Abstract：
:Lifestyle factors and medical history are known to influence risk of non-Hodgkin lymphoma (NHL). Whether these factors affect the prognosis of NHL, especially its subtypes, is unclear. To investigate this, the association between these factors and all-cause and lymphoma-related mortality was assessed in a population-based cohort of 1,523 Swedish NHL patients included in the Scandinavian Lymphoma Etiology study in 1999-2002. Participants contributed time from NHL diagnosis until death or October 1, 2010, with virtually complete follow-up through linkage to the Swedish Cause of Death Register. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using stratified and multivariable-adjusted Cox regression models. During a median follow-up of 8.8 years, 670 patients (44%) died, with the majority of deaths attributed to lymphoma (86%). Current versus never smoking at diagnosis was associated with increased rate of all-cause death for all NHL (HR = 1.5, 1.2-1.8) and diffuse large B-cell lymphoma (HR = 1.8, 1.2-2.7). Low educational level (HR = 1.3, 1.1-1.7, <9 vs. >12 years) and NHL risk-associated autoimmune disease (HR = 1.4, 1.0-1.8) were associated with death for all NHL combined. However, evidence of an association with lymphoma-related death was limited. Body mass index, recent sunbathing and family history of hematopoietic malignancy were not consistently associated with death after NHL or its specific subtypes. These results add to the evidence that cigarette smoking, socioeconomic status and certain autoimmune diseases affect survival after NHL. Further investigations are needed to determine how these factors should be incorporated into clinical prognostic assessment.
journal_name
Int J Cancerjournal_title
International journal of cancerauthors
Simard JF,Baecklund F,Chang ET,Baecklund E,Hjalgrim H,-Olov Adami H,Glimelius B,Smedby KEdoi
10.1002/ijc.27944subject
Has Abstractpub_date
2013-06-01 00:00:00pages
2659-66issue
11eissn
0020-7136issn
1097-0215journal_volume
132pub_type
杂志文章abstract：:Angiogenesis inhibitors have been used to treat some cancers, but the therapeutic potential of these agents for gastric cancer has remained unclear. To investigate their therapeutic potential, we examined the effect of ZD6474, an agent that selectively targets vascular endothelial growth factor receptor-2 (VEGFR-2; KD...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.21340
更新日期：2006-01-15 00:00:00
abstract：:Effects of pretreatment with BCG, strain Japan, on tumor growth were studied using a transplatable methylcholanthrene (MCA)-induced fibrosarcoma in C3H/He mice. Injection of BCG7 weeks before tumor inoculation at a site distant from the tumor caused a slight inhibition of tumor growth. A low dose of tumor cells did no...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910210112
更新日期：1978-01-15 00:00:00
abstract：:Quality of life outcomes provide essential information for patients and physicians in oncology care. However, the validity of progression-free survival (PFS) as a surrogate for quality of life, and the inclusion and reporting of quality of life endpoints in clinical trials, is unclear. We performed a retrospective stu...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.31957
更新日期：2019-04-01 00:00:00
abstract：:The effects on breast cancer mortality seen after 16 years of biennial screening of younger women are assessed in this prospective cohort study. Since 1975 some 13,500 women, aged 35-49 in 1975, were invited to participate in the Nijmegen screening programme comprising a mammographic examination every 2 years. By the ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910600614
更新日期：1995-03-16 00:00:00
abstract：:Cytotoxic antibodies against glioblastoma-associated antigen(s) have been sought for in glioma patient sera. Complement-dependent cytotoxicity (CDC) I and antibody-dependent cell-mediated cytotoxicity (ADCC) assays were used to test sera from 80 patients using 51 Cr labelled target cells derived from eight different g...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910250209
更新日期：1980-02-15 00:00:00
abstract：:The growth properties of a human melanoma cell line (MeWo) and of a variant (MeWo-LC1) endowed with higher metastatic potential in nude mice were compared using hormonally-defined serum-free media. The two cell lines failed to arrest in G0 following serum deprivation, and responded to INS and MSA but not to EGF, PDGF ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910370120
更新日期：1986-01-15 00:00:00
abstract：:Oncogenic HPV types are the major cause of worldwide cervical cancer, but only a small proportion of infected women will develop high-grade cervical intraepithelial neoplasia or cancer (CIN2/3+). We performed a prospective study including 781 women with normal, atypical squamous cells of undetermined significance (ASC...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.11222
