducted on 256 southern Chinese with cervical intraepithelial neoplasia grade III (CIN III) or invasive cervical cancer (ICC) and on 258 controls to examine the associations between HLA-B alleles, infection with high-risk human papillomaviruses (HPVs) and the development of cervical neop...

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    pub_type: 杂志文章


    authors: Chan PK,Cheung JL,Cheung TH,Lin CK,Tam AO,Chan DP,Zhou DX,Lo KW,Yim SF,Siu SS

    更新日期:2006-03-15 00:00:00

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    pub_type: 杂志文章


    authors: Zucker S,DiMassimo BI,Lysik RM,Vuaridel-Bonanomi E

    更新日期:1991-01-21 00:00:00