更新日期：2003-09-01 00:00:00
abstract：:There is good evidence for an association between Epstein-Barr virus (EBV) and Hodgkin's disease (HD). In approximately one-third of cases, the EBV genome is detectable in Reed-Sternberg (RS) cells and there is expression of the viral nuclear antigen EBNA-1 and the latent membrane protein LMP-1. Expression of LMP-2 ha...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19970807)72:4<614::aid-ijc
更新日期：1997-08-07 00:00:00
abstract：:The standard treatment for invasive bladder cancer is radical cystectomy. In selected patients, bladder-sparing therapy can be performed by transurethral resection (TURBT) and radio-chemotherapy (RCT) or radiotherapy (RT). Our published in vitro data suggest that the Neuropilin-2 (NRP2)/VEGF-C axis plays a role in the...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.28987
更新日期：2015-01-15 00:00:00
abstract：:Benign breast disease (BBD) is an established breast cancer (BC) risk factor, but it is unclear whether the magnitude of the association applies to women at familial or genetic risk. This information is needed to improve BC risk assessment in clinical settings. Using the Prospective Family Study Cohort, we used Cox pr...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.32112
更新日期：2019-07-15 00:00:00
abstract：:The effect of interferon on the long-term clinical outcome of patients with chronic hepatitis C remains unclear. This study included 594 patients with chronic hepatitis C who received interferon-alpha therapy (Interferon group) and 144 patients with chronic hepatitis C who did not receive interferon (Control group). T...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：
更新日期：2000-09-01 00:00:00
abstract：:The ability of verapamil to overcome resistance to adriamycin in a multidrug-resistant derivative of the V79 cell line (LZ), grown as multicellular spheroids or as monolayers, was examined. Verapamil was much less effective in overcoming resistance to adriamycin in spheroids than in monolayers. Verapamil increased the...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910590222
更新日期：1994-10-15 00:00:00
abstract：:Epidemiologic evidence on the association of antioxidant intake and prostate cancer incidence is inconsistent. Total antioxidant intake and prostate cancer incidence have not previously been examined. Using the ferric-reducing antioxidant potential (FRAP) assay, the total antioxidant content (TAC) of diet and suppleme...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.28438
更新日期：2014-03-01 00:00:00
abstract：:Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors of the digestive tract. These tumors span a wide clinical spectrum from benign to malignant and have long been recognized for their nearly absolute resistance to chemotherapy and radiation treatment. We reviewed the worldwide experience on ...
journal_title：International journal of cancer
pub_type： 杂志文章,评审
doi：10.1002/ijc.11374
更新日期：2003-11-01 00:00:00
abstract：:A clonal cell line, 1-1ras1000, transformed by the activated c-Ha-ras oncogene, does not form metastases after i.v. injection into mice (experimental metastasis assay). Here, we show that this cell line is useful as a recipient to detect metastasis-inducing genes, using a transfection assay. Cells (1-1ras1000) were su...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/(sici)1097-0215(19970328)71:1<88::aid-ijc1
更新日期：1997-03-28 00:00:00
abstract：:Although childhood exposure to ionizing radiation is a well-established risk factor for thyroid cancer, the risk associated with adulthood exposure remains unclear. We prospectively examined the association between cumulative, low-to-moderate dose occupational radiation exposure to the thyroid and thyroid cancer incid...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.31270
更新日期：2018-11-01 00:00:00
abstract：:The effects of the tumor promoter -12-O-tetradecanoyl phorbol-13-acetate, its analogues, and other tumor promoters, on the proliferation of human skin fibroblasts (SF) have been investigated. We have previously shown (Kopelovich and Bias, 1979), that TPA caused a biphasic (upward concave) dose effect in the cloning ef...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910340608
更新日期：1984-12-15 00:00:00
abstract：:While the association between fruit consumption and bladder cancer risk has been extensively reported, studies have had inadequate statistical power to investigate associations between types of fruit and bladder cancer risk satisfactorily. Fruit consumption in relation to bladder cancer risk was investigated by poolin...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.33008
更新日期：2020-10-15 00:00:00
abstract：:As with cyclooxygenase (COX)-2, genetic disruption of COX-1 gene or pharmacologic inhibition of its activity has been shown to decrease the number of intestinal polyps in Apc gene-deficient mice. The present study was designed to investigate the combined effects of COX-1 and COX-2 selective inhibitors on spontaneous p...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.20012
更新日期：2004-04-20 00:00:00
abstract：:A pilot case-control study on bladder cancer, with population-based controls matched for each of 74 cases, has been conducted in two industrial areas of Southern Belgium in order to analyze the influence of tobacco use and occupation. Observed bladder cancer risk for smokers is more than 5 times higher than that for n...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910390304
更新日期：1987-03-15 00:00:00
abstract：:A human ovarian adenocarcinoma cell line (PE04) has been established as a xenograft in nude mice. In vitro, this cell line is estrogen receptor (ER)-positive and its growth is stimulated by 17 beta-estradiol at concentrations between 10(-12) and 10(-6) M. When xenografted, PE04 cells remain ER-positive and also posses...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910550323
更新日期：1993-09-30 00:00:00
abstract：:The relationship between breast cancer and radiation treatment for cervical cancer was evaluated in an international study of 953 women who subsequently developed breast cancer and 1,806 matched controls. Radiation doses to the breast (average 0.31 Gy) and ovaries (average 32 Gy) were reconstructed for exposed subject...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910440103
更新日期：1989-07-15 00:00:00
abstract：:BW 5147 lymphoma cells are non-invasive tumor cells which do not generate experimental metastases following i.v. inoculation. In contrast, s.c. and intra-splenic (i.s.) growth of BW cells resulted in widespread colonization of liver and spleen. Cells derived from either s.c. tumors or metastatic lesions did generate m...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910410514
更新日期：1988-05-15 00:00:00
abstract：:Oligodeoxynucleotides containing CpG motifs (CpG-ODN) display broad immunostimulating activity and are currently under clinical trial in various malignancies, including recurrent glioblastomas. Combining CpG-ODN with another therapy that could induce antigen release might enhance tumor-specific immune response. We inv...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.21131
更新日期：2005-10-10 00:00:00
abstract：:TDE2, a gene with sequence similarity to the mouse testicular tumor-differentially-expressed (Tde1/MUSTETU) gene, was identified by serial analysis of gene expression (SAGE) in nonsmall cell lung cancers (NSCLC). Here we characterized the TDE2 gene and determined its transcript levels in a panel of lung tumors, adjace...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.11391
更新日期：2003-11-01 00:00:00
abstract：:Human papilloma virus (HPV) infection is considered as an important aetiological factor for anal squamous cell carcinoma (ASCC) but is not sufficient for tumour progression. This carcinoma is poorly understood at the molecular level. Using the largest cohort of cases to date we investigated the molecular mechanisms un...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.23028
更新日期：2007-12-15 00:00:00
abstract：:Oncogenic PIK3CA mutations contribute to colorectal tumorigenesis by activating AKT signaling to decrease apoptosis and increase tumor invasion. A synergistic association of PIK3CA mutation with KRAS mutation has been suggested to increase AKT signaling and resistance to antiepidermal growth factor receptor inhibitor ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.26440
更新日期：2012-08-15 00:00:00
abstract：:Some ovarian cancer cells in vivo are in a reversible quiescent state where they can contribute to cancer spread under favorable growth conditions. The serine/threonine kinase Mirk/dyrk1B was expressed in each of seven ovarian cancer cell lines and in 21 of 28 resected human ovarian cancers, and upregulated in 60% of ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.25692
更新日期：2011-07-15 00:00:00
abstract：:High BMI is a well-known risk factor for postmenopausal breast cancer. There have been some reports of excess risk in association with weight gain and WHR, but little is known about the influence of body fatness per se. Using data from the Malmö Diet and Cancer Study, a prospective cohort study, 12,159 postmenopausal ...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.10799
更新日期：2003-01-10 00:00:00
abstract：:In Greenland, the incidence of cervical cancer is 5.7 times higher than in Denmark among women aged 20-39. From Nuuk (Greenland) and Nykøbing Falster (Denmark) a sample of 800 women aged 20-39 years was drawn at random. A total of 586 and 661 women were investigated in Greenland and Denmark respectively. All women had...
journal_title：International journal of cancer
pub_type： 杂志文章
doi：10.1002/ijc.2910410408
更新日期：1988-04-15 00:00:00